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Stock-Based Compensation (Tables)

12 Months Ended

Dec. 31, 2022

Stock-Based Compensation

Schedule of share-based compensation expense

Stock-based compensation expense was included in general and administrative as follows in the accompanying statements of comprehensive loss:

​	​	​	​	​	​	​
​	Year Ended					​
​	December 31,					​
​	​	2022	​		2021	​
General and administrative	$	854	​	$	662	​

​

Schedule of stock option plan activity

​

​	​	​	​	​	​	​	​	​	​	​	​
​	​	​	​	​	​	​	Weighted‑	​	​	​	​
​	​	​	​	Weighted		​	Average	​	Aggregate		​
​	​	​	​	Average		​	Remaining	​	Intrinsic		​
​	​	Number of	​	Exercise		​	Contractual	​	Value		​
​	​	Options	​	Price		​	Term (years)	​	(in thousands)		​
Outstanding at January 1, 2021	​	30,676	​	$	108.32	​	8.5	​	$	—	​
Granted	​	22,555	​	$	67.80	​	—	​	$	—	​
Exercised	​	(6,096)	​	$	17.90	​	—	​	$	364	​
Forfeited/Cancelled	​	(14,637)	​	$	57.89	​	—	​	$	—	​
Outstanding at December 31, 2021	​	32,498	​	$	119.72	​	9.3	​	$	—	​
Granted	​	5,995	​	$	17.83	​	—	​	$	—	​
Exercised	​	-	​	$	—	​	—	​	$	—	​
Forfeited/Cancelled	​	(2,000)	​	$	181.20	​	—	​	$	—	​
Outstanding at December 31, 2022	​	36,493	​	$	99.62	​	8.5	​	$	-	​
Vested and expected to vest at December 31, 2022	​	36,493	​	$	99.62	​	8.5	​	$	-	​
Options exercisable at December 31, 2022	​	17,903	​	$	146.70	​	8.1	​	$	-	​
​	​	​	​	​	​	​	​	​	​	​	​

​

Schedule of unvested stock options

The following table summarizes the Company’s unvested stock options as of and for the year ended December 31, 2022:

​	​	​	​	​	​
​	​	​	​	Weighted
​	​	​	​	Average
​	​	Number of	​	Grant Date
​	​	Options	​	Fair Value
Nonvested at January 1, 2022	​	25,725	​	$	59.09
Granted	​	5,995	​	$	12.43
Vested	​	(12,018)	​	$	64.90
Forfeited/Cancelled	​	(1,112)	​	$	117.26
Nonvested as of December 31, 2022	​	18,590	​	$	36.81

​

Schedule of assumptions used in the Black Scholes option-pricing model

​

​	​	​	​	​	​	​	​	​	​
​	​	​	Year Ended
​	​	​	December 31,
​		​	2022			​	2021
​	​	​	​	​	​	​	​	​	​
Expected stock price volatility	​	​	​	80.7-85.2	%	​	​	79.0-80.4	%
Expected life of options (years)	​	​	​	5.5-5.8	​	​	​	5.8	​
Expected dividend yield	​	​	​	—	%	​	​	—	%
Risk free interest rate	​	​	​	1.72-3.08	%	​	​	0.93-1.33	%

​

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