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Shareholders' Equity - Additional Information (Details) $ / shares in Units, $ in Thousands |  |  |  |  |  |  |  |  |  | 1 Months Ended | 3 Months Ended | 14 Months Ended |  |  |  |  |
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Feb. 12, 2021 $ / shares shares | Feb. 10, 2021 USD ($) $ / shares shares | Feb. 09, 2021 USD ($) $ / shares shares | Feb. 08, 2021 $ / shares shares | Feb. 03, 2021 $ / shares shares | Oct. 31, 2020 $ / shares shares | Oct. 27, 2020 $ / shares shares | Jul. 02, 2020 $ / shares shares | Jun. 03, 2020 $ / shares shares | Jun. 30, 2020 $ / shares shares | Mar. 31, 2022 USD ($) Vote $ / shares shares | Mar. 31, 2022 USD ($) $ / shares shares | Dec. 31, 2021 $ / shares shares | Mar. 31, 2021 shares | Jan. 28, 2021 $ / shares shares | Jun. 05, 2020 $ / shares shares | Apr. 27, 2018 $ / shares shares
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ordinary shares, shares issued |  |  |  |  |  |  |  |  |  |  | 183,353,418 | 183,353,418 | 182,775,282 |  |  |  |
Ordinary shares, par value | $ / shares |  |  |  |  |  |  |  |  |  |  | $ 0.01 | $ 0.01 | $ 0.01 |  | $ 0.01 |  |
Proceeds from registered direct offerings, net of transaction costs | $ |  |  |  |  |  |  |  |  |  |  | $ 546 |  |  |  |  |  |
Number of warrants to purchase preferred shares |  |  |  |  |  |  |  |  |  |  | 380,000 | 380,000 |  |  |  |  |
Ordinary shares, shares authorized |  |  |  |  |  |  |  |  |  |  | 300,000,000 | 300,000,000 | 300,000,000 |  | 150,000,000 |  |
Number of vote per common share | Vote |  |  |  |  |  |  |  |  |  |  | 1 |  |  |  |  |  |
Common stock rights and preferences |  |  |  |  |  |  |  |  |  |  | The holders of ordinary shares currently have no preemptive or other subscription rights, and there are no redemption or sinking fund provisions with respect to such shares |  |  |  |  |  |
Undesignated preferred shares, par value | $ / shares |  |  |  |  |  |  |  |  |  |  | $ 0.01 | $ 0.01 | $ 0.01 |  |  |  |
Undesignated preferred shares, authorized |  |  |  |  |  |  |  |  |  |  | 100,000,000 | 100,000,000 | 100,000,000 |  |  |  |
Undesignated preferred shares issued |  |  |  |  |  |  |  |  |  |  | 0 | 0 | 0 |  |  |  |
Undesignated Preferred Shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Undesignated preferred shares, par value | $ / shares |  |  |  |  |  |  |  |  |  |  | $ 0.01 | $ 0.01 |  |  |  |  |
Undesignated preferred shares, authorized |  |  |  |  |  |  |  |  |  |  | 100,000,000 | 100,000,000 |  |  |  |  |
Designated Preferred Shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Undesignated preferred shares issued |  |  |  |  |  |  |  |  |  |  | 0 | 0 |  | 0 |  |  |
Silicon Valley Bank and Life Sciences Fund II LLC | Series B Convertible Preferred Shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of warrants to purchase preferred shares |  |  |  |  |  |  |  |  |  |  | 19,890 | 19,890 |  |  |  |  | 19,890
Warrants to purchase preferred shares, exercise price | $ / shares |  |  |  |  |  |  |  |  |  |  | $ 18.85 | $ 18.85 |  |  |  |  | $ 18.85
Exchangeable Notes |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ordinary shares, shares issued |  |  |  |  |  |  |  |  |  |  | 53,888,331 | 53,888,331 |  |  |  |  |
Aggregate principal amount of exchangeable notes | $ |  |  |  |  |  |  |  |  |  |  |  | $ 39,201 |  |  |  |  |
Aggregate principal amount | $ |  |  |  |  |  |  |  |  |  |  | $ 12,607 | $ 12,607 |  |  |  |  |
Ordinary Shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of warrants to purchase preferred shares |  |  |  |  |  |  |  |  |  |  | 19,890 | 19,890 |  |  |  |  | 19,890
October Offering |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ordinary shares, par value | $ / shares |  |  |  |  |  |  |  |  |  |  | $ 0.01 | $ 0.01 |  |  |  |  |
Proceeds from registered direct offerings, net of transaction costs | $ |  |  |  |  |  |  |  |  |  |  | $ 13,885 |  |  |  |  |  |
Number of warrants to purchase preferred shares |  |  |  |  |  | 1,884,615 |  |  |  |  | 20,890,516 | 20,890,516 |  |  |  |  |
Warrants to purchase preferred shares, exercise price | $ / shares |  |  |  |  |  | $ 0.8125 | $ 0.65 |  |  |  |  |  |  |  |  |  |
Warrants expiry date |  |  |  |  |  | Oct. 22, 2025 | Oct. 27, 2025 |  |  |  |  |  |  |  |  |  |
Percentage of ordinary shares issued to purchase warrants |  |  |  |  |  | 7.00% |  |  |  |  |  |  |  |  |  |  |
October Offering | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of warrants to purchase preferred shares |  |  |  |  |  |  | 20,192,307 |  |  |  |  |  |  |  |  |  |
February Underwritten Offering |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants to purchase preferred shares, exercise price | $ / shares |  | $ 1.4375 |  | $ 1.4375 |  |  |  |  |  |  |  |  |  |  |  |  |
