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Quarterly Financial Data (Unaudited) - Schedule of Quarterly Financial Data (Detail) (USD $) In Thousands, except Share data, unless otherwise specified	1 Months Ended	3 Months Ended								12 Months Ended
	Apr. 30, 2014	Dec. 31, 2014	Sep. 30, 2014	Jun. 30, 2014	Mar. 31, 2014	Dec. 31, 2013	Sep. 30, 2013	Jun. 30, 2013	Mar. 31, 2013	Dec. 31, 2014	Dec. 31, 2013	Dec. 31, 2012
Quarterly Financial Information Disclosure [Abstract]
Revenue				$ 33us-gaap_Revenues	$ 47us-gaap_Revenues	$ 6us-gaap_Revenues				$ 80us-gaap_Revenues	$ 6us-gaap_Revenues	$ 625us-gaap_Revenues
Operating expenses:
Research and development		4,701us-gaap_ResearchAndDevelopmentExpense	2,928us-gaap_ResearchAndDevelopmentExpense	2,648us-gaap_ResearchAndDevelopmentExpense	1,495us-gaap_ResearchAndDevelopmentExpense	1,440us-gaap_ResearchAndDevelopmentExpense	1,586us-gaap_ResearchAndDevelopmentExpense	3,195us-gaap_ResearchAndDevelopmentExpense	3,479us-gaap_ResearchAndDevelopmentExpense	11,772us-gaap_ResearchAndDevelopmentExpense	9,700us-gaap_ResearchAndDevelopmentExpense	15,807us-gaap_ResearchAndDevelopmentExpense
General and administrative		2,607us-gaap_GeneralAndAdministrativeExpense	2,441us-gaap_GeneralAndAdministrativeExpense	2,029us-gaap_GeneralAndAdministrativeExpense	1,510us-gaap_GeneralAndAdministrativeExpense	1,575us-gaap_GeneralAndAdministrativeExpense	1,227us-gaap_GeneralAndAdministrativeExpense	1,392us-gaap_GeneralAndAdministrativeExpense	1,972us-gaap_GeneralAndAdministrativeExpense	8,587us-gaap_GeneralAndAdministrativeExpense	6,166us-gaap_GeneralAndAdministrativeExpense	6,393us-gaap_GeneralAndAdministrativeExpense
Total operating expenses		7,308us-gaap_OperatingExpenses	5,369us-gaap_OperatingExpenses	4,677us-gaap_OperatingExpenses	3,005us-gaap_OperatingExpenses	3,015us-gaap_OperatingExpenses	2,813us-gaap_OperatingExpenses	4,587us-gaap_OperatingExpenses	5,451us-gaap_OperatingExpenses	20,359us-gaap_OperatingExpenses	15,866us-gaap_OperatingExpenses	22,200us-gaap_OperatingExpenses
Other income (expense):
Interest income		4us-gaap_InvestmentIncomeInterest	2us-gaap_InvestmentIncomeInterest	2us-gaap_InvestmentIncomeInterest	1us-gaap_InvestmentIncomeInterest	1us-gaap_InvestmentIncomeInterest			1us-gaap_InvestmentIncomeInterest	9us-gaap_InvestmentIncomeInterest	2us-gaap_InvestmentIncomeInterest	2us-gaap_InvestmentIncomeInterest
Interest expense		(163)us-gaap_InterestExpense	(191)us-gaap_InterestExpense	(268)us-gaap_InterestExpense	(461)us-gaap_InterestExpense	(430)us-gaap_InterestExpense	(378)us-gaap_InterestExpense	(326)us-gaap_InterestExpense	(353)us-gaap_InterestExpense	(1,083)us-gaap_InterestExpense	(1,487)us-gaap_InterestExpense	(567)us-gaap_InterestExpense
Loss on extinguishment of debt	(2,493)us-gaap_GainsLossesOnExtinguishmentOfDebt			(2,493)us-gaap_GainsLossesOnExtinguishmentOfDebt						(2,493)us-gaap_GainsLossesOnExtinguishmentOfDebt
Decrease in value of preferred stock warrant liability					504us-gaap_FairValueAdjustmentOfWarrants	(42)us-gaap_FairValueAdjustmentOfWarrants	(7)us-gaap_FairValueAdjustmentOfWarrants	20us-gaap_FairValueAdjustmentOfWarrants	231us-gaap_FairValueAdjustmentOfWarrants	504us-gaap_FairValueAdjustmentOfWarrants	202us-gaap_FairValueAdjustmentOfWarrants	39us-gaap_FairValueAdjustmentOfWarrants
Total other income (expense) — net		(159)us-gaap_OtherNonoperatingIncomeExpense	(189)us-gaap_OtherNonoperatingIncomeExpense	(2,759)us-gaap_OtherNonoperatingIncomeExpense	44us-gaap_OtherNonoperatingIncomeExpense	(471)us-gaap_OtherNonoperatingIncomeExpense	(385)us-gaap_OtherNonoperatingIncomeExpense	(306)us-gaap_OtherNonoperatingIncomeExpense	(121)us-gaap_OtherNonoperatingIncomeExpense	(3,063)us-gaap_OtherNonoperatingIncomeExpense	(1,283)us-gaap_OtherNonoperatingIncomeExpense	(526)us-gaap_OtherNonoperatingIncomeExpense
Net loss attributable to common stockholders		$ (7,467)us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic	$ (5,558)us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic	$ (7,403)us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic	$ (2,914)us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic	$ (3,480)us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic	$ (3,198)us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic	$ (4,893)us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic	$ (5,572)us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic	$ (23,342)us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic	$ (17,143)us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic	$ (22,174)us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic
Net loss per share attributable to common stockholders:
Basic and diluted		$ (0.37)us-gaap_EarningsPerShareBasicAndDiluted	$ (0.28)us-gaap_EarningsPerShareBasicAndDiluted	$ (0.44)us-gaap_EarningsPerShareBasicAndDiluted	$ (3.70)us-gaap_EarningsPerShareBasicAndDiluted	$ (4.45)us-gaap_EarningsPerShareBasicAndDiluted	$ (4.40)us-gaap_EarningsPerShareBasicAndDiluted	$ (7.96)us-gaap_EarningsPerShareBasicAndDiluted	$ (9.09)us-gaap_EarningsPerShareBasicAndDiluted	$ (1.60)us-gaap_EarningsPerShareBasicAndDiluted	$ (25.05)us-gaap_EarningsPerShareBasicAndDiluted	$ (36.39)us-gaap_EarningsPerShareBasicAndDiluted
Weighted-average common shares outstanding:
Basic and diluted		20,125,009us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted	20,124,574us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted	16,883,716us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted	786,986us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted	782,335us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted	726,987us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted	614,662us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted	612,836us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted	14,548,516us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted	684,330us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted	609,344us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted

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