<SEC-DOCUMENT>0001193125-20-274638.txt : 20201022
<SEC-HEADER>0001193125-20-274638.hdr.sgml : 20201022
<ACCEPTANCE-DATETIME>20201022214924
ACCESSION NUMBER:		0001193125-20-274638
CONFORMED SUBMISSION TYPE:	S-1MEF
PUBLIC DOCUMENT COUNT:		7
<REFERENCE-462B>333-249432
FILED AS OF DATE:		20201022
DATE AS OF CHANGE:		20201022
EFFECTIVENESS DATE:		20201022

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Iterum Therapeutics plc
		CENTRAL INDEX KEY:			0001659323
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			L2
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-1MEF
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-249621
		FILM NUMBER:		201255921

	BUSINESS ADDRESS:	
		STREET 1:		BLOCK 2 FLOOR 3, HARCOURT CENTRE
		STREET 2:		HARCOURT STREET
		CITY:			DUBLIN
		STATE:			L2
		ZIP:			2
		BUSINESS PHONE:		(872) 225-6077

	MAIL ADDRESS:	
		STREET 1:		BLOCK 2 FLOOR 3, HARCOURT CENTRE
		STREET 2:		HARCOURT STREET
		CITY:			DUBLIN
		STATE:			L2
		ZIP:			2

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Iterum Therapeutics Ltd
		DATE OF NAME CHANGE:	20151124
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-1MEF
<SEQUENCE>1
<FILENAME>d873161ds1mef.htm
<DESCRIPTION>S-1MEF
<TEXT>
<HTML><HEAD>
<TITLE>S-1MEF</TITLE>
</HEAD>
 <BODY BGCOLOR="WHITE">


<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>As filed with the Securities and Exchange Commission on October&nbsp;22, 2020 </B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="right"><B>Registration <FONT STYLE="white-space:nowrap">No.&nbsp;333-&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT>
</B></P> <P STYLE="font-size:4pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P> <P STYLE="line-height:1.0pt;margin-top:0pt;margin-bottom:0pt;border-bottom:1px solid #000000">&nbsp;</P>
<P STYLE="line-height:3.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1px solid #000000">&nbsp;</P> <P STYLE="margin-top:4pt; margin-bottom:0pt; font-size:18pt; font-family:Times New Roman" ALIGN="center"><B>UNITED STATES </B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:18pt; font-family:Times New Roman" ALIGN="center"><B>SECURITIES AND EXCHANGE COMMISSION </B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:12pt; font-family:Times New Roman" ALIGN="center"><B>Washington, DC 20549 </B></P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P><center>
<P STYLE="line-height:6.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #000000;width:21%">&nbsp;</P></center> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:18pt; font-family:Times New Roman" ALIGN="center"><B>FORM <FONT
STYLE="white-space:nowrap">S-1</FONT> </B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:18pt; font-family:Times New Roman" ALIGN="center"><B>REGISTRATION STATEMENT </B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:12pt; font-family:Times New Roman" ALIGN="center"><B><I>UNDER </I></B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:12pt; font-family:Times New Roman" ALIGN="center"><B><I>THE
SECURITIES ACT OF&nbsp;1933 </I></B></P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P><center> <P STYLE="line-height:6.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #000000;width:21%">&nbsp;</P></center>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:24pt; font-family:Times New Roman" ALIGN="center"><B>ITERUM THERAPEUTICS PLC </B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>(Exact name of registrant as specified in its charter) </B></P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P><center>
<P STYLE="line-height:6.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #000000;width:21%">&nbsp;</P></center> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" ALIGN="center">


<TR>

<TD WIDTH="34%"></TD>

<TD VALIGN="bottom"></TD>
<TD WIDTH="32%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="32%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" ALIGN="center"><B>Ireland</B></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top" ALIGN="center"><B>2834</B></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top" ALIGN="center"><B><FONT STYLE="white-space:nowrap">98-1283148</FONT></B></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:8pt">
<TD VALIGN="top" ALIGN="center"><B>(State or other Jurisdiction<BR>of Incorporation or Organization)</B></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top" ALIGN="center"><B>(Primary Standard Industrial<BR>Classification Code Number)</B></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top" ALIGN="center"><B>(I.R.S. Employer<BR>Identification No.)</B></TD></TR>
</TABLE> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>Block 2 Floor 3, Harcourt Centre, </B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>Harcourt Street, </B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>Dublin
2, </B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>Ireland </B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>+353
1 9038920 </B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>(Address, including zip code, and telephone number, including area code, of registrant&#146;s principal executive offices)
</B></P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P><center> <P STYLE="line-height:6.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #000000;width:21%">&nbsp;</P></center>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>Corey N. Fishman </B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>President and Chief Executive Officer </B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>200 South Wacker Drive, Suite 2550 </B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>Chicago, Illinois 60606 </B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B><FONT
STYLE="white-space:nowrap">(312)&nbsp;778-6070</FONT> </B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>(Name, address, including zip code, and telephone number, including area code,
of agent for service) </B></P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P><center> <P STYLE="line-height:6.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #000000;width:21%">&nbsp;</P></center>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B><I>Copies to: </I></B></P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" ALIGN="center">


<TR>

<TD WIDTH="50%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="48%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>Brian A. Johnson</B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>Wilmer Cutler Pickering Hale and Dorr LLP</B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>7 World Trade Center</B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>250
Greenwich Street</B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>New York, New York 10007</B></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>Telephone: <FONT STYLE="white-space:nowrap">(212)&nbsp;230-8800</FONT></B></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top" ALIGN="center"><B>Robert F. Charron, Esq.<BR>Ellenoff Grossman&nbsp;&amp; Schole&nbsp;LLP<BR>1345 Avenue of the Americas<BR>New York, New York 10105<BR><FONT STYLE="white-space:nowrap">(212)&nbsp;370-1300</FONT></B></TD></TR>
</TABLE> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P><center> <P STYLE="line-height:6.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #000000;width:21%">&nbsp;</P></center>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman"><B>Approximate date of commencement of proposed sale to the public: </B>As soon as practicable after this registration statement is declared effective.<B>
</B> </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule&nbsp;415
under the Securities Act of 1933 check the following box:&nbsp;&nbsp;&#9746; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">If this Form is filed to register additional securities for
an offering pursuant to Rule&nbsp;462(b) under the Securities Act, please check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same
<FONT STYLE="white-space:nowrap">offering.&nbsp;&nbsp;&#9746;&nbsp;&nbsp;&nbsp;&nbsp;333-249432</FONT> </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">If this Form is a post-effective
amendment filed pursuant to Rule&nbsp;462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering.&nbsp;&nbsp;&#9744; </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">If this Form is a post-effective amendment filed pursuant to Rule&nbsp;462(d) under the Securities Act, check the following box and list the
Securities Act registration statement number of the earlier effective registration statement for the same offering.&nbsp;&nbsp;&#9744; </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a
<FONT STYLE="white-space:nowrap">non-accelerated</FONT> filer, a smaller reporting company or an emerging growth company. See the definitions of &#147;large accelerated filer,&#148; &#147;accelerated filer,&#148; &#147;smaller reporting
company&#148; and &#147;emerging growth company&#148; in <FONT STYLE="white-space:nowrap">Rule&nbsp;12b-2</FONT> of the Exchange Act. </P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" ALIGN="center">


<TR>

<TD WIDTH="25%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="26%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="23%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="23%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="bottom">Large&nbsp;accelerated&nbsp;filer&nbsp;&nbsp;&#9744;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom">Accelerated&nbsp;filer&nbsp;&nbsp;&#9744;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT STYLE="white-space:nowrap">Non-accelerated&nbsp;filer&nbsp;&nbsp;&#9746;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom">Smaller&nbsp;reporting&nbsp;company&nbsp;&nbsp;&#9746;</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom">Emerging growth company&nbsp;&nbsp;&#9746;</TD></TR>
</TABLE> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended
transition period for complying with any new or revised financial accounting standards provided pursuant to Section&nbsp;7(a)(2)(B) of the Securities Act.&nbsp;&nbsp;&#9746; </P>
<P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P><center> <P STYLE="line-height:6.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #000000;width:21%">&nbsp;</P></center>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>CALCULATION OF REGISTRATION FEE </B></P> <P STYLE="font-size:4pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" ALIGN="center">


