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v3.23.3

Statements of Cash Flows (Unaudited) - USD ($) | 3 Months Ended | 9 Months Ended
--- | --- | ---
Sep. 30, 2023 | Sep. 30, 2022 | Sep. 30, 2023 | Sep. 30, 2022
Cash flows used in operating activities: |  |  |  |
Net loss | $ (27,110,000) | $ (26,701,000) | $ (85,304,000) | $ (109,054,000)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities: |  |  |  |
Acquired in-process research and development |  | 1,500,000 |  | 3,000,000
Depreciation and amortization | 1,000,000.0 | 900,000 | 2,914,000 | 2,733,000
Share-based compensation |  |  | 9,351,000 | 15,477,000
Amortization of premium and discount on marketable securities, net |  |  | (1,188,000) | 1,206,000
Loss on disposal of property and equipment | 0 | 0 | 463,000 | 0
Impairment of long-lived assets | 5,390,000 |  | 5,390,000 |
Changes in operating assets and liabilities: |  |  |  |
Prepaid expenses and other current assets, and other assets |  |  | 3,478,000 | 1,701,000
Prepaid research and development |  |  | 4,859,000 | 310,000
Right of use assets and operating lease liabilities |  |  | (97,000) | 478,000
Accounts payable |  |  | (1,316,000) | (4,979,000)
Accrued expenses and other current and noncurrent liabilities |  |  | 2,702,000 | (5,061,000)
Net cash provided by (used in) operating activities |  |  | (58,748,000) | (94,189,000)
Cash flows provided by (used in) investing activities: |  |  |  |
Purchases of marketable securities |  |  | (101,640,000) | (116,304,000)
Sales or maturities of marketable securities |  |  | 159,410,000 | 149,661,000
Purchases of technology licenses |  |  |  | (3,000,000)
Purchases of property and equipment |  |  | (133,000) | (1,800,000)
Net cash provided by (used in) investing activities |  |  | 57,637,000 | 28,557,000
Cash flows provided by (used in) financing activities: |  |  |  |
Proceeds from the exercise of stock options |  |  |  | 128,000
Proceeds from the issuance of common stock under employee stock purchase plan |  |  | 89,000 | 243,000
Payments for insurance premium financing |  |  |  | (1,136,000)
Net cash provided by (used in) financing activities |  |  | 89,000 | (765,000)
Net increase (decrease) in cash and cash equivalents |  |  | (1,022,000) | (66,397,000)
Cash and cash equivalents at beginning of period |  |  | 34,601,000 | 128,965,000
Cash and cash equivalents at end of period | $ 33,579,000 | $ 62,568,000 | 33,579,000 | 62,568,000
Supplemental disclosure of non-cash investing and financing activities: |  |  |  |
Unrealized gain (loss) on marketable securities |  |  | $ 774,000 | (1,055,000)
Property and equipment in accounts payable and accrued expenses and other current liabilities |  |  |  | 45,000
Right of use assets recognized upon the adoption of Topic 842 |  |  |  | (20,375,000)
Operating lease liabilities recognized upon the adoption of Topic 842 |  |  |  | $ 27,296,000

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