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Nature of business and basis of presentation (Details Textual) - USD ($)
$ in Thousands
3 Months Ended 12 Months Ended
Dec. 31, 2016
Sep. 30, 2016
Jun. 30, 2016
Mar. 31, 2016
Dec. 31, 2015
Sep. 30, 2015
Jun. 30, 2015
Mar. 31, 2015
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
General [Line Items]                      
Loss $ (3,073) $ (4,670) $ (3,685) $ (4,594) $ (4,829) $ (3,551) $ (3,686) $ (3,299) $ (16,022) $ (15,365) $ (7,022)
Retained Earnings (Accumulated Deficit) (39,809)       $ (23,787)       (39,809) $ (23,787)  
Cash Equivalents And Short Term Investments $ 9,878               $ 9,878