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Commitments and Contingencies - Operating Leases - (Details) - USD ($)
$ in Thousands
1 Months Ended 12 Months Ended
Apr. 30, 2022
May 14, 2021
Feb. 01, 2021
Feb. 01, 2020
Dec. 31, 2021
May 31, 2019
Dec. 31, 2022
Dec. 31, 2021
Sep. 14, 2022
Commitments and Contingencies                  
Right-of-use assets and other         $ 105     $ 105  
DA-1726 | Dong-A                  
Commitments and Contingencies                  
Developmental and regulatory milestone payment eligible to be received                 $ 178,000
DA-1241 | Dong-A                  
Commitments and Contingencies                  
Developmental and regulatory milestone payment eligible to be received                 $ 138,000
Korea                  
Commitments and Contingencies                  
Term of contract           5 years      
Option to renew           true      
Renewal term           5 years      
Gain or loss of extinguished unamortized right-of-use asset and lease liabilities $ 0                
Non-cash expense related to Korea lease             $ 8 24  
Operating lease cash payments             11 32  
Head Quarters in Boston Lease                  
Commitments and Contingencies                  
Term of contract   6 months 6 months 1 year          
Monthly rental cost   $ 3 $ 3 $ 21 1        
Rent concessions granted by the landlord   $ 2 $ 1 $ 32          
Lease expense             $ 16 48  
Right-of-use assets and other         $ 0     $ 0