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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Cash flows from operating activities:      
Net loss $ (39,594) $ (23,342) $ (17,143)
Adjustments to reconcile net loss to net cash used in operating activities:      
Stock-based compensation 2,375 885 622
Noncash rent expense (41) 29 (1)
Change in carrying value of preferred stock warrant liability   (504) (202)
Depreciation and amortization 192 126 197
(Gain) loss on disposal of property and equipment (6) (28) 7
Loss on extinguishment of debt   2,493  
Amortization of debt discount and deferred financing costs 739 215 215
Changes in operating assets and liabilities:      
Accounts receivable, prepaid expenses and other current assets 342 (695) (209)
Accounts payable 795 341 14
Accrued expenses 3,283 1,419 (114)
Net cash used in operating activities (31,915) (19,061) (16,614)
Cash flows from investing activities:      
Purchases of property and equipment (277) (225) (7)
Proceeds from sale of property and equipment 23 40  
Increase in restricted cash (230)    
Net cash used in investing activities (484) (185) (7)
Cash flows from financing activities:      
Proceeds from sale of common stock 2,628 140 35
Proceeds from public stock offering, net 37,185 59,862  
Proceeds from loan payable 21,000    
Proceeds from issuance of convertible promissory notes   8,500 8,824
Payments on loan payable (3,321) (3,348) (3,084)
Cash paid for debt issuance costs (359) (222) (373)
Net cash provided by financing activities 57,133 64,932 5,402
Net increase (decrease) in cash and cash equivalents 24,734 45,686 (11,219)
Cash and cash equivalents — Beginning of year 51,174 5,488 16,707
Cash and cash equivalents — End of year 75,908 51,174 5,488
Supplemental disclosures of noncash investing and financing activities:      
Purchase of property and equipment in accounts payable 177    
Conversion of redeemable convertible preferred stock into common stock   81,526 2,226
Conversion of convertible notes and accrued interest into common stock, net   20,129  
Reclassification of warrants to additional paid-in capital   424  
Warrants issued with term loan facility 824    
Supplemental cash flow information — Interest paid $ 1,000 $ 400 $ 664