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Shareholders' Equity - Additional Information (Details) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1 Months Ended | 3 Months Ended | 9 Months Ended | 14 Months Ended | 48 Months Ended | 56 Months Ended | 63 Months Ended |  |  |
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Sep. 30, 2025 USD ($) $ / shares shares | Apr. 28, 2025 USD ($) $ / shares shares | Feb. 19, 2025 USD ($) | Jan. 31, 2025 USD ($) shares | Dec. 10, 2024 USD ($) | Aug. 09, 2024 USD ($) $ / shares shares | Oct. 07, 2022 USD ($) $ / shares | Feb. 12, 2021 $ / shares shares | Feb. 10, 2021 $ / shares shares | Feb. 08, 2021 $ / shares shares | Oct. 31, 2020 $ / shares shares | Oct. 27, 2020 $ / shares shares | Jul. 02, 2020 $ / shares shares | Jun. 05, 2020 $ / shares shares | Jun. 03, 2020 $ / shares shares | Apr. 27, 2018 USD ($) $ / shares shares | Jun. 30, 2020 $ / shares shares | Sep. 30, 2025 USD ($) $ / shares shares | Sep. 30, 2025 USD ($) Vote $ / shares shares | Sep. 30, 2024 USD ($) | Sep. 30, 2025 USD ($) $ / shares shares | Jan. 31, 2025 USD ($) shares | Sep. 30, 2025 USD ($) $ / shares shares | Sep. 30, 2025 USD ($) $ / shares shares | Jun. 29, 2025 shares | Dec. 31, 2024 USD ($) $ / shares shares | May 03, 2023 $ / shares shares
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Increase to authorized ordinary shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 60,000,000
Ordinary shares, par value | $ / shares | $ 0.01 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 0.01 | $ 0.01 |  | $ 0.01 |  | $ 0.01 | $ 0.01 |  | $ 0.01 | $ 0.01
Aggregate offering price of shares | $ | $ 490,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 490,000 | $ 490,000 |  | $ 490,000 |  | $ 490,000 | $ 490,000 |  | $ 315,000 |
Ordinary shares, shares authorized | 80,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 80,000,000 | 80,000,000 |  | 80,000,000 |  | 80,000,000 | 80,000,000 |  | 80,000,000 |
Number of vote per common share | Vote |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1 |  |  |  |  |  |  |  |
Common stock rights and preferences |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | There are no redemption or sinking fund provisions with respect to the authorized ordinary shares. |  |  |  |  |  |  |  |
Authorized amount for sale of stock | $ |  |  | $ 150,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ordinary shares, shares issued | 48,991,860 | 3,040,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 48,991,860 | 48,991,860 |  | 48,991,860 |  | 48,991,860 | 48,991,860 |  | 31,534,233 |
Price per ordinary share | $ / shares |  | $ 0.9 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Prefunded warrants to purchase shares of common stock |  | 2,515,556 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Prefunded warrant issued per share | $ / shares |  | $ 0.89 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net proceeds from issuance of common stock | $ |  | $ 4,177,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate gross proceeds from ordinary shares | $ |  | $ 5,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from registered direct offerings, net of transaction costs | $ |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 16,909,000 | $ 12,814,000 |  |  |  |  |  |  |
Aggregate principal amount of exchangeable notes | $ |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 40,691,000 |  |  |  |  |
Accrued and unpaid interest | $ |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 3,071,000 |  |  |  |  |
Warrants to purchase ordinary share, exercise price | $ / shares |  | $ 0.01 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Undesignated preferred shares, par value | $ / shares | $ 0.01 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 0.01 | $ 0.01 |  | $ 0.01 |  | $ 0.01 | $ 0.01 |  | $ 0.01 |
Undesignated preferred shares, authorized | 100,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 100,000,000 | 100,000,000 |  | 100,000,000 |  | 100,000,000 | 100,000,000 |  | 100,000,000 |
Undesignated preferred shares issued | 0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 0 | 0 |  | 0 |  | 0 | 0 |  | 0 |
Sales Agreement With H.C. Wainwright |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ordinary shares, par value | $ / shares |  |  |  |  |  |  | $ 0.01 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of ordinary shares sold |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 6,860,532 |  |  |  |  |  |  |  |  |
Offering price per ordinary share | $ / shares | $ 0.79 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 0.79 | $ 0.79 |  | $ 0.79 |  | $ 0.79 | $ 0.79 |  |  |
