<SEC-DOCUMENT>0001144204-14-037353.txt : 20140624
<SEC-HEADER>0001144204-14-037353.hdr.sgml : 20140624
<ACCEPTANCE-DATETIME>20140612172514
ACCESSION NUMBER:		0001144204-14-037353
CONFORMED SUBMISSION TYPE:	S-8
PUBLIC DOCUMENT COUNT:		7
FILED AS OF DATE:		20140612
DATE AS OF CHANGE:		20140612
EFFECTIVENESS DATE:		20140612

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			TRANSGENOMIC INC
		CENTRAL INDEX KEY:			0001043961
		STANDARD INDUSTRIAL CLASSIFICATION:	LABORATORY ANALYTICAL INSTRUMENTS [3826]
		IRS NUMBER:				911789357
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-8
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-196712
		FILM NUMBER:		14908020

	BUSINESS ADDRESS:	
		STREET 1:		12325 EMMET ST
		CITY:			OMAHA
		STATE:			NE
		ZIP:			68164
		BUSINESS PHONE:		4027385480

	MAIL ADDRESS:	
		STREET 1:		12325 EMMET STREET
		CITY:			OMAHA
		STATE:			NE
		ZIP:			68164
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-8
<SEQUENCE>1
<FILENAME>v381278_s8.htm
<DESCRIPTION>S-8
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    <TD STYLE="width: 70%; text-align: center; font-size: 10pt"><font style="font-size: 10pt">As filed with the Securities and Exchange Commission on June 12, 2014</font></td>
    <TD STYLE="width: 30%; text-align: center; font-size: 10pt"><font style="font-size: 10pt">Registration No. 333-</font></td></tr>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>UNITED STATES</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>SECURITIES AND
EXCHANGE COMMISSION</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>Washington, D.C.
20549</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>

<P STYLE="font: 18pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>FORM S-8</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">REGISTRATION STATEMENT</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">UNDER</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">THE SECURITIES ACT
OF 1933</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>

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<P STYLE="font: 24pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>Transgenomic, Inc.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">(Exact name of registrant as specified in
its charter)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
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    <TD STYLE="width: 39%; border-bottom: Black 1pt solid; text-align: center"><font style="font-size: 10pt">Delaware</font></td>
    <TD STYLE="width: 20%; padding-bottom: 1pt"><font style="font-size: 10pt">&nbsp;</font></td>
    <TD STYLE="width: 41%; border-bottom: Black 1pt solid; text-align: center"><font style="font-size: 10pt">91-1789357</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: center"><font style="font-size: 10pt">(State or other jurisdiction of incorporation or organization)</font></td>
    <TD><font style="font-size: 10pt">&nbsp;&nbsp;</font></td>
    <TD STYLE="text-align: center"><font style="font-size: 10pt">(I.R.S. Employer Identification No.)</font></td></tr>
</table>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; text-align: center; margin-bottom: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">12325 Emmet Street</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Omaha, Nebraska 68164</P>




<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>



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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Address of Principal Executive Offices)
(Zip Code)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0.5in">&nbsp;</P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0.5in"></P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0.5in"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">2006 Equity Incentive Plan</P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Full title of the plan)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Paul Kinnon</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">President and Chief Executive Officer</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Transgenomic, Inc.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">12325 Emmet Street</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Omaha, Nebraska 68164</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(402) 452-5400</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"></P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Name, address and telephone number, including
area code, of agent for service)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0.5in"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Copies to:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Jeffrey T. Hartlin, Esq.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Paul Hastings LLP</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">1117 S. California Avenue</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Palo Alto, California 94304</P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0.5in"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Indicate by check mark whether the registrant is a large accelerated
filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of &ldquo;large accelerated
filer,&rdquo; &ldquo;accelerated filer&rdquo; and &ldquo;smaller reporting company&rdquo; in Rule 12b-2 of the Exchange Act.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
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    <TD STYLE="width: 25%; font-size: 10pt"><FONT STYLE="font-size: 10pt">Large accelerated filer <FONT STYLE="font-family: Wingdings 2">&pound;</FONT></FONT></TD>
    <TD STYLE="width: 25%; text-align: center; font-size: 10pt"><FONT STYLE="font-size: 10pt">Accelerated filer <FONT STYLE="font-family: Wingdings 2">&pound;</FONT></FONT></TD>
    <TD STYLE="width: 25%">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">Non-accelerated filer <FONT STYLE="font-family: Wingdings 2">&pound;</FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">(Do not check if a smaller reporting company)</P></TD>
    <TD STYLE="width: 25%; text-align: right; font-size: 10pt"><FONT STYLE="font-size: 10pt">Smaller reporting company <FONT STYLE="font-family: Wingdings">&#120;</FONT></FONT></TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>CALCULATION OF REGISTRATION FEE</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 9in"><B>&nbsp;</B></P>

