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Note 8 - Commitments and Contingencies (Details Textual) - USD ($) |  | 1 Months Ended | 12 Months Ended
--- | --- | --- | ---
Mar. 16, 2020 | Mar. 31, 2023 | Jun. 30, 2022 | Aug. 31, 2019 | Mar. 31, 2018 | Dec. 31, 2022 | Dec. 31, 2021
Operating Lease, Weighted Average Remaining Lease Term (Year) |  |  |  |  |  | 4 years 2 months 12 days |
Operating Lease, Weighted Average Discount Rate, Percent |  |  |  |  |  | 9.60% |
Research and Development Expense, Total |  |  |  |  |  | $ 18,968,000 | $ 14,418,000
Employee Agreements, Termination Benefits Provided To Key Employees, Aggregate Amount |  |  |  |  |  | 900,000 |
Houston Pharmaceuticals, Inc [Member] |  |  |  |  |  |  |
Related Party Transaction, Expenses from Transactions with Related Party |  |  |  |  |  |  | 234,000
Houston Pharmaceuticals, Inc [Member] | Consulting Agreement on Licensed Molecules [Member] |  |  |  |  |  |  |
Other Commitment, Total | $ 43,500 |  |  |  |  |  |
Houston Pharmaceuticals, Inc [Member] | Agreement Providing Access to Laboratory Equipment [Member] |  |  |  |  |  |  |
Other Commitment, Total | $ 15,000 |  |  |  |  |  |
Other Commitments, Cancellation Period (Day) | 60 days |  |  |  |  |  |
IPX Memorial Drive Investors LLC [Member] |  |  |  |  |  |  |
Lessee, Operating Lease, Term of Contract (Month) |  |  |  |  | 66 months |  |
Lessee, Operating Lease, Renewal Term (Year) |  |  |  |  | 5 years |  |
Olympia Drive W Bellfort LLC [Member] |  |  |  |  |  |  |
Operating Lease, Rent Expense, Annual Increase In Rent, Percent |  |  |  | 3.00% | 3.00% |  |
Houston Pharmaceuticals, Inc [Member] |  |  |  |  |  |  |
Percentage of Rent Payable By Co-Lessee |  |  |  | 50.00% |  |  |
Percentage Of Sub-lease Income Allocable To Co-lessee |  |  |  | 50.00% |  |  |
Sublease Income |  |  |  |  |  | 45,000 | 42,000
MD Anderson [Member] |  |  |  |  |  |  |
License Agreements Expense |  |  |  |  |  | 264,000 | 267,000
Payments For Research And Development Agreement |  |  | $ 1,300,000 |  |  |  |
Research and Development Expense, Total |  |  |  |  |  | 1,133,000 | $ 697,000
MD Anderson [Member] | Maximum [Member] |  |  |  |  |  |  |
License Agreement Annual License Fee |  |  |  |  |  | 100,000 |
MD Anderson [Member] | Maximum [Member] | Submission Of N D A And Receipt Of First Marketing Approval For Sale Of A Licensed Product [Member] |  |  |  |  |  |  |
Milestone Payment Liabilities |  |  |  |  |  | $ 600,000 |
WPD Pharmaceuticals [Member] | Subsequent Event [Member] |  |  |  |  |  |  |
Payments for Termination of Commitment |  | $ 700,000 |  |  |  |  |
Stock Issued During Period, Value, Termination of Agreement |  | $ 800,000 |  |  |  |  |

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