<SEC-DOCUMENT>0001140361-22-007668.txt : 20220303
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<ACCEPTANCE-DATETIME>20220303161530
ACCESSION NUMBER:		0001140361-22-007668
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20220301
FILED AS OF DATE:		20220303
DATE AS OF CHANGE:		20220303

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Smith David V
		CENTRAL INDEX KEY:			0001229447

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-41008
		FILM NUMBER:		22708914

	MAIL ADDRESS:	
		STREET 1:		6035 STONERIDGE DRIVE
		CITY:			PLEASANTON
		STATE:			CA
		ZIP:			94588

	FORMER NAME:	
		FORMER CONFORMED NAME:	SMITH DAVID V
		DATE OF NAME CHANGE:	20030429

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			IO Biotech, Inc.
		CENTRAL INDEX KEY:			0001865494
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				870909276
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		OLE MAALOES VEH 3
		CITY:			COPENHAGEN
		STATE:			G7
		ZIP:			2200
		BUSINESS PHONE:		4570702980

	MAIL ADDRESS:	
		STREET 1:		OLE MAALOES VEH 3
		CITY:			COPENHAGEN
		STATE:			G7
		ZIP:			2200
</SEC-HEADER>
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<SEQUENCE>1
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<DESCRIPTION>FORM 3
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    <periodOfReport>2022-03-01</periodOfReport>

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    <issuer>
        <issuerCik>0001865494</issuerCik>
        <issuerName>IO Biotech, Inc.</issuerName>
        <issuerTradingSymbol>IOBT</issuerTradingSymbol>
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            <rptOwnerCik>0001229447</rptOwnerCik>
            <rptOwnerName>Smith David V</rptOwnerName>
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            <rptOwnerStreet1>C/O IO BIOTECH, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>OLE MAALOES VEH 3</rptOwnerStreet2>
            <rptOwnerCity>COPENHAGEN</rptOwnerCity>
            <rptOwnerState>G7</rptOwnerState>
            <rptOwnerZipCode>2200</rptOwnerZipCode>
            <rptOwnerStateDescription>DENMARK</rptOwnerStateDescription>
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            <isDirector>true</isDirector>
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    <remarks>Exhibit List: Exhibit 24 - Power of Attorney</remarks>

