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Note 5 - Property, Plant and Equipment - Major Classes of Property, Plant and Equipment (Details) - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020
Property, plant and equipment, gross |  | $ 21,702,817 | $ 38,071,129
Less: Accumulated depreciation and amortization |  | (9,441,496) | (9,227,566)
Property, plant and equipment, net |  | 12,261,321 | 28,843,563
Depreciation and amortization expense (1) | [1] | 742,287 | 1,389,145
Land [Member] |  |  |
Property, plant and equipment, gross |  | 2,220,000 | 6,929,000
Building [Member] |  |  |
Property, plant and equipment, gross |  | 6,634,039 | 15,917,000
Building Improvements [Member] |  |  |
Property, plant and equipment, gross |  | 5,842,989 | 8,141,791
Machinery and Equipment [Member] |  |  |
Property, plant and equipment, gross |  | 3,289,860 | 3,340,005
Furniture and Fixtures [Member] |  |  |
Property, plant and equipment, gross |  | 546,765 | 613,765
Computer Equipment [Member] |  |  |
Property, plant and equipment, gross |  | 504,037 | 493,349
Software Development [Member] |  |  |
Property, plant and equipment, gross |  | 431,331 | 435,593
Transportation Equipment [Member] |  |  |
Property, plant and equipment, gross |  | 114,511 | 114,511
Lab Equipment [Member] |  |  |
Property, plant and equipment, gross |  | 1,992,179 | 1,992,179
Construction in Progress [Member] |  |  |
Property, plant and equipment, gross |  | $ 127,106 | $ 93,936
[1] | (1) Includes amortization expense of $112,310 and $124,550 for the year ending December 31, 2021 and the year ended December31, 2020, respectively. Such amortization expense relates to other capitalized and intangibles assets.

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