<TR>

<TD WIDTH="72%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="13%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="13%"></TD></TR>


<TR STYLE="font-size:1px; ">
<TD COLSPAN="5" VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:1.00px solid #000000">&nbsp;</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:8pt">
<TD VALIGN="bottom" ALIGN="center" STYLE="BORDER-TOP:1px solid #000000"><B>Title of Each Class&nbsp;of Securities<BR>to be Registered<BR></B></TD>
<TD VALIGN="bottom" STYLE=" BORDER-LEFT:1px solid #000000; BORDER-TOP:1px solid #000000">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP ALIGN="center" STYLE="BORDER-TOP:1px solid #000000"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Proposed</B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Maximum<BR>Aggregate</B></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Offering&nbsp;Price(1)(2)(3)<BR></B></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-LEFT:1px solid #000000; BORDER-TOP:1px solid #000000">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP ALIGN="center" STYLE="BORDER-TOP:1px solid #000000"><B>Amount of<BR>Registration Fee(1)<BR></B></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-TOP:1px solid #000000"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Ordinary Shares, nominal value $0.01 per share(3)</P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-LEFT:1px solid #000000; BORDER-TOP:1px solid #000000">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP ALIGN="center" STYLE="BORDER-TOP:1px solid #000000">$2,500,000</TD>
<TD VALIGN="bottom" STYLE=" BORDER-LEFT:1px solid #000000; BORDER-TOP:1px solid #000000">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP ALIGN="center" STYLE="BORDER-TOP:1px solid #000000">$272.75</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-TOP:1px solid #000000"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman"><FONT STYLE="white-space:nowrap">Pre-funded</FONT> Warrants
to purchase Ordinary Shares(3)</P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-LEFT:1px solid #000000; BORDER-TOP:1px solid #000000">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-TOP:1px solid #000000"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-LEFT:1px solid #000000; BORDER-TOP:1px solid #000000">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-TOP:1px solid #000000"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-TOP:1px solid #000000"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Ordinary Shares issuable upon exercise of <FONT
STYLE="white-space:nowrap">Pre-funded</FONT> Warrants(3)(4)</P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-LEFT:1px solid #000000; BORDER-TOP:1px solid #000000">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-TOP:1px solid #000000"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-LEFT:1px solid #000000; BORDER-TOP:1px solid #000000">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-TOP:1px solid #000000"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-TOP:1px solid #000000"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Warrants to purchase Ordinary Shares (3)(4)(5)</P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-LEFT:1px solid #000000; BORDER-TOP:1px solid #000000">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-TOP:1px solid #000000"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-LEFT:1px solid #000000; BORDER-TOP:1px solid #000000">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-TOP:1px solid #000000"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-TOP:1px solid #000000"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Ordinary Shares issuable upon exercise of
Warrants(3)(4)(5)</P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-LEFT:1px solid #000000; BORDER-TOP:1px solid #000000">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP ALIGN="center" STYLE="BORDER-TOP:1px solid #000000">$1,875,000</TD>
<TD VALIGN="bottom" STYLE=" BORDER-LEFT:1px solid #000000; BORDER-TOP:1px solid #000000">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP ALIGN="center" STYLE="BORDER-TOP:1px solid #000000">$204.57</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-TOP:1px solid #000000"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Placement agent warrants to purchase Ordinary Shares and
Ordinary Shares issuable upon exercise thereof(6)</P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-LEFT:1px solid #000000; BORDER-TOP:1px solid #000000">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP ALIGN="center" STYLE="BORDER-TOP:1px solid #000000">$218,750</TD>
<TD VALIGN="bottom" STYLE=" BORDER-LEFT:1px solid #000000; BORDER-TOP:1px solid #000000">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP ALIGN="center" STYLE="BORDER-TOP:1px solid #000000">$23.87</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-TOP:1px solid #000000"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">&nbsp;&nbsp;&nbsp;&nbsp;Total</P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-LEFT:1px solid #000000; BORDER-TOP:1px solid #000000">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP ALIGN="center" STYLE="BORDER-TOP:1px solid #000000">$4,593,750</TD>
<TD VALIGN="bottom" STYLE=" BORDER-LEFT:1px solid #000000; BORDER-TOP:1px solid #000000">&nbsp;</TD>
<TD VALIGN="bottom" NOWRAP ALIGN="center" STYLE="BORDER-TOP:1px solid #000000">$501.19</TD></TR>
<TR STYLE="font-size:1px; ">
<TD COLSPAN="5" VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:1.00px solid #000000">&nbsp;</P></TD></TR>
<TR STYLE="font-size:1px; ">
<TD COLSPAN="5" VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:1.00px solid #000000">&nbsp;</P></TD></TR>
</TABLE>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left">(1)</TD>
<TD ALIGN="left" VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman; " ALIGN="left">Estimated solely for the purpose of calculating the registration fee pursuant to Rule&nbsp;457(o) under the
Securities Act of 1933, as amended. Represents only the additional number of securities being registered. Does not include the securities that the registrant previously registered on the registration statement on Form
<FONT STYLE="white-space:nowrap">S-1,</FONT> as amended (File No.&nbsp;333-249432). </P></TD></TR></TABLE>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left">(2)</TD>
<TD ALIGN="left" VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman; " ALIGN="left">Pursuant to Rule&nbsp;416(a) under the Securities Act of 1933, as amended, this registration statement shall
also cover an indeterminate number of additional securities that may from time to time be offered or issued to prevent dilution as a result of share splits, share dividends, dividends or other distributions, reclassifications, or similar
transactions. </P></TD></TR></TABLE>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left">(3)</TD>
<TD ALIGN="left" VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman; " ALIGN="left">The proposed maximum aggregate offering price of the Ordinary Shares and Warrants will be reduced on a <FONT
STYLE="white-space:nowrap"><FONT STYLE="white-space:nowrap">dollar-for-dollar</FONT></FONT> basis based on the offering price of any <FONT STYLE="white-space:nowrap">Pre-funded</FONT> Warrants and Warrants issued in the offering, and the proposed
maximum aggregate offering price of the <FONT STYLE="white-space:nowrap">Pre-funded</FONT> Warrants and Warrants to be issued in the offering will be reduced on a
<FONT STYLE="white-space:nowrap"><FONT STYLE="white-space:nowrap">dollar-for-dollar</FONT></FONT> basis based on the offering price of any Ordinary Shares and Warrants issued in the offering. Accordingly, the proposed maximum aggregate offering
price of the Ordinary Shares or <FONT STYLE="white-space:nowrap">Pre-funded</FONT> Warrants, as applicable, and Warrants is $2,500,000. </P></TD></TR></TABLE>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left">(4)</TD>
<TD ALIGN="left" VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman; " ALIGN="left">Filing fee included with the Ordinary Shares or <FONT STYLE="white-space:nowrap">Pre-funded</FONT> Warrants, as
applicable. </P></TD></TR></TABLE>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left">(5)</TD>
<TD ALIGN="left" VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman; " ALIGN="left">Pursuant to Staff Compliance and Disclosure Interpretation 240.06, equals the aggregate exercise price of the
Warrants. Each Warrant offered with an Ordinary Share or <FONT STYLE="white-space:nowrap">Pre-funded</FONT> Warrant, as applicable, is a Warrant to purchase 0.75 of an Ordinary Share. </P></TD></TR></TABLE>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left">(6)</TD>
<TD ALIGN="left" VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman; " ALIGN="left">Represents warrants issuable to H.C. Wainwright&nbsp;&amp;&nbsp;Co.,&nbsp;LLC, or its designees, to purchase a
number of Ordinary Shares equal to 7.0% of the aggregate number of Ordinary Shares and <FONT STYLE="white-space:nowrap">Pre-funded</FONT> Warrants being offered at an exercise price equal to 125% of the combined public offering price per Ordinary
Share and Warrant. </P></TD></TR></TABLE> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P><center> <P STYLE="line-height:6.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #000000;width:21%">&nbsp;</P></center>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><B>The Registration Statement shall become effective upon filing in accordance with Rule 462(b) under the Securities Act of 1933, as
amended.</B> </P> <P STYLE="font-size:10pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P> <P STYLE="line-height:1.0pt;margin-top:0pt;margin-bottom:0pt;border-bottom:1px solid #000000">&nbsp;</P>
<P STYLE="line-height:3.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1px solid #000000">&nbsp;</P>
</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always">
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">


