<SEC-DOCUMENT>0001144204-12-018102.txt : 20120329
<SEC-HEADER>0001144204-12-018102.hdr.sgml : 20120329
<ACCEPTANCE-DATETIME>20120329164310
ACCESSION NUMBER:		0001144204-12-018102
CONFORMED SUBMISSION TYPE:	424B5
PUBLIC DOCUMENT COUNT:		2
FILED AS OF DATE:		20120329
DATE AS OF CHANGE:		20120329

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			NeoStem, Inc.
		CENTRAL INDEX KEY:			0000320017
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-MISC HEALTH & ALLIED SERVICES, NEC [8090]
		IRS NUMBER:				222343568
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		424B5
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-173855
		FILM NUMBER:		12724511

	BUSINESS ADDRESS:	
		STREET 1:		420 LEXINGTON AVENUE
		STREET 2:		SUITE 450
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10170
		BUSINESS PHONE:		212-584-4171

	MAIL ADDRESS:	
		STREET 1:		420 LEXINGTON AVENUE
		STREET 2:		SUITE 450
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10170

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	PHASE III MEDICAL INC/DE
		DATE OF NAME CHANGE:	20030819

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	CORNICHE GROUP INC /DE
		DATE OF NAME CHANGE:	19951117

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	FIDELITY MEDICAL INC
		DATE OF NAME CHANGE:	19951025
</SEC-HEADER>
<DOCUMENT>
<TYPE>424B5
<SEQUENCE>1
<FILENAME>v307713_424b5.htm
<DESCRIPTION>RULE 424B5
<TEXT>
<HTML>
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     <TITLE></TITLE>
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<BODY STYLE="font: 10pt Times New Roman, Times, Serif">

<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><B>Filed Pursuant to Rule 424(b)(5)</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><B>Registration No. 333-173855</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>PROSPECTUS SUPPLEMENT</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>(To the Prospectus Dated June 13, 2011)</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; text-align: center; margin-bottom: 0pt"><FONT STYLE="color: Black"><B>15,000,000 Units</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><IMG SRC="logo.jpg" ALT="">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black"><B>&nbsp;</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black"><B>Units Consisting
of</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black"><B>One Share
of Common Stock and</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black"><B>a Warrant
to Purchase One Share of Common Stock</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black"><B>&nbsp;</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12pt"><FONT STYLE="color: Black">We are
offering 15,000,000&nbsp;units, with each unit consisting of one share of our common stock and
a warrant to purchase one share of our common stock (and the shares of common stock
issuable from time to time upon exercise of the offered warrants), pursuant to this prospectus supplement and the
accompanying prospectus. The purchase price for each unit is $0.40. Each warrant
will have an exercise price of $0.51 per share, will become exercisable six months after
issuance (or such earlier date as may be hereafter designated by us) and will expire five years  from the date
of issuance. Units will not be issued or certificated.&nbsp;&nbsp;The shares of common stock and the warrants are
immediately separable and will be issued separately, but will be purchased together in this offering.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12pt"><FONT STYLE="color: Black">Our common stock
is traded on the NYSE Amex under the symbol &ldquo;NBS&rdquo;. On March 28, 2012, the last reported sale price of our common
stock was $0.51 per share. There is no established public trading market for the warrants and we do not expect a market to develop.
In addition, we do not intend to apply for the listing of the warrants on any national securities exchange.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12pt"><FONT STYLE="color: Black">As of March 23,
2012, the aggregate market value of our outstanding common stock held by non-affiliates (our &ldquo;public float&rdquo;) was approximately
$58,337,700 which was calculated based on 81,024,527 shares of outstanding common stock held by non-affiliates and on a price
per share of $0.72, the closing price of our common stock on February 7, 2012. With the exception of the securities being offered
hereunder, we have not offered any securities pursuant to General Instruction I.B.6 of Form S-3 during the 12 calendar months
prior to and including the date of this prospectus supplement.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12pt"><FONT STYLE="color: Black"><B>Our business
and an investment in our securities involve significant risks. See &ldquo;Risk Factors&rdