<SEC-DOCUMENT>0001213900-25-127110.txt : 20251231
<SEC-HEADER>0001213900-25-127110.hdr.sgml : 20251231
<ACCEPTANCE-DATETIME>20251231160519
ACCESSION NUMBER:		0001213900-25-127110
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20251229
FILED AS OF DATE:		20251231
DATE AS OF CHANGE:		20251231

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Szot Matthew K
		CENTRAL INDEX KEY:			0001401385
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-41596
		FILM NUMBER:		251617501

	MAIL ADDRESS:	
		STREET 1:		802 NORTH DOUTY STREET
		CITY:			HANFORD
		STATE:			CA
		ZIP:			93230

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Cadrenal Therapeutics, Inc.
		CENTRAL INDEX KEY:			0001937993
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				880860746
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		822 A1A NORTH
		STREET 2:		SUITE 306
		CITY:			PONTE VEDRA
		STATE:			FL
		ZIP:			32082
		BUSINESS PHONE:		904-300-0701

	MAIL ADDRESS:	
		STREET 1:		822 A1A NORTH
		STREET 2:		SUITE 306
		CITY:			PONTE VEDRA
		STATE:			FL
		ZIP:			32082
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>ownership.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0508</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2025-12-29</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0001937993</issuerCik>
        <issuerName>Cadrenal Therapeutics, Inc.</issuerName>
        <issuerTradingSymbol>CVKD</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001401385</rptOwnerCik>
            <rptOwnerName>Szot Matthew K</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O CADRENAL THERAPEUTICS, INC.,</rptOwnerStreet1>
            <rptOwnerStreet2>822, A1A NORTH, SUITE 306</rptOwnerStreet2>
            <rptOwnerCity>PONTE VEDRA,</rptOwnerCity>
            <rptOwnerState>FL</rptOwnerState>
            <rptOwnerZipCode>32082</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Chief Financial Officer</officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <aff10b5One>1</aff10b5One>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2025-12-29</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionTimeliness></transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>9933</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>6.97</value>
                    <footnoteId id="F1"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>0</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">Represents shares of the Issuer's common stock sold by the Reporting Person in accordance with a Rule 10b5-1 trading arrangement adopted by the Reporting Person on September 18, 2025, in multiple transactions at prices ranging from $6.83 through $7.37, inclusive, having a weighted average price as shown in column 4 of $6.97. The Reporting Person undertakes to provide to the registrant, any security holder of the registrant, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Matthew K. Szot</signatureName>
        <signatureDate>2025-12-31</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
