<SEC-DOCUMENT>0001144204-16-128843.txt : 20161021
<SEC-HEADER>0001144204-16-128843.hdr.sgml : 20161021
<ACCEPTANCE-DATETIME>20161021080023
ACCESSION NUMBER:		0001144204-16-128843
CONFORMED SUBMISSION TYPE:	8-K
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20161020
ITEM INFORMATION:		Regulation FD Disclosure
ITEM INFORMATION:		Financial Statements and Exhibits
FILED AS OF DATE:		20161021
DATE AS OF CHANGE:		20161021

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Moleculin Biotech, Inc.
		CENTRAL INDEX KEY:			0001659617
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				474671999
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		8-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-37758
		FILM NUMBER:		161945303

	BUSINESS ADDRESS:	
		STREET 1:		2575 WEST BELLFORT
		STREET 2:		SUITE 333
		CITY:			HOUSTON
		STATE:			TX
		ZIP:			77054
		BUSINESS PHONE:		713-300-5160

	MAIL ADDRESS:	
		STREET 1:		2575 WEST BELLFORT
		STREET 2:		SUITE 333
		CITY:			HOUSTON
		STATE:			TX
		ZIP:			77054
</SEC-HEADER>
<DOCUMENT>
<TYPE>8-K
<SEQUENCE>1
<FILENAME>v450825_8k.htm
<DESCRIPTION>FORM 8-K
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<P STYLE="margin-top: 0; text-align: center; margin-bottom: 0">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-transform: uppercase; text-align: center">UNITED STATES</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-transform: uppercase; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-transform: uppercase; text-align: center">SECURITIES
AND EXCHANGE COMMISSION</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-transform: uppercase; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-transform: uppercase; text-align: center">Washington,
D.C. 20549</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-transform: uppercase; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-transform: uppercase; text-align: center">FORM 8-K</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-transform: uppercase; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-transform: uppercase; text-align: center">CURRENT
REPORT</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-transform: uppercase; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-transform: uppercase; text-align: center">Pursuant
to Section 13 or 15(d) of the Securities Exchange Act of 1934</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-transform: uppercase; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-transform: uppercase; text-align: center">Date of
Report (date of Earliest Event Reported): October 21, 2016 (October 20, 2016)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-transform: uppercase; text-align: center">moleculin
biotech, INC.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">(Exact Name of Registrant as Specified in
its Charter)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR>
    <TD STYLE="width: 32%; font-weight: normal; text-align: center; layout-grid-mode: line"><FONT STYLE="font-size: 10pt"><B>DELAWARE</B></FONT></TD>
    <TD STYLE="vertical-align: top; width: 2%; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</TD>
    <TD STYLE="width: 32%; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>001-37758</B></FONT></TD>
    <TD STYLE="vertical-align: top; width: 2%; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</TD>
    <TD STYLE="width: 32%; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>47-4671997</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 10pt">(State or Other Jurisdiction of<BR>
 Incorporation or Organization)</FONT></TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 10pt">(Commission File No.)</FONT></TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center">&nbsp;</TD>
    <TD STYLE="padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 10pt">(I.R.S. Employer Identification No.)</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><FONT STYLE="text-transform: uppercase"><B>2575
WEST BELLFORT, SUITE 333, HOUSTON TX 77054</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">(Address of principal executive offices
and zip code)</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-transform: uppercase; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-transform: uppercase; text-align: center">(713) 300-5160</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">(Registrant&rsquo;s telephone number, including
area code)</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-transform: uppercase; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-transform: uppercase; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">(Former name or former
address, if changed from last report)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Check the appropriate box below if the
Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions
(<I>see </I>General Instruction A.2. below):</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left"><FONT STYLE="font-family: Wingdings">&#168;</FONT></TD><TD STYLE="text-align: justify">Written communications pursuant to Rule 425 under the
Securities Act (17 CFR 230.425)</TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left"><FONT STYLE="font-family: Wingdings">&#168;</FONT></TD><TD STYLE="text-align: justify">Soliciting material pursuant to Rule 14a-12 under the
Exchange Act (17 CFR 240.14a-12)</TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left"><FONT STYLE="font-family: Wingdings">&#168;</FONT></TD><TD STYLE="text-align: justify">Pre-commencement communications pursuant to Rule 14d-2(b)
under the Exchange Act (17 CFR 240.14d-2(b))</TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left"><FONT STYLE="font-family: Wingdings">&#168;</FONT></TD><TD STYLE="text-align: justify">Pre-commencement communications pursuant to Rule 13e-4(c)
under the Exchange Act (17 CFR 240.13e-14(c)).</TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>&nbsp;</B></P>

