<SEC-DOCUMENT>0001250853-23-000046.txt : 20230801
<SEC-HEADER>0001250853-23-000046.hdr.sgml : 20230801
<ACCEPTANCE-DATETIME>20230801153726
ACCESSION NUMBER:		0001250853-23-000046
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		<ITEMS>06b
FILED AS OF DATE:		20230801
DATE AS OF CHANGE:		20230801
EFFECTIVENESS DATE:		20230801

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			LIXTE BIOTECHNOLOGY HOLDINGS, INC.
		CENTRAL INDEX KEY:			0001335105
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				202903526
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-488474
		FILM NUMBER:		231131397

	BUSINESS ADDRESS:	
		STREET 1:		248 ROUTE 25A
		STREET 2:		NO. 2
		CITY:			EAST SETAUKET
		STATE:			NY
		ZIP:			11733
		BUSINESS PHONE:		310 203 2902

	MAIL ADDRESS:	
		STREET 1:		248 ROUTE 25A
		STREET 2:		NO. 2
		CITY:			EAST SETAUKET
		STATE:			NY
		ZIP:			11733

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	SRKP 7 INC
		DATE OF NAME CHANGE:	20050803
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
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        <cik>0001335105</cik>
        <entityName>LIXTE BIOTECHNOLOGY HOLDINGS, INC.</entityName>
        <issuerAddress>
            <street1>680 East Colorado Boulevard</street1>
            <street2>Suite 180</street2>
            <city>Pasadena</city>
            <stateOrCountry>CA</stateOrCountry>
            <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
            <zipCode>11733</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>6318307092</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
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    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>John</firstName>
                <lastName>Kovach</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>680 East Colorado Boulevard</street1>
                <street2>Suite 180</street2>
                <city>Pasadena</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>91101</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>James</firstName>
                <lastName>Miser</lastName>
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                <city>Pasadena</city>
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                <zipCode>91101</zipCode>
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            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Robert</firstName>
                <lastName>Weingarten</lastName>
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                <street1>680 East Colorado Boulevard</street1>
                <street2>Suite 180</street2>
                <city>Pasadena</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>91101</zipCode>
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                <zipCode>91101</zipCode>
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                <city>Pasadena</city>
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                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>91101</zipCode>
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            <relationshipClarification></relationshipClarification>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Regina</firstName>
                <lastName>Brown</lastName>
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                <street1>680 East Colorado Boulevard</street1>
                <street2>Suite 180</street2>
                <city>Pasadena</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>91101</zipCode>
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            <relatedPersonRelationshipList>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Yun</firstName>
                <lastName>Yen</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
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                <street2>Suite 180</street2>
                <city>Pasadena</city>
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                <firstName>Rene</firstName>
                <lastName>Bernards</lastName>
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                <street1>680 East Colorado Boulevard</street1>
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                <city>Pasadena</city>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Bas</firstName>
                <lastName>van der Baan</lastName>
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                <street1>680 East Colorado Boulevard</street1>
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    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06b</item>
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        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2023-07-20</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isOptionToAcquireType>true</isOptionToAcquireType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>3500000</minimumInvestmentAccepted>
        <salesCompensationList>
            <recipient>
                <recipientName>A.G.P. / ALLIANCE GLOBAL PARTNERS</recipientName>
                <recipientCRDNumber>8361</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>88 POST ROAD WEST</street1>
                    <street2>2ND FLOOR</street2>
                    <city>WESTPORT</city>
                    <stateOrCountry>CT</stateOrCountry>
                    <stateOrCountryDescription>CONNECTICUT</stateOrCountryDescription>
                    <zipCode>06880</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>NY</state>
                    <description>NEW YORK</description>
                </statesOfSolicitationList>
                <foreignSolicitation>false</foreignSolicitation>
            </recipient>
        </salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>3500000</totalOfferingAmount>
            <totalAmountSold>3500000</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse>The common stock warrants being offered hereunder are being offered as part of a broader offering which includes the public sale of shares of common stock and pre-funded warrants.  The total offering amount is $3,500,000.</clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>1</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>210000</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>LIXTE BIOTECHNOLOGY HOLDINGS, INC.</issuerName>
                <signatureName>/s/ John S. Kovach</signatureName>
                <nameOfSigner>John S. Kovach</nameOfSigner>
                <signatureTitle>Chief Executive Officer</signatureTitle>
                <signatureDate>2023-08-01</signatureDate>
            </signature>
        </signatureBlock>
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</SEC-DOCUMENT>
