    <SEC-DOCUMENT>0001193125-18-175433-index.html : 20180525
    <SEC-HEADER>0001193125-18-175433.hdr.sgml : 20180525
    <ACCEPTANCE-DATETIME>20180525164809
    ACCESSION NUMBER:		0001193125-18-175433
    CONFORMED SUBMISSION TYPE:	424B4
    PUBLIC DOCUMENT COUNT:		7
    FILED AS OF DATE:		20180525
    DATE AS OF CHANGE:		20180525

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			Iterum Therapeutics plc
    		CENTRAL INDEX KEY:			0001659323
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				000000000
    		STATE OF INCORPORATION:			L2
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		424B4
    		SEC ACT:		1933 Act
    		SEC FILE NUMBER:	333-224582
    		FILM NUMBER:		18862174

    	BUSINESS ADDRESS:
    		STREET 1:		BLOCK 2 FLOOR 3, HARCOURT CENTRE
    		STREET 2:		HARCOURT STREET
    		CITY:			DUBLIN
    		STATE:			L2
    		ZIP:			2
    		BUSINESS PHONE:		(872) 225-6077

    	MAIL ADDRESS:
    		STREET 1:		BLOCK 2 FLOOR 3, HARCOURT CENTRE
    		STREET 2:		HARCOURT STREET
    		CITY:			DUBLIN
    		STATE:			L2
    		ZIP:			2

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	Iterum Therapeutics Ltd
    		DATE OF NAME CHANGE:	20151124
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>424B4
    <SEQUENCE>1
    <FILENAME>d522368d424b4.htm
    <DESCRIPTION>424B4
    <TEXT>
    Document 1 - file: d522368d424b4.htm

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    <SEQUENCE>2
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    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 2 - file: g522368g19c10.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>3
    <FILENAME>g522368g20i14.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 3 - file: g522368g20i14.jpg

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    <DOCUMENT>
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    <SEQUENCE>4
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    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 4 - file: g522368g29x80.jpg

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    <DOCUMENT>
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    <SEQUENCE>5
    <FILENAME>g522368g43z47.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 5 - file: g522368g43z47.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>6
    <FILENAME>g522368g47p15.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 6 - file: g522368g47p15.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>7
    <FILENAME>g522368g73n73.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 7 - file: g522368g73n73.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>