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Cover Page
 12 Months Ended
Dec. 31, 2023
Document Information [Line Items]  
Document Type S-1
Amendment Flag false
Entity Registrant Name Q32 BIO INC.
Entity Central Index Key 0001661998
Entity Incorporation, State or Country Code DE
Entity Tax Identification Number 47-3468154
Entity Address, Address Line One 830 Winter Street
Entity Address, City or Town Waltham
Entity Address, State or Province MA
Entity Address, Postal Zip Code 02451
City Area Code 781
Local Phone Number 999-0232
Entity Primary SIC Number 2834
Entity Filer Category Non-accelerated Filer
Entity Small Business true
Entity Emerging Growth Company false
Business Contact [Member]  
Document Information [Line Items]  
Contact Personnel Name Jodie Morrison
Entity Address, Address Line One 830 Winter Street
Entity Address, City or Town Waltham
Entity Address, State or Province MA
Entity Address, Postal Zip Code 02451
City Area Code 781
Local Phone Number 999-0232