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Commitments and Contingencies (Details Textual) - USD ($) |  |  |  | 1 Months Ended | 12 Months Ended |  |  |  |  |  |
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May 02, 2016 | Nov. 02, 2015 | Oct. 08, 2015 | Oct. 07, 2016 | Aug. 19, 2016 | May 31, 2016 | Feb. 29, 2016 | Oct. 19, 2015 | Dec. 31, 2016 | Jun. 30, 2016 | Apr. 30, 2016 | Jan. 31, 2016 | Dec. 31, 2015 | Oct. 31, 2015 | Aug. 31, 2015
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights |  |  |  |  |  | 107,802 |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights |  |  |  |  |  | $ 7.50 |  |  |  |  |  |  |  |  |
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Liabilities |  |  |  |  |  | $ 1,000,000 |  |  |  |  |  |  |  |  |
Business Combination, Consideration Transferred, Equity Interests Issued and Issuable |  |  |  |  |  | 750,000 |  |  |  |  |  |  |  |  |
Deferred Compensation Liability, Classified, Noncurrent |  |  |  |  |  |  |  |  | $ 87,500 |  |  |  | $ 0 |  |
Milestone Payment Description |  |  |  |  |  |  |  | The amended milestone payments are as follows: (i) commencement of Phase III Study for first licensed drug/product within the United States, Europe, China or Japan - $150,000; (ii) submission of the first NDA within the United States - $500,000; and (iii) receipt of first marketing approval for sale of a license product in the United States - $600,000. |  |  |  |  |  |  |
Mr. Louis [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Severance Costs |  |  |  | $ 100,000 |  |  |  |  |  |  |  |  |  |  |
Separation Agreement Description |  |  |  | Pursuant to the Separation Agreement, Mr. Ploth will be permitted to exercise 25% of the options to purchase common stock granted to him in December 2015, or 50,000 shares, until May 2020. |  |  |  |  |  |  |  |  |  |  |
Moleculin LLC [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Payments for Other Fees |  |  |  |  |  | 306,186 |  |  |  |  |  |  |  |  |
Patent Law Firm [Member] | Minimum Fee and patent Expenses [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contractual Obligation, Total |  |  |  |  |  |  |  |  |  |  |  |  | 42,504 | $ 65,504 |
Bonwick Capital Partners LLC [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Letter Agreements Terms |  |  |  |  |  |  | the Company agreed to: a) pay success fees equal to 7% of the gross proceeds from any form of financing; and b) issue five-year warrants to purchase 7% of the Companys equity securities sold with a cashless exercise provision, exercisable at 125% of the price per share of the Companys common stock paid by investors in the transaction. In addition, the Company agreed to reimburse Bonwick for all of its out-of-pocket expenses incurred in connection with the offering, not to exceed $25,000, and fees and expenses of their counsel not to exceed $100,000. |  |  |  |  |  |  |  |
Success Fee Percentage |  |  |  |  |  |  | 7.00% |  |  |  |  |  |  |  |
Class of Warrant or Right, Percentage of Securities Called by Warrants or Rights |  |  |  |  |  |  | 7.00% |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price Percentage Threshold |  |  |  |  |  |  | 125.00% |  |  |  |  |  |  |  |
Payments for Underwriting Expense |  |  |  |  |  |  | $ 50,000 |  |  |  |  |  |  |  |
Bonwick Capital Partners LLC [Member] | IPO [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Reimburement of Expenses |  |  |  |  |  | 6,266 |  |  |  |  |  |  |  |  |
Payments of Stock Issuance Costs |  |  |  |  |  | $ 646,872 |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights |  |  |  |  |  | 107,802 |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights |  |  |  |  |  | $ 7.50 |  |  |  |  |  |  |  |  |
Bonwick Capital Partners LLC [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Reimbursement Payable, Offering Costs |  |  |  |  |  |  | 25,000 |  |  |  |  |  |  |  |
Reimbursement Payable, Fees and Expenses of Counsel |  |  |  |  |  |  | $ 100,000 |  |  |  |  |  |  |  |
MD Anderson [Member] | Minimum Fee and patent Expenses [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contractual Obligation, Total |  |  | $ 98,108 |  |  |  |  |  |  |  |  |  | $ 45,000 | 98,108 |
MD Anderson [Member] | Minimum Annual Royalty [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contractual Obligation, Total |  |  | 65,504 |  |  |  |  |  |  |  |  |  |  |  |
Chief Executive Officer [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Officers' Compensation |  |  |  |  |  |  |  |  | 300,000 |  |  |  |  |  |
Deferred Compensation Liability, Classified, Noncurrent |  |  |  |  |  |  |  |  | $ 87,500 | $ 12,500 |  |  |  |  |
Chief Financial Officer and Executive Vice President [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Officers' Compensation |  |  |  |  | $ 250,000 |  |  |  |  |  |  |  |  |  |
Deferred Compensation Arrangement with Individual, Maximum Contractual Term |  |  |  |  | 3 years |  |  |  |  |  |  |  |  |  |
Chief Financial Officer and Executive Vice President [Member] | Employee Stock Option [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Deferred Compensation Arrangement with Individual, Shares Issued |  |  |  |  | 400,000 |  |  |  |  |  |  |  |  |  |
Deferred Compensation Arrangement with Individual, Exercise Price |  |  |  |  | $ 5.85 |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period |  |  |  |  | 10 years |  |  |  |  |  |  |  |  |  |
Patent and Technology License Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contractual Obligation, Total |  |  |  |  |  |  |  |  |  |  | $ 91,186 | $ 175,000 |  | $ 125,000 |
Payments for Royalties |  | $ 125,000 |  |  |  |  |  |  |  |  |  |  |  |  |
License Agreement, Maintenance Fee | $ 20,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
License Agreement, Maintenance Fee Annual Increase | 10,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Payments for Other Fees |  |  | 300,000 |  |  |  |  |  |  |  |  |  |  |  |
License Agreement, Maintenance Fee - Maximum Payable Per Year | $ 100,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Patent and Technology License Agreement [Member] | Servicing Fee payable [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contractual Obligation, Due First Anniversary April 2, 2013 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 10,000
Contractual Obligation, Due Second Anniversary |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 20,000
Contractual Obligation, Due Third Anniversary |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 40,000
Contractual Obligation, Due Fourth Anniversary |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 60,000
Contractual Obligation, Due Fifth Anniversary |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 80,000
Contractual Obligation, Due Sixth Anniversary |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 100,000
Patent and Technology License Agreement [Member] | Minimum Annual Royalty [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contractual Obligation, Due in Next Fiscal Year, After Product Approval |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 200,000
Contractual Obligation, Due in Second Year, After Product Approval |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 400,000
Contractual Obligation, Due in Third Year, After Product Approval |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 600,000
Patent and Technology License Agreement [Member] | Letter Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Payments for Other Fees |  |  | $ 691,186 |  |  |  |  |  |  |  |  |  |  |  |

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