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    <TD STYLE="font-size: 10pt; text-align: center; border-bottom: Black 1pt solid; border-top: Black 2.5pt double">Title of securities to be registered</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt; border-top: Black 2.5pt double">&nbsp;</TD>
    <TD COLSPAN="2" NOWRAP STYLE="font-size: 10pt; text-align: center; border-bottom: Black 1pt solid; border-top: Black 2.5pt double"><P STYLE="margin-top: 0; margin-bottom: 0">Amount to be registered</P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0">(1)</P></TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt; border-top: Black 2.5pt double">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; border-top: Black 2.5pt double">&nbsp;</TD>
    <TD COLSPAN="2" NOWRAP STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; border-bottom: Black 1pt solid; border-top: Black 2.5pt double"><P STYLE="margin-top: 0; margin-bottom: 0">Proposed maximum <BR>offering <BR>price per</P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0">share</P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0">(2)</P></TD><TD STYLE="padding-bottom: 1pt; font: 10pt Times New Roman, Times, Serif; border-top: Black 2.5pt double">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; border-top: Black 2.5pt double">&nbsp;</TD>
    <TD COLSPAN="2" NOWRAP STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; border-bottom: Black 1pt solid; border-top: Black 2.5pt double"><P STYLE="margin-top: 0; margin-bottom: 0">Proposed maximum <BR>aggregate <BR>offering</P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0">price</P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0">(2)</P></TD><TD STYLE="padding-bottom: 1pt; font: 10pt Times New Roman, Times, Serif; border-top: Black 2.5pt double">&nbsp;</TD><TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-bottom: 1pt; border-top: Black 2.5pt double">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; border-bottom: Black 1pt solid; border-top: Black 2.5pt double">Amount of <BR>registration fee</TD><TD STYLE="padding-bottom: 1pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="width: 44%; font-size: 10pt; text-align: center; padding-bottom: 1pt">Common Stock, par value $0.01 per share</TD><TD STYLE="width: 2%; font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="width: 1%; border-bottom: Black 1pt solid; font-size: 10pt; text-align: left"></TD><TD STYLE="width: 10%; border-bottom: Black 1pt solid; font-size: 10pt; text-align: right">833,333</TD><TD STYLE="width: 1%; padding-bottom: 1pt; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 2%; font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="width: 1%; border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">$</TD><TD STYLE="width: 10%; border-bottom: Black 1pt solid; font-size: 10pt; text-align: right">3.64</TD><TD STYLE="width: 1%; padding-bottom: 1pt; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 2%; font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="width: 1%; border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">$</TD><TD STYLE="width: 10%; border-bottom: Black 1pt solid; font-size: 10pt; text-align: right">3,033,332.12</TD><TD STYLE="width: 1%; padding-bottom: 1pt; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 2%; font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="width: 1%; border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">$</TD><TD STYLE="width: 10%; border-bottom: Black 1pt solid; font-size: 10pt; text-align: right">390.69</TD><TD STYLE="width: 1%; padding-bottom: 1pt; font-size: 10pt; text-align: left">&nbsp;</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0.5in">&nbsp;</P>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<tr style="vertical-align: top">
    <td style="width: 7%"><font style="font-size: 10pt">(1)</font></td>
    <td style="width: 93%"><font style="font-size: 10pt">Pursuant to Rule 416(a) of the Securities Act of 1933, as amended (the &ldquo;Securities Act&rdquo;), this Registration Statement shall also cover any additional shares of the Registrant&rsquo;s Common Stock that become issuable under the 2006 Equity Incentive Plan by reason of any stock dividend, stock split, recapitalization or other similar transaction effected without receipt of consideration that increases the number of outstanding shares of the Registrant&rsquo;s Common Stock.</font></td></tr>
</table>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<tr style="vertical-align: top">
    <td style="width: 7%"><font style="font-size: 10pt">(2)</font></td>
    <td style="width: 93%"><font style="font-size: 10pt">Estimated solely for the purpose of calculating the amount of the registration fee pursuant to Rule 457(c) and Rule 457(h) of the Securities Act.&nbsp;&nbsp;The offering price per share and aggregate offering price are based upon the average of the high and low prices for the Registrant&rsquo;s Common Stock as reported on The Nasdaq Capital Market on June 9, 2014, a date within five business days prior to the filing of this Registration Statement.</font></td></tr>
</table>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>REGISTRATION OF ADDITIONAL SECURITIES</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Transgenomic, Inc.,
a Delaware corporation, has filed this Registration Statement on Form S-8 to register under the Securities Act of 1933, as amended,
the offer and sale of an additional 833,333 shares of common stock, par value $0.01 per share (the &ldquo;Common Stock&rdquo;),
issuable pursuant to the Transgenomic, Inc. 2006 Equity Incentive Plan (the &ldquo;2006 Plan&rdquo;). The 2006 Plan, including
the shares available for issuance under the 2006 Plan, has been previously approved by the Registrant&rsquo;s stockholders.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Pursuant to the
Registration Statement on Form S-8 (File No. 333-41714) filed by the Registrant with the Securities and Exchange Commission
(the &ldquo;Commission&rdquo;) on July 19, 2000 (the &ldquo;2000 Registration Statement&rdquo;), the Registrant previously
registered 500,000 shares of Common Stock issuable pursuant to the 2006 Plan. The Registrant also filed: (i) a Registration
Statement on Form S-8 (File No. 333-69334) with the Commission on September 13, 2001 (the &ldquo;2001 Registration
Statement&rdquo;), pursuant to which the Registrant registered an additional 83,333 shares of Common Stock issuable pursuant
to the 2006 Plan, and (ii) a Registration Statement on Form S-8 (File No. 333-139999) with the Commission on January 16, 2007
(the &ldquo;2007 Registration Statement&rdquo; and, together with the 2000 Registration Statement and the 2001 Registration Statement, the &ldquo;Prior Registration Statements&rdquo;), pursuant to which the Registrant registered an additional 250,000 shares of
Common Stock issuable pursuant to the 2006 Plan. All share amounts set forth in this Registration Statement on Form S-8 give
effect to the 1-for-12 reverse split of the Common Stock effected on January 24, 2014.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>INCORPORATION BY REFERENCE OF CONTENTS
OF</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>REGISTRATION STATEMENTS ON FORM S-8</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">In accordance with
General Instruction E to Form S-8, the contents of the Prior Registration Statements are hereby incorporated by reference.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0.5in"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right; text-indent: 0.5in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>PART II </B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>INFORMATION REQUIRED IN THE REGISTRATION
STATEMENT </B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>ITEM 3. INCORPORATION OF DOCUMENTS BY REFERENCE. </B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">The following documents filed by the Registrant
with the Commission are hereby incorporated by reference into this Registration Statement:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; margin-left: 24.5pt; width: 95%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left"><FONT STYLE="font-size: 10pt">(a)</FONT></TD><TD STYLE="text-align: justify; padding-left: 5pt"><FONT STYLE="font-size: 10pt">The Registrant&rsquo;s
Annual Report on Form 10-K for the fiscal year ended December 31, 2013, filed with the Commission on March 27, 2014;</FONT></TD>
</TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; margin-left: 24.5pt; width: 95%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left"><FONT STYLE="font-size: 10pt">(b)</FONT></TD><TD STYLE="text-align: justify; padding-left: 5pt"><FONT STYLE="font-size: 10pt">The Registrant&rsquo;s
Quarterly Report on Form 10-Q for the quarter ended March 31, 2014, filed with the Commission on May 15, 2014;</FONT></TD>
</TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; margin-left: 24.5pt; width: 95%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left"><FONT STYLE="font-size: 10pt">(c)</FONT></TD><TD STYLE="text-align: justify; padding-left: 5pt"><FONT STYLE="font-size: 10pt">The Registrant&rsquo;s
Current Reports on Form 8-K filed with the Commission on (i) January 14, 2014, (ii) January 16, 2014, (iii) January 28, 2014,
(iv) March&nbsp;6, 2014, (v) March 12, 2014, (vi) March 19, 2014, (vii) May 6, 2014, (viii) May 14, 2014, and (ix) May 15, 2014; and</FONT></TD>
</TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; margin-left: 24.5pt; width: 95%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left"><FONT STYLE="font-size: 10pt">(d)</FONT></TD><TD STYLE="text-align: justify; padding-left: 5pt"><FONT STYLE="font-size: 10pt">The description of the
Registrant&rsquo;s Common Stock set forth in the prospectus included in the Registrant&rsquo;s Registration Statement on Form
S-1 (File No. 333-187285), initially filed with the Commission on March 15, 2013, as amended from time to time.</FONT></TD>
</TR></TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">All other reports and other documents subsequently
filed by the Registrant pursuant to Sections 13(a), 13(c), 14 or 15(d) of the Securities Exchange Act of 1934, as amended (the
&ldquo;Exchange Act&rdquo;), prior to the filing of a post-effective amendment which indicates that all securities offered hereby
have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference into
this Registration Statement and to be a part of this Registration Statement from the date of the filing of such reports and documents,
except as to any portion of any future annual or quarterly report to stockholders or document or current report furnished under
Items 2.02 or 7.01 of Form 8-K that is not deemed filed under such provisions.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">For the purposes of this Registration Statement,
any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified
or superseded to the extent that a statement contained herein or in any other subsequently filed document that also is or is deemed
to be incorporated by reference herein modifies or supersedes such statement. Any such statement so modified or superseded shall
not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">You should rely only on the information
provided or incorporated by reference in this Registration Statement or any related prospectus. The Registrant has not authorized
anyone to provide you with different information. You should not assume that the information in this Registration Statement or
any related prospectus is accurate as of any date other than the date on the front of the document.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">You may contact the Registrant in writing
or orally to request copies of the above-referenced filings, without charge (excluding exhibits to such documents unless such exhibits
are specifically incorporated by reference into the information incorporated into this Registration Statement). Requests for such
information should be directed to:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">Transgenomic, Inc.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">12325 Emmet Street</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">Omaha, Nebraska 68164</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">(402) 452-5400</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">Attn: Corporate Secretary</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>ITEM 6. INDEMNIFICATION OF DIRECTORS AND OFFICERS. </B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">The Registrant is incorporated under the
laws of the State of Delaware. Section 145 of the General Corporation Law of the State of Delaware (the &ldquo;DGCL&rdquo;) provides
that a Delaware corporation may indemnify any persons who are, or are threatened to be made, parties to any threatened, pending
or completed action, suit or proceeding, whether civil, criminal, administrative or investigative (other than an action by or in
the right of such corporation), by reason of the fact that such person is or was an officer, director, employee or agent of such
corporation, or is or was serving at the request of such person as an officer, director, employee or agent of another corporation
or enterprise. The indemnity may include expenses (including attorneys&rsquo; fees), judgments, fines and amounts paid in settlement
actually and reasonably incurred by such person in connection with such action, suit or proceeding, provided that such person acted
in good faith and in a manner he or she reasonably believed to be in or not opposed to the corporation&rsquo;s best interests and,
with respect to any criminal action or proceeding, had no reasonable cause to believe that his or her conduct was illegal.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">Additionally, a Delaware corporation may
indemnify any persons who are, or are threatened to be made, a party to any threatened, pending or completed action or suit by
or in the right of the corporation by reason of the fact that such person is or was an officer, director, employee or agent of
such corporation, or is or was serving at the request of such corporation as an officer, director, employee or agent of another
corporation or enterprise. The indemnity may include expenses (including attorneys&rsquo; fees) actually and reasonably incurred
by such person in connection with the defense or settlement of such action or suit provided such person acted in good faith and
in a manner he or she reasonably believed to be in or not opposed to the corporation&rsquo;s best interests, except that no indemnification
is permitted without judicial approval if the officer or director is adjudged to be liable to the corporation. Where an officer
or director is successful on the merits or otherwise in the defense of any action, suit or proceeding referred to above, or in
defense of any claim, issue or matter therein, the corporation must indemnify him or her against the expenses (including attorneys&rsquo;
fees) that such officer or director has actually and reasonably incurred. The Registrant&rsquo;s Third Amended and Restated Certificate
of Incorporation, as amended from time to time, and Amended and Restated Bylaws provide for the indemnification of its directors
and officers to the fullest extent permitted under the DGCL.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">The Registrant&rsquo;s Amended and Restated
Bylaws provide that expenses incurred by any officer or director in defending any such action, suit or proceeding in advance of
its final disposition shall be paid by the Registrant upon delivery to the Registrant of an undertaking, by or on behalf of such
director or officer, to repay all amounts so advanced if it shall ultimately be determined by final judicial decision from which
there is no further right to appeal that such director or officer is not entitled to be indemnified by the Registrant.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">The Registrant has an insurance policy
covering its directors and executive officers with respect to certain liabilities, including liabilities arising under the Securities
Act or otherwise.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>ITEM 8. EXHIBITS</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<tr>
    <TD STYLE="vertical-align: bottom; width: 7%; text-align: justify"><font style="font-size: 10pt"><b>Exhibit Number</b></font></td>
    <TD STYLE="vertical-align: top; width: 1%; text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <TD STYLE="vertical-align: top; width: 92%; text-align: justify"><font style="font-size: 10pt">&nbsp;&nbsp;</font></td></tr>
<tr>
    <TD STYLE="vertical-align: bottom; text-align: justify"><font style="font-size: 10pt"><b>&nbsp;</b></font></td>
    <TD STYLE="vertical-align: top; text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <TD STYLE="vertical-align: top; text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: right"><font style="font-size: 10pt">4.1</font></td>
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">Third Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.1 to the Registrant's Quarterly Report on Form 10-Q filed on November 14, 2005).</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: right">&nbsp;</td>
    <TD STYLE="text-align: justify">&nbsp;</td>
    <TD STYLE="text-align: justify">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: right"><font style="font-size: 10pt">4.2</font></td>
    <TD STYLE="text-align: justify">&nbsp;</td>
    <TD> Certificate of Amendment of Third Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.1 to the Registrant's Current Report on Form 8-K filed on May 29, 2012).</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: right">&nbsp;</td>
    <TD STYLE="text-align: justify">&nbsp;</td>
    <TD STYLE="text-align: justify">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: right"><font style="font-size: 10pt">4.3</font></td>
    <TD STYLE="text-align: justify">&nbsp;</td>
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">Certificate of Amendment of Third Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.1 to the Registrant&rsquo;s Current Report on Form 8-K filed on January 28, 2014).</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: right">&nbsp;</td>
    <TD STYLE="text-align: justify">&nbsp;</td>
    <TD STYLE="text-align: justify">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: right"><font style="font-size: 10pt">4.4</font></td>
    <TD STYLE="text-align: justify">&nbsp;</td>
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">Certificate of Amendment of Certificate of Designation of Series A Convertible Preferred Stock of the Registrant (incorporated by reference to Exhibit 3.1 to the Registrant&rsquo;s Current Report on Form 8-K filed on March 6, 2014).</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: right">&nbsp;</td>
    <TD STYLE="text-align: justify">&nbsp;</td>
    <TD STYLE="text-align: justify">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: right"><font style="font-size: 10pt">4.5</font></td>
    <TD STYLE="text-align: justify">&nbsp;</td>
    <TD> Certificate of Designation of Series B Convertible Preferred Stock of the Registrant (incorporated by reference to Exhibit 3.2 to the Registrant&rsquo;s Current Report on Form 8-K filed on March 6, 2014).</td></tr>
</TABLE>

