<SEC-DOCUMENT>0001140361-23-039639.txt : 20230814
<SEC-HEADER>0001140361-23-039639.hdr.sgml : 20230814
<ACCEPTANCE-DATETIME>20230814154510
ACCESSION NUMBER:		0001140361-23-039639
CONFORMED SUBMISSION TYPE:	SC 13D/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20230814
DATE AS OF CHANGE:		20230814

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			IO Biotech, Inc.
		CENTRAL INDEX KEY:			0001865494
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				870909276
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-93023
		FILM NUMBER:		231169296

	BUSINESS ADDRESS:	
		STREET 1:		OLE MAALOES VEH 3
		CITY:			COPENHAGEN
		STATE:			G7
		ZIP:			2200
		BUSINESS PHONE:		4570702980

	MAIL ADDRESS:	
		STREET 1:		OLE MAALOES VEH 3
		CITY:			COPENHAGEN
		STATE:			G7
		ZIP:			2200

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Lundbeckfond Invest A/S
		CENTRAL INDEX KEY:			0001591046
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			G7
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A

	BUSINESS ADDRESS:	
		STREET 1:		SCHERFIGSVEJ 7
		CITY:			COPENHAGEN
		STATE:			G7
		ZIP:			DK-2100
		BUSINESS PHONE:		4540307375