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<TD STYLE="width: 0in"></TD><TD STYLE="width: 1in; text-align: left"><B>Item 7.01.</B></TD><TD STYLE="text-align: justify"><B>Regulation FD Disclosure.</B></TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">On October 20, 2016,
Moleculin Biotech, Inc. (the &ldquo;Company&rdquo;) held a live conference call. In connection with the call, the Company is furnishing
the conference call script attached as Exhibit 99.1 hereto, which is incorporated by reference to this Item 7.01.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">The information contained
in Item 7.01 of this Current Report on Form 8-K, including Exhibit 99.1, is being furnished and shall not be deemed to be &ldquo;filed&rdquo;
for the purpose of the Securities Exchange Act of 1934, as amended (&ldquo;Exchange Act&rdquo;), nor shall it be deemed incorporated
by reference in any filing under the Exchange Act or the Securities Act of 1933, as amended, unless specifically identified therein
as being incorporated by reference.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>&nbsp;</B></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0in"></TD><TD STYLE="width: 1in; text-align: left"><B>Item 9.01</B></TD><TD STYLE="text-align: justify"><B>Financial Statements and Exhibits.</B></TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>&nbsp;</B></P>

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<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.5in; text-align: left">(d)</TD><TD STYLE="text-align: justify">Exhibits.</TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

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<TD STYLE="width: 0in"></TD><TD STYLE="width: 1in; text-align: left"><B>Exhibit No.</B></TD><TD STYLE="text-align: justify"><B>Description</B></TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0in"></TD><TD STYLE="width: 1in; text-align: left">99.1</TD><TD STYLE="text-align: justify">Conference Call Script dated October 20, 2016</TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>&nbsp;</B></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;SIGNATURE</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Pursuant to the requirements
of the Securities and Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned
hereunto duly authorized.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-bottom: 1pt; text-align: justify">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-bottom: 1pt; text-align: justify"><FONT STYLE="font-size: 10pt"><B>MOLECULIN BIOTECH, INC.</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-bottom: 1pt; text-align: justify">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-bottom: 1pt; text-align: justify">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-bottom: 1pt; text-align: justify; width: 50%"><FONT STYLE="font-size: 10pt">Date:&nbsp;&nbsp;October 21, 2016</FONT></TD>
    <TD STYLE="padding-bottom: 1pt; text-align: justify; width: 1%">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt; text-align: justify; width: 49%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-bottom: 1pt; text-align: justify">&nbsp;</TD>
    <TD NOWRAP STYLE="padding-bottom: 1pt; text-align: justify"><FONT STYLE="font-size: 10pt">By:</FONT>&nbsp;&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt; text-align: justify; border-bottom: Black 1pt solid"><FONT STYLE="font-size: 10pt">&nbsp;/s/ Jonathan Foster</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-bottom: 1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt; text-align: justify"><FONT STYLE="font-size: 10pt">Jonathan Foster</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-bottom: 1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt; text-align: justify"><FONT STYLE="font-size: 10pt">Chief Financial Officer&nbsp;&nbsp;</FONT></TD></TR>
</TABLE>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in; text-align: justify">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>EXHIBIT INDEX</B></P>

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<TD STYLE="width: 0in"></TD><TD STYLE="width: 1in; text-align: left"><B><U>Exhibit No.</U></B></TD><TD STYLE="text-align: justify"><B><U>Description</U></B></TD>
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<TD STYLE="width: 0in; padding-top: 4pt"></TD><TD STYLE="width: 1in; text-align: left; padding-top: 4pt">99.1</TD><TD STYLE="text-align: justify; padding-top: 4pt">Conference Call Script dated October 20, 2016</TD>
</TR></TABLE>

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<FILENAME>v450825_ex99-1.htm
<DESCRIPTION>EXHIBIT 99.1
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<P STYLE="margin: 0; text-align: right"><B>Exhibit 99.1</B></P>

