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Share-Based Payments - Compensation expense (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Share-Based Compensation      
Share-based compensation expenses $ 3,408 $ 2,362 $ 2,069
Warrants      
Share-Based Compensation      
Compensation for arranging investors to subscribe for shares 100    
Research and development      
Share-Based Compensation      
Share-based compensation expenses 1,496 1,021 896
General and administrative      
Share-Based Compensation      
Share-based compensation expenses $ 1,912 $ 1,341 $ 1,173