<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>EXPLANATORY NOTE AND INCORPORATION BY REFERENCE </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">This registration statement is being filed with respect to the registration of (i)&nbsp;additional ordinary shares, nominal value $0.01 per
share (each an &#147;Ordinary Share&#148;), together with a warrant to purchase 0.75 of an Ordinary Share (each a &#147;Warrant&#148;), (ii) additional <FONT STYLE="white-space:nowrap">pre-funded</FONT> warrants to purchase one Ordinary Share (each
a <FONT STYLE="white-space:nowrap">&#147;Pre-funded</FONT> Warrant&#148;), together with a Warrant and (iii)&nbsp;additional placement agent warrants to purchase 7.0% of the aggregate number of Ordinary Shares and
<FONT STYLE="white-space:nowrap">Pre-funded</FONT> Warrants being offered (each a &#147;Placement Agent Warrant&#148;), of Iterum Therapeutics plc, an Irish public limited company, as set forth in the Registration Statement and the prospectus
contained therein, pursuant to Rule&nbsp;462(b) under the Securities Act of 1933, as amended. The contents of the earlier registration statement on Form <FONT STYLE="white-space:nowrap">S-1,</FONT> as amended
<FONT STYLE="white-space:nowrap">(File&nbsp;No.&nbsp;333-249432),</FONT> which was declared effective by the Securities and Exchange Commission (the &#147;Commission&#148;) on October&nbsp;22, 2020, are incorporated in this registration statement by
reference. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The required opinions and consents are listed on an Exhibit Index attached hereto and filed herewith. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The registrant hereby certifies to the Commission that (i)&nbsp;it has instructed its bank to pay the Commission the filing fee set forth in
the cover page of this registration statement by wire transfer of such amount to the Commission&#146;s account as soon as practicable (but no later than the close of business on October&nbsp;23, 2020); (ii) it will not revoke such instruction; and
(iii)&nbsp;it has sufficient funds in the relevant account to cover the amount of such filing fee. </P>
</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always">
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">


<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>EXHIBIT INDEX </B></P>
<P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" ALIGN="center">


<TR>

<TD></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="49%"></TD>

<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD></TD>

<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD WIDTH="8%"></TD>

<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD WIDTH="12%"></TD>

<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD WIDTH="9%"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:8pt">
<TD VALIGN="bottom" ALIGN="center"><B>Exhibit<BR>No.</B></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center"><B>Description of Document</B></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Filed with</B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>this</B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Registration</B></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Statement</B></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Incorporated</B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>by&nbsp;Reference</B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>herein
from</B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Form or</B></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Schedule</B></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center"><B>Filing&nbsp;Date</B></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>SEC&nbsp;File</B></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Number</B></P></TD></TR>


<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" NOWRAP ALIGN="center">5.1</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top"><A HREF="d873161dex51.htm">Opinion of A&amp;L Goodbody </A></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center">X</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" NOWRAP ALIGN="center">5.2</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top"><A HREF="d873161dex52.htm">Opinion of Wilmer Cutler Pickering Hale and Dorr LLP </A></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center">X</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" NOWRAP ALIGN="center">23.1</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top"><A HREF="d873161dex231.htm">Consent of KPMG, Independent Registered Public Accounting Firm </A></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center">X</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" NOWRAP ALIGN="center">23.2</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top"><A HREF="d873161dex51.htm">Consent of A&amp;L Goodbody (included in Exhibit 5.1) </A></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center">X</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" NOWRAP ALIGN="center">23.3</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top"><A HREF="d873161dex52.htm">Consent of Wilmer Cutler Pickering Hale and Dorr LLP (included in Exhibit 5.2) </A></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center">X</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" NOWRAP ALIGN="center">24.1</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top"><A HREF="http://www.sec.gov/Archives/edgar/data/1659323/000119312520267344/d80934ds1.htm">Power of Attorney </A></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center"><FONT STYLE="white-space:nowrap">S-1</FONT> (Exhibit&nbsp;24.1)</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center">October&nbsp;9,&nbsp;2020</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center"><FONT STYLE="white-space:nowrap">333-249432</FONT></TD></TR>
</TABLE>
</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always">
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">


<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>SIGNATURES </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Pursuant to the requirements of the Securities Act of 1933, the registrant has duly caused this Registration Statement on <FONT
STYLE="white-space:nowrap">Form&nbsp;S-1</FONT> to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Chicago, State of Illinois, on October&nbsp;22, 2020. </P>
<P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt">


<TR>

<TD WIDTH="45%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="4%"></TD>

<TD VALIGN="bottom"></TD>
<TD WIDTH="3%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="45%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="3"><B>ITERUM THERAPEUTICS PLC</B></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Date: October&nbsp;22, 2020</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">By:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">/s/ Corey N. Fishman</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">Name: Corey N. Fishman</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">Title: Chief Executive Officer</TD></TR>
</TABLE> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Pursuant to the requirements of the Securities Act of 1933, as amended, this registration statement has been signed by the
following persons in the capacities and on the dates indicated. </P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" ALIGN="center">


<TR>

<TD WIDTH="35%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="32%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="31%"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:8pt">
<TD VALIGN="bottom" NOWRAP ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Signature</B></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Title</B></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Date</B></P></TD></TR>


<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">/s/ Corey N. Fishman</P></TD>
<TD VALIGN="bottom" ROWSPAN="2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ROWSPAN="2">Chief Executive Officer and Director <BR>(Principal Executive Officer)</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom">October&nbsp;22, 2020</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Corey N. Fishman</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">/s/ Judith M. Matthews</P></TD>
<TD VALIGN="bottom" ROWSPAN="2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ROWSPAN="2"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Chief Financial Officer</P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:10pt; font-family:Times New Roman">(Principal Financial and Accounting Officer)</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom">October&nbsp;22, 2020</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Judith M. Matthews</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">*</P></TD>
<TD VALIGN="bottom" ROWSPAN="2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ROWSPAN="2">Interim Chairman of the Board of Directors</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom">October&nbsp;22, 2020</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Brenton K. Ahrens</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">*</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom">Director</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom">October&nbsp;22, 2020</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Mark Chin</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">*</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom">Director</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom">October&nbsp;22, 2020</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Patrick J. Heron</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">*</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom">Director</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom">October&nbsp;22, 2020</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Ronald M. Hunt</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">*</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom">Director</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom">October&nbsp;22, 2020</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">David G. Kelly</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">*</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom">Director</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom">October&nbsp;22, 2020</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Shahzad Malik, M.D.</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD></TR>
</TABLE> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="40%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt">


<TR>

<TD WIDTH="10%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="89%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">*By:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">/s/ Corey N. Fishman</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">Corey N. Fishman</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT STYLE="white-space:nowrap"><FONT STYLE="white-space:nowrap">Attorney-in-fact</FONT></FONT></TD></TR>
</TABLE>
</DIV></Center>

</BODY></HTML>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>2
<FILENAME>d873161dex51.htm
<DESCRIPTION>EX-5.1
<TEXT>
<HTML><HEAD>
<TITLE>EX-5.1</TITLE>
</HEAD>
 <BODY BGCOLOR="WHITE">


<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="right"><B>Exhibit 5.1 </B></P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" ALIGN="center">


<TR>

<TD WIDTH="58%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD></TD>
<TD></TD>
<TD></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" ROWSPAN="6" STYLE="BORDER-RIGHT:1px solid #000000; padding-left:8pt">


