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Warants (Details) - $ / shares
 3 Months Ended 12 Months Ended
Mar. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Warrants Details      
Warrant remaining to purchase a total shares of common stock   80,000  
Warrant remaining to purchase a total shares of common stock at an exercise price per share   $ 8.1  
Warrants to purchase shares will expire on October 17, 2019   80,000  
Warrant to purchase shares expired on January 10, 2016   10,938  
Warrant to purchase shares will expire on June 4, 2016   1,563  
Warrant to purchase shares of common stock 80,000 12,500 12,500
Warrant to purchase shares of common stock at an exercise price per share $ 4.13 $ 16 $ 16.00
Warrant to purchase shares of common stock 1,621,500 10,186 10,186
Warrant to purchase shares of common stock at an exercise price per share $ 4.00 $ 30 $ 30.00
Warrant to purchase shares of common stock   71,297 71,297
Warrant to purchase shares of common stock at an exercise price per share   $ 30 $ 30.00