<P STYLE="margin: 0; text-align: right">&nbsp;</P>

<P STYLE="margin: 0; text-align: right"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>OPERATOR: </B>Welcome to the Moleculin Biotech, Inc.&rsquo;s
Conference Call to provide a general corporate update and to discuss positive developments regarding Annamycin. First &ndash; let
me introduce Jonathan P. Foster, Executive Vice President and Chief Financial Officer.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>JON:</B> Thank you, Operator. Let me get some administrative
matters out of the way. First &ndash; this is a conference call only. There will be no Q&amp;A at the end as we are nearing release
of our third quarter Form 10Q. Second &ndash; let me read the following statement:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Some of the statements in this conference call will be forward-looking
statements within the meaning of Section 27A of the Securities Act of 1933, Section 21E of the Securities Exchange Act of 1934
and the Private Securities Litigation Reform Act of 1995, which involve risks and uncertainties. Forward-looking statements in
this conference call include, without limitation, the ability of the agreement with Dermin to reduce the expenditures required
of Moleculin for clinical trial drug production and to shorten the time required to produce clinical supplies and the ability of
Moleculin to increase the maximum tolerable dose of and begin expanded clinical trials on Annamycin by the first half of 2017.
These statements relate to future events, future expectations, plans and prospects. Although Moleculin Biotech believes that the
expectations reflected in such forward-looking statements are reasonable as of the date made, expectations may prove to have been
materially different from the results expressed or implied by such forward-looking statements. Moleculin Biotech has attempted
to identify forward-looking statements by terminology including ''believes,'' ''estimates,'' ''anticipates,'' ''expects,'' ''plans,''
''projects,'' ''intends,'' ''potential,'' ''may,'' ''could,'' ''might,'' ''will,'' ''should,'' ''approximately'' or other words
that convey uncertainty of future events or outcomes to identify these forward-looking statements. These statements are only predictions
and involve known and unknown risks, uncertainties, and other factors, including those discussed under the heading &quot;Risk Factors&quot;
in our Registration Statement on Form S-1 originally filed with the Securities and Exchange Commission on February 1, 2016, as
amended (Registration No. 333-209323) and updated from time to time via the Company&rsquo;s filings with the SEC.&nbsp; Any forward-looking
statements contained in this release speak only as of its date. We undertake no obligation to update any forward-looking statements
contained in this release to reflect events or circumstances occurring after its date or to reflect the occurrence of unanticipated
events.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">With that out of the way, let me introduce to you Moleculin&rsquo;s
Chairman and Chief Executive Officer, Wally Klemp.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>WALLY: </B>Thanks, Jon and good evening everyone. I am very
pleased to welcome you to the Corporate Update Call for Moleculin Biotech, Inc. The purpose of this call is not just to provide
a general corporate update, but it&rsquo;s also to discuss some important positive news. As a broad overview: Moleculin is making
good progress against its stated goals and remains on track for the milestones set forth in our S-1 for the IPO this past May.
What&rsquo;s more, we now have some significantly positive findings from our detailed review of the last clinical trial for Annamycin.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">The recent negative trend in our stock price has caused a number
of shareholders to ask for an update on Moleculin directly from the Company. While part of this call may do just that, I need to
be clear that, as management of a public company, it&rsquo;s not appropriate for us to speculate as to why our stock price moves
up or down. Regardless, however, we can say that the fundamentals of our business and our plan remain intact and, as such (and
in our opinion), do not justify a precipitous loss in perceived company value as compared with our IPO.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">So, let me start this update by reviewing what our plan has
been and what the key milestones were for measuring progress. As we set forth in our S-1 for the IPO, a prior developer had conducted
a clinical trial with Annamycin, but then they subsequently failed to maintain their Investigational New Drug status (or, IND)
with the FDA. Our stated plan was to conduct a detailed review of the clinical results generated by that prior developer. We would
then use those results to reestablish an IND in order to continue clinical trials of Annamycin. With a new IND in place and after
production of Annamycin for clinical trials and approval from the appropriate Institutional Review Boards, we would then be in
a position to begin expanded clinical trials of this important drug.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Although no specific timeline was given for these activities
or for the beginning of the next clinical trial, we did provide guidance that we believed our IPO proceeds were sufficient for
approximately 16 months of operations from the date of the IPO. We further believed this was sufficient time to begin generating
Phase II data indicating whether Annamycin was capable of repeating the impressive results that were produced in that last clinical
trial.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">So, where are we now? Well, first of all, all of the guidance
I&rsquo;ve just recounted from our S-1 continues to be reasonable and appropriate. We continue to be on track for accomplishing
just what we set out to do and <FONT STYLE="color: #1D1E1F">expect to begin our expanded clinical trials on Annamycin by the first
half of next year.</FONT> Furthermore, several positive developments have recently occurred that we believe may put us in a better
position than we had hoped.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">One of these positive developments is the recent agreement we
reached with Dermin that was disclosed in our October 7<SUP>th</SUP> press release. As a reminder, Dermin is a licensee of Annamycin
