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Stock-Based Compensation - Summary of Stock Option Activity for Employee, Director and Nonemployee Awards (Detail) - USD ($)
$ / shares in Units, $ in Thousands
3 Months Ended 12 Months Ended
Mar. 31, 2017
Dec. 31, 2016
Number of shares    
Number of Shares, Outstanding 4,020,288  
Number of Shares, Granted 1,479,450  
Number of Shares, Exercised 0  
Number of Shares, Forfeited (58,633)  
Number of Shares, Outstanding 5,441,105 4,020,288
Number of Shares, Options exercisable 1,913,734  
Number of Shares, Options vested and expected to vest 4,956,695  
Weighted-Average Exercise Price    
Weighted-Average Exercise Price, Outstanding $ 4.31  
Weighted-Average Exercise Price, Granted 0.82  
Weighted-Average Exercise Price, Exercised 0  
Weighted-Average Exercise Price, Forfeited 4.21  
Weighted-Average Exercise Price, Outstanding 3.36 $ 4.31
Weighted-Average Exercise Price, Options exercisable 5.03  
Weighted-Average Exercise Price, Options vested and expected to vest $ 3.56  
Weighted-Average Remaining Contractual Life (Years)    
Weighted-Average Remaining Contractual Life (Years) 8 years 7 months 6 days 8 years 4 months 24 days
Weighted-Average Remaining Contractual Life (Years), Options exercisable 7 years 8 months 12 days  
Weighted-Average Remaining Contractual Life (Years), Options vested and expected to vest 8 years 6 months  
Aggregate Intrinsic Value    
Aggregate Intrinsic Value, Outstanding $ 0  
Aggregate Intrinsic Value, Outstanding 0  
Aggregate Intrinsic Value, Options exercisable 0  
Aggregate Intrinsic Value, Options vested and expected to vest $ 0