	MAIL ADDRESS:	
		STREET 1:		SCHERFIGSVEJ 7
		CITY:			COPENHAGEN
		STATE:			G7
		ZIP:			DK-2100
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13D/A
<SEQUENCE>1
<FILENAME>brhc20057431_sc13da.htm
<DESCRIPTION>SC 13D/A
<TEXT>
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      <div style="text-align: center; color: rgb(0, 0, 0); font-size: 14pt; font-weight: bold;">UNITED STATES</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-size: 12pt; font-weight: bold;">Washington, D.C.&#160; 20549</div>
      <div>
        <hr noshade="noshade" align="center" style="height: 2px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;"></div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-size: 18pt; font-weight: bold;">SCHEDULE 13D</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">Under the Securities Exchange Act of 1934</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">(Amendment No. 1)*</div>
      <div><font style="color: #000000;"> </font><br>
      </div>
      <div style="text-align: center; color: rgb(0, 0, 0); font-size: 24pt; font-weight: bold;"><u>IO Biotech, Inc.</u></div>
      <div style="text-align: center; color: #000000;">&#160;(Name of Issuer)</div>
      <div><font style="color: #000000;"> </font><br>
      </div>
      <div style="text-align: center; color: #000000; font-weight: bold;"><u>Common Stock, par value $0.001 per share</u></div>
      <div style="text-align: center; color: #000000;">&#160;(Title of Class of Securities)</div>
      <div><font style="color: #000000;"> </font><br>
      </div>
      <div style="text-align: center; color: #000000; font-weight: bold;"><u>449778109</u></div>
      <div style="text-align: center; color: #000000;">&#160;(CUSIP Number)</div>
      <div><font style="color: #000000;"> </font><br>
      </div>
      <div style="text-align: center; color: #000000; font-weight: bold;">Christian Elling</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">Lundbeckfond Invest A/S</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">Scherfigsvej 7</div>
      <div style="text-align: center; color: #000000; font-weight: bold;">DK-2100 Copenhagen &#216;</div>
      <div style="text-align: center; color: #000000; font-weight: bold;"><u>+45&#160; 2062 1276</u></div>
      <div style="text-align: center; color: #000000;">(Name, Address and Telephone Number of Person</div>
      <div style="text-align: center; color: #000000;">Authorized to Receive Notices and Communications)</div>
      <div><br>
      </div>
      <div style="text-align: center; color: #000000; font-weight: bold;"><u>August 9, 2023</u></div>
      <div style="text-align: center; color: #000000;">(Date of Event which Requires Filing of this Statement)</div>
      <div><font style="color: #000000;"> </font><br>
      </div>
      <div style="text-align: justify; color: #000000;">If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of &#167;&#167;240.13d-1(e),
        240.13d-1(f) or 240.13d-1(g), check the following box. &#9744;</div>
      <div><font style="color: #000000;"> </font><br>
      </div>
      <div style="text-align: justify; color: #000000;">Note: Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits.&#160; See Rule 13d-7 for other parties to whom copies are to be sent.</div>
      <div><font style="color: #000000;"> </font><br>
      </div>
      <div style="text-align: justify; color: #000000;">* The remainder of this cover page shall be filled out for a reporting person&#8217;s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing
        information which would alter the disclosures provided in a prior cover page.</div>
      <div><font style="color: #000000;"> </font><br>
      </div>
      <div style="text-align: justify; color: #000000;">The information required in the remainder of this cover page shall not be deemed to be &#8220;filed&#8221; for the purpose of Section 18 of the Securities Exchange Act of 1934 (&#8220;Act&#8221;) or otherwise subject to the
        liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).</div>
      <div><font style="color: #000000;"> </font><br>
      </div>
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                <td style="width: 50%; vertical-align: top;">
                  <div style="color: #000000;">CUSIP NO. 449778109</div>
                </td>
                <td style="width: 50%; vertical-align: top;">
                  <div style="text-align: right; color: #000000;">Page <font class="BRPFPageNumber">2</font> of 5 Pages</div>
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                <td rowspan="3" style="BORDER-TOP: #000000 1pt solid; VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; BORDER-LEFT: #000000 1pt solid; WIDTH: 6.36%">
                  <div style="FONT-SIZE: 18pt; FONT-WEIGHT: bold; TEXT-ALIGN: center">1</div>
                </td>
                <td colspan="3" style="BORDER-TOP: #000000 1pt solid; VERTICAL-ALIGN: middle; BORDER-LEFT: #000000 1pt solid; WIDTH: 86.4%">
                  <div style="FONT-WEIGHT: bold; TEXT-ALIGN: left">NAMES OF REPORTING PERSONS</div>
                </td>
                <td style="BORDER-TOP: #000000 1pt solid; VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
                <td style="BORDER-TOP: #000000 1pt solid; BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 5.01%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
              </tr>
              <tr>
                <td colspan="3" rowspan="2" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; PADDING-LEFT: 2pt; BORDER-LEFT: #000000 1pt solid; WIDTH: 86.4%">
                  <div style="text-align: left; color: #000000;">Lundbeckfond Invest A/S</div>
                </td>
                <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
                <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 5.01%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
              </tr>
              <tr>
                <td style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 2.59%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
                <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 5.01%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
              </tr>
              <tr style="HEIGHT: 13px">
                <td rowspan="3" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; BORDER-LEFT: #000000 1pt solid; WIDTH: 6.36%">
                  <div style="FONT-SIZE: 18pt; FONT-WEIGHT: bold; TEXT-ALIGN: center">2</div>
                </td>
                <td colspan="3" style="VERTICAL-ALIGN: middle; BORDER-LEFT: #000000 1pt solid; WIDTH: 86.4%">
                  <div style="FONT-WEIGHT: bold; TEXT-ALIGN: left">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</div>
                </td>
                <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                  <div style="TEXT-ALIGN: right">(a)</div>
                </td>
                <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: middle; PADDING-RIGHT: 2px; WIDTH: 5.01%">
                  <div style="FONT-FAMILY: ''Times New Roman''; TEXT-ALIGN: left">&#9744;</div>
                </td>
              </tr>
              <tr>
                <td colspan="3" rowspan="2" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; BORDER-LEFT: #000000 1pt solid; WIDTH: 86.4%">&#160;</td>
                <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                  <div style="TEXT-ALIGN: right">(b)</div>
                </td>
                <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: middle; PADDING-RIGHT: 2px; WIDTH: 5.01%">
                  <div style="FONT-FAMILY: ''Times New Roman''; TEXT-ALIGN: left">&#9746;</div>
                </td>
              </tr>
              <tr>
                <td style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 2.59%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
                <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 5.01%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
              </tr>
              <tr>
                <td rowspan="3" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; BORDER-LEFT: #000000 1pt solid; WIDTH: 6.36%">
                  <div style="FONT-SIZE: 18pt; FONT-WEIGHT: bold; TEXT-ALIGN: center">3</div>
                </td>
                <td colspan="3" style="VERTICAL-ALIGN: middle; BORDER-LEFT: #000000 1pt solid; WIDTH: 86.4%; BACKGROUND-COLOR: #bfbfbf">
                  <div style="FONT-WEIGHT: bold; TEXT-ALIGN: left">SEC USE ONLY</div>
                </td>
                <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%; BACKGROUND-COLOR: #bfbfbf">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
                <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 5.01%; BACKGROUND-COLOR: #bfbfbf">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
              </tr>
              <tr style="BACKGROUND-COLOR: #bfbfbf">