that was able to access Polish grant funds to conduct their own parallel development efforts. Part of their process was to produce
Annamycin for use in their planned clinical trials, and there was some hope that Moleculin would be able to use that same drug
production for our own clinical trials.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">It&rsquo;s important to understand that Annamycin is a relatively
expensive drug to produce, as are all of the currently approved anthracyclines. Back when we filed the S-1 and went public we could
not provide assurance that any of the drug Dermin had produced using Polish grant proceeds would be available for our use. Accordingly,
we budgeted as though we would have to produce all of the drug required for our planned clinical trial using our own IPO proceeds.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">As we announced on the 7<SUP>th</SUP>, however, we were finally
able to reach an agreement with Dermin that now allows us to use their drug inventory for our clinical trials. This reduces our
planned expenditures for drug production over the coming year and improves our confidence that we will have adequate cash to achieve
our stated goals.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Another positive that we are announcing for the first time on
this call is that our review of the prior developer&rsquo;s data suggests that Annamycin may, in fact, have greater potential for
efficacy than we originally believed. This has to do with the establishment of what is called the Maximum Tolerable Dose, or MTD.
Now, this gets a little detailed, but it is extremely important, so it&rsquo;s worth making sure everyone understands.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">In previous disclosures I have explained that in the last clinical
trial, patients treated with Annamycin had failed an average of 5 prior induction therapy attempts with the standard of care first-line
therapy. This prompted justifiable speculation that, if we could treat patients sooner, say, after only 1 or 2 first-line induction
failures, we might see even better performance from Annamycin.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">As a reminder, 8 patients received Annamycin in the Phase II
arm of that last trial and 3 completely cleared their bone marrow blasts, which is considered the key indicator for qualifying
for a curative bone marrow transplant. Now, to be clear, we believe Annamycin could qualify for accelerated approval on the basis
of an even lower response rate than this, however, if we match or even improve upon these results in the next trial, that could
make Annamycin even more important and valuable than we had hoped.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">With this in mind, and now that we have had the opportunity
to review the prior developer&rsquo;s data in detail, we have made an important new discovery. Not only does it appear that patients
fare better if they receive Annamycin after fewer failed first-line attempts, it also appears that this high number of prior failures
may have caused Annamycin&rsquo;s MTD to be understated. This is potentially a major positive development for us, so let me explain
further.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">In the last trial, before the Phase II arm was conducted, a
Phase I arm was used to establish the MTD or Maximum Tolerable Dose. Just to clarify how this works, you typically begin a Phase
I trial by enrolling the first few patients at a relatively low dose and then determine whether they experience any unacceptable
toxic side effects. We call these Dose Limiting Toxicities or DLTs. If those first few patients have no DLTs, then the dose is
increased for the next few patients and so on until DLTs begin showing up. As soon as any DLTs are experienced, the dose is backed
down to a lower level and, if the DLTs go away, that lower level becomes the MTD.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">It turns out to be important that this last clinical trial was
conducted at 4 different treatment centers, with one of those centers being much more heavily focused on experimental trials. As
a result, the patients treated at this particular facility had failed significantly more first-line therapies than the average
for the overall trial. This was quite evident when we reviewed the detailed data, and it appears to have skewed the outcome.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">In particular, the 3 patients that experienced the DLTs that
led to the establishment of our current Maximum Tolerable Dose were all from the site where patients had an unusually high number
of first-line failures. And, the Dose Limiting Toxicity was the same in all 3 cases; namely: mucositis, a painful inflammation
and ulceration of the mucous membranes that line the digestive tract.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">For the record, mucositis is the number 2 DLT for the currently
approved anthracyclines, like daunorubicin and doxorubicin. Importantly, their number 1 DLT is cardiotoxicity, and of course, one
of the key advantages of Annamycin is that it is non-cardiotoxic. This is one of the biggest reasons it is so important to get
this drug approved and on the market. We should never forget that even the lucky patients who beat acute leukemia by making it
to a curative bone marrow transplant will, more often than not, have their lives diminished due to the damage done to their hearts
by the anthracyclines used in their induction therapy.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">So, back to the important and positive new data. Of the 3 patients
in the last clinical trial who experienced mucositis (the same patients who caused our MTD to be set to the next lower level),
one of them had failed 19 prior induction therapy attempts. Another had failed 16 and the other had failed 15. Now, just try to
imagine how far gone these patients had to have been when they finally received our drug. These are truly outliers in the sense
that our drug would not normally be administered to patients who were this far gone. And, it is reasonable to assume that their
sensitivity to mucositis, which can increase with successive treatments, was at a very high level.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">As a result of these 3 DLTs, the MTD of Annamycin was limited
to just 150 mg/m2 and that was the dosing level given to the 8 patients who participated in the Phase II arm to assess efficacy.
