    <SEC-DOCUMENT>0001493152-21-025555-index.html : 20211015
    <SEC-HEADER>0001493152-21-025555.hdr.sgml : 20211015
    <ACCEPTANCE-DATETIME>20211015161615
    ACCESSION NUMBER:		0001493152-21-025555
    CONFORMED SUBMISSION TYPE:	S-1/A
    PUBLIC DOCUMENT COUNT:		31
    FILED AS OF DATE:		20211015
    DATE AS OF CHANGE:		20211015

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			Hillstream BioPharma Inc.
    		CENTRAL INDEX KEY:			0001861657
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				842642541
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		S-1/A
    		SEC ACT:		1933 Act
    		SEC FILE NUMBER:	333-259821
    		FILM NUMBER:		211326249

    	BUSINESS ADDRESS:
    		STREET 1:		1200 ROUTE 22 EAST
    		CITY:			BRIDGEWATER
    		STATE:			NJ
    		ZIP:			08807
    		BUSINESS PHONE:		302-743-2995

    	MAIL ADDRESS:
    		STREET 1:		245 MAIN STREET
    		STREET 2:		SUITE 204
    		CITY:			CHESTER
    		STATE:			NJ
    		ZIP:			07930
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>S-1/A
    <SEQUENCE>1
    <FILENAME>forms-1a.htm
    <TEXT>
    Document 1 - file: forms-1a.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-3.5
    <SEQUENCE>2
    <FILENAME>ex3-5.htm
    <TEXT>
    Document 2 - file: ex3-5.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-23.1
    <SEQUENCE>3
    <FILENAME>ex23-1.htm
    <TEXT>
    Document 3 - file: ex23-1.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>4
    <FILENAME>ex3-5_001.jpg
    <TEXT>
    Document 4 - file: ex3-5_001.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>5
    <FILENAME>ex3-5_002.jpg
    <TEXT>
    Document 5 - file: ex3-5_002.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>6
    <FILENAME>logo_001.jpg
    <TEXT>
    Document 6 - file: logo_001.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>7
    <FILENAME>drsa_001.jpg
    <TEXT>
    Document 7 - file: drsa_001.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>8
    <FILENAME>drsa_03.jpg
    <TEXT>
    Document 8 - file: drsa_03.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>9
    <FILENAME>drsa_002.jpg
    <TEXT>
    Document 9 - file: drsa_002.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>10
    <FILENAME>drsa_003.jpg
    <TEXT>
    Document 10 - file: drsa_003.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>11
    <FILENAME>drsa_004.jpg
    <TEXT>
    Document 11 - file: drsa_004.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>12
    <FILENAME>drsa_005.jpg
    <TEXT>
    Document 12 - file: drsa_005.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>13
    <FILENAME>drsa_006.jpg
    <TEXT>
    Document 13 - file: drsa_006.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>14
    <FILENAME>drsa_007.jpg
    <TEXT>
    Document 14 - file: drsa_007.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>15
    <FILENAME>drsa_008.jpg
    <TEXT>
    Document 15 - file: drsa_008.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>16
    <FILENAME>drsa_009.jpg
    <TEXT>
    Document 16 - file: drsa_009.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>17
    <FILENAME>drsa_010.jpg
    <TEXT>
    Document 17 - file: drsa_010.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>18
    <FILENAME>drsa_011.jpg
    <TEXT>
    Document 18 - file: drsa_011.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>19
    <FILENAME>drsa_012.jpg
    <TEXT>
    Document 19 - file: drsa_012.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>20
    <FILENAME>drsa_025.jpg
    <TEXT>
    Document 20 - file: drsa_025.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>21
    <FILENAME>drsa_014.jpg
    <TEXT>
    Document 21 - file: drsa_014.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>22
    <FILENAME>drsa_015.jpg
    <TEXT>
    Document 22 - file: drsa_015.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>23
    <FILENAME>drsa_016.jpg
    <TEXT>
    Document 23 - file: drsa_016.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>24
    <FILENAME>drsa_017.jpg
    <TEXT>
    Document 24 - file: drsa_017.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>25
    <FILENAME>drsa_018.jpg
    <TEXT>
    Document 25 - file: drsa_018.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>26
    <FILENAME>drsa_019.jpg
    <TEXT>
    Document 26 - file: drsa_019.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>27
    <FILENAME>drsa_020.jpg
    <TEXT>
    Document 27 - file: drsa_020.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>28
    <FILENAME>drsa_021.jpg
    <TEXT>
    Document 28 - file: drsa_021.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>29
    <FILENAME>drsa_022.jpg
    <TEXT>
    Document 29 - file: drsa_022.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>30
    <FILENAME>drsa_023.jpg
    <TEXT>
    Document 30 - file: drsa_023.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>31
    <FILENAME>drsa_024.jpg
    <TEXT>
    Document 31 - file: drsa_024.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>