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Stock-Based Compensation - Summary of Stock Option Activity for Employee, Director and Nonemployee Awards (Detail) - USD ($)
$ / shares in Units, $ in Thousands
3 Months Ended 12 Months Ended
Mar. 31, 2016
Dec. 31, 2015
Number of shares    
Number of Shares, Outstanding 3,454,926  
Number of Shares, Granted 547,070  
Number of Shares, Forfeited (10,410)  
Number of Shares, Outstanding 3,991,586 3,454,926
Number of Shares, Options expected to vest 2,695,996  
Number of Shares, Options exercisable 1,159,945  
Weighted-Average Exercise Price    
Weighted-Average Exercise Price, Outstanding $ 5.39  
Weighted-Average Exercise Price, Granted 2.98  
Weighted-Average Exercise Price, Forfeited 4.88  
Weighted-Average Exercise Price, Outstanding 5.06 $ 5.39
Weighted-Average Exercise Price, Options expected to vest 4.79  
Weighted-Average Exercise Price, Options exercisable $ 5.72  
Weighted-Average Remaining Contractual Life (Years)    
Weighted-Average Remaining Contractual Life (Years) 8 years 9 months 18 days 8 years 10 months 24 days
Weighted-Average Remaining Contractual Life (Years), Options expected to vest - March 31, 2016 9 years 3 months 18 days  
Weighted-Average Remaining Contractual Life (Years), Options exercisable - March 31, 2016 7 years 8 months 12 days  
Aggregate Intrinsic Value    
Aggregate Intrinsic Value, Outstanding $ 19  
Aggregate Intrinsic Value, Options expected to vest $ 18