                <td colspan="3" rowspan="2" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; BORDER-LEFT: #000000 1pt solid; WIDTH: 86.4%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
                <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
                <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 5.01%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
              </tr>
              <tr style="BACKGROUND-COLOR: #bfbfbf">
                <td style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 2.59%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
                <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 5.01%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
              </tr>
              <tr>
                <td rowspan="3" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; BORDER-LEFT: #000000 1pt solid; WIDTH: 6.36%">
                  <div style="FONT-SIZE: 18pt; FONT-WEIGHT: bold; TEXT-ALIGN: center">4</div>
                </td>
                <td colspan="3" style="VERTICAL-ALIGN: middle; BORDER-LEFT: #000000 1pt solid; WIDTH: 86.4%">
                  <div style="FONT-WEIGHT: bold; TEXT-ALIGN: left">SOURCE OF FUNDS (SEE INSTRUCTIONS)</div>
                </td>
                <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
                <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 5.01%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
              </tr>
              <tr>
                <td colspan="3" rowspan="2" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; PADDING-LEFT: 2pt; BORDER-LEFT: #000000 1pt solid; WIDTH: 86.4%">
                  <div style="text-align: left; color: #000000;">WC</div>
                </td>
                <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
                <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 5.01%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
              </tr>
              <tr>
                <td style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 2.59%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
                <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 5.01%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
              </tr>
              <tr>
                <td rowspan="3" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; BORDER-LEFT: #000000 1pt solid; WIDTH: 6.36%">
                  <div style="FONT-SIZE: 18pt; FONT-WEIGHT: bold; TEXT-ALIGN: center">5</div>
                </td>
                <td colspan="3" style="VERTICAL-ALIGN: middle; BORDER-LEFT: #000000 1pt solid; WIDTH: 86.4%">
                  <div style="FONT-WEIGHT: bold; TEXT-ALIGN: left">CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(D) OR 2(E)</div>
                </td>
                <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
                <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: middle; PADDING-RIGHT: 2px; WIDTH: 5.01%">
                  <div style="FONT-FAMILY: ''Times New Roman''; TEXT-ALIGN: left">&#9744;</div>
                </td>
              </tr>
              <tr>
                <td colspan="3" rowspan="2" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; BORDER-LEFT: #000000 1pt solid; WIDTH: 86.4%">&#160;</td>
                <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
                <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 5.01%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
              </tr>
              <tr>
                <td style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 2.59%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
                <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 5.01%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
              </tr>
              <tr>
                <td rowspan="3" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; BORDER-LEFT: #000000 1pt solid; WIDTH: 6.36%">
                  <div style="FONT-SIZE: 18pt; FONT-WEIGHT: bold; TEXT-ALIGN: center">6</div>
                </td>
                <td colspan="3" style="VERTICAL-ALIGN: middle; BORDER-LEFT: #000000 1pt solid; WIDTH: 86.4%">
                  <div style="FONT-WEIGHT: bold; TEXT-ALIGN: left">CITIZENSHIP OR PLACE OF ORGANIZATION</div>
                </td>
                <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
                <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 5.01%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
              </tr>
              <tr>
                <td colspan="3" rowspan="2" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; PADDING-LEFT: 2pt; BORDER-LEFT: #000000 1pt solid; WIDTH: 86.4%">
                  <div style="text-align: left; color: #000000;">Denmark</div>
                </td>
                <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
                <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 5.01%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
              </tr>
              <tr>
                <td style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 2.59%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
                <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 5.01%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
              </tr>
              <tr>
                <td colspan="2" rowspan="12" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; FONT-WEIGHT: bold; BORDER-LEFT: #000000 1pt solid; WIDTH: 12.71%">
                  <div style="TEXT-ALIGN: center">NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH</div>
                </td>
                <td rowspan="3" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; BORDER-LEFT: #000000 1pt solid; WIDTH: 6.36%">
                  <div style="FONT-SIZE: 18pt; FONT-WEIGHT: bold; TEXT-ALIGN: center">7</div>
                </td>
                <td style="VERTICAL-ALIGN: middle; BORDER-LEFT: #000000 1pt solid; WIDTH: 76.38%">
                  <div style="FONT-WEIGHT: bold; TEXT-ALIGN: left">SOLE VOTING POWER</div>
                </td>
                <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
                <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 5.01%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
              </tr>
              <tr>
                <td rowspan="2" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; PADDING-LEFT: 2pt; BORDER-LEFT: #000000 1pt solid; WIDTH: 76.38%">
                  <div style="text-align: left; color: #000000;">21,851,920 (1)</div>
                </td>
                <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
                <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 5.01%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
              </tr>
              <tr>
                <td style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 2.59%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
                <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 5.01%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
              </tr>
              <tr>
                <td rowspan="3" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; BORDER-LEFT: #000000 1pt solid; WIDTH: 6.36%">
                  <div style="FONT-SIZE: 18pt; FONT-WEIGHT: bold; TEXT-ALIGN: center">8</div>
                </td>
                <td style="VERTICAL-ALIGN: middle; BORDER-LEFT: #000000 1pt solid; WIDTH: 76.38%">
                  <div style="FONT-WEIGHT: bold; TEXT-ALIGN: left">SHARED VOTING POWER</div>
                </td>
                <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
                <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 5.01%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
              </tr>
              <tr>
                <td rowspan="2" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; PADDING-LEFT: 2pt; BORDER-LEFT: #000000 1pt solid; WIDTH: 76.38%">
                  <div style="text-align: left; color: #000000;">0</div>
                </td>
                <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
                <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 5.01%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
              </tr>
              <tr>
                <td style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 2.59%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
                <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 5.01%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
              </tr>
              <tr>
                <td rowspan="3" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; BORDER-LEFT: #000000 1pt solid; WIDTH: 6.36%">
                  <div style="FONT-SIZE: 18pt; FONT-WEIGHT: bold; TEXT-ALIGN: center">9</div>
                </td>
                <td style="VERTICAL-ALIGN: middle; BORDER-LEFT: #000000 1pt solid; WIDTH: 76.38%">