    <ownerSignature>
        <signatureName>/s/ Brian Burkavage, Attorney-in-Fact for David V. Smith</signatureName>
        <signatureDate>2022-03-03</signatureDate>
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<DOCUMENT>
<TYPE>EX-24
<SEQUENCE>2
<FILENAME>brhc10034758_ex24.htm
<DESCRIPTION>EXHIBIT 24
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    <div style="text-align: right;"> <font style="font-weight: bold;">Exhibit 24</font><br>
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      <div style="text-align: center; font-weight: bold;">POWER OF ATTORNEY</div>
      <div>&#160;</div>
      <div style="text-indent: 36pt;">Know all by these presents, that the undersigned hereby makes, constitutes and appoints each of <u>Keith Vendola</u>, <u>Mai-Britt Zocca</u>, and <u>Brian Burkavage</u>, or any of them acting individually, and with
        full power of substitution, the undersigned's true and lawful attorney-in-fact to:</div>
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            <td style="width: 27pt; vertical-align: top; color: rgb(31, 31, 31);">(1)</td>
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              <div style="color: rgb(31, 31, 31);">prepare, execute in the undersigned's name and on the undersigned's behalf, and submit to the U.S. Securities and Exchange Commission (the "SEC") a Form ID, including amendments thereto, and any other
                documents necessary or appropriate to obtain codes and passwords enabling the undersigned to make electronic filings with the SEC of reports required by Section 16(a) of the Securities Exchange Act of 1934 or any rule or regulation of the
                SEC;</div>
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      <div>&#160;</div>
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            <td style="width: 27pt; vertical-align: top; color: rgb(31, 31, 31);">(2)</td>
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              <div style="font-family: 'Times New Roman', Times, serif;"><font style="font-family: 'Times New Roman'; color: rgb(31, 31, 31);">execute for and on behalf of the undersigned, in the undersigned's capacity as an officer and/or director of </font><font style="font-family: 'Times New Roman';">IO Biotech, Inc., <font style="color: rgb(31, 31, 31);">a Delaware corporation (the "Company"), Forms 3, 4, and 5, including amendments thereto, in accordance with Section 16(a) of the Securities
                    Exchange Act of 1934 and the rules and regulations thereunder;</font></font></div>
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      <div>&#160;</div>
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            <td style="width: 27pt; vertical-align: top;">(3)</td>
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              <div style="color: rgb(31, 31, 31);">do and perform any and all acts for and on behalf of the undersigned which may be necessary or desirable to complete and execute any such Form 3, 4, or 5, complete and execute any amendment or amendments
                thereto, and timely file such form with the SEC and any stock exchange or similar authority; and</div>
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            <td style="width: 27pt; vertical-align: top;">(4)</td>
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              <div style="color: rgb(31, 31, 31);">take any other action of any type whatsoever in connection with the foregoing which, in the opinion of such attorney-in-fact, may be of benefit to, in the best interest of, or legally required by, the
                undersigned, it being understood that the documents executed by such attorney-in-fact on behalf of the undersigned pursuant to this Power of Attorney shall be in such form and shall contain such terms and conditions as such attorney-in-fact
                may approve in such attorney-in-fact's discretion.</div>
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      <div>&#160;</div>
      <div style="text-indent: 36pt; color: rgb(31, 31, 31);">The undersigned hereby grants to each such attorney-in-fact full power and authority to do and perform any and every act and thing whatsoever requisite, necessary, or proper to be done in the
        exercise of any of the rights and powers herein granted, as fully to all intents and purposes as the undersigned might or could do if personally present, with full power of substitution or revocation, hereby ratifying and confirming all that such
        attorney-in-fact, or such attorney-in-fact's substitute or substitutes, shall lawfully do or cause to be done by virtue of this power of attorney and the rights and powers herein granted. The undersigned acknowledges that the foregoing
        attorneys-in-fact, in serving in such capacity at the request of the undersigned, are not assuming, nor is the Company assuming, any of the undersigned's responsibilities to comply with Section 16 of the Securities Exchange Act of 1934.</div>
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      <div style="text-indent: 36pt; font-family: 'Times New Roman', Times, serif;"><font style="font-family: 'Times New Roman'; color: rgb(31, 31, 31);">This Power of Attorney shall remain in full force and effect until the undersigned is no longer
          required to file Forms 3, 4, and 5 with respect to the undersigned's holdings of and transactions in securities issued by the Company, unless earlier (a) revoked by the undersigned </font><font style="font-family: 'Times New Roman'; color: rgb(63, 63, 63);">i</font><font style="font-family: 'Times New Roman'; color: rgb(31, 31, 31);">n a signed writing delivered to the foregoing attorneys-in-fact or (b) superseded by a new power of attorney regarding the purposes outlined herein at
          a later date.</font></div>
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      <div style="font-family: 'Times New Roman', Times, serif;">IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney to be executed as of this<font style="font-family: 'Times New Roman';">&#160;<u> &#160;&#160; 1&#160; &#160; </u>&#160;<font style="color: rgb(31, 31, 31);">day of</font>&#160;<u>&#160; &#160; March&#160; &#160; </u>,<font style="color: rgb(31, 31, 31);"> 2022.</font></font></div>
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              <div style="color: rgb(31, 31, 31);">/s/ David V. Smith</div>
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              <div style="color: rgb(31, 31, 31);">Signature</div>
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              <div style="color: rgb(31, 31, 31);">David V. Smith</div>
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              <div style="color: rgb(31, 31, 31);">Print Name</div>
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