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Cover - shares
 3 Months Ended
Mar. 31, 2026
May 12, 2026
Cover [Abstract]    
Document Type 10-Q  
Amendment Flag false  
Document Quarterly Report true  
Document Transition Report false  
Document Period End Date Mar. 31, 2026  
Document Fiscal Period Focus Q1  
Document Fiscal Year Focus 2026  
Current Fiscal Year End Date --12-31  
Entity File Number 001-39717  
Entity Registrant Name LIXTE BIOTECHNOLOGY HOLDINGS, INC.  
Entity Central Index Key 0001335105  
Entity Tax Identification Number 20-2903526  
Entity Incorporation, State or Country Code DE  
Entity Address, Address Line One 433 Plaza Real  
Entity Address, Address Line Two Suite 275  
Entity Address, City or Town Boca Raton  
Entity Address, State or Province FL  
Entity Address, Postal Zip Code 33432  
City Area Code (631)  
Local Phone Number 830-7092  
Title of 12(b) Security Common Stock, par value $0.0001 per share  
Trading Symbol LIXT  
Security Exchange Name NASDAQ  
Entity Current Reporting Status Yes  
Entity Interactive Data Current Yes  
Entity Filer Category Non-accelerated Filer  
Entity Small Business true  
Entity Emerging Growth Company false  
Entity Shell Company false  
Entity Common Stock, Shares Outstanding   12,382,944