<IMG SRC="g873161img51.jpg" ALT="LOGO">
</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top"><B></B><B>A&amp;L Goodbody</B><B></B><B></B></TD>
<TD VALIGN="bottom" ROWSPAN="6">&nbsp;&nbsp;</TD>
<TD ROWSPAN="6" VALIGN="top"><B></B>&nbsp;<BR> <P STYLE="margin-bottom:0pt; margin-top:0pt; font-size:10pt; font-family:Times New Roman"></P> <P STYLE="margin-bottom:0pt; margin-top:0pt; font-size:10pt; font-family:Times New Roman"></P>
<P STYLE="margin-bottom:0pt; margin-top:0pt; font-size:10pt; font-family:Times New Roman"></P> <P STYLE="margin-bottom:0pt; margin-top:0pt; font-size:10pt; font-family:Times New Roman"></P>
<P STYLE="margin-bottom:1pt; margin-top:0pt; font-size:10pt; font-family:Times New Roman"></P></TD>
<TD ROWSPAN="6" VALIGN="top" ALIGN="right"><B></B>Dublin<BR> <P STYLE="margin-bottom:0pt; margin-top:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="right">Belfast</P>
<P STYLE="margin-bottom:0pt; margin-top:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="right">London</P> <P STYLE="margin-bottom:0pt; margin-top:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="right">New York</P>
<P STYLE="margin-bottom:0pt; margin-top:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="right">San&nbsp;Francisco</P> <P STYLE="margin-bottom:1pt; margin-top:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="right">Palo Alto</P></TD>

<TD ROWSPAN="6" NOWRAP VALIGN="top"><B></B>&nbsp;<BR> <P STYLE="margin-bottom:0pt; margin-top:0pt; font-size:10pt; font-family:Times New Roman">&nbsp;</P>
<P STYLE="margin-bottom:0pt; margin-top:0pt; font-size:10pt; font-family:Times New Roman">&nbsp;</P> <P STYLE="margin-bottom:0pt; margin-top:0pt; font-size:10pt; font-family:Times New Roman">&nbsp;</P>
<P STYLE="margin-bottom:0pt; margin-top:0pt; font-size:10pt; font-family:Times New Roman">&nbsp;</P> <P STYLE="margin-bottom:1pt; margin-top:0pt; font-size:10pt; font-family:Times New Roman">&nbsp;</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top">International&nbsp;Financial&nbsp;Services&nbsp;Centre</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top">25-28 North Wall Quay, Dublin 1</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top">D01 H104</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top">T: +353 1 649 2000</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top">DX:&nbsp;29&nbsp;Dublin&nbsp;&nbsp;|&nbsp;&nbsp;www.algoodbody.com</TD></TR>
</TABLE> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" ALIGN="center">


