<SEC-DOCUMENT>0001225208-21-009709.txt : 20210629
<SEC-HEADER>0001225208-21-009709.hdr.sgml : 20210629
<ACCEPTANCE-DATETIME>20210629183237
ACCESSION NUMBER:		0001225208-21-009709
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20210625
FILED AS OF DATE:		20210629
DATE AS OF CHANGE:		20210629

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Kavanagh Kathleen Claire
		CENTRAL INDEX KEY:			0001833100

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-37941
		FILM NUMBER:		211059588

	MAIL ADDRESS:	
		STREET 1:		23460 N. 19TH AVE SUITE 110
		CITY:			PHOENIX
		STATE:			AZ
		ZIP:			85027

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			SenesTech, Inc.
		CENTRAL INDEX KEY:			0001680378
		STANDARD INDUSTRIAL CLASSIFICATION:	AGRICULTURE CHEMICALS [2870]
		IRS NUMBER:				202079805
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		3140 N. CADEN COURT
		STREET 2:		SUITE 1
		CITY:			FLAGSTAFF
		STATE:			AZ
		ZIP:			86004
		BUSINESS PHONE:		(928) 779 - 4143

	MAIL ADDRESS:	
		STREET 1:		3140 N. CADEN COURT
		STREET 2:		SUITE 1
		CITY:			FLAGSTAFF
		STATE:			AZ
		ZIP:			86004
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>doc4.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2021-06-25</periodOfReport>

    <issuer>
        <issuerCik>0001680378</issuerCik>
        <issuerName>SenesTech, Inc.</issuerName>
        <issuerTradingSymbol>SNES</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001833100</rptOwnerCik>
            <rptOwnerName>Kavanagh Kathleen Claire</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O SENESTECH, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>23460 N. 19TH AVE, STE 110</rptOwnerStreet2>
            <rptOwnerCity>PHOENIX</rptOwnerCity>
            <rptOwnerState>AZ</rptOwnerState>
            <rptOwnerZipCode>85027</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable></nonDerivativeTable>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Stock Option (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>1.6600</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2021-06-25</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>45368.0000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0.0000</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <value>2026-06-25</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>45368.0000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>45368.0000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">The option vests and becomes exercisable as to 25% of the total shares on the first day of each calendar quarter following the date of grant, with 100% of the options fully vested on earlier of the first anniversary of the grant date or the first annual meeting of stockholders of the Company after the grant date (subject to the recipient's continued service to the Company through such vesting date).</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Thomas C. Chesterman, Attorney-in-fact</signatureName>
        <signatureDate>2021-06-29</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