                  <div style="FONT-WEIGHT: bold; TEXT-ALIGN: left">SOLE DISPOSITIVE POWER</div>
                </td>
                <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
                <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 5.01%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
              </tr>
              <tr>
                <td rowspan="2" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; PADDING-LEFT: 2pt; BORDER-LEFT: #000000 1pt solid; WIDTH: 76.38%">
                  <div style="text-align: left; color: #000000;">21,851,920 (1)</div>
                </td>
                <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
                <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 5.01%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
              </tr>
              <tr>
                <td style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 2.59%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
                <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 5.01%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
              </tr>
              <tr>
                <td rowspan="3" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; BORDER-LEFT: #000000 1pt solid; WIDTH: 6.36%">
                  <div style="FONT-SIZE: 18pt; FONT-WEIGHT: bold; TEXT-ALIGN: center">10</div>
                </td>
                <td style="VERTICAL-ALIGN: middle; BORDER-LEFT: #000000 1pt solid; WIDTH: 76.38%">
                  <div style="FONT-WEIGHT: bold; TEXT-ALIGN: left">SHARED DISPOSITIVE POWER</div>
                </td>
                <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
                <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 5.01%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
              </tr>
              <tr>
                <td rowspan="2" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; PADDING-LEFT: 2pt; BORDER-LEFT: #000000 1pt solid; WIDTH: 76.38%">
                  <div style="text-align: left; color: #000000;">0</div>
                </td>
                <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
                <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 5.01%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
              </tr>
              <tr>
                <td style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 2.59%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
                <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 5.01%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
              </tr>
              <tr>
                <td rowspan="3" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; BORDER-LEFT: #000000 1pt solid; WIDTH: 6.36%">
                  <div style="FONT-SIZE: 18pt; FONT-WEIGHT: bold; TEXT-ALIGN: center">11</div>
                </td>
                <td colspan="3" style="VERTICAL-ALIGN: middle; BORDER-LEFT: #000000 1pt solid; WIDTH: 86.4%">
                  <div style="FONT-WEIGHT: bold; TEXT-ALIGN: left">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</div>
                </td>
                <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
                <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 5.01%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
              </tr>
              <tr>
                <td colspan="3" rowspan="2" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; PADDING-LEFT: 2pt; BORDER-LEFT: #000000 1pt solid; WIDTH: 86.4%">
                  <div style="text-align: left; color: #000000;">21,851,920 (1)</div>
                </td>
                <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
                <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 5.01%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
              </tr>
              <tr>
                <td style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 2.59%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
                <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 5.01%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
              </tr>
              <tr>
                <td rowspan="3" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; BORDER-LEFT: #000000 1pt solid; WIDTH: 6.36%">
                  <div style="FONT-SIZE: 18pt; FONT-WEIGHT: bold; TEXT-ALIGN: center">12</div>
                </td>
                <td colspan="3" style="VERTICAL-ALIGN: middle; BORDER-LEFT: #000000 1pt solid; WIDTH: 86.4%">
                  <div style="FONT-WEIGHT: bold; TEXT-ALIGN: left">CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)</div>
                </td>
                <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
                <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: middle; PADDING-RIGHT: 2px; WIDTH: 5.01%">
                  <div style="FONT-FAMILY: ''Times New Roman''; TEXT-ALIGN: left">&#9744;</div>
                </td>
              </tr>
              <tr>
                <td colspan="3" rowspan="2" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; BORDER-LEFT: #000000 1pt solid; WIDTH: 86.4%">&#160;</td>
                <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
                <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 5.01%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
              </tr>
              <tr>
                <td style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 2.59%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
                <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 5.01%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
              </tr>
              <tr>
                <td rowspan="3" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; BORDER-LEFT: #000000 1pt solid; WIDTH: 6.36%">
                  <div style="FONT-SIZE: 18pt; FONT-WEIGHT: bold; TEXT-ALIGN: center">13</div>
                </td>
                <td colspan="3" style="VERTICAL-ALIGN: middle; BORDER-LEFT: #000000 1pt solid; WIDTH: 86.4%">
                  <div style="FONT-WEIGHT: bold; TEXT-ALIGN: left">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)</div>
                </td>
                <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
                <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 5.01%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
              </tr>
              <tr>
                <td colspan="3" rowspan="2" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; PADDING-LEFT: 2pt; BORDER-LEFT: #000000 1pt solid; WIDTH: 86.4%">
                  <div style="text-align: left; color: #000000;">29.6% (2)</div>
                </td>
                <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
                <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 5.01%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
              </tr>
              <tr>
                <td style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 2.59%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
                <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 5.01%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
              </tr>
              <tr>
                <td rowspan="3" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; BORDER-LEFT: #000000 1pt solid; WIDTH: 6.36%">
                  <div style="FONT-SIZE: 18pt; FONT-WEIGHT: bold; TEXT-ALIGN: center">14</div>
                </td>
                <td colspan="3" style="VERTICAL-ALIGN: middle; BORDER-LEFT: #000000 1pt solid; WIDTH: 86.4%">
                  <div style="FONT-WEIGHT: bold; TEXT-ALIGN: left">TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)</div>
                </td>
                <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
                <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 5.01%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
              </tr>
              <tr>
                <td colspan="3" rowspan="2" style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; PADDING-LEFT: 2pt; BORDER-LEFT: #000000 1pt solid; WIDTH: 86.4%">
                  <div style="text-align: left; color: #000000;">CO</div>
                </td>
                <td style="VERTICAL-ALIGN: middle; WIDTH: 2.59%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
                <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; WIDTH: 5.01%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
              </tr>
              <tr>
                <td style="VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 2.59%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
                <td style="BORDER-RIGHT: #000000 1pt solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 1pt solid; WIDTH: 5.01%">
                  <div style="TEXT-ALIGN: left">&#160;</div>
                </td>
              </tr>