<TR>

<TD WIDTH="9%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="88%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Date</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top"><B>|&nbsp;&nbsp;</B> 22 October 2020</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Our ref</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top"><B>|&nbsp;&nbsp;</B> 01416740</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Your ref</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top"><B>|&nbsp;&nbsp;</B></TD></TR>
</TABLE> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Iterum Therapeutics plc </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Block
2, Floor 3 </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Harcourt Centre, Harcourt Street </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Dublin 2, </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Ireland </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman"><B>Iterum Therapeutics plc</B> (the <B>Company</B>)
</P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Dear Sirs </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">We are acting as Irish Counsel to the Company,
a public limited company incorporated under the laws of Ireland (registration number 563531), in connection with the filing of a registration statement (the <B>Registration Statement</B>) on Form <FONT STYLE="white-space:nowrap">S-1</FONT> to be
filed by the Company under the Securities Act of 1933, as amended (the <B>Securities Act</B>), pursuant to which we understand the Company will register the offering, issuance and sale by the Company of the following securities (the
<B>Securities</B>): </P> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="5%">&nbsp;</TD>
<TD WIDTH="3%" VALIGN="top" ALIGN="left">&#149;</TD>
<TD WIDTH="1%" VALIGN="top">&nbsp;</TD>
<TD ALIGN="left" VALIGN="top"> <P ALIGN="left" STYLE=" margin-top:0pt ; margin-bottom:0pt; font-family:Times New Roman; font-size:10pt">ordinary shares in the capital of the Company with a nominal value of US$0.01 each (<B>Ordinary Shares</B>) up to
a maximum aggregate amount of $2,500,000 (the <B>Offering</B> <B>Shares</B>); </P></TD></TR></TABLE> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="5%">&nbsp;</TD>
<TD WIDTH="3%" VALIGN="top" ALIGN="left">&#149;</TD>
<TD WIDTH="1%" VALIGN="top">&nbsp;</TD>
<TD ALIGN="left" VALIGN="top"> <P ALIGN="left" STYLE=" margin-top:0pt ; margin-bottom:0pt; font-family:Times New Roman; font-size:10pt"><FONT STYLE="white-space:nowrap">pre-funded</FONT> warrants (the
<B><FONT STYLE="white-space:nowrap">Pre-Funded</FONT> Warrants</B>) to purchase Ordinary Shares up to a maximum aggregate amount of $2,500,000 (the <B><FONT STYLE="white-space:nowrap">Pre-Funded</FONT> Warrant Shares</B>); </P></TD></TR></TABLE>
<P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="5%">&nbsp;</TD>
<TD WIDTH="3%" VALIGN="top" ALIGN="left">&#149;</TD>
<TD WIDTH="1%" VALIGN="top">&nbsp;</TD>
<TD ALIGN="left" VALIGN="top"> <P ALIGN="left" STYLE=" margin-top:0pt ; margin-bottom:0pt; font-family:Times New Roman; font-size:10pt">warrants (the <B>Warrants</B>) to purchase Ordinary Shares up to a maximum aggregate amount of $1,875,000 (the
<B>Warrant Shares</B>); and </P></TD></TR></TABLE> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="5%">&nbsp;</TD>
<TD WIDTH="3%" VALIGN="top" ALIGN="left">&#149;</TD>
<TD WIDTH="1%" VALIGN="top">&nbsp;</TD>
<TD ALIGN="left" VALIGN="top"> <P ALIGN="left" STYLE=" margin-top:0pt ; margin-bottom:0pt; font-family:Times New Roman; font-size:10pt">placement agent warrants (the <B>Placement Agent Warrants</B>) to purchase Ordinary Shares up to a maximum
aggregate amount of $218,750 (the <B>Placement Agent Shares</B>, and together with the Offering Shares, the <FONT STYLE="white-space:nowrap">Pre-Funded</FONT> Warrant Shares and the Warrant Shares,<B> </B>the<B> Shares</B>), </P></TD></TR></TABLE>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">pursuant to the terms of the Registration Statement, the prospectus incorporated by reference therein, and any amendments or supplements thereto. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">In connection with this Opinion, we have reviewed copies of: </P> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="1%">&nbsp;</TD>
<TD WIDTH="2%" VALIGN="top" ALIGN="left">&#149;</TD>
<TD WIDTH="1%" VALIGN="top">&nbsp;</TD>
<TD ALIGN="left" VALIGN="top"> <P ALIGN="left" STYLE=" margin-top:0pt ; margin-bottom:0pt; font-family:Times New Roman; font-size:10pt">the Registration Statement; and </P></TD></TR></TABLE>
<P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="1%">&nbsp;</TD>
<TD WIDTH="2%" VALIGN="top" ALIGN="left">&#149;</TD>
<TD WIDTH="1%" VALIGN="top">&nbsp;</TD>
<TD ALIGN="left" VALIGN="top"> <P ALIGN="left" STYLE=" margin-top:0pt ; margin-bottom:0pt; font-family:Times New Roman; font-size:10pt">copies of such corporate records of the Company as we have deemed necessary as a basis for the opinions
hereinafter expressed. </P></TD></TR></TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="line-height:1.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #000000">&nbsp;</P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:7pt; font-family:Times New Roman">CE Gill&nbsp;&nbsp;&#149;&nbsp;&nbsp;JG Grennan&nbsp;&nbsp;&#149;&nbsp;&nbsp;PD White&nbsp;&nbsp;&#149;&nbsp;&nbsp;VJ Power&nbsp;&nbsp;&#149;&nbsp;&nbsp;LA
Kennedy&nbsp;&nbsp;&#149;&nbsp;&nbsp;SM Doggett&nbsp;&nbsp;&#149;&nbsp;&nbsp;B McDermott&nbsp;&nbsp;&#149;&nbsp;&nbsp;C Duffy&nbsp;&nbsp;&#149;&nbsp;&nbsp;PV Maher&nbsp;&nbsp;&#149;&nbsp;&nbsp;S O&#146;Riordan&nbsp;&nbsp;&#149;&nbsp;&nbsp;MP
McKenna&nbsp;&nbsp;&#149;&nbsp;&nbsp;KA Feeney&nbsp;&nbsp;&#149;&nbsp;&nbsp;M Sherlock&nbsp;&nbsp;&#149;&nbsp;&nbsp;E MacNeill </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:7pt; font-family:Times New Roman">KP
Allen&nbsp;&nbsp;&#149;&nbsp;&nbsp;EA Roberts&nbsp;&nbsp;&#149;&nbsp;&nbsp;C Rogers&nbsp;&nbsp;&#149;&nbsp;&nbsp;G O&#146;Toole&nbsp;&nbsp;&#149;&nbsp;&nbsp;JN Kelly&nbsp;&nbsp;&#149;&nbsp;&nbsp;N O&#146;Sullivan&nbsp;&nbsp;&#149;&nbsp;&nbsp;MJ
Ward&nbsp;&nbsp;&#149;&nbsp;&nbsp;AC Burke&nbsp;&nbsp;&#149;&nbsp;&nbsp;D Widger&nbsp;&nbsp;&#149;&nbsp;&nbsp;C Christle&nbsp;&nbsp;&#149;&nbsp;&nbsp;S O&#146;Croinin&nbsp;&nbsp;&#149;&nbsp;&nbsp;JW Yarr&nbsp;&nbsp;&#149;&nbsp;&nbsp;DR
Baxter&nbsp;&nbsp;&#149;&nbsp;&nbsp;A McCarthy &nbsp;&nbsp;&#149;&nbsp;&nbsp;JF Whelan </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:7pt; font-family:Times New Roman">JB Somerville&nbsp;&nbsp;&#149;&nbsp;&nbsp;MF
Barr&nbsp;&nbsp;&#149;&nbsp;&nbsp;AM Curran&nbsp;&nbsp;&#149;&nbsp;&nbsp;A Roberts&nbsp;&nbsp;&#149;&nbsp;&nbsp;M Dale&nbsp;&nbsp;&#149;&nbsp;&nbsp;RM Moore&nbsp;&nbsp;&#149;&nbsp;&nbsp;D Main&nbsp;&nbsp;&#149;&nbsp;&nbsp;J
Cahir&nbsp;&nbsp;&#149;&nbsp;&nbsp;M Traynor&nbsp;&nbsp;&#149;&nbsp;&nbsp;PM Murray&nbsp;&nbsp;&#149;&nbsp;&nbsp;P Walker&nbsp;&nbsp;&#149;&nbsp;&nbsp;K Furlong&nbsp;&nbsp;&#149;&nbsp;&nbsp;PT Fahy&nbsp;&nbsp;&#149;&nbsp;&nbsp;D
Inverarity&nbsp;&nbsp;&#149;&nbsp;&nbsp;M Coghlan&nbsp;&nbsp;&#149;&nbsp;&nbsp;DR Francis </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:7pt; font-family:Times New Roman">A Casey&nbsp;&nbsp;&#149;&nbsp;&nbsp;B
Hosty&nbsp;&nbsp;&#149;&nbsp;&nbsp;M O&#146;Brien&nbsp;&nbsp;&#149;&nbsp;&nbsp;L Mulleady&nbsp;&nbsp;&#149;&nbsp;&nbsp;K Ryan&nbsp;&nbsp;&#149;&nbsp;&nbsp;E Hurley&nbsp;&nbsp;&#149;&nbsp;&nbsp;G Stanley&nbsp;&nbsp;&#149;&nbsp;&nbsp;D
Dagostino&nbsp;&nbsp;&#149;&nbsp;&nbsp;R Grey&nbsp;&nbsp;&#149;&nbsp;&nbsp;R Lyons&nbsp;&nbsp;&#149;&nbsp;&nbsp;J Sheehy&nbsp;&nbsp;&#149;&nbsp;&nbsp;C Morrissey&nbsp;&nbsp;&#149;&nbsp;&nbsp;C Carroll&nbsp;&nbsp;&#149;&nbsp;&nbsp;SE
Carson&nbsp;&nbsp;&#149;&nbsp;&nbsp;P Diggin </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:7pt; font-family:Times New Roman">J Williams&nbsp;&nbsp;&#149;&nbsp;&nbsp;A O&#146;Beirne&nbsp;&nbsp;&#149;&nbsp;&nbsp;MD
Cole&nbsp;&nbsp;&#149;&nbsp;&nbsp;G Conheady&nbsp;&nbsp;&#149;&nbsp;&nbsp;J Dallas&nbsp;&nbsp;&#149;&nbsp;&nbsp;SM Lynch&nbsp;&nbsp;&#149;&nbsp;&nbsp;M McElhinney&nbsp;&nbsp;&#149;&nbsp;&nbsp;C Owens&nbsp;&nbsp;&#149;&nbsp;&nbsp;AD
Ion&nbsp;&nbsp;&#149;&nbsp;&nbsp;K O&#146;Connor&nbsp;&nbsp;&#149;&nbsp;&nbsp;JH Milne&nbsp;&nbsp;&#149;&nbsp;&nbsp;T Casey&nbsp;&nbsp;&#149;&nbsp;&nbsp;M Doyle&nbsp;&nbsp;&#149;&nbsp;&nbsp;CJ Comerford &nbsp;&nbsp;&#149;&nbsp;&nbsp;R Marron </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:7pt; font-family:Times New Roman">D Berkery&nbsp;&nbsp;&#149;&nbsp;&nbsp;K O&#146;Shaughnessy&nbsp;&nbsp;&#149;&nbsp;&nbsp;S O&#146;Connor&nbsp;&nbsp;&#149;&nbsp;&nbsp;SE
Murphy&nbsp;&nbsp;&#149;&nbsp;&nbsp;D Nangle&nbsp;&nbsp;&#149;&nbsp;&nbsp;L Butler&nbsp;&nbsp;&#149;&nbsp;&nbsp;A Lawler&nbsp;&nbsp;&#149;&nbsp;&nbsp;C &Oacute; Conluain&nbsp;&nbsp;&#149;&nbsp;&nbsp;N McMahon&nbsp;&nbsp;&#149;&nbsp;&nbsp;HP
Brandt&nbsp;&nbsp;&#149;&nbsp;&nbsp;A Sheridan </P> <P STYLE="margin-top:4pt; margin-bottom:0pt; font-size:7pt; font-family:Times New Roman">Consultants: SW Haughey&nbsp;&nbsp;&#149;&nbsp;&nbsp;Professor JCW Wylie&nbsp;&nbsp;&#149;&nbsp;&nbsp;AF
Browne&nbsp;&nbsp;&#149;&nbsp;&nbsp;MA Greene&nbsp;&nbsp;&#149;&nbsp;&nbsp; AV Fanagan&nbsp;&nbsp;&#149;&nbsp;&nbsp; PM Law </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always">
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">


