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Note 5 - Property, Plant and Equipment - Major Classes of Property, Plant and Equipment (Details) - USD ($) | 12 Months Ended
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Dec. 31, 2018 | Dec. 31, 2017
Property, plant and equipment, gross |  | $ 37,376,110 | $ 35,522,568
Less: Accumulated depreciation and amortization |  | (6,973,552) | (6,683,111)
Property, plant and equipment, net |  | 30,402,558 | 28,839,457
Depreciation and amortization | [1] | 1,141,161 | 867,277
Land [Member] |  |  |
Property, plant and equipment, gross |  | 6,929,000 | 6,929,000
Building [Member] |  |  |
Property, plant and equipment, gross |  | 15,920,925 | 15,917,925
Building Improvements [Member] |  |  |
Property, plant and equipment, gross |  | 6,603,121 | 5,805,045
Machinery and Equipment [Member] |  |  |
Property, plant and equipment, gross |  | 3,385,357 | 3,246,877
Furniture and Fixtures [Member] |  |  |
Property, plant and equipment, gross |  | 611,190 | 563,959
Computer Equipment [Member] |  |  |
Property, plant and equipment, gross |  | 487,007 | 587,147
Software Development [Member] |  |  |
Property, plant and equipment, gross |  | 441,376 | 427,441
Transportation Equipment [Member] |  |  |
Property, plant and equipment, gross |  | 65,995 | 65,994
Lab Equipment [Member] |  |  |
Property, plant and equipment, gross |  | 1,985,179 | 1,979,180
Construction in Progress [Member] |  |  |
Property, plant and equipment, gross |  | $ 946,960 |
[1] | Includes amortization expense of $115,800 and $45,645 for the year ending December 31, 2018 and the year ended December 31, 2017, respectively. Such amortization expense relates to other capitalized and intangibles assets.

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- Definition Amount of accumulated depreciation, depletion and amortization for physical assets used in the normal conduct of business to produce goods and services. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 360 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=6391035&loc=d3e2868-110229 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.14) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 + Details
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- Definition Amount after accumulated depreciation, depletion and amortization of physical assets used in the normal conduct of business to produce goods and services and not intended for resale. Examples include, but are not limited to, land, buildings, machinery and equipment, office equipment, and furniture and fixtures. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02(14)) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 360 -SubTopic 10 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6391035&loc=d3e2868-110229 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 944 -SubTopic 210 -Section S99 -Paragraph 1 -Subparagraph (SX 210.7-03(a)(8)) -URI http://asc.fasb.org/extlink&oid=6879938&loc=d3e572229-122910 Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02(13)) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 + Details
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