          </table>
        </div>
      </div>
      <div><br>
      </div>
      <table cellspacing="0" cellpadding="0" id="z03f039a31d6c4d70b1abae6c9bd15dce" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 18pt;">&#160;</td>
            <td style="width: 27pt; vertical-align: top; color: rgb(0, 0, 0);">(1)</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div style="color: rgb(0, 0, 0);">The board of directors of Lundbeckfond Invest A/S, consisting of Steffen Kragh, Lars Holmqvist, Susanne Kr&#252;ger Kj&#230;r, Michael Kj&#230;r, Peter Sch&#252;tze, Svend Andersen, Henrik Sindal Jensen, Katja Barnkob, Mikkel
                Helmer Nielsen, and Morten Aagaard, and Lene Skole, the chief executive officer of Lundbeckfond Invest A/S, may be deemed to share voting and investment authority over the shares held by Lundbeckfond Invest A/S. No individual member of the
                board of directors of Lundbeckfond Invest A/S is deemed to hold any beneficial ownership in the shares held by Lundbeckfond Invest A/S.</div>
            </td>
          </tr>

      </table>
      <table cellspacing="0" cellpadding="0" id="z41ba099ee9d843daac99e1d5a87d6a08" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 18pt;"><br>
            </td>
            <td style="width: 27pt; vertical-align: top; color: rgb(0, 0, 0);">(2)</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div style="color: rgb(0, 0, 0);">Calculation is based on the sum of (i) 65,880,914 shares of Common Stock outstanding as of August 10, 2023, as reported in the Issuer&#8217;s Quarterly Report on Form 10-Q, filed with the Securities and Exchange
                Commission on August 11, 2023, and (ii) 7,901,234 shares of Common Stock the Reporting Person has the right to acquire upon exercise of Warrants (as defined herein), which have been added to the total shares of Common Stock outstanding for
                purposes of calculating the Reporting Person&#8217;s beneficial ownership percentage in accordance with Rule 13d-3(d)(1)(i) under the Act.<br>
              </div>
            </td>
          </tr>