<Center><DIV STYLE="width:8.5in" align="left">

 <P STYLE="margin-top:0pt;margin-bottom:0pt">


<IMG SRC="g873161img51.jpg" ALT="LOGO">
 </P> <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">In rendering this Opinion, we have examined, and have assumed the truth and accuracy of the contents of, all
such corporate records, documents and certificates of officers of the Company and of public officials as to factual matters and have conducted such searches on 22 October 2020 (being the last practicable date on which searches could be conducted) in
public registries in Ireland as we have deemed necessary or appropriate for the purposes of this Opinion but have made no independent investigation regarding such factual matters. In our examination we have assumed the (continued) truth and accuracy
of the information contained in such documents, the genuineness of all signatures, the authenticity of all documents submitted to us as originals, the conformity to original documents of all documents submitted to us as certified or photostatic
copies and the authenticity of the originals of such documents. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">We have further assumed: </P>
<P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left">1</TD>
<TD ALIGN="left" VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman; " ALIGN="left">that as of today&#146;s date and at each time Securities are issued, none of the resolutions and authorities of
the shareholders or directors of the Company upon which we have relied have been varied, amended or revoked in any respect or have expired, and that the Securities will be issued in accordance with such resolutions and authorities and the terms of
the applicable agreement relating to the Securities; </P></TD></TR></TABLE> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left">2</TD>
<TD ALIGN="left" VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman; " ALIGN="left">that at each time Shares will be issued, a sufficient number of ordinary shares of the Company, nominal value
$0.01 per share, will remain authorised and available for issuance by the Board pursuant to the constitution of the Company; </P></TD></TR></TABLE> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left">3</TD>
<TD ALIGN="left" VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman; " ALIGN="left">that any issue of Shares will be paid up in consideration of the receipt by the Company prior to, or
simultaneously with, the issue of the Shares of cash at least equal to the nominal value of such Shares; </P></TD></TR></TABLE> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left">4</TD>
<TD ALIGN="left" VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman; " ALIGN="left">that the issuance of the Securities will be in compliance with the Companies Act 2014, the Irish Takeover Panel
Act 1997, Takeover Rules 2013, and all applicable Irish company, takeover, securities, market abuse, insider dealing laws and other rules and regulations; </P></TD></TR></TABLE> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left">5</TD>
<TD ALIGN="left" VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman; " ALIGN="left">that the filing of the Registration Statement with the Securities and Exchange Commission (<B>SEC</B>) has been
authorised by all necessary actions under all applicable laws other than Irish law; </P></TD></TR></TABLE> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left">6</TD>
<TD ALIGN="left" VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman; " ALIGN="left">that when filed with the SEC, the Registration Statement will not differ in any material respect from the
drafts that we have examined; </P></TD></TR></TABLE> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left">7</TD>
<TD ALIGN="left" VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman; " ALIGN="left">the absence of fraud on the part of the Company and its respective officers, employees, agents and advisors;
and </P></TD></TR></TABLE> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left">8</TD>
<TD ALIGN="left" VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman; " ALIGN="left">that: (i)&nbsp;the Company will be fully solvent at the time of and immediately following the issue of any
Securities; (ii)&nbsp;no resolution or petition for the appointment of a liquidator or examiner will be passed or presented prior to the issue of any Securities; (iii)&nbsp;no receiver will have been appointed in relation to any of the assets or
undertaking of the Company prior to the issue of any Securities; and (iv)&nbsp;no composition in satisfaction of debts, scheme of arrangement, or compromise or arrangement with creditors or members (or any class of creditors or members) will be
proposed, sanctioned or approved in relation to the Company prior to the issue of the Securities. </P></TD></TR></TABLE> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Subject to the foregoing and to the
within additional qualifications and assumptions, and based upon searches carried out in the Irish Companies Registration Office and the Central Office of the High Court on 22 October 2020, we are of the opinion that: </P>
<P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="1%">&nbsp;</TD>
<TD WIDTH="2%" VALIGN="top" ALIGN="left">&#149;</TD>
<TD WIDTH="1%" VALIGN="top">&nbsp;</TD>
<TD ALIGN="left" VALIGN="top"> <P ALIGN="left" STYLE=" margin-top:0pt ; margin-bottom:0pt; font-family:Times New Roman; font-size:10pt">the Company is a company duly incorporated under the laws of Ireland and validly existing under the laws of
Ireland; </P></TD></TR></TABLE> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="1%">&nbsp;</TD>
<TD WIDTH="2%" VALIGN="top" ALIGN="left">&#149;</TD>
<TD WIDTH="1%" VALIGN="top">&nbsp;</TD>
<TD ALIGN="left" VALIGN="top"> <P ALIGN="left" STYLE=" margin-top:0pt ; margin-bottom:0pt; font-family:Times New Roman; font-size:10pt">the Offering Shares, when delivered against due payment thereof, will be validly issued, fully paid and not
subject to calls for any additional payments <FONT STYLE="white-space:nowrap">(&#147;non-assessable&#148;);</FONT> </P></TD></TR></TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="line-height:1.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #000000">&nbsp;</P>
<P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">2 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always">
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">


<Center><DIV STYLE="width:8.5in" align="left">

 <P STYLE="margin-top:0pt;margin-bottom:0pt">


<IMG SRC="g873161img51.jpg" ALT="LOGO">
 </P> <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>

<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="1%">&nbsp;</TD>
<TD WIDTH="2%" VALIGN="top" ALIGN="left">&#149;</TD>
<TD WIDTH="1%" VALIGN="top">&nbsp;</TD>
<TD ALIGN="left" VALIGN="top"> <P ALIGN="left" STYLE=" margin-top:0pt ; margin-bottom:0pt; font-family:Times New Roman; font-size:10pt">the Warrants, the <FONT STYLE="white-space:nowrap">Pre-Funded</FONT> Warrants and the Placement Agent Warrants
when (i)&nbsp;delivered against due payment therefor; and (ii)&nbsp;the applicable Warrant, <FONT STYLE="white-space:nowrap">Pre-Funded</FONT> Warrant or Placement Agent Warrant has been duly authorized, executed and delivered by the Company and the
other parties thereto, will be duly authorized, validly issued and binding obligations of the Company; and </P></TD></TR></TABLE> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="1%">&nbsp;</TD>
<TD WIDTH="2%" VALIGN="top" ALIGN="left">&#149;</TD>
<TD WIDTH="1%" VALIGN="top">&nbsp;</TD>
<TD ALIGN="left" VALIGN="top"> <P ALIGN="left" STYLE=" margin-top:0pt ; margin-bottom:0pt; font-family:Times New Roman; font-size:10pt">the Warrant Shares, the <FONT STYLE="white-space:nowrap">Pre-Funded</FONT> Warrant Shares and the Placement Agent
Shares when (i)&nbsp;delivered against due payment therefor; and (ii)&nbsp;the applicable Warrant, <FONT STYLE="white-space:nowrap">Pre-Funded</FONT> Warrant or Placement Agent Warrant has been duly authorized, executed and delivered by the Company
and the other parties thereto, will be validly issued, fully paid and not subject to calls for any additional payments <FONT STYLE="white-space:nowrap">(&#147;non-assessable&#148;).</FONT> </P></TD></TR></TABLE>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">In rendering this Opinion we have confined ourselves to matters of Irish law. We express no opinion on any laws other than the laws of Ireland (and the
interpretation thereof) in force as at the date hereof. This Opinion speaks only as of its date. We are not under any obligation to update this Opinion from time to time, nor to notify you of any change of law, facts or circumstances referred to or
relied upon in the giving of this Opinion. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">This Opinion is given solely for the benefit of the addressee of this Opinion and may not be relied upon by
any other person without our prior written consent, provided, however, that it may be relied upon by persons entitled to rely on it pursuant to applicable provisions of US federal securities laws. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">This Opinion is also strictly confined to the matters expressly stated herein and is not to be read as extending by implication or otherwise to any other
matter. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">We hereby consent to the filing of this Opinion with the SEC as an exhibit to the Registration Statement in accordance with the requirements of
Item 601(b)(5) of Regulation <FONT STYLE="white-space:nowrap">S-K</FONT> of the Securities Act, and to the use of our name therein and in the related prospectus and in any prospectus supplement under the caption &#147;Legal Matters.&#148; </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">The Opinion is governed by and construed in accordance with the laws of Ireland. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Yours faithfully </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman"><B>/s/ A&amp;L Goodbody </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman"><FONT STYLE="white-space:nowrap"><FONT STYLE="white-space:nowrap">M-51904722-3</FONT></FONT> </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="line-height:1.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #000000">&nbsp;</P>
<P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">3 </P>

</DIV></Center>

</BODY></HTML>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.2
<SEQUENCE>3
<FILENAME>d873161dex52.htm
<DESCRIPTION>EX-5.2
<TEXT>
<HTML><HEAD>
<TITLE>EX-5.2</TITLE>
</HEAD>
 <BODY BGCOLOR="WHITE">


