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Commitments and Contingencies - Additional Information (Detail) $ in Thousands |  | 1 Months Ended | 4 Months Ended | 12 Months Ended |
--- | --- | --- | --- | --- | ---
Dec. 31, 2021 USD ($) ft² | Dec. 31, 2021 USD ($) ft² | Dec. 31, 2019 USD ($) shares | Dec. 31, 2023 USD ($) | Dec. 31, 2022 USD ($) | Dec. 31, 2019 USD ($) | Sep. 30, 2019 USD ($)
Commitment And Contingencies [Line Items] |  |  |  |  |  |  |
Research and development expenses |  |  |  | $ 31,729 | $ 35,814 |  |
Executive insurance reserve |  |  |  | 5,000 |  |  |
License Agreement With The University Of Colorado [Member] |  |  |  |  |  |  |
Commitment And Contingencies [Line Items] |  |  |  |  |  |  |
Development and sales milestone payment payable |  |  |  | $ 2,200 |  |  |
Percentage of sublicense fees |  |  |  | 15.00% |  |  |
Period of obligation to pay royalties |  |  |  | 20 years |  |  |
Research and development expenses |  |  |  | $ 0 | 50 |  |
License Agreement With Bristol Mayers Equib Company [Member] |  |  |  |  |  |  |
Commitment And Contingencies [Line Items] |  |  |  |  |  |  |
Percentage of sublicense fees |  |  | 60.00% |  |  |  |
Period of obligation to pay royalties |  |  | 12 years |  |  |  |
Upfront payment made |  |  | $ 8,000 |  |  |  |
Commercial milestone payment payable |  |  | $ 215,000 |  |  | $ 215,000 |
Royalty as a percentage of sales |  |  | 10.00% |  |  |  |
In process research and development expense recognized |  |  |  |  |  | 14,600 |
License Agreement With Bristol Mayers Equib Company [Member] | Cash Consideration [Member] |  |  |  |  |  |  |
Commitment And Contingencies [Line Items] |  |  |  |  |  |  |
In process research and development expense recognized |  |  |  |  |  | 8,000 |
License Agreement With Bristol Mayers Equib Company [Member] | Temporary Equity [Member] |  |  |  |  |  |  |
Commitment And Contingencies [Line Items] |  |  |  |  |  |  |
In process research and development expense recognized |  |  |  |  |  | 6,600 |
License Agreement With Bristol Mayers Equib Company [Member] | Maximum [Member] | Tranche One [Member] |  |  |  |  |  |  |
Commitment And Contingencies [Line Items] |  |  |  |  |  |  |
Development and sales milestone payment payable |  |  | $ 49,000 |  |  | 49,000 |
License Agreement With Bristol Mayers Equib Company [Member] | Maximum [Member] | Tranche Two [Member] |  |  |  |  |  |  |
Commitment And Contingencies [Line Items] |  |  |  |  |  |  |
Development and sales milestone payment payable |  |  |  |  |  |  | $ 49,000
License Agreement With Bristol Mayers Equib Company [Member] | Maximum [Member] | Tranche Three [Member] |  |  |  |  |  |  |
Commitment And Contingencies [Line Items] |  |  |  |  |  |  |
Development and sales milestone payment payable |  |  |  |  |  |  | 49,000
License Agreement With Bristol Mayers Equib Company [Member] | Minimum [Member] | Tranche One [Member] |  |  |  |  |  |  |
Commitment And Contingencies [Line Items] |  |  |  |  |  |  |
Development and sales milestone payment payable |  |  | $ 32,000 |  |  | $ 32,000 |
License Agreement With Bristol Mayers Equib Company [Member] | Minimum [Member] | Tranche Two [Member] |  |  |  |  |  |  |
Commitment And Contingencies [Line Items] |  |  |  |  |  |  |
Development and sales milestone payment payable |  |  |  |  |  |  | 32,000
License Agreement With Bristol Mayers Equib Company [Member] | Minimum [Member] | Tranche Three [Member] |  |  |  |  |  |  |
Commitment And Contingencies [Line Items] |  |  |  |  |  |  |
Development and sales milestone payment payable |  |  |  |  |  |  | $ 32,000
License Agreement With Bristol Mayers Equib Company [Member] | Series A Redeemable Preferred Stock [Member] |  |  |  |  |  |  |
Commitment And Contingencies [Line Items] |  |  |  |  |  |  |
Stock issued during period shares purchase of assets | shares |  |  | 6,628,788 |  |  |  |
Waltham Massauchets [Member] |  |  |  |  |  |  |
Commitment And Contingencies [Line Items] |  |  |  |  |  |  |
Office space leased | ft² | 15,000 | 15,000 |  |  |  |  |
Operating lease expiration year and month | 2031-12 |  |  |  |  |  |
Lessee, operating lease, lease not yet commenced, renewal term | 5 years | 5 years |  |  |  |  |
Sublease aggregate base rent obligation | $ 970 | $ 970 |  |  |  |  |
Percentage increase in initial annual base rent per square foot. |  | 3.00% |  |  |  |  |
Annual Rent Operating lease Aggregate After Increase |  | $ 11,100 |  |  |  |  |
Security deposit |  |  |  |  | 647 |  |
Operating lease weighted average remaining lease term |  |  |  | 8 years |  |  |
Operating lease weighted average discount rate |  |  |  | 7.50% |  |  |
Waltham Massauchets [Member] | Restricted Cash And Cash Equivalents Non Current [Member] |  |  |  |  |  |  |
Commitment And Contingencies [Line Items] |  |  |  |  |  |  |
Lessee tenant improvement allowance |  |  |  |  | $ 400 |  |

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