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Condensed Consolidated Statements of Operations (unaudited) - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2016
Mar. 31, 2015
Operating expenses:    
Research and development $ 9,770 $ 5,021
General and administrative 3,118 2,681
Total operating expenses 12,888 7,702
Other income (expense):    
Interest income 16 3
Interest expense (663) (721)
Other expense (7) (8)
Total other expense, net (654) (726)
Net loss attributable to common stockholders $ (13,542) $ (8,428)
Net loss per share attributable to common stockholders:    
Basic and diluted $ (0.49) $ (0.41)
Weighted-average common shares outstanding:    
Basic and diluted 27,362,643 20,350,557