<P STYLE="margin: 0">&nbsp;</P>

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<P STYLE="margin: 0"></P>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>



<P STYLE="margin: 0"></P>



<P STYLE="margin: 0"></P>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 7%; text-align: right"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">4.6</FONT></TD>
    <TD STYLE="width: 1%; text-align: justify">&nbsp;</TD>
    <TD STYLE="width: 92%; text-align: justify"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Amended and Restated Bylaws of the Registrant (incorporated by reference to Exhibit 3(ii) to the Registrant&rsquo;s Current Report on Form 8-K filed on May 25, 2007).</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: right"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">4.7</FONT></TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Form of Certificate of the Registrant&rsquo;s Common Stock (incorporated by reference to Exhibit 4 to the Registrant&rsquo;s Registration Statement on Form S-1 (Registration No. 333-32174) filed on March 10, 2000).</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: right"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">4.8</FONT></TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Form of Series A Convertible Preferred Stock Warrant issued to Third Security Senior Staff 2008 LLC, Third Security Staff 2010 LLC and Third Security Incentive 2010 LLC (incorporated by reference to Exhibit 4.2 to the Registrant&rsquo;s Current Report on Form 8-K filed on January 4, 2011).</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: right"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">4.9</FONT></TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Registration Rights Agreement, dated December 29, 2010, by and among the Registrant, Third Security Senior Staff 2008 LLC, Third Security Staff 2010 LLC and Third Security Incentive 2010 LLC (incorporated by reference to Exhibit 4.3 to the Registrant&rsquo;s Current Report on Form 8-K filed on January 4, 2011).</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: right"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">4.10</FONT></TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">First Amendment to Registration Rights Agreement dated November 8, 2011 (incorporated by reference to Exhibit 4.2 to the Registrant&rsquo;s Current Report on Form 8-K filed on November 14, 2011).</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: right"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">4.11</FONT></TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Form of Warrant issued by the Registrant to the Third Security Entities on February 7, 2012 (incorporated by reference to Exhibit 10.2 to the Registrant&rsquo;s Current Report on Form 8-K filed on February 7, 2012).</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: right"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">4.12</FONT></TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Form of Warrant issued by the Registrant to the Investors on February 7, 2012 (incorporated by reference to Exhibit 10.3 to the Registrant&rsquo;s Current Report on Form 8-K filed on February 7, 2012).</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: right"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">4.13</FONT></TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Form of Registration Rights Agreement entered into by and among the Registrant, the Third Security Entities and the Investors dated February 2, 2012 (incorporated by reference to Exhibit 10.4 to the Registrant&rsquo;s Current Report on Form 8-K filed on February 7, 2012).</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: right"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">4.14</FONT></TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Registration Rights Agreement, entered into by and among the Registrant and the Investors, dated January 24, 2013 (incorporated by reference to Exhibit 10.3 to the Registrant&rsquo;s Current Report on Form 8-K/A filed on January 31, 2013).</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: right"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">4.15</FONT></TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Form of Warrant issued by the Registrant to the Investors on January 30, 2013 (incorporated by reference to Exhibit 10.2 to the Registrant&rsquo;s Current Report on Form 8-K/A filed on January 31, 2013).</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: right"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">4.16</FONT></TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Registration Rights Agreement, dated as of March 5, 2014, by and among the Registrant, Third Security Senior Staff 2008 LLC, Third Security Staff 2014 LLC and Third Security Incentive 2010 LLC (incorporated by reference to Exhibit 4.1 to the Registrant&rsquo;s Current Report on Form 8-K filed on March 6, 2014).</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: right"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">5.1</FONT></TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Opinion of Paul Hastings LLP.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: right"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">23.1</FONT></TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Consent of Ernst &amp; Young LLP, Independent Registered Public Accounting Firm.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: right"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">23.2</FONT></TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Consent of McGladrey LLP, Independent Registered Public Accounting Firm.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: right"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">23.3</FONT></TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Consent of Paul Hastings LLP is contained in Exhibit 5.1 to this Registration Statement.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: right"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">24.1</FONT></TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Power of Attorney is contained on the signature page.</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>ITEM 9. UNDERTAKINGS. </B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(a) The Registrant hereby undertakes:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">(1) To file, during any period in which
offers or sales are being made, a post-effective amendment to this Registration Statement:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">(i) To include any prospectus required
by Section 10(a)(3) of the Securities Act;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">(ii) To reflect in the prospectus any facts
or events arising after the effective date of this Registration Statement (or the most recent post-effective amendment thereof)
which, individually or in the aggregate, represent a fundamental change in the information set forth in this Registration Statement;
and</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">(iii) To include any material information
with respect to the plan of distribution not previously disclosed in this Registration Statement or any material change to such
information in this Registration Statement;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 24.45pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 24.45pt"><I>Provided, however, that: </I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 24.45pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">(A) paragraphs (a)(1)(i) and (a)(1)(ii)
do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained in reports
filed with or furnished to the Commission by the Registrant pursuant to Section 13 or Section 15(d) of the Exchange Act that are
incorporated by reference in this Registration Statement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">(2) That, for the purpose of determining
any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating
to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial <I>bona fide</I>
offering thereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt">(3) To remove from registration by means
of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(b) The Registrant hereby undertakes that, for purposes of determining
any liability under the Securities Act, each filing of the Registrant&rsquo;s annual report pursuant to Section 13(a) or Section
15(d) of the Exchange Act that is incorporated by reference in this Registration Statement shall be deemed to be a new registration
statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the
initial <I>bona fide</I> offering thereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(h) Insofar as indemnification for liabilities arising under
the Securities Act may be permitted to directors, officers and controlling persons of the Registrant pursuant to the foregoing
provisions, or otherwise, the Registrant has been advised that in the opinion of the Commission such indemnification is against
public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification
against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling
person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or
controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel
the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification
by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SIGNATURES</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Pursuant to the requirements of the Securities
Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements
for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of Omaha, State of Nebraska, on June 12, 2014.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<tr style="vertical-align: top">