      </table>
      <div> <br>
      </div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="width: 100%;" class="BRPFPageFooter"></div>
        <div class="BRPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
        <div style="width: 100%;" class="BRPFPageHeader">
          <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

              <tr>
                <td style="width: 50%; vertical-align: top;">
                  <div style="color: #000000;">CUSIP NO. 449778109</div>
                </td>
                <td style="width: 50%; vertical-align: top;">
                  <div style="text-align: right; color: #000000;">Page <font class="BRPFPageNumber">3</font> of 5 Pages</div>
                </td>
              </tr>

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        </div>
      </div>
      <div style="text-align: justify; color: #000000;"><font style="font-weight: bold;">Explanatory Note:&#160; </font>Pursuant to Rule 13d-2 of the Securities Exchange Act, as amended, this Amendment No. 1 to the Schedule 13D (&#8220;Amendment No. 1&#8221;) amends
        certain items of the Schedule 13D filed with the Securities and Exchange Commission on November 19, 2021 (the &#8220;Original Schedule 13D&#8221; and, together with this Amendment No. 1, the &#8220;Schedule 13D&#8221;), relating to the common stock, par value $0.001 per
        share (the &#8220;Common Stock&#8221;), of IO Biotech, Inc. (the &#8220;Issuer&#8221; or the &#8220;Company&#8221;).&#160; All capitalized terms contained herein but not otherwise defined shall have the meanings ascribed to such terms in the Schedule 13D.</div>
      <div style="text-align: justify; color: #000000;">&#160;&#160;</div>
      <div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%;" id="z432e4015e97145219579fce5e390ff85" class="DSPFListTable">

            <tr style="vertical-align: top;">
              <td style="text-align: right; vertical-align: top; width: 45pt;">
                <div style="text-align: left; color: #000000; font-weight: bold;">Item 3.</div>
              </td>
              <td style="text-align: left; vertical-align: top; width: auto;">
                <div style="color: #000000; font-weight: bold;">Source and Amount of Funds or Other Consideration</div>
              </td>
            </tr>

        </table>
      </div>
      <div><br>
      </div>
      <div>
        <div style="text-align: justify; color: #000000; font-style: italic;">Item 3 of the Schedule 13D is hereby amended and supplemented as follows:</div>
        <div><br>
        </div>
        <div style="text-align: justify; color: #000000;">On August 7, 2023, the Company and certain institutional investors (&#8220;Purchasers&#8221;), including the Reporting Person, entered into a Securities Purchase Agreement (the &#8220;Purchase Agreement&#8221;), pursuant
          to which the Company agreed to sell and issue (i) 37,065,647 shares of Common Stock and (ii) 37,065,647 warrants to purchase up to 37,065,647 shares of Common Stock (the &#8220;Warrants&#8221;), at a purchase price of $2.025 per share of Common Stock and
          Warrant (the &#8220;Private Placement&#8221;).&#160; The Private Placement closed on August 9, 2023 (the &#8220;Closing&#8221;).</div>
        <div><br>
        </div>
        <div style="text-align: justify; color: #000000;">Pursuant to the Purchase Agreement, at the Closing on August 9, 2023, the Reporting Person purchased 7,901,234 shares of Common Stock and 7,901,234 Warrants from the Company for an aggregate
          purchase price of $15,999,998.85, or $1.90 per share of Common Stock and $0.125 per Warrant.&#160; The Warrants have an exercise price of $2.47 per share and are exercisable at any time on or after August 9, 2023 and on or prior to 5:00 p.m. Eastern
          time on the earlier of (i) February 9, 2027, and (ii) one day prior to the closing of an Acquisition of the Company, as defined in the Form of Warrant, attached as Exhibit 4.1 to the Issuer&#8217;s Current Report on Form 8-K, filed with the Securities
          and Exchange Commission on August 7, 2023.</div>
        <div><br>
        </div>
        <div style="text-align: justify; color: #000000;">Each of the foregoing purchases was funded by the working capital of the Reporting Person.</div>
        <div><br>
        </div>
        <div style="text-align: justify; color: #000000;">The foregoing summary of the Purchase Agreement and Warrants does not purport to be complete and is qualified in its entirety by reference to the full text of each of the Purchase Agreement and the
          Form of Warrant, each of which is attached hereto as an exhibit to this Amendment No. 1 and is incorporated by reference.</div>
      </div>
      <br>
      <div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%;" id="z509fd2a634c149609259c40687f964d4" class="DSPFListTable">

            <tr style="vertical-align: top;">
              <td style="text-align: right; vertical-align: top; width: 45pt;">
                <div style="text-align: justify;"><font style="font-weight: bold; color: #000000;">Item 4.</font></div>
              </td>
              <td style="text-align: left; vertical-align: top; width: auto;">
                <div style="text-align: justify;"><font style="font-weight: bold; color: rgb(0, 0, 0);">Purpose of Transaction</font></div>
              </td>
            </tr>

        </table>
      </div>
      <div><br>
      </div>
      <div style="text-align: justify; color: #000000; font-style: italic;">Item 4 of the Schedule 13D is hereby amended and supplemented as follows:</div>
      <div><br>
      </div>
      <div style="text-align: justify; color: #000000;">The response to Item 3 of this Amendment No. 1 is incorporated by reference herein.</div>
      <div><br>
      </div>
      <div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%;" id="zc7c1a9dc7a784703a30b2eaeeb07c6c4" class="DSPFListTable">

