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INCOME TAXES, Stautory Income Tax Rate to Income Taxes (Details) - USD ($) | 12 Months Ended
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Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Statutory Income Tax Rate to Income Before Income Taxes [Abstract] |  |  |
Loss before provision for income tax | $ (16,421,807) | $ (5,196,931) | $ (19,505,470)
Effect of differing tax rates | 700,336 | 91,397 | 33,047
Effect of non-deductible expenses | 396,826 | 95,659 | 36,694
Effect of research and development deduction | (204,807) | (147,155) | (232,963)
Effect of valuation allowance | 3,213,097 | 1,259,332 | 5,039,590
Total income tax expense | $ 0 | $ 0 | $ 0
Effective income tax rate | 0.00% | 0.00% | 0.00%
PRC [Member] |  |  |
Statutory Income Tax Rate to Income Before Income Taxes [Abstract] |  |  |
Loss before provision for income tax | $ (5,477,857) | $ 108,221 | $ (13,779,840)
Statutory income tax rate | 25.00% | 25.00% | 25.00%
Income tax expense at the statutory rate | $ (4,105,452) | $ (1,299,233) | $ (4,876,368)

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