<SEC-DOCUMENT>0001354488-13-006674.txt : 20131129
<SEC-HEADER>0001354488-13-006674.hdr.sgml : 20131128
<ACCEPTANCE-DATETIME>20131129111221
ACCESSION NUMBER:		0001354488-13-006674
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		<ITEMS>06b
FILED AS OF DATE:		20131129
DATE AS OF CHANGE:		20131129
EFFECTIVENESS DATE:		20131129

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			OXYGEN BIOTHERAPEUTICS, INC.
		CENTRAL INDEX KEY:			0000034956
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH [8731]
		IRS NUMBER:				262593535
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			0430

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-207209
		FILM NUMBER:		131249479

	BUSINESS ADDRESS:	
		STREET 1:		ONE COPLEY PARKWAY
		STREET 2:		SUITE 490
		CITY:			MORRISVILLE
		STATE:			NC
		ZIP:			27560
		BUSINESS PHONE:		919-806-4414

	MAIL ADDRESS:	
		STREET 1:		ONE COPLEY PARKWAY
		STREET 2:		SUITE 490
		CITY:			MORRISVILLE
		STATE:			NC
		ZIP:			27560

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	SYNTHETIC BLOOD INTERNATIONAL INC
		DATE OF NAME CHANGE:	19920703

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	SINEQUANON CORP
		DATE OF NAME CHANGE:	19901219

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	FEDERATED FRANCHISES INC
		DATE OF NAME CHANGE:	19760907
</SEC-HEADER>
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            <street2>SUITE 490</street2>
            <city>MORRISVILLE</city>
            <stateOrCountry>NC</stateOrCountry>
            <stateOrCountryDescription>NORTH CAROLINA</stateOrCountryDescription>
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                <firstName>John</firstName>
                <lastName>Kelley</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>ONE Copley Parkway</street1>
                <street2>Suite 490</street2>
                <city>Morrisville</city>
                <stateOrCountry>NC</stateOrCountry>
                <stateOrCountryDescription>NORTH CAROLINA</stateOrCountryDescription>
                <zipCode>27560</zipCode>
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                <street2>Suite 490</street2>
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                <stateOrCountryDescription>NORTH CAROLINA</stateOrCountryDescription>
                <zipCode>27560</zipCode>
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                <street2>Suite 490</street2>
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                <stateOrCountryDescription>NORTH CAROLINA</stateOrCountryDescription>
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                <street1>ONE Copley Parkway</street1>
                <street2>Suite 490</street2>
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                <stateOrCountryDescription>NORTH CAROLINA</stateOrCountryDescription>
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                <street2>Suite 490</street2>
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        <relatedPersonInfo>
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                <lastName>Rallis</lastName>
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                <street1>ONE Copley Parkway</street1>
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    <offeringData>
        <industryGroup>
            <industryGroupType>Pharmaceuticals</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>$1,000,001 - $5,000,000</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06b</item>
        </federalExemptionsExclusions>
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            <dateOfFirstSale>
                <value>2013-11-13</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
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        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>true</isBusinessCombinationTransaction>
            <clarificationOfResponse>Company's acquisition of certain assets of Phyxius Pharma, Inc. on 11/13/13. The Company issued 1,366,844 shares of common stock and 32,992 shares of Series E convertible preferred stock (convertible into 3,299,200 shares of common stock).</clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>6579122</totalOfferingAmount>
            <totalAmountSold>6579122</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse>Based on $1.41 per share on 10/18/13, and the Company issuing approximately 4.7 million shares of common stock and preferred stock convertible into common stock.</clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>4</totalNumberAlreadyInvested>
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            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>OXYGEN BIOTHERAPEUTICS, INC.</issuerName>
                <signatureName>/s/ Michael B. Jebsen</signatureName>
                <nameOfSigner>Michael B. Jebsen</nameOfSigner>
                <signatureTitle>Chief Financial Officer</signatureTitle>
                <signatureDate>2013-11-27</signatureDate>
            </signature>
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