<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="right"><B>Exhibit 5.2 </B></P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" ALIGN="center">


<TR>

<TD WIDTH="51%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="48%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-right:3.80em" ALIGN="right">


<IMG SRC="g873161g1023040247400.jpg" ALT="LOGO">
</P></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">October&nbsp;22, 2020</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ALIGN="right"> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-right:3.80em; font-size:10pt; font-family:Times New Roman" ALIGN="right">+1 212 230 8800 (t)</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-right:3.80em; font-size:10pt; font-family:Times New Roman" ALIGN="right">+1 212 230 8888 (f)</P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; margin-right:3.80em; font-size:10pt; font-family:Times New Roman" ALIGN="right">wilmerhale.com</P></TD></TR>
</TABLE> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Iterum Therapeutics plc </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Block 2
Floor 3, Harcourt Centre </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Harcourt Street, </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Dublin 2, Ireland
</P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Re:&nbsp;&nbsp;&nbsp;&nbsp;<U>Registration Statement on Form <FONT STYLE="white-space:nowrap">S-1</FONT></U> </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Ladies and Gentlemen: </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">This opinion is furnished to you in
connection with&nbsp;the Registration Statement on Form <FONT STYLE="white-space:nowrap">S-1</FONT> (the &#147;Registration Statement&#148;) filed by Iterum Therapeutics plc, an Irish public limited company (the &#147;Company&#148;), with the
Securities and Exchange Commission (the &#147;Commission&#148;) pursuant to Rule 462(b) under the Securities Act of 1933, as amended (the &#147;Securities Act&#148;), for the registration of (i)&nbsp;ordinary shares (the &#147;Shares&#148;) of the
Company, nominal value $0.01 per share (the &#147;Ordinary Shares&#148;) with a proposed maximum aggregate offering price of up to $2,500,000, (ii) warrants to purchase Ordinary Shares (the &#147;Ordinary Share Warrants&#148;) with a proposed
maximum aggregate offering price of up to $1,875,000, (iii) <FONT STYLE="white-space:nowrap">pre-funded</FONT> warrants to purchase Ordinary Shares (the <FONT STYLE="white-space:nowrap">&#147;Pre-Funded</FONT> Warrants&#148;) with a proposed maximum
aggregate offering price of up to $2,500,000, and (iv)&nbsp;placement agent warrants to purchase Ordinary Shares (the &#147;Placement Agent Warrants,&#148; and together with the Ordinary Share Warrants and
<FONT STYLE="white-space:nowrap">Pre-Funded</FONT> Warrants, the &#147;Warrants&#148;) with a proposed maximum aggregate price of $218,750. The Shares and the Warrants are herein collectively referred to as the &#147;Securities.&#148; </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">The Shares, Ordinary Share Warrants, and <FONT STYLE="white-space:nowrap">Pre-Funded</FONT> Warrants are to be offered and sold by the Company pursuant to a
securities purchase agreement (the &#147;Purchase Agreement&#148;), between the Company and the purchasers named therein (the &#147;Purchasers&#148;), the form of which has been incorporated by reference into the Registration Statement. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">We are acting as United States counsel for the Company in connection with the issue and sale by the Company of the Securities. We have examined copies of the
Registration Statement as filed with the Commission. We have examined and relied upon the Purchase Agreement and the forms of Warrants, which have been incorporated by reference into the Registration Statement. For purposes of this opinion, we have
also examined the opinion letter of A&amp;L Goodbody, Irish counsel for the Company, dated the date hereof and filed as Exhibit 5.1 to the Company&#146;s Registration Statement (the &#147;ALG Opinion&#148;). We have also examined and relied upon
originals </P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P> <P STYLE="margin-top:0pt;margin-bottom:0pt" ALIGN="center">


<IMG SRC="g873161g59i42.jpg" ALT="LOGO">
 </P>
</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always">
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">


<Center><DIV STYLE="width:8.5in" align="left">


<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" ALIGN="center">

<TR>

<TD WIDTH="35%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="32%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="31%"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="right">


<IMG SRC="g873161g1023040247400.jpg" ALT="LOGO">
&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">October 22, 2020</P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:10pt; font-family:Times New Roman">Page 2</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD></TR></TABLE> <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">
or copies of such corporate records of the Company, such other agreements and instruments, such certificates of public officials, and such other documents, instruments and certificates as we have
deemed necessary as a basis for the opinions hereinafter expressed. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">In our examination of the documents referred to above, we have assumed the
genuineness of all signatures, the legal capacity and competence of all individual signatories, the authenticity, accuracy and completeness of all documents submitted to us as originals, the conformity to original documents of all documents
submitted to us as copies, the authenticity of such original documents and the completeness and accuracy of the corporate records of the Company provided to us by the Company. Insofar as this opinion relates to factual matters, we have assumed,
without independent investigation, that representations of officers and directors of the Company and documents furnished to us by the Company are true and correct. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">We have also assumed, consistent with the ALG Opinion, that (i)&nbsp;the Company is incorporated and validly existing under the laws of the Republic of
Ireland; (ii)&nbsp;the Company has all requisite power and authority to execute and deliver, and to perform its obligations under the Purchase Agreement and the Warrants; (iii)&nbsp;the Purchase Agreement has been duly authorized, executed and
delivered by the Company under the laws of the Republic of Ireland and (iv)&nbsp;the Warrants have been duly authorized, executed and delivered by the Company under the laws of the Republic of Ireland. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Our opinion below is qualified to the extent that it may be subject to or affected by (i)&nbsp;applicable bankruptcy, insolvency, reorganization,
receivership, moratorium, fraudulent conveyance or similar laws relating to or affecting the rights or remedies of creditors generally, (ii)&nbsp;duties and standards imposed on creditors and parties to contracts, including, without limitation,
requirements of materiality, good faith, reasonableness and fair dealing, (iii)&nbsp;general equitable principles, and (iv)&nbsp;applicable usury laws of jurisdictions other than the State of New York. Furthermore, we express no opinion as to the
availability of any equitable or specific remedy upon any breach of any of the agreements as to which we are opining herein, or any of the agreements, documents or obligations referred to therein, or to the successful assertion of any equitable
defenses, inasmuch as the availability of such remedies or the success of any equitable defenses may be subject to the discretion of a court. We also express no opinion herein as to any provision of any agreement (a)&nbsp;that may be deemed to or
construed to waive any right of the Company; (b)&nbsp;to the effect that rights and remedies are not exclusive, that every right or remedy is cumulative and may be exercised in addition to or with any other right or remedy and does not preclude
recourse to one or more other rights or remedies; (c)&nbsp;relating to the effect of invalidity or unenforceability of any provision of an agreement on the validity or enforceability of any other provision thereof; (d)&nbsp;requiring the payment of
penalties, consequential damages or liquidated damages; (e)&nbsp;which is in violation of public policy, including, without limitation, any provision relating to indemnification and contribution with respect to securities law matters; (f)&nbsp;which
provides that the terms of any agreement may not be waived or modified except in </P>
</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always">
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">


<Center><DIV STYLE="width:8.5in" align="left">


<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" ALIGN="center">

<TR>

<TD WIDTH="35%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="32%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="31%"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="right">


