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Share incentive plan (Tables)

12 Months Ended

Dec. 31, 2016

Disclosure of Compensation Related Costs, Share-based Payments [Abstract]

Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

The fair value of each Ordinary share option issued was estimated at the date of grant using the following weighted-average assumptions:

		Year ended December 31,
		2016			2015			2014
Risk-free interest rate			1.18%-2.06%			1.30% -1.90%			1.55%-2.21%
Expected option term (years)			5.00-7.00			5.12-7.00			5.12-7.00
Expected price volatility			79.34%-90.65%			70.40%-83.74%			69.49%-84.63%
Dividend yield			0%			0%			0%

Schedule of Share-based Compensation, Shares Authorized under Stock Option Plans, by Exercise Price Range [Table Text Block]

A summary of option activity as of December 31, 2016, and the year then ended is presented below:

										Weighted-
										Average
						Weighted-				Remaining				Aggregate
		Number of				Average				Contractual				Intrinsic
		Stock Options				Exercise Price				Term (Years)				Value
Outstanding, January 1, 2016			2,103,502			$	5.81				8.52			$	1,584,753
Exercised			-				-
Granted			1,658,416			$	2.21
Forfeited/Expired			(1,110,137)			$	6.16
Outstanding, December 31, 2016			2,651,781			$	3.41				7.74			$	419,840
Exercisable, December 31, 2016			1,300,224			$	4.47				6.00			$	419,696
Vested and expected to vest, December 31, 2016			2,651,781			$	3.41				7.74			$	419,840

Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block]

Share-based compensation expense is classified in the consolidated statements of operations as follows:

		December 31,
		2016				2015				2014
		U.S. dollars in thousands
Research and development expenses		$	531			$	381			$	83
Pre-commercialization expenses			(147)				159				-
General and administrative expenses			316				2,083				653
		$	700			$	2,623			$	736

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Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (h)(1)
-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901

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-Publisher FASB
-Name Accounting Standards Codification
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-Section 50
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-Name Accounting Standards Codification
-Topic 718
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- Definition

Tabular disclosure of option exercise prices, by grouped ranges, including the upper and lower limits of the price range, the number of shares under option, weighted average exercise price and remaining contractual option terms.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901

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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
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-Section 50
-Paragraph 2
-Subparagraph (f)(2)
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