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Share incentive plan (Details 1) - Employee Stock Option [Member] - USD ($)	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2015
Number of Options Outstanding, January 1, 2016 (in shares)	2,103,502
Number of Stock Options, Exercised	0
Number of Stock Options ,Granted	1,658,416
Number of Stock Options, Forfeited/Expired	(1,110,137)
Number of Options Outstanding, December 31, 2016 (in shares)	2,651,781	2,103,502
Number of Stock Options, Exercisable, December 31, 2016	1,300,224
Number of Options Vested and expected to vest, December 31, 2016 (in shares)	2,651,781
Weighted-Average Exercise Price, Exercised	$ 0
Weighted-Average Exercise Price, Granted	2.21
Weighted-Average Exercise Price, Forfeited/Expired	6.16
Weighted Average Exercise Price Outstanding, December 31, 2016 (in dollars per share)	3.41
Weighted-Average Exercise Price, Exercisable, December 31, 2016	4.47
Weighted-Average Exercise Price, Vested and expected to vest, December 31, 2016	$ 3.41
Weighted-Average Remaining Contractual Term (Years)	7 years 8 months 26 days	8 years 6 months 7 days
Weighted-Average Remaining Contractual Term (Years) Exercisable, December 31,2016	6 years
Weighted-Average Remaining Contractual Term (Years) Vested and expected to vest, December 31, 2016	7 years 8 months 26 days
Aggregate Intrinsic Value, Outstanding, January 1, 2016	$ 1,584,753
Aggregate Intrinsic Outstanding, December 31, 2016	419,840	$ 1,584,753
Aggregate Intrinsic Value Exercisable, December 31, 2016	419,696
Aggregate Intrinsic Value Exercisable Vested and expected to vest, December 31, 2016	$ 419,840

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The number of shares into which fully or partially vested stock options outstanding as of the balance sheet date can be currently converted under the option plan.

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The weighted-average price as of the balance sheet date at which grantees can acquire the shares reserved for issuance on vested portions of options outstanding and currently exercisable under the stock option plan.

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For presentations that combine terminations, the number of shares under options that were cancelled during the reporting period as a result of occurrence of a terminating event specified in contractual agreements pertaining to the stock option plan or that expired.

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Weighted average price of options that were either forfeited or expired.

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Gross number of share options (or share units) granted during the period.

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Amount by which the current fair value of the underlying stock exceeds the exercise price of options outstanding.

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Number of options outstanding, including both vested and non-vested options.

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Amount by which the current fair value of the underlying stock exceeds the exercise price of fully vested and expected to vest options outstanding.

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As of the balance sheet date, the number of shares into which fully vested and expected to vest stock options outstanding can be converted under the option plan.

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As of the balance sheet date, the weighted-average exercise price for outstanding stock options that are fully vested or expected to vest.

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Weighted average price at which option holders acquired shares when converting their stock options into shares.

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Weighted average per share amount at which grantees can acquire shares of common stock by exercise of options.

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Amount of difference between fair value of the underlying shares reserved for issuance and exercise price of vested portions of options outstanding and currently exercisable.

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Weighted average remaining contractual term for vested portions of options outstanding and currently exercisable or convertible, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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Number of share options (or share units) exercised during the current period.

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