Offering closing date |  | Feb. 10, 2021 |  | Feb. 08, 2021 |  |  |  |  |  |  |  |  |  |  |  |  |
Additional ordinary shares that can be purchased by underwriter |  | 5,217,391 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants expiry date |  | Feb. 03, 2026 |  | Feb. 03, 2026 |  |  |  |  |  |  |  |  |  |  |  |  |
Percentage of ordinary shares issued to purchase warrants |  | 7.00% |  | 7.00% |  |  |  |  |  |  |  |  |  |  |  |  |
February Underwritten Offering | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of warrants to purchase preferred shares |  | 365,217 |  | 2,434,783 |  |  |  |  |  |  |  |  |  |  |  |  |
February Underwritten Offering | Underwriting Agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ordinary shares, shares issued |  |  |  |  | 34,782,609 |  |  |  |  |  |  |  |  |  |  |  |
Ordinary shares, par value | $ / shares |  |  |  |  | $ 0.01 |  |  |  |  |  |  |  |  |  |  |  |
Offering closing date |  |  |  |  | Feb. 08, 2021 |  |  |  |  |  |  |  |  |  |  |  |
February Underwritten Offering | Pursuant to the Underwriting Agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ordinary shares, shares issued |  | 40,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate gross proceeds from ordinary shares | $ |  | $ 46,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from registered direct offerings, net of transaction costs | $ |  | $ 42,119 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Additional ordinary shares that can be purchased by underwriter |  | 5,217,391 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
February 2021 Underwritten Offering | Underwriting Agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Offering price per share | $ / shares |  |  |  |  | $ 1.15 |  |  |  |  |  |  |  |  |  |  |  |
Private Placement | Securities Purchase Agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of warrants to purchase preferred shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 208,023 |
Warrants to purchase preferred shares, exercise price | $ / shares |  |  |  |  |  |  |  |  | $ 1.62 |  |  |  |  |  |  | $ 2.1031 |
Warrants expiry date |  |  |  |  |  |  |  |  | Dec. 05, 2025 |  | Apr. 27, 2028 |  |  |  |  |  |
Private Placement | Securities Purchase Agreement | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of warrants to purchase preferred shares |  |  |  |  |  |  |  |  | 1,485,885 |  |  |  |  |  |  |  |
Private Placement | June 30 SPA |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from registered direct offerings, net of transaction costs | $ |  |  |  |  |  |  |  |  |  |  | $ 1,796 |  |  |  |  |  |
Number of warrants to purchase preferred shares |  |  |  |  |  |  |  | 236,088 |  |  | 1,264,757 | 1,264,757 |  |  |  |  |
Warrants to purchase preferred shares, exercise price | $ / shares |  |  |  |  |  |  |  | $ 1.8531 |  | $ 1.42 |  |  |  |  |  |  |
Warrants expiry date |  |  |  |  |  |  |  | Jun. 30, 2025 |  | Jan. 02, 2026 |  |  |  |  |  |  |
Percentage of ordinary shares issued to purchase warrants |  |  |  |  |  |  |  | 7.00% |  |  |  |  |  |  |  |  |
Private Placement | June 30 SPA | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of warrants to purchase preferred shares |  |  |  |  |  |  |  |  |  | 1,686,343 |  |  |  |  |  |  |
Private Placement | Exchangeable Notes |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate principal amount of exchangeable notes | $ |  |  |  |  |  |  |  |  |  |  |  | $ 39,201 |  |  |  |  |
February Registered Direct Offering |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ordinary shares, shares issued |  |  | 17,500,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ordinary shares, par value | $ / shares |  |  | $ 0.01 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Offering price per share | $ / shares |  |  | $ 2.00 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate gross proceeds from ordinary shares | $ |  |  | $ 35,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from registered direct offerings, net of transaction costs | $ |  |  | $ 32,235 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants to purchase preferred shares, exercise price | $ / shares | $ 2.50 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Offering closing date | Feb. 12, 2021 |  | Feb. 12, 2021 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants expiry date | Feb. 09, 2026 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Percentage of ordinary shares issued to purchase warrants | 7.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
February Registered Direct Offering | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of warrants to purchase preferred shares | 1,225,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

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