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <td colspan="3" style="text-align: justify"><font style="font-size: 10pt"><b>Transgenomic, Inc.</b></font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="width: 53%; text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <TD STYLE="width: 5%; text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <TD STYLE="width: 34%; text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <TD STYLE="width: 8%; text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">By: </font></td>
    <TD STYLE="padding-bottom: 1.5pt; text-align: justify; border-bottom: Black 1pt solid"><font style="font-size: 10pt">/s/ Paul Kinnon</font></td>
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td></tr>
<tr>
    <TD STYLE="vertical-align: top; text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <TD STYLE="vertical-align: top; text-align: justify"><font style="font-size: 10pt">Name:</font></td>
    <TD STYLE="vertical-align: bottom; text-align: justify"><font style="font-size: 10pt">Paul Kinnon</font></td>
    <TD STYLE="vertical-align: top; text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">Title:</font></td>
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">President and Chief Executive Officer</font></td>
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td></tr>
</table>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>POWER OF ATTORNEY</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><FONT STYLE="font-variant: small-caps"><B>Know
All Persons By These Presents</B></FONT>, that each person whose signature appears below constitutes and appoints Paul Kinnon and
Mark P. Colonnese, and each or any one of them, his true and lawful attorney-in-fact and agent, with full power of substitution
and resubstitution, for him and in his name, place and stead, in any and all capacities, to sign any and all amendments (including
post-effective amendments) to this Registration Statement, and to file the same, with all exhibits thereto, and other documents
in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each
of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection
therewith, as fully to all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said
attorneys-in-fact and agents, or any of them, or their or his substitutes or substitute, may lawfully do or cause to be done by
virtue hereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Pursuant to the requirements of the Securities
Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<tr style="vertical-align: top">
    <TD STYLE="width: 30%; border-bottom: Black 1pt solid; text-align: center"><font style="font-size: 10pt">SIGNATURE</font></td>
    <TD STYLE="width: 1%; padding-bottom: 1pt; text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <TD STYLE="width: 41%; border-bottom: Black 1pt solid; text-align: center"><font style="font-size: 10pt">TITLE</font></td>
    <TD STYLE="width: 2%; padding-bottom: 1pt; text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <TD STYLE="width: 26%; border-bottom: Black 1pt solid; text-align: center"><font style="font-size: 10pt">DATE</font></td></tr>
<tr>
    <td style="text-align: justify"><font style="font-size: 10pt">&nbsp;&nbsp;</font></td>
    <td style="vertical-align: top; text-align: justify"><font style="font-size: 10pt">&nbsp;&nbsp;</font></td>
    <td style="vertical-align: top; text-align: justify"><font style="font-size: 10pt">&nbsp;&nbsp;</font></td>
    <td style="vertical-align: top; text-align: justify"><font style="font-size: 10pt">&nbsp;&nbsp;</font></td>
    <td style="vertical-align: top; text-align: justify"><font style="font-size: 10pt">&nbsp;&nbsp;</font></td></tr>
<tr>
    <TD STYLE="vertical-align: bottom; padding-bottom: 1pt; text-align: justify; border-bottom: Black 1pt solid"><font style="font-size: 10pt">/s/ Paul Kinnon</font></td>
    <TD STYLE="vertical-align: top; text-align: justify; padding-bottom: 1pt"><font style="font-size: 10pt">&nbsp;</font></td>
    <TD STYLE="vertical-align: top; text-align: justify; padding-bottom: 1pt"><font style="font-size: 10pt">President, Chief Executive Officer and</font></td>
    <TD STYLE="vertical-align: top; text-align: justify; padding-bottom: 1pt"><font style="font-size: 10pt">&nbsp;</font></td>
    <TD STYLE="vertical-align: top; text-align: center; padding-bottom: 1pt"><font style="font-size: 10pt">June 12, 2014</font></td></tr>
<tr style="vertical-align: top">
    <td style="text-align: justify"><font style="font-size: 10pt">Paul Kinnon</font></td>
    <td style="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="text-align: justify"><font style="font-size: 10pt">Director (Principal Executive Officer)</font></td>
    <td style="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td></tr>
<tr>
    <td style="text-align: justify"><font style="font-size: 10pt">&nbsp;&nbsp;</font></td>
    <td style="vertical-align: top; text-align: justify"><font style="font-size: 10pt">&nbsp;&nbsp;</font></td>
    <td style="vertical-align: top; text-align: justify"><font style="font-size: 10pt">&nbsp;&nbsp;</font></td>
    <td style="vertical-align: top; text-align: justify"><font style="font-size: 10pt">&nbsp;&nbsp;</font></td>
    <td style="vertical-align: top; text-align: justify"><font style="font-size: 10pt">&nbsp;&nbsp;</font></td></tr>
<tr>
    <TD STYLE="vertical-align: bottom; padding-bottom: 1.5pt; text-align: justify; border-bottom: Black 1pt solid"><font style="font-size: 10pt">/s/ Mark P. Colonnese</font></td>
    <td style="vertical-align: top; text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="vertical-align: top; text-align: justify"><FONT STYLE="font-size: 10pt">Executive Vice President and</FONT> Chief</td>
    <td style="vertical-align: top; text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="vertical-align: top; text-align: center"><font style="font-size: 10pt">June 12, 2014</font></td></tr>
<tr style="vertical-align: top">
    <td style="text-align: justify"><font style="font-size: 10pt">Mark P. Colonnese</font></td>
    <td style="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="text-align: justify"><P STYLE="margin-top: 0; margin-bottom: 0">Financial Officer (Principal Financial</P>
                                    <P STYLE="margin-top: 0; margin-bottom: 0">Officer and Principal Accounting Officer)</P></td>
    <td style="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td></tr>
<tr>
    <td style="text-align: justify"><font style="font-size: 10pt">&nbsp;&nbsp;</font></td>
    <td style="vertical-align: top; text-align: justify"><font style="font-size: 10pt">&nbsp;&nbsp;</font></td>
    <td style="vertical-align: top; text-align: justify"><font style="font-size: 10pt">&nbsp;&nbsp;</font></td>
    <td style="vertical-align: top; text-align: justify"><font style="font-size: 10pt">&nbsp;&nbsp;</font></td>
    <td style="vertical-align: top; text-align: justify"><font style="font-size: 10pt">&nbsp;&nbsp;</font></td></tr>
<tr>
    <TD STYLE="vertical-align: bottom; padding-bottom: 1.5pt; text-align: justify; border-bottom: Black 1pt solid"><font style="font-size: 10pt">/s/ Rodney S. Markin</font></td>
    <td style="vertical-align: top; text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="vertical-align: top; text-align: justify"><font style="font-size: 10pt">Director</font></td>
    <td style="vertical-align: top; text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="vertical-align: top; text-align: center"><font style="font-size: 10pt">June 12, 2014</font></td></tr>
<tr style="vertical-align: top">
    <td style="text-align: justify"><font style="font-size: 10pt">Rodney S. Markin</font></td>
    <td style="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="text-align: justify">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <td style="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="text-align: justify">&nbsp;</td></tr>
<tr>
    <TD STYLE="vertical-align: bottom; padding-bottom: 1.5pt; text-align: justify; border-bottom: Black 1pt solid"><font style="font-size: 10pt">/s/ John D. Thompson</font></td>
    <td style="vertical-align: top; text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="vertical-align: top; text-align: justify"><font style="font-size: 10pt">Director</font></td>
    <td style="vertical-align: top; text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="vertical-align: top; text-align: center"><font style="font-size: 10pt">June 12, 2014</font></td></tr>
<tr style="vertical-align: top">
    <td style="text-align: justify"><font style="font-size: 10pt">John D. Thompson</font></td>
    <td style="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="text-align: justify">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <td style="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="text-align: justify">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="padding-bottom: 1.5pt; text-align: justify; border-bottom: Black 1pt solid"><font style="font-size: 10pt">/s/ Robert M. Patzig</font></td>
    <td style="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="text-align: justify"><font style="font-size: 10pt">Director</font></td>
    <td style="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="text-align: center"><font style="font-size: 10pt">June 12, 2014</font></td></tr>
<tr style="vertical-align: top">
    <td style="text-align: justify"><font style="font-size: 10pt">Robert M. Patzig</font></td>
    <td style="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="text-align: justify">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <td style="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="text-align: justify">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="padding-bottom: 1.5pt; text-align: justify; border-bottom: Black 1pt solid"><font style="font-size: 10pt">/s/ Doit L. Koppler II</font></td>
    <td style="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="text-align: justify"><font style="font-size: 10pt">Director</font></td>
    <td style="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="text-align: center"><font style="font-size: 10pt">June 12, 2014</font></td></tr>
<tr style="vertical-align: top">