            <tr style="vertical-align: top;">
              <td style="text-align: right; vertical-align: top; width: 45pt;">
                <div style="text-align: justify;"><font style="font-weight: bold; color: #000000;">Item 5.</font></div>
              </td>
              <td style="text-align: left; vertical-align: top; width: auto;">
                <div style="text-align: justify;"><font style="font-weight: bold; color: rgb(0, 0, 0);">Interest in Securities of the Issuer</font></div>
              </td>
            </tr>

        </table>
      </div>
      <div><br>
      </div>
      <div style="text-align: justify; color: #000000; font-style: italic;">Item 5(a)-(c) of the Schedule 13D is hereby amended and supplemented as follows:</div>
      <div><br>
      </div>
      <div style="text-align: justify; color: #000000;">(a, b) As of the date hereof, the Reporting Person may be deemed to be the beneficial owner of 21,851,920 shares of Common Stock, which represents approximately 29.6% of the total number of shares of
        Common Stock outstanding.&#160; The board of directors of the Reporting Person, including Steffen Kragh, Lars Holmqvist, Susanne Kr&#252;ger Kj&#230;r, Michael Kj&#230;r, Peter Sch&#252;tze, Svend Andersen, Henrik Sindal Jensen, Katja Barnkob, Mikkel Helmer Nielsen, and
        Morten Aagaard, and Lene Skole, the chief executive officer of the Reporting Person, may be deemed to share voting and investment authority over the shares held by the Reporting Person.&#160; Neither Lene Skole nor any individual member of the Reporting
        Person&#8217;s board of directors is deemed to hold any beneficial ownership in the shares held by the Reporting Person.</div>
      <div><br>
      </div>
      <div style="text-align: justify; color: rgb(0, 0, 0);">The beneficial ownership percentage reported herein was calculated based on the sum of (i) 65,880,914 shares of Common Stock outstanding as of August 10, 2023, as reported in the Issuer&#8217;s
        Quarterly Report on Form 10-Q, filed with the Securities and Exchange Commission on August 11, 2023, and (ii) 7,901,234 shares of Common Stock the Reporting Person has the right to acquire upon exercise of Warrants, which have been added to the
        total shares of Common Stock outstanding for purposes of calculating the Reporting Person&#8217;s beneficial ownership percentage in accordance with Rule 13d-3(d)(1)(i) under the Act.</div>
      <div><br>
      </div>
      <div style="text-align: justify; color: #000000;">(c) The response to Item 3 of this Amendment No. 1 is incorporated by reference herein.&#160; Except for the transactions reported herein, there have been no transactions in shares of Common Stock by the
        Reporting Person in the past sixty days.</div>
      <div><br>
      </div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div style="width: 100%;" class="BRPFPageFooter"></div>
        <div class="BRPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
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          <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

              <tr>
                <td style="width: 50%; vertical-align: top;">
                  <div style="color: #000000;">CUSIP NO. 449778109</div>
                </td>
                <td style="width: 50%; vertical-align: top;">
                  <div style="text-align: right; color: #000000;">Page <font class="BRPFPageNumber">4</font> of 5 Pages</div>
                </td>
              </tr>

