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Share incentive plan (Tables) | 12 Months Ended
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Dec. 31, 2016
Disclosure of Compensation Related Costs, Share-based Payments [Abstract] |
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] | The fair value of each Ordinary share option issued was estimated at the date of grant using the following weighted-average assumptions:
|  | Year ended December 31, |
|  | 2016 |  | 2015 |  | 2014 |
Risk-free interest rate |  |  | 1.18%-2.06% |  |  | 1.30% -1.90% |  |  | 1.55%-2.21% |
Expected option term (years) |  |  | 5.00-7.00 |  |  | 5.12-7.00 |  |  | 5.12-7.00 |
Expected price volatility |  |  | 79.34%-90.65% |  |  | 70.40%-83.74% |  |  | 69.49%-84.63% |
Dividend yield |  |  | 0% |  |  | 0% |  |  | 0% |
Schedule of Share-based Compensation, Shares Authorized under Stock Option Plans, by Exercise Price Range [Table Text Block] | A summary of option activity as of December 31, 2016, and the year then ended is presented below:
|  |  |  |  |  |  |  | Weighted- |  |  |  |
|  |  |  |  |  |  |  | Average |  |  |  |
|  |  |  |  | Weighted- |  |  | Remaining |  |  | Aggregate |
|  | Number of |  |  | Average |  |  | Contractual |  |  | Intrinsic |
|  | Stock Options |  |  | Exercise Price |  |  | Term (Years) |  |  | Value |
Outstanding, January 1, 2016 |  |  | 2,103,502 |  |  | $ | 5.81 |  |  |  | 8.52 |  |  | $ | 1,584,753 |
Exercised |  |  | - |  |  |  | - |  |  |  |  |  |  |  |  |
Granted |  |  | 1,658,416 |  |  | $ | 2.21 |  |  |  |  |  |  |  |  |
Forfeited/Expired |  |  | (1,110,137) |  |  | $ | 6.16 |  |  |  |  |  |  |  |  |
Outstanding, December 31, 2016 |  |  | 2,651,781 |  |  | $ | 3.41 |  |  |  | 7.74 |  |  | $ | 419,840 |
Exercisable, December 31, 2016 |  |  | 1,300,224 |  |  | $ | 4.47 |  |  |  | 6.00 |  |  | $ | 419,696 |
Vested and expected to vest, December 31, 2016 |  |  | 2,651,781 |  |  | $ | 3.41 |  |  |  | 7.74 |  |  | $ | 419,840 |
Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block] | Share-based compensation expense is classified in the consolidated statements of operations as follows:
|  | December 31, |
|  | 2016 |  |  | 2015 |  |  | 2014 |
|  | U.S. dollars in thousands |
Research and development expenses |  | $ | 531 |  |  | $ | 381 |  |  | $ | 83 |
Pre-commercialization expenses |  |  | (147) |  |  |  | 159 |  |  |  | - |
General and administrative expenses |  |  | 316 |  |  |  | 2,083 |  |  |  | 653 |
|  | $ | 700 |  |  | $ | 2,623 |  |  | $ | 736 |

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- Definition Tabular disclosure of option exercise prices, by grouped ranges, including the upper and lower limits of the price range, the number of shares under option, weighted average exercise price and remaining contractual option terms. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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