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Note 6 - Equity (Details Textual) $ / shares in Units, $ in Thousands | 1 Months Ended | 12 Months Ended |
--- | --- | --- | ---
May 31, 2022 shares | Jun. 30, 2021 USD ($) $ / shares shares | Feb. 28, 2021 USD ($) $ / shares shares | Jan. 31, 2021 USD ($) shares | Dec. 31, 2022 USD ($) $ / shares shares | Dec. 31, 2021 USD ($) shares | Oct. 04, 2018 USD ($)
Preferred Stock, Shares Issued, Total (in shares) | shares |  |  |  |  | 0 | 0 |
Proceeds from Issuance of Common Stock | $ |  |  |  |  | $ 0 | $ 74,684 |
Share Based Compensation Arrangement by Share Based Payment Award, Options, Grants in Period, Aggregate Fair Value | $ |  |  |  |  | 1,100 | $ 1,700 |
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount, Total | $ |  |  |  |  | $ 1,500 |  |
The 2015 Stock Plan [Member] |  |  |  |  |  |  |
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Additional Shares Authorized (in shares) | shares | 2,000,000 |  |  |  |  |  |
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant (in shares) | shares | 3,750,001 |  |  |  | 752,296 |  |
Share-Based Payment Arrangement, Option [Member] |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period (Year) |  |  |  |  | 10 years |  |
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount, Total | $ |  |  |  |  | $ 2,500 |  |
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition (Year) |  |  |  |  | 2 years 4 months 24 days |  |
Share-Based Payment Arrangement, Option [Member] | Employees [Member] |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period (Year) |  |  |  |  | 4 years |  |
Share-Based Payment Arrangement, Option [Member] | Director [Member] | Minimum [Member] |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period (Year) |  |  |  |  | 1 year |  |
Share-Based Payment Arrangement, Option [Member] | Director [Member] | Maximum [Member] |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period (Year) |  |  |  |  | 3 years |  |
Restricted Stock Units (RSUs) [Member] |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period (Year) |  |  |  |  | 4 years |  |
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount, Total | $ |  |  |  |  | $ 1,100 |  |
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition (Year) |  |  |  |  | 2 years 9 months 18 days |  |
Share Based Compensation Arrangement by Share Based Payment Award, Number of Installment Periods |  | 4 |  |  | 4 |  |
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period (in shares) | shares |  | 150,000 |  |  | 452,334 |  |
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value (in dollars per share) | $ / shares |  | $ 3.73 |  |  | $ 1.49 |  |
The 2021 ATM Agreement [Member] |  |  |  |  |  |  |
Stock Issued During Period, Shares, New Issues (in shares) | shares |  |  |  |  | 0 | 0 |
At Market Issuance Sales Agreement, Maximum Aggregate Offering Price | $ |  | $ 50,000 |  |  |  |  |
Underwritten Public Offering [Member] |  |  |  |  |  |  |
Stock Issued During Period, Shares, New Issues (in shares) | shares |  |  | 14,273,684 |  |  |  |
Shares Issued, Price Per Share (in dollars per share) | $ / shares |  |  | $ 4.75 |  |  |  |
Proceeds from Issuance of Common Stock | $ |  |  | $ 78,000 |  |  |  |
Over-Allotment Option [Member] |  |  |  |  |  |  |
Stock Issued During Period, Shares, New Issues (in shares) | shares |  |  | 2,141,052 |  |  |  |
Lincoln Park Transaction [Member] |  |  |  |  |  |  |
Purchase Agreement, Common Stock, Maximum Aggregate Commitment | $ |  |  |  |  |  |  | $ 20,000
Stock Issued During Period, Shares, Commitment Consideration (in shares) | shares |  | 107,788 |  |  |  |  |
Purchase Agreement, Maximum Aggregate Commitment, Number of Additional Shares Issued (in shares) | shares |  | 53,893 |  |  |  |  |
Stock Issued During Period, Value, Additional Commitment Shares | $ |  | $ 400 |  |  |  |  |
The 2020 ATM Agreement [Member] |  |  |  |  |  |  |
Stock Issued During Period, Shares, New Issues (in shares) | shares |  |  |  | 468,684 |  |  |
Proceeds from Issuance of Common Stock | $ |  |  |  | $ 2,900 |  |  |

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