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Basis of Presentation - Additional Information (Details) |  |  |  |  |  |  |  |  | 3 Months Ended | 9 Months Ended | 12 Months Ended | 48 Months Ended |  |  |  |  |  |
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Apr. 28, 2025 USD ($) $ / shares shares | Feb. 19, 2025 USD ($) | Jan. 31, 2025 USD ($) shares | Dec. 10, 2024 USD ($) | Aug. 09, 2024 USD ($) $ / shares shares | Oct. 07, 2022 USD ($) $ / shares | Sep. 08, 2020 USD ($) Debtinstrument | Jan. 21, 2020 USD ($) Debtinstrument | Sep. 30, 2025 USD ($) $ / shares shares | Sep. 30, 2024 USD ($) | Sep. 30, 2025 USD ($) $ / shares shares | Sep. 30, 2024 USD ($) | Dec. 31, 2024 USD ($) $ / shares shares | Jan. 31, 2025 USD ($) shares | May 03, 2023 $ / shares | Oct. 17, 2022 USD ($) | Feb. 10, 2021 $ / shares | Feb. 08, 2021 $ / shares | Oct. 31, 2020 $ / shares | Oct. 27, 2020 $ / shares
Organization Consolidation And Presentation Of Financial Statements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net losses |  |  |  |  |  |  |  |  | $ 8,979,000 | $ 6,094,000 | $ 20,379,000 | $ 18,192,000 | $ 24,774,000 |  |  |  |  |  |  |
Accumulated deficit |  |  |  |  |  |  |  |  | $ 506,451,000 |  | $ 506,451,000 |  | $ 486,072,000 |  |  |  |  |  |  |
Aggregate principal amount of exchangeable notes |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 40,691,000 |  |  |  |  |  |
Ordinary shares, shares issued | shares | 3,040,000 |  |  |  |  |  |  |  | 48,991,860 |  | 48,991,860 |  | 31,534,233 |  |  |  |  |  |  |
Price per ordinary share | $ / shares | $ 0.9 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Prefunded warrants to purchase shares of common stock | shares | 2,515,556 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Prefunded warrant issued per share | $ / shares | $ 0.89 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate gross proceeds from ordinary shares | $ 5,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net proceeds from issuance of common stock | $ 4,177,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Accrued and unpaid interest |  |  |  |  |  |  |  |  |  |  |  |  |  | 3,071,000 |  |  |  |  |  |
Cash and cash equivalents |  |  |  |  |  |  |  |  | $ 11,002,000 |  | $ 11,002,000 |  | $ 24,125,000 |  |  |  |  |  |  |
Ordinary shares, par value | $ / shares |  |  |  |  |  |  |  |  | $ 0.01 |  | $ 0.01 |  | $ 0.01 |  | $ 0.01 |  |  |  |  |
Warrants to purchase ordinary share, exercise price | $ / shares | $ 0.01 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Authorized amount for sale of stock |  | $ 150,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Value of shares and securities may offer and sell |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 100,000,000 |  |  |  |
Sales Agreement With H.C. Wainwright |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ordinary shares, par value | $ / shares |  |  |  |  |  | $ 0.01 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Sales Agreement With H.C. Wainwright | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
May offer and sell ordinary shares for additional aggregate offering price |  |  |  | $ 25,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
May offer and sell ordinary shares for aggregate gross sales proceeds |  |  |  |  |  | $ 16,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
2024 Rights Offering |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of units sold | shares |  |  |  |  | 6,121,965 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Subscription price per whole unit | $ / shares |  |  |  |  | $ 1.21 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants to purchase ordinary share, exercise price | $ / shares |  |  |  |  | $ 1.21 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate net proceeds from rights offering |  |  |  |  | $ 5,430,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
2024 Rights Offering | 1-Year Warrant |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of shares that can be purchased with each warrant | shares |  |  |  |  | 0.5 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants to purchase ordinary share, exercise price | $ / shares |  |  |  |  |  |  |  |  | 1.21 |  | 1.21 |  |  |  |  |  |  |  |  |
2024 Rights Offering | 5-Year Warrants |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants to purchase ordinary share, exercise price | $ / shares |  |  |  |  | $ 1.21 |  |  |  | $ 1.21 |  | $ 1.21 |  |  |  |  |  |  |  |  |
October Offering |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants to purchase ordinary share, exercise price | $ / shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 12.1875 | $ 9.75
February Underwritten Offering |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants to purchase ordinary share, exercise price | $ / shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 21.5625 | $ 21.5625 |  |
2025 Exchangeable Notes | Private Placement and Rights Offering |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate principal amount |  |  |  |  |  |  | $ 51,808,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Debt instrument interest rate |  |  |  |  |  |  |  | 6.50% |  |  |  |  |  |  |  |  |  |  |  |
2025 Exchangeable Notes | Private Placement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate principal amount |  |  |  |  |  |  |  | $ 51,588,000 |  |  |  |  |  |  |  |  |  |  |  |
Debt instrument price per unit |  |  |  |  |  |  |  | 1,000 |  |  |  |  |  |  |  |  |  |  |  |
RLNs | Private Placement and Rights Offering |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate principal amount |  |  |  |  |  |  | $ 500 | 104,000 |  |  |  |  |  |  |  |  |  |  |  |
RLNs | Private Placement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate principal amount |  |  |  |  |  |  |  | $ 103,000 |  |  |  |  |  |  |  |  |  |  |  |
Number of debt instruments within each notes | Debtinstrument |  |  |  |  |  |  | 50 | 50 |  |  |  |  |  |  |  |  |  |  |  |
Exchangeable Notes |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate principal amount of exchangeable notes |  |  | $ 11,117,000 |  |  |  |  |  |  |  |  |  |  | $ 40,691,000 |  |  |  |  |  |
Ordinary shares, shares issued | shares |  |  | 3,760,155 |  |  |  |  |  | 3,760,155 |  | 3,760,155 |  |  | 3,760,155 |  |  |  |  |  |
Accrued and unpaid interest |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 3,071,000 |  |  |  |  |  |
Accrued interest balance amount |  |  | $ 3,628,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Repayment of aggregate principal amount |  |  | $ 11,117,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Exchangeable Notes | Private Placement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Organization Consolidation And Presentation Of Financial Statements [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate principal amount of exchangeable notes |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 40,691,000 |  |  |  |  |  |

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