Proceeds from registered direct offerings, net of transaction costs | $ |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 5,417,000 |  |  |  |  |  |  |  |  |
Maximum | Sales Agreement With H.C. Wainwright |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
May offer and sell ordinary shares for aggregate gross sales proceeds | $ |  |  |  |  |  |  | $ 16,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
May offer and sell ordinary shares for additional aggregate offering price | $ |  |  |  |  | $ 25,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Loan and Security Agreement | Silicon Valley Bank (SVB) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Loan and security agreement entered date |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | Apr. 27, 2018 |  |  |  |  |  |  |  |
Maximum amount available under agreement | $ |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 30,000,000 |  |  |  |  |  |  |  |  |  |  |
Long-Term Line of Credit | $ |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 15,000,000 |  |  |  |  |  |  |  |  |  |  |
2024 Rights Offering |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Subscription price per whole unit | $ / shares |  |  |  |  |  | $ 1.21 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate gross proceeds from rights offering | $ |  |  |  |  |  | $ 7,408,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate net proceeds from rights offering | $ |  |  |  |  |  | $ 5,430,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of units sold |  |  |  |  |  | 6,121,965 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants to purchase ordinary share, exercise price | $ / shares |  |  |  |  |  | $ 1.21 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Private Placement | Securities Purchase Agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of warrants to purchase ordinary shares |  |  |  |  |  |  |  |  |  |  |  |  |  | 13,868 |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants to purchase ordinary share, exercise price | $ / shares |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 31.5465 | $ 24.3 |  |  |  |  |  |  |  |  |  |  |  |
Warrants expiry date |  |  |  |  |  |  |  |  |  |  |  |  |  | Jun. 03, 2025 | Dec. 05, 2025 |  |  |  |  |  |  |  |  |  |  |  |
Warrants exercisable date |  |  |  |  |  |  |  |  |  |  |  |  |  | Jun. 03, 2020 |  |  |  |  |  |  |  |  |  |  |  |  |
Percentage of ordinary shares issued to purchase warrants |  |  |  |  |  |  |  |  |  |  |  |  |  | 7.00% |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants exercised | 0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 0 | 0 |  | 0 |  | 0 | 0 |  |  |
Private Placement | Securities Purchase Agreement | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of warrants to purchase ordinary shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 99,057 |  |  |  |  |  |  |  |  |  |  |  |
Private Placement | June 30 SPA |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of warrants to purchase ordinary shares |  |  |  |  |  |  |  |  |  |  |  |  | 15,739 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants to purchase ordinary share, exercise price | $ / shares |  |  |  |  |  |  |  |  |  |  |  |  | $ 27.7965 |  |  |  | $ 21.3 |  |  |  |  |  |  |  |  |  |
Warrants expiry date | Jun. 30, 2025 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | Jan. 02, 2026 |  |  |  |  |  |  |  |  |  |
Percentage of ordinary shares issued to purchase warrants |  |  |  |  |  |  |  |  |  |  |  |  | 7.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from exercise of warrants related to registered direct offering | $ |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 1,796,000 |  |  |
Warrants exercised | 84,317 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 84,317 | 84,317 |  | 84,317 |  | 84,317 | 84,317 | 0 |  |
Private Placement | June 30 SPA | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of warrants to purchase ordinary shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 112,422 |  |  |  |  |  |  |  |  |  |
October Offering |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from registered direct offerings, net of transaction costs | $ |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 13,885,000 |  |  |  |  |  |  |  |
Number of warrants to purchase ordinary shares |  |  |  |  |  |  |  |  |  |  | 125,641 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of warrants exercised for ordinary shares | 1,392,701 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,392,701 | 1,392,701 |  | 1,392,701 |  | 1,392,701 | 1,392,701 |  |  |
