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License Agreement (Details) - USD ($) $ in Thousands		12 Months Ended
	Mar. 31, 2015	Dec. 31, 2016	Dec. 31, 2015
License Agreements
Issuance of common stock		$ 30,278	$ 911
Common Stock
License Agreements
Issuance of stock (in shares)		3,027,755	677,685
Issuance of common stock		$ 3	$ 3
Pfizer, Inc. | License Agreement
License Agreements
Percentage of shares of common stock offering issued to Pfizer	15.00%
Pfizer, Inc. | License Agreement | Common Stock
License Agreements
Issuance of stock (in shares)	675,250
Issuance of common stock	$ 900
Pfizer, Inc. | License Agreement | Common Stock | Minimum
License Agreements
Ownership by Pfizer	5.00%
Pfizer, Inc. | License Agreement | Milestone Payments | Maximum
License Agreements
Potential payments upon achievement of certain milestones	$ 37,000

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