<SEC-DOCUMENT>0000899243-18-008660.txt : 20180327
<SEC-HEADER>0000899243-18-008660.hdr.sgml : 20180327
<ACCEPTANCE-DATETIME>20180327182624
ACCESSION NUMBER:		0000899243-18-008660
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20180327
FILED AS OF DATE:		20180327
DATE AS OF CHANGE:		20180327

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Rock Springs Capital LLC
		CENTRAL INDEX KEY:			0001735397
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-38433
		FILM NUMBER:		18716651

	BUSINESS ADDRESS:	
		STREET 1:		650 SOUTH EXETER STREET
		STREET 2:		SUITE 1070
		CITY:			BALTIMORE
		STATE:			MD
		ZIP:			21202
		BUSINESS PHONE:		410-220-0142

	MAIL ADDRESS:	
		STREET 1:		650 SOUTH EXETER STREET
		STREET 2:		SUITE 1070
		CITY:			BALTIMORE
		STATE:			MD
		ZIP:			21202

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Rock Springs Capital Management LP
		CENTRAL INDEX KEY:			0001595725
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-38433
		FILM NUMBER:		18716653

	BUSINESS ADDRESS:	
		STREET 1:		650 SOUTH EXETER STREET
		STREET 2:		SUITE 1070
		CITY:			BALTIMORE
		STATE:			MD
		ZIP:			21202
		BUSINESS PHONE:		4102200129

	MAIL ADDRESS:	
		STREET 1:		650 SOUTH EXETER STREET
		STREET 2:		SUITE 1070
		CITY:			BALTIMORE
		STATE:			MD
		ZIP:			21202

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Rock Springs Capital Master Fund LP
		CENTRAL INDEX KEY:			0001735393
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-38433
		FILM NUMBER:		18716652

	BUSINESS ADDRESS:	
		STREET 1:		650 SOUTH EXETER STREET
		STREET 2:		SUITE 1070
		CITY:			BALTIMORE
		STATE:			MD
		ZIP:			21202
		BUSINESS PHONE:		410-220-0142

	MAIL ADDRESS:	
		STREET 1:		190 ELGIN AVENUE
		CITY:			GEORGE TOWN
		STATE:			E9
		ZIP:			KY1 9001

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Homology Medicines, Inc.
		CENTRAL INDEX KEY:			0001661998
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				473468154
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		45 WIGGINS AVE.
		CITY:			BEDFORD
		STATE:			MA
		ZIP:			01730
		BUSINESS PHONE:		857-305-1825

	MAIL ADDRESS:	
		STREET 1:		45 WIGGINS AVE.
		CITY:			BEDFORD
		STATE:			MA
		ZIP:			01730
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>doc3.xml
<DESCRIPTION>FORM 3 SUBMISSION
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2018-03-27</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001661998</issuerCik>
        <issuerName>Homology Medicines, Inc.</issuerName>
        <issuerTradingSymbol>FIXX</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001595725</rptOwnerCik>
            <rptOwnerName>Rock Springs Capital Management LP</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>650 SOUTH EXETER ST. SUITE 1070</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>BALTIMORE</rptOwnerCity>
            <rptOwnerState>MD</rptOwnerState>
            <rptOwnerZipCode>21202</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001735393</rptOwnerCik>
            <rptOwnerName>Rock Springs Capital Master Fund LP</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O INTERTRUST CORPORATE SERVICES</rptOwnerStreet1>
            <rptOwnerStreet2>(CAYMAN) LIMITED 190 ELGIN AVENUE</rptOwnerStreet2>
            <rptOwnerCity>GEORGE TOWN, GRAND CAYMAN</rptOwnerCity>
            <rptOwnerState>E9</rptOwnerState>
            <rptOwnerZipCode>KY1-9005</rptOwnerZipCode>
            <rptOwnerStateDescription>CAYMAN ISLANDS</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001735397</rptOwnerCik>
            <rptOwnerName>Rock Springs Capital LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>650 SOUTH EXETER ST. SUITE 1070</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>BALTIMORE</rptOwnerCity>
            <rptOwnerState>MD</rptOwnerState>
            <rptOwnerZipCode>21202</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Series B Preferred Stock</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <footnoteId id="F1"/>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <footnoteId id="F1"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>395845</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnote</value>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">The preferred stock is convertible into the Issuer's common stock on a one-for-one basis at the holder's election and has no expiration date. The preferred stock will automatically convert into common stock upon the closing of the Issuer's initial public offering.</footnote>
        <footnote id="F2">The securities reported herein are held of record by Rock Springs Capital Master Fund LP (&quot;Master Fund&quot;). Rock Springs Capital LLC (&quot;RSC&quot;) is the general partner of Rock Springs Capital Management LP (&quot;RSCM&quot;) which is the investment manager to Master Fund. RSC and RSCM may therefore be deemed to have or share beneficial ownership of the Series B Preferred Stock held directly by Master Fund.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>Rock Springs Capital Master Fund LP, By: Rock Springs Capital Management LP, By: /s/Graham McPhail, Managing Member</signatureName>
        <signatureDate>2018-03-27</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>Rock Springs Capital LLC, By: /s/Graham McPhail, Managing Member</signatureName>
        <signatureDate>2018-03-27</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>Rock Springs Capital Management LP, Rock Springs Capital LLC, By: /s/Graham McPhail, Managing Member</signatureName>
        <signatureDate>2018-03-27</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