And, again, those results were quite impressive. However, if you exclude the heavily treated &ldquo;outlier&rdquo; patients in
the Phase I arm, our read of the data suggests that the MTD could have been closer to 250 mg/m2, nearly double the level that was
actually used in that Phase II arm.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Specifically, among the patients at the other centers in this
trial (most of whom had failed only 1 or 2 previous induction therapies), mucositis was not a DLT, even at dosing levels up to
250 mg/m2. We view this as a very encouraging development because it means we may have an opportunity to increase the MTD for our
next trial from 150 mg/m2 to 200 or even 250 mg/m2. If that turns out to be the case, it could significantly increase the chance
for positive outcomes in our next trial.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">One thing I would like to add about this last clinical trial
relates to what is called &ldquo;tumor lysis syndrome&rdquo; or &ldquo;TLS&rdquo;. We reported this in our S-1, but since that
time, several investors have asked for us to clarify what this means. For background, of the 3 patients who completely cleared
their bone marrow blasts with Annamycin in that trial, 2 of those patients succumbed to TLS. This is where the systemic burden
of destroyed cancer cells becomes so great that the patient can go into kidney and other organ failures. Essentially, if the patient
has a high level of leukemic cells and the chemotherapy works better than expected, TLS can result.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Thankfully, now that this is known, steps can be taken in advance
of treatment to protect patients from this outcome. I have discussed this data with numerous hematology-oncologists, and all agree
that regardless of the onset of TLS, the fact that these patients completely cleared their bone marrow blasts should be considered
an indication that Annamycin showed significant activity.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">So, how does all this relate to our plans going forward? Well,
now with the discovery that we may be able to increase our MTD, we need to adjust our strategy to take full advantage of this opportunity.
This means adding in a Phase I arm to our next Phase II trial, which will add some expense to our development effort. However,
we believe the money we will save by utilizing the Dermin drug inventory will cover us on this added expense. On the back end,
it probably adds several months to the eventual final approval of the drug, but we still see ourselves on track to generate useful
Phase II data by the second half of next year, which is in line with our original timeline set out during the IPO.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Speaking of managing expenses, I&rsquo;d like to use this call
to officially welcome our new Executive Vice President &amp; Chief Financial Officer, Jon Foster, who joined us in August. Jon&hellip;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>JON</B>: Thanks, Wally. I have to tell you, I am thrilled
to be a part of Moleculin, especially considering how important Annamycin can become to the lives of so many. I lost my Father
to leukemia, so I know first hand how devastating it can be to face this disease with the current limited options. Wally and I
have worked together in a prior public company, so it&rsquo;s also a luxury to be able to hit the ground running with this team.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">As Wally described, we continue to see ourselves having more
than 12 months of cash in the bank on our way to generating Phase II results with Annamycin. Specifically, we ended September with
approximately $6 million in cash on hand. That said, this is still &ldquo;biotech&rdquo;, so part of the reason I am here is to
make sure we make the right moves as a company to ensure we can withstand the inevitable speed bumps that all drug development
companies encounter and execute on opportunities to push the rest of our portfolio further along. So, let&rsquo;s be clear that
Moleculin will always be evaluating opportunities to increase cash resources. In that vein, let me remind everyone that our S-1
and subsequent 10-Q filings contain important disclosures about the risks associated with our industry and with Moleculin specifically.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>WALLY</B>: Thanks, Jon, and we really are glad to have you
on board. Now, appropriately, most of our update has been about Annamycin. With the recent blockbuster exit by Celator to Jazz
Pharmaceuticals, garnering $1.5 billion for their improved AML drug, Vyxeos, it is natural for investors to wonder what that could
mean for Annamycin.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">As a reminder, Vyxeos is simply a new method of delivering daunorubicin
that resulted in an average increase in survival of about 3 months. Unfortunately, their drug is still cardiotoxic and still fails
to get the vast majority of AML patients qualified for a bone marrow transplant. With this new news about our potential to increase
the MTD for Annamycin, we feel even more strongly that Annamycin could represent another important advancement for AML patients.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">With that said, we continue to make progress on our other development
platforms. WP1066 continues to benefit from additional grant-funded research at MD Anderson Cancer Center and we have recently
indicated growing interest within the scientific community regarding WP1122, and finally, we continue to consider additional opportunities
for sponsored research with MD Anderson.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Well, that brings us to the conclusion of this update. So, in
closing let me say in summary, we continue to be on track for the development milestones set forth at the outset of our IPO and
recent positive developments have given us cause to suggest that the opportunity with Annamycin could be better than we had originally
hoped.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Thank you for listening today and we look forward to reporting
more important progress soon!</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Good night and take care.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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