Warrants to purchase ordinary share, exercise price | $ / shares |  |  |  |  |  |  |  |  |  |  | $ 12.1875 | $ 9.75 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants expiry date |  |  |  |  |  |  |  |  |  |  | Oct. 22, 2025 | Oct. 27, 2025 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Percentage of ordinary shares issued to purchase warrants |  |  |  |  |  |  |  |  |  |  | 7.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
October Offering | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of warrants to purchase ordinary shares |  |  |  |  |  |  |  |  |  |  |  | 1,346,153 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
February Underwritten Offering |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Offering closing date |  |  |  |  |  |  |  |  | Feb. 10, 2021 | Feb. 08, 2021 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Additional ordinary shares that can be purchased by underwriter |  |  |  |  |  |  |  |  | 347,826 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of warrants exercised for ordinary shares | 25,333 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 25,333 | 25,333 |  | 25,333 |  | 25,333 | 25,333 |  |  |
Warrants to purchase ordinary share, exercise price | $ / shares |  |  |  |  |  |  |  |  | $ 21.5625 | $ 21.5625 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants expiry date |  |  |  |  |  |  |  |  | Feb. 03, 2026 | Feb. 03, 2026 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Percentage of ordinary shares issued to purchase warrants |  |  |  |  |  |  |  |  | 7.00% | 7.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from warrants connected to registered direct offerings | $ |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 546,000 |  |  |  |
February Underwritten Offering | Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of warrants to purchase ordinary shares |  |  |  |  |  |  |  |  | 24,347 | 162,318 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
February Registered Direct Offering |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Offering closing date |  |  |  |  |  |  |  | Feb. 12, 2021 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of warrants to purchase ordinary shares |  |  |  |  |  |  |  | 81,666 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants to purchase ordinary share, exercise price | $ / shares |  |  |  |  |  |  |  | $ 37.5 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants expiry date |  |  |  |  |  |  |  | Feb. 09, 2026 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Percentage of ordinary shares issued to purchase warrants |  |  |  |  |  |  |  | 7.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants to Purchase 19,890 Ordinary Shares | Silicon Valley Bank and Life Sciences Fund II LLC |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants expiry date |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | Apr. 27, 2028 |  |  |  |  |  |  |  |  |  |  |
1-Year Warrant | 2024 Rights Offering |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of shares that can be purchased with each warrant |  |  |  |  |  | 0.5 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from registered direct offerings, net of transaction costs | $ |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 1,040,000 |  |  |  |  |  |
Number of warrants to purchase ordinary shares |  |  |  |  |  | 3,060,982 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants to purchase ordinary share, exercise price | $ / shares | $ 1.21 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 1.21 | $ 1.21 |  | $ 1.21 |  | $ 1.21 | $ 1.21 |  |  |
Warrants exercised | 859,825 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 859,825 | 859,825 |  | 859,825 |  | 859,825 | 859,825 |  |  |
5-Year Warrants | 2024 Rights Offering |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from registered direct offerings, net of transaction costs | $ |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 804,000 |  |  |  |  |  |
Number of warrants to purchase ordinary shares |  |  |  |  |  | 6,121,965 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants to purchase ordinary share, exercise price | $ / shares | $ 1.21 |  |  |  |  | $ 1.21 |  |  |  |  |  |  |  |  |  |  |  | $ 1.21 | $ 1.21 |  | $ 1.21 |  | $ 1.21 | $ 1.21 |  |  |
Warrants exercised | 664,802 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 664,802 | 664,802 |  | 664,802 |  | 664,802 | 664,802 |  |  |
Series B Convertible Preferred Shares | Silicon Valley Bank and Life Sciences Fund II LLC |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of warrants to purchase ordinary shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 19,890 |  |  |  |  |  |  |  |  |  |  |