<IMG SRC="g873161g1023040247400.jpg" ALT="LOGO">
&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">October 22, 2020</P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:10pt; font-family:Times New Roman">Page 3</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD></TR></TABLE> <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">
writing; (g)&nbsp;purporting to indemnify any person against his, her or its own negligence or misconduct; or (h)&nbsp;relating to choice of law or consent to jurisdiction. We express no opinion
herein as to the laws of any jurisdiction other than the state laws of the State of New York. We have not acted as counsel for the Company with respect to matters of Irish law or other applicable foreign law. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Based upon and subject to the foregoing, we are of the opinion that when the Warrants have been duly executed by the Company and are delivered and paid for in
accordance with the terms and conditions of the Purchase Agreement and the prospectus which has been incorporated by reference into the Registration Statement, the Warrants will constitute valid and binding obligations of the Company. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Please note that we are opining only as to the matters expressly set forth herein, and no opinion should be inferred as to any other matters. This opinion is
based upon currently existing statutes, rules, regulations and judicial decisions and is rendered as of the date hereof, and we disclaim any obligation to advise you of any change in any of the foregoing sources of law or subsequent developments in
law or changes in facts or circumstances that might affect any matters or opinions set forth herein. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">We hereby consent to the filing of this opinion with
the Commission, in accordance with the requirements of Item&nbsp;601(b)(5) of Regulation <FONT STYLE="white-space:nowrap">S-K</FONT> under the Securities Act, as an exhibit to the Registration Statement and to the use of our name therein and in the
related prospectus under the caption &#147;Legal Matters.&#148; In giving such consent, we do not hereby admit that we are in the category of persons whose consent is required under Section&nbsp;7 of the Securities Act or the rules and regulations
of the Commission. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Very truly yours, </P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="40%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt">


<TR>

<TD WIDTH="7%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="92%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">WILMER CUTLER PICKERING HALE AND DORR LLP</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">By:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">/s/ Brian A. Johnson</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">Brian A. Johnson, a Partner</TD></TR>
</TABLE>
</DIV></Center>

</BODY></HTML>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>4
<FILENAME>d873161dex231.htm
<DESCRIPTION>EX-23.1
<TEXT>
<HTML><HEAD>
<TITLE>EX-23.1</TITLE>
</HEAD>
 <BODY BGCOLOR="WHITE">


<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="right"><B>Exhibit 23.1 </B></P>
<P STYLE="margin-top:24pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>Consent of Independent Registered Public Accounting Firm </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">The Board of Directors </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Iterum Therapeutics plc: </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">We consent to the use of our report incorporated by reference herein. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Our report dated March&nbsp;12, 2020 contains an explanatory paragraph that states that the Company has suffered recurring losses from operations and has a
net capital deficiency, which raise substantial doubt about its ability to continue as a going concern. The consolidated financial statements do not include any adjustments that might result from the outcome of that uncertainty. Also, our report on
the consolidated financial statements refers to a change to the method of accounting for leases as of January&nbsp;1, 2019 due to the adoption of ASC Topic 842,<I>&nbsp;Leases.</I> </P>
<P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="40%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt">


<TR>

<TD WIDTH="100%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">/s/ KPMG</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Dublin, Ireland</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">October&nbsp;22, 2020</TD></TR>
</TABLE>
</DIV></Center>

</BODY></HTML>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>5
<FILENAME>g873161g1023040247400.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
begin 644 g873161g1023040247400.jpg
M_]C_X  02D9)1@ ! 0$ 8 !@  #_VP!#  @&!@<&!0@'!P<)"0@*#!0-# L+
M#!D2$P\4'1H?'AT:'!P@)"XG("(L(QP<*#<I+# Q-#0T'R<Y/3@R/"XS-#+_
MVP!# 0D)"0P+#!@-#1@R(1PA,C(R,C(R,C(R,C(R,C(R,C(R,C(R,C(R,C(R
M,C(R,C(R,C(R,C(R,C(R,C(R,C(R,C+_P  1"  0 'L# 2(  A$! Q$!_\0
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=OI7AC4KFQ@40PS2GRF=4^7.U@".G<<CGO0!__]D!

end
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>6
<FILENAME>g873161g59i42.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
begin 644 g873161g59i42.jpg
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M 0$! 0$! 0        $" P0%!@<("0H+$  " 0,# @0#!04$!    7T! @,
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MYC!O$Q9G<*K=-HP,-Z]J */_  DMS]BN)_LT6^+55T\#><$&14W=.OS9Q[4
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M%-I=W$0$Y.3;OM(;Y1C.001GO0!?M?$%[<W<5G'IRRW"1PR76R7"QK(3@C<
M3@*2?I@<T 6/#VM3:S9+<SV\-MYI;RHUFWLP5BI)&!CD#UZT 0:_;337=G]B
MOKB*\$\<F%E*QI"K R;EZ$%<CGN1C&* ,O4KC5-$UFZN98_M;74,[69CN),1
ME(]P5HB=N#MQN'?ZT 3>&[VZ.LV]L;B2Y@GTB"[=W8MB4L1N&>FX9XZ?+Q0
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M+[_+&YOE./\ 6>_2@!)/&$D%M=W<FG9M+)WAN)$F'R2K@8 .#@L< X'')XH
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M,OB63R%6W2W:Y*,2C2@;<2A.Y'/).,C)&* (1XKF5HG,,4D)@+XCR6=PC,5
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50N04!SCI^5 $K(C##(",YY% '__9

end
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>7
<FILENAME>g873161img51.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
begin 644 g873161img51.jpg
M_]C_X  02D9)1@ ! 0$ R #&  #_X@Q824-#7U!23T9)3$4  0$   Q(3&EN
M;P(0  !M;G1R4D="(%A96B 'S@ "  D !@ Q  !A8W-P35-&5     !)14,@
M<U)'0@                  ]M8  0    #3+4A0("
M                                             !%C<')T   !4
M #-D97-C   !A    &QW='!T   !\    !1B:W!T   "!    !1R6%E:   "
M&    !1G6%E:   "+    !1B6%E:   "0    !1D;6YD   "5    '!D;61D
M   "Q    (AV=65D   #3    (9V:65W   #U    "1L=6UI   #^    !1M
M96%S   $#    "1T96-H   $,     QR5%)#   $/   " QG5%)#   $/
M" QB5%)#   $/   " QT97AT     $-O<'ER:6=H=" H8RD@,3DY."!(97=L
M971T+5!A8VMA<F0@0V]M<&%N>0  9&5S8P         2<U)'0B!)14,V,3DV
M-BTR+C$              !)S4D="($E%0S8Q.38V+3(N,0
M                                                    6%E:(
M     /-1  $    !%LQ865H@                     %A96B        !O
MH@  ./4   .06%E:(        &*9  "WA0  &-I865H@        )*    ^$
M  "VSV1E<V,         %DE%0R!H='1P.B\O=W=W+FEE8RYC:
M    %DE%0R!H='1P.B\O=W=W+FEE8RYC:
M                                  !D97-C         "Y)14,@-C$Y
M-C8M,BXQ($1E9F%U;'0@4D="(&-O;&]U<B!S<&%C92 M('-21T(
M     "Y)14,@-C$Y-C8M,BXQ($1E9F%U;'0@4D="(&-O;&]U<B!S<&%C92 M
M('-21T(                             9&5S8P         L4F5F97)E
M;F-E(%9I97=I;F<@0V]N9&ET:6]N(&EN($E%0S8Q.38V+3(N,0
M    +%)E9F5R96YC92!6:65W:6YG($-O;F1I=&EO;B!I;B!)14,V,3DV-BTR
M+C$                                  '9I97<      !.D_@ 47RX
M$,\4  /MS  $$PL  UR>     5A96B       $P)5@!0    5Q_G;65A<P
M       !                         H\    "<VEG(     !#4E0@8W5R
M=@        0     !0 *  \ %  9 !X (P H "T ,@ W #L 0 !% $H 3P!4
M %D 7@!C &@ ;0!R '< ? "! (8 BP"0 )4 F@"? *0 J0"N +( MP"\ ,$
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M])5?E<F6-):?EPJ7=9?@F$R8N)DDF9"9_)IHFM6;0INOG!R<B9SWG62=TIY
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M# P,# P,# P,#/_  !$( "8 N0,!(@ "$0$#$0'_Q  ?   !!0$! 0$! 0
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M:][PG))+K=HW:1G53R<5Y1X"_;)^'/Q)\5+HNC^*K&>_F.R"*5);?SV]$:1
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M\T_L$>(M0^%WQC\3?#O5M.N/#[:L/[4L-/N&#-:$=$!!(8&+ R/^>8'&*O\
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M(9L'H.9 /J5 KU;X1?L)>"_A+XQAUY6UCQ!J]L0;6YU:Y6<V;#(#HH4 , 2
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#'__9

end
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
