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Share-Based Payments - Compensation expense (Details) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018
Share-Based Compensation |  |  |
Share-based compensation expenses | $ 3,408 | $ 2,362 | $ 2,069
Warrants |  |  |
Share-Based Compensation |  |  |
Compensation for arranging investors to subscribe for shares | 100 |  |
Research and development |  |  |
Share-Based Compensation |  |  |
Share-based compensation expenses | 1,496 | 1,021 | 896
General and administrative |  |  |
Share-Based Compensation |  |  |
Share-based compensation expenses | $ 1,912 | $ 1,341 | $ 1,173

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