          </table>
        </div>
      </div>
      <table cellspacing="0" cellpadding="0" id="z50e715d122a24e45a48753e4705451fc" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 45pt; vertical-align: top; color: rgb(0, 0, 0); font-weight: bold;">Item 6.</td>
            <td style="width: auto; vertical-align: top;">
              <div style="color: rgb(0, 0, 0); font-weight: bold;">Contracts, Arrangements, Understandings or Relationships with Respect to Securities of the Issuer.</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <div style="color: #000000; font-style: italic;">Item 6 of the Schedule 13D is hereby amended and supplemented as follows:</div>
      <div><br>
      </div>
      <div style="color: #000000;">The response to Item 3 of this Amendment No. 1 is incorporated by reference herein.</div>
      <div><br>
      </div>
      <div style="color: #000000; font-style: italic;">Registration Rights Agreement</div>
      <div><br>
      </div>
      <div style="text-align: justify; color: rgb(0, 0, 0);">On August 7, 2023, the Company entered into a registration rights agreement (the &#8220;Registration Rights Agreement&#8221;) with the Purchasers.&#160; Under the terms of the Registration Rights Agreement, the
        Company has agreed to prepare and file, within 30 days after the Closing (the &#8220;Filing Deadline&#8221;), one or more registration statements with the Securities and Exchange Commission to register for resale the shares of Common Stock issued under the
        Purchase Agreement and the shares of Common Stock issuable upon conversion of the Warrants issued pursuant to the Purchase Agreement, and to cause the applicable registration statements to become effective within a specified period after the Filing
        Deadline.</div>
      <div><br>
      </div>
      <div style="text-align: justify; color: rgb(0, 0, 0);">The foregoing summary of the Registration Rights Agreement does not purport to be complete and is qualified in its entirety by reference to the full text of the Registration Rights Agreement,
        which is attached hereto as an exhibit to this Amendment No. 1 and is incorporated by reference.</div>
      <div><br>
      </div>
      <div style="text-align: justify; color: rgb(0, 0, 0);">Except as otherwise set forth in this Amendment No. 1, there are no contracts, arrangements, understandings, or relationships between the Reporting Person and any other person with respect to any
        securities of the Issuer.</div>
      <div><br>
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            <td style="width: 45pt; vertical-align: top; color: rgb(0, 0, 0); font-weight: bold;">Item 7.</td>
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              <div style="color: rgb(0, 0, 0); font-weight: bold;">Material to be Filed as Exhibits.</div>
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      <div style="text-align: justify;"><font style="color: rgb(0, 0, 0);">Exhibit 99.4</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160; <font style="color: rgb(0, 0, 0);">Purchase Agreement, dated as of August 7, 2023 (incorporated by reference to Exhibit 10.1 to the Issuer&#8217;s Current
          Report on Form 8-K, filed with the Securities and Exchange Commission on August 7, 2023).</font></div>
      <div><br>
      </div>
      <div style="text-align: justify;"><font style="color: rgb(0, 0, 0);">Exhibit 99.5</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160; <font style="color: rgb(0, 0, 0);">Form of Warrant (incorporated by reference to Exhibit 4.1 to the Issuer&#8217;s Current Report on Form 8-K, filed with the
          Securities and Exchange Commission on August 7, 2023).</font></div>
      <div><br>
      </div>
      <div style="text-align: justify;"><font style="color: rgb(0, 0, 0);">Exhibit 99.6:</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160; <font style="color: rgb(0, 0, 0);">Registration Rights Agreement, dated as of August 7, 2023 (incorporated by reference to Exhibit 4.2 to the Issuer&#8217;s
          Current Report on Form 8-K, filed with the Securities and Exchange Commission on August 7, 2023).</font></div>
      <div><font style="color: rgb(0, 0, 0);"> <br>
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                  <div style="color: #000000;">CUSIP NO. 449778109</div>
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                  <div style="text-align: right; color: #000000;">Page <font class="BRPFPageNumber">5</font> of 5 Pages</div>
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      <div style="text-align: center; color: #000000; font-weight: bold;">SIGNATURE</div>
      <div><br>
      </div>
      <div style="text-align: justify; text-indent: 36pt; color: #000000;">After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.</div>
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            <td style="width: 50%; vertical-align: top;" colspan="1">&#160;</td>
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              <div style="margin-left: 0.5pt; color: rgb(0, 0, 0); font-weight: bold;">LUNDBECKFOND INVEST A/S</div>
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            <td style="width: 50%; vertical-align: middle;" colspan="1">&#160;</td>
            <td style="width: 2.98%; vertical-align: middle;">&#160;</td>
            <td style="vertical-align: middle;">&#160;</td>
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            <td style="width: 50%; vertical-align: top; padding-bottom: 2px;" colspan="1">&#160;</td>
            <td style="width: 2.98%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="margin-left: 0.5pt; color: rgb(0, 0, 0);">By:</div>
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            <td style="width: 46.94%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
              <div style="margin-left: 0.5pt; color: rgb(0, 0, 0);">/s/ Brian Burkavage</div>
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            <td style="width: 50%; vertical-align: middle;" colspan="1">&#160;</td>
            <td style="vertical-align: middle;" colspan="2">&#160;</td>
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            <td style="vertical-align: top;" colspan="2">
              <div style="margin-left: 0.5pt; color: rgb(0, 0, 0);">Name: Brian Burkavage</div>
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            <td style="width: 50%; vertical-align: top;" colspan="1">&#160;</td>
            <td style="vertical-align: top;" colspan="2">
              <div style="margin-left: 0.5pt; color: rgb(0, 0, 0);">Title: Attorney-in-Fact for Christian Elling, Managing Partner, and Lene Skole, Chief Executive Officer</div>
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            <td style="width: 50%; vertical-align: middle;" colspan="1">&#160;</td>
            <td style="width: 2.98%; vertical-align: middle;">&#160;</td>
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              <div style="text-align: justify; color: #000000;">Date: August 14, 2023</div>
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      <div style="color: #000000; font-style: italic;">
        <div style="color: #000000; font-style: italic;">Attention: Intentional misstatements or omissions of fact constitute federal violations (see 18 U.S.C. 1001).</div>
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