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Warants (Details) - $ / shares | 3 Months Ended | 12 Months Ended
--- | --- | ---
Mar. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Warrants Details |  |  |
Warrant remaining to purchase a total shares of common stock |  | 80,000 |
Warrant remaining to purchase a total shares of common stock at an exercise price per share |  | $ 8.1 |
Warrants to purchase shares will expire on October 17, 2019 |  | 80,000 |
Warrant to purchase shares expired on January 10, 2016 |  | 10,938 |
Warrant to purchase shares will expire on June 4, 2016 |  | 1,563 |
Warrant to purchase shares of common stock | 80,000 | 12,500 | 12,500
Warrant to purchase shares of common stock at an exercise price per share | $ 4.13 | $ 16 | $ 16.00
Warrant to purchase shares of common stock | 1,621,500 | 10,186 | 10,186
Warrant to purchase shares of common stock at an exercise price per share | $ 4.00 | $ 30 | $ 30.00
Warrant to purchase shares of common stock |  | 71,297 | 71,297
Warrant to purchase shares of common stock at an exercise price per share |  | $ 30 | $ 30.00

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