    <td style="text-align: justify"><font style="font-size: 10pt">Doit L. Koppler II</font></td>
    <td style="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="text-align: justify">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <td style="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="text-align: justify">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="padding-bottom: 1.5pt; text-align: justify; border-bottom: Black 1pt solid"><font style="font-size: 10pt">/s/ Michael A. Luther</font></td>
    <td style="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="text-align: justify"><font style="font-size: 10pt">Director</font></td>
    <td style="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="text-align: center"><font style="font-size: 10pt">June 12, 2014</font></td></tr>
<tr style="vertical-align: top">
    <td style="text-align: justify"><font style="font-size: 10pt">Michael A. Luther</font></td>
    <td style="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <td style="text-align: justify">&nbsp;</td></tr>
</table>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B></B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>EXHIBIT INDEX</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<tr>
    <TD STYLE="vertical-align: bottom; width: 7%; text-align: justify"><font style="font-size: 10pt"><b>Exhibit Number</b></font></td>
    <TD STYLE="vertical-align: top; width: 1%; text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <TD STYLE="vertical-align: top; width: 92%; text-align: justify"><font style="font-size: 10pt">&nbsp;&nbsp;</font></td></tr>
<tr>
    <TD STYLE="vertical-align: bottom; text-align: justify"><font style="font-size: 10pt"><b>&nbsp;</b></font></td>
    <TD STYLE="vertical-align: top; text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <TD STYLE="vertical-align: top; text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: right"><font style="font-size: 10pt">4.1</font></td>
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">Third Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.1 to the Registrant's Quarterly Report on Form 10-Q filed on November 14, 2005).</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: right">&nbsp;</td>
    <TD STYLE="text-align: justify">&nbsp;</td>
    <TD STYLE="text-align: justify">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: right"><font style="font-size: 10pt">4.2</font></td>
    <TD STYLE="text-align: justify">&nbsp;</td>
    <TD>Certificate of Amendment of Third Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.1 to the Registrant's Current Report on Form 8-K filed on May 29, 2012).</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: right">&nbsp;</td>
    <TD STYLE="text-align: justify">&nbsp;</td>
    <TD STYLE="text-align: justify">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: right"><font style="font-size: 10pt">4.3</font></td>
    <TD STYLE="text-align: justify">&nbsp;</td>
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">Certificate of Amendment of Third Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.1 to the Registrant&rsquo;s Current Report on Form 8-K filed on January 28, 2014).</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: right">&nbsp;</td>
    <TD STYLE="text-align: justify">&nbsp;</td>
    <TD STYLE="text-align: justify">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: right"><font style="font-size: 10pt">4.4</font></td>
    <TD STYLE="text-align: justify">&nbsp;</td>
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">Certificate of Amendment of Certificate of Designation of Series A Convertible Preferred Stock of the Registrant (incorporated by reference to Exhibit 3.1 to the Registrant&rsquo;s Current Report on Form 8-K filed on March 6, 2014).</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: right">&nbsp;</td>
    <TD STYLE="text-align: justify">&nbsp;</td>
    <TD STYLE="text-align: justify">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: right"><font style="font-size: 10pt">4.5</font></td>
    <TD STYLE="text-align: justify">&nbsp;</td>
    <TD>Certificate of Designation of Series B Convertible Preferred Stock of the Registrant (incorporated by reference to Exhibit 3.2 to the Registrant&rsquo;s Current Report on Form 8-K filed on March 6, 2014).</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: right">&nbsp;</td>
    <TD STYLE="text-align: justify">&nbsp;</td>
    <TD STYLE="text-align: justify">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: right"><font style="font-size: 10pt">4.6</font></td>
    <TD STYLE="text-align: justify">&nbsp;</td>
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">Amended and Restated Bylaws of the Registrant (incorporated by reference to Exhibit 3(ii) to the Registrant&rsquo;s Current Report on Form 8-K filed on May 25, 2007).</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: right">&nbsp;</td>
    <TD STYLE="text-align: justify">&nbsp;</td>
    <TD STYLE="text-align: justify">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: right"><font style="font-size: 10pt">4.7</font></td>
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">Form of Certificate of the Registrant&rsquo;s Common Stock (incorporated by reference to Exhibit 4 to the Registrant&rsquo;s Registration Statement on Form S-1 (Registration No. 333-32174) filed on March 10, 2000).</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: right"><font style="font-size: 10pt">&nbsp;</font></td>
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: right"><font style="font-size: 10pt">4.8</font></td>
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">Form of Series A Convertible Preferred Stock Warrant issued to Third Security Senior Staff 2008 LLC, Third Security Staff 2010 LLC and Third Security Incentive 2010 LLC (incorporated by reference to Exhibit 4.2 to the Registrant&rsquo;s Current Report on Form 8-K filed on January 4, 2011).</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: right"><font style="font-size: 10pt">&nbsp;</font></td>
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: right"><font style="font-size: 10pt">4.9</font></td>
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">Registration Rights Agreement, dated December 29, 2010, by and among the Registrant, Third Security Senior Staff 2008 LLC, Third Security Staff 2010 LLC and Third Security Incentive 2010 LLC (incorporated by reference to Exhibit 4.3 to the Registrant&rsquo;s Current Report on Form 8-K filed on January 4, 2011).</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: right"><font style="font-size: 10pt">&nbsp;</font></td>
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: right"><font style="font-size: 10pt">4.10</font></td>
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">First Amendment to Registration Rights Agreement dated November 8, 2011 (incorporated by reference to Exhibit 4.2 to the Registrant&rsquo;s Current Report on Form 8-K filed on November 14, 2011).</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: right">&nbsp;</td>
    <TD STYLE="text-align: justify">&nbsp;</td>
    <TD STYLE="text-align: justify">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: right"><font style="font-size: 10pt">4.11</font></td>
    <TD STYLE="text-align: justify">&nbsp;</td>
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">Form of Warrant issued by the Registrant to the Third Security Entities on February 7, 2012 (incorporated by reference to Exhibit 10.2 to the Registrant&rsquo;s Current Report on Form 8-K filed on February 7, 2012).</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: right">&nbsp;</td>
    <TD STYLE="text-align: justify">&nbsp;</td>
    <TD STYLE="text-align: justify">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: right"><font style="font-size: 10pt">4.12</font></td>
    <TD STYLE="text-align: justify">&nbsp;</td>
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">Form of Warrant issued by the Registrant to the Investors on February 7, 2012 (incorporated by reference to Exhibit 10.3 to the Registrant&rsquo;s Current Report on Form 8-K filed on February 7, 2012).</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: right">&nbsp;</td>
    <TD STYLE="text-align: justify">&nbsp;</td>
    <TD STYLE="text-align: justify">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: right"><font style="font-size: 10pt">4.13</font></td>
    <TD STYLE="text-align: justify">&nbsp;</td>
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">Form of Registration Rights Agreement entered into by and among the Registrant, the Third Security Entities and the Investors dated February 2, 2012 (incorporated by reference to Exhibit 10.4 to the Registrant&rsquo;s Current Report on Form 8-K filed on February 7, 2012).</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: right">&nbsp;</td>
    <TD STYLE="text-align: justify">&nbsp;</td>
    <TD STYLE="text-align: justify">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: right"><font style="font-size: 10pt">4.14</font></td>
    <TD STYLE="text-align: justify">&nbsp;</td>
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">Registration Rights Agreement, entered into by and among the Registrant and the Investors, dated January 24, 2013 (incorporated by reference to Exhibit 10.3 to the Registrant&rsquo;s Current Report on Form 8-K/A filed on January 31, 2013).</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: right">&nbsp;</td>
    <TD STYLE="text-align: justify">&nbsp;</td>
    <TD STYLE="text-align: justify">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: right"><font style="font-size: 10pt">4.15</font></td>
    <TD STYLE="text-align: justify">&nbsp;</td>
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">Form of Warrant issued by the Registrant to the Investors on January 30, 2013 (incorporated by reference to Exhibit 10.2 to the Registrant&rsquo;s Current Report on Form 8-K/A filed on January 31, 2013).</font></td></tr>
</TABLE>