Warrants to purchase ordinary share, exercise price | $ / shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 282.75 |  |  |  |  |  |  |  |  |  |  |
Undesignated Preferred Shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Undesignated preferred shares, par value | $ / shares | $ 0.01 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 0.01 | $ 0.01 |  | $ 0.01 |  | $ 0.01 | $ 0.01 |  |  |
Undesignated preferred shares, authorized | 100,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 100,000,000 | 100,000,000 |  | 100,000,000 |  | 100,000,000 | 100,000,000 |  |  |
Designated Preferred Shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Undesignated preferred shares issued | 0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 0 | 0 |  | 0 |  | 0 | 0 |  |  |
Ordinary Shares | Silicon Valley Bank and Life Sciences Fund II LLC |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of warrants to purchase ordinary shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,326 |  |  |  |  |  |  |  |  |  |  |
Exchangeable Notes |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ordinary shares, shares issued | 3,760,155 |  |  | 3,760,155 |  |  |  |  |  |  |  |  |  |  |  |  |  | 3,760,155 | 3,760,155 |  | 3,760,155 | 3,760,155 | 3,760,155 | 3,760,155 |  |  |
Aggregate principal amount of exchangeable notes | $ |  |  |  | $ 11,117,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 40,691,000 |  |  |  |  |
Accrued and unpaid interest | $ |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 3,071,000 |  |  |  |  |
Accrued interest | $ |  |  |  | $ 3,628,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 3,628,000 |  |  |  |  |
Exchangeable Notes | Private Placement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate principal amount of exchangeable notes | $ |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 40,691,000 |  |  |  |  |

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- Definition The carrying value as of the balance sheet date of the current and noncurrent portions of long-term obligations drawn from a line of credit, which is a bank's commitment to make loans up to a specific amount. Examples of items that might be included in the application of this element may consist of letters of credit, standby letters of credit, and revolving credit arrangements, under which borrowings can be made up to a maximum amount as of any point in time conditional on satisfaction of specified terms before, as of and after the date of drawdowns on the line. Includes short-term obligations that would normally be classified as current liabilities but for which (a) postbalance sheet date issuance of a long term obligation to refinance the short term obligation on a long term basis, or (b) the enterprise has entered into a financing agreement that clearly permits the enterprise to refinance the short-term obligation on a long term basis and the following conditions are met (1) the agreement does not expire within 1 year and is not cancelable by the lender except for violation of an objectively determinable provision, (2) no violation exists at the BS date, and (3) the lender has entered into the financing agreement is expected to be financially capable of honoring the agreement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02(22)) -SubTopic 10 -Topic 210 -Publisher FASB -URI https://asc.fasb.org/1943274/2147480566/210-10-S99-1 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 942 -SubTopic 210 -Name Accounting Standards Codification -Section S99 -Paragraph 1 -Subparagraph (SX 210.9-03(16)) -Publisher FASB -URI https://asc.fasb.org/1943274/2147478546/942-210-S99-1 Reference 3: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 944 -SubTopic 210 -Name Accounting Standards Codification -Section S99 -Paragraph 1 -Subparagraph (SX 210.7-03(a)(16)(a)(2)) -Publisher FASB -URI https://asc.fasb.org/1943274/2147478777/944-210-S99-1 + Details
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- Definition Face amount or stated value per share of preferred stock nonredeemable or redeemable solely at the option of the issuer. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 210 -SubTopic 10 -Name Accounting Standards Codification -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02(28)) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480566/210-10-S99-1 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Topic 505 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 13 -Subparagraph (a) -Publisher FASB -URI https://asc.fasb.org/1943274/2147481112/505-10-50-13 + Details
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