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Income Taxes - Reconciliation of Income Tax Expense Computed at Statutory Federal Income Tax Rate to Income Taxes (Detail)	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014
Income Tax Disclosure [Abstract]
Federal income tax expense at statutory rate	34.00%	34.00%
State income tax, net of federal benefit	5.00%	4.50%
Permanent differences	(0.50%)	(3.70%)
Research and development credit	0.90%	0.80%
Stock compensation	(0.70%)	(0.90%)
Expiration of state net operating loss	(0.00%)	(1.70%)
Other	0.40%	(0.80%)
Change in valuation allowance	(39.10%)	(32.20%)
Effective income tax rate	0.00%	0.00%

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Effective Income Tax Rate Reconciliation Expiration of State Net Operating Loss.

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Effective income tax rate reconciliation, permanent differences.

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Percentage of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations.

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Percentage of domestic federal statutory tax rate applicable to pretax income (loss).

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Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to changes in the valuation allowance for deferred tax assets.

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Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to equity-based compensation costs.

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Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to research tax credit.

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