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Employee benefits plan (Details Textual) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Severance Costs $ 65 $ 131 $ 34
Defined Contribution Plan, Employer Matching Contribution, Percent of Match 100.00%    
Defined Contribution Plan, Maximum Annual Contributions Per Employee, Percent 4.00%    
Defined Contribution Plan, Employer Discretionary Contribution Amount $ 42 $ 11  
Other Postretirement Defined Benefit Plan, Liabilities 19    
Termination Expenses 1,907    
Research and Development Expense [Member]      
Termination Expenses 145    
General and Administrative Expense [Member]      
Termination Expenses $ 1,762