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    <TD STYLE="text-align: right; width: 7%"><font style="font-size: 10pt">4.16</font></td>
    <TD STYLE="text-align: justify; width: 1%">&nbsp;</td>
    <TD STYLE="text-align: justify; width: 92%"><font style="font-size: 10pt">Registration Rights Agreement, dated as of March 5, 2014, by and among the Registrant, Third Security Senior Staff 2008 LLC, Third Security Staff 2014 LLC and Third Security Incentive 2010 LLC (incorporated by reference to Exhibit 4.1 to the Registrant&rsquo;s Current Report on Form 8-K filed on March 6, 2014).</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: right"><font style="font-size: 10pt">&nbsp;</font></td>
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: right"><font style="font-size: 10pt">5.1</font></td>
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">Opinion of Paul Hastings LLP.</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: right"><font style="font-size: 10pt">&nbsp;</font></td>
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: right"><font style="font-size: 10pt">23.1</font></td>
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">Consent of Ernst &amp; Young LLP, Independent Registered Public Accounting Firm.</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: right">&nbsp;</td>
    <TD STYLE="text-align: justify">&nbsp;</td>
    <TD STYLE="text-align: justify">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: right"><font style="font-size: 10pt">23.2</font></td>
    <TD STYLE="text-align: justify">&nbsp;</td>
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">Consent of McGladrey LLP, Independent Registered Public Accounting Firm.</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: right">&nbsp;</td>
    <TD STYLE="text-align: justify">&nbsp;</td>
    <TD STYLE="text-align: justify">&nbsp;</td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: right"><font style="font-size: 10pt">23.3</font></td>
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">Consent of Paul Hastings LLP is contained in Exhibit 5.1 to this Registration Statement.</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: right"><font style="font-size: 10pt">&nbsp;</font></td>
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td></tr>
<tr style="vertical-align: top">
    <TD STYLE="text-align: right"><font style="font-size: 10pt">24.1</font></td>
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">&nbsp;</font></td>
    <TD STYLE="text-align: justify"><font style="font-size: 10pt">Power of Attorney is contained on the signature page.</font></td></tr>
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<TYPE>EX-5.1
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<FILENAME>v381278_ex5-1.htm
<DESCRIPTION>EXHIBIT 5.1
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: right"><B>Exhibit 5.1</B></P>



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    <td><img src="image_004.jpg" alt="PH_Logo" style="width: 183px; height: 54px"></td></tr>
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    <TD STYLE="width: 52%; font-size: 10pt">June 12, 2014</td>
    <TD STYLE="width: 48%; text-align: right; font-size: 10pt">79049.00001</td></tr>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 5.75pt 0pt 0.5in; text-indent: -0.5in">Transgenomic, Inc.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 5.75pt 0pt 0.5in; text-indent: -0.5in">12325 Emmet Street</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 5.75pt 0pt 0.5in; text-indent: -0.5in">Omaha, Nebraska 68164</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 5.75pt 0pt 0.5in; text-indent: -0.5in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">Re:</TD><TD STYLE="padding-right: 5.65pt">Registration Statement on Form S-8</TD></TR></TABLE>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Ladies and Gentlemen:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We have acted as counsel to Transgenomic,
Inc., a Delaware corporation (the &ldquo;<B><I>Company</I></B>&rdquo;), in connection with the registration statement on Form S-8
to be filed by the Company with the U.S. Securities and Exchange Commission (the &ldquo;<B><I>Commission</I></B>&rdquo;) on or
about the date hereof (the &ldquo;<B><I>Registration Statement</I></B>&rdquo;) to effect registration under the Securities Act
of 1933, as amended (the &ldquo;<B><I>Securities Act</I></B>&rdquo;), of an aggregate of 833,333 shares (the &ldquo;<B><I>Shares</I></B>&rdquo;)
of the Company&rsquo;s common stock, $0.01 par value per share, issuable upon the exercise of awards to be granted by the Company
pursuant to the Company&rsquo;s 2006 Equity Incentive Plan, as amended (the &ldquo;<B><I>Plan</I></B>&rdquo;).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">As such counsel and for purposes of our
opinion set forth below, we have examined and relied upon originals or copies, certified or otherwise identified to our satisfaction,
of such documents, resolutions, certificates and instruments of the Company and corporate records furnished to us by the Company,
and have reviewed certificates of public officials, statutes, records and such other instruments and documents as we have deemed
necessary or appropriate as a basis for the opinion set forth below, including, without limitation:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

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<TD STYLE="width: 35pt"></TD><TD STYLE="width: 35pt">(i)</TD><TD STYLE="text-align: justify">the Registration Statement;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 35pt"></TD><TD STYLE="width: 35pt">(ii)</TD><TD STYLE="text-align: justify">the Third Amended and Restated Certificate of Incorporation of the Company, as amended, the Certificate
of Amendment of Certificate of Designation of Series A Convertible Preferred Stock of the Company and the Certificate of Designation
of Series B Convertible Preferred Stock of the Company, each as certified as of June 12, 2014 by the Office of the Secretary of
State of the State of Delaware;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 35pt"></TD><TD STYLE="width: 35pt">(iii)</TD><TD STYLE="text-align: justify">the Amended and Restated Bylaws of the Company as presently in effect, as certified by an officer
of the Company as of June 12, 2014;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 35pt"></TD><TD STYLE="width: 35pt">(vi)</TD><TD STYLE="text-align: justify">the Plan and the forms of award agreements related thereto; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 35pt"></TD><TD STYLE="width: 35pt">(vii)</TD><TD STYLE="text-align: justify">a certificate, dated as of June 12, 2014, from the Office of the Secretary of State of the State
of Delaware, as to the existence and good standing of the Company in the State of Delaware (the &ldquo;<B><I>Good Standing Certificate</I></B>&rdquo;).</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">In addition to the foregoing, we have made
such investigations of law as we have deemed necessary or appropriate as a basis for the opinion set forth herein.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: right">&nbsp; <IMG SRC="image_005.jpg" ALT="PaloAlto" STYLE="width: 453px; height: 30px"></P>




<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp; <IMG SRC="image_006.jpg" ALT="PH_Logo" STYLE="width: 144px; height: 42px"></P>




<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Transgenomic, Inc.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">June 12, 2014</P>

<P STYLE="margin: 0pt 0">Page <FONT STYLE="font: 10pt Times New Roman, Times, Serif">2</FONT></P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">In such examination and in rendering the
opinion expressed below, we have assumed, without independent investigation or verification: (i) the genuineness of all signatures
on all agreements, instruments, corporate records, certificates and other documents submitted to us; (ii) the authenticity and
completeness of all agreements, instruments, corporate records, certificates and other documents submitted to us as originals;
(iii) that all agreements, instruments, corporate records, certificates and other documents submitted to us as certified, electronic,
facsimile, conformed, photostatic or other copies conform to originals thereof, and that such originals are authentic and complete;
(iv) the legal capacity and authority of all persons or entities, other than the Company, executing all agreements, instruments,
corporate records, certificates and other documents submitted to us; (v) the due authorization, execution and delivery of all agreements,
instruments, corporate records, certificates and other documents by all parties thereto, other than the Company; (vi) that the
statements contained in the certificates and comparable documents of public officials, officers and representatives of the Company
and other persons on which we have relied for the purposes of this opinion letter are true and correct; (vii) that there has not
been any change in the good standing status of the Company from that reported in the Good Standing Certificate; and (viii) that
the officers and directors of the Company have properly exercised their fiduciary duties. As to all questions of fact material
to this opinion letter, and as to the materiality of any fact or other matter referred to herein, we have relied (without independent
investigation) upon representations and certificates or comparable documents of officers and representatives of the Company. Our
knowledge of the Company and its legal and other affairs is limited by the scope of our engagement, which scope includes the delivery
of this opinion letter. We do not represent the Company with respect to all legal matters or issues. The Company may employ other
independent counsel and, to our knowledge, handles certain legal matters and issues without the assistance of independent counsel.
We have also assumed that the individual issuances, grants or awards under the Plan will be duly authorized by all necessary corporate
action of the Company and duly issued, granted or awarded and exercised in accordance with the requirements of law and the Plan
(and the agreements and awards duly adopted thereunder and in accordance therewith).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Based upon the foregoing, and in reliance
thereon, and subject to the limitations, qualifications and exceptions set forth herein, we are of the opinion that the Shares
are duly authorized and, when issued and sold as described in the Registration Statement and in accordance with the Plan and the
applicable award agreements thereunder (including the receipt by the Company of the full consideration therefor), will be validly
issued, fully paid and nonassessable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Without limiting any of the other limitations,
exceptions and qualifications stated elsewhere herein, we express no opinion with regard to the applicability or effect of the
laws of any jurisdiction other than the General Corporation Law of the State of Delaware as in effect on the date hereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">This opinion letter deals only with the specified legal issues
expressly addressed herein, and you should not infer any opinion that is not explicitly stated herein from any matter addressed
in this opinion letter.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><IMG SRC="image_006.jpg" ALT="PH_Logo" STYLE="width: 144px; height: 42px">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Transgenomic, Inc.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">June 12, 2014</P>

<P STYLE="margin: 0pt 0">Page <FONT STYLE="font: 10pt Times New Roman, Times, Serif">3</FONT></P>

<P STYLE="margin: 0pt 0"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</FONT></P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">This opinion letter is rendered solely
in connection with the issuance and delivery of the Shares as described in the Registration Statement and in accordance with the
terms of the Plan and the applicable award agreements thereunder. This opinion letter is rendered as of the date hereof, and we
assume no obligation to advise you or any other person with regard to any change after the date hereof in the circumstances or
the law that may bear on the matters set forth herein even if the change may affect the legal analysis or a legal conclusion or
other matters in this opinion letter.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We hereby consent to the filing of this
opinion letter as Exhibit 5.1 to the Registration Statement. In giving such consent, we do not hereby admit that we are within
the category of persons whose consent is required under Section 7 of the Securities Act or the rules or regulations of the Commission
thereunder.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Very truly yours,</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">/s/ Paul Hastings LLP</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>3
<FILENAME>v381278_ex23-1.htm
<DESCRIPTION>EXHIBIT 23.1
<TEXT>
<HTML>
<HEAD>
     <TITLE></TITLE>
</HEAD>
<BODY STYLE="font: 10pt Times New Roman, Times, Serif">

<P STYLE="margin: 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><B>Exhibit 23.1</B></P>



<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="margin: 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Consent of Independent Registered Public
Accounting Firm</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">We consent to the incorporation by reference
in the Registration Statement (Form S-8) pertaining to the Transgenomic, Inc. 2006 Equity Incentive Plan of our report dated March
27, 2014, with respect to the consolidated financial statements of Transgenomic, Inc. included in its Annual Report (Form 10-K)
for the year ended December 31, 2013, filed with the Securities and Exchange Commission.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">/s/ Ernst &amp; Young LLP</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Hartford, CT</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">June 12, 2014</P>



<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="margin: 0"></P>

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<DOCUMENT>
<TYPE>EX-23.2
<SEQUENCE>4
<FILENAME>v381278_ex23-2.htm
<DESCRIPTION>EXHIBIT 23.2
<TEXT>
<HTML>
<HEAD>
     <TITLE></TITLE>
</HEAD>
<BODY STYLE="font: 10pt Times New Roman, Times, Serif">

<P STYLE="margin: 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><B>Exhibit 23.2</B></P>



<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="margin: 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>CONSENT OF INDEPENDENT REGISTERED PUBLIC
ACCOUNTING FIRM</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">We consent to the incorporation by reference in this Registration
Statement on Form S-8 of Transgenomic, Inc. and Subsidiary of our report dated March 14, 2013, relating to our audit of the consolidated
financial statements of Transgenomic, Inc. and Subsidiary as of December 31, 2012 and for the years ended December 31, 2012 and
2011, included in the Annual Report on Form 10-K for the year ended December 31, 2013.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">/s/ McGladrey LLP</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Omaha, Nebraska</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">June 12, 2014</P>



<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="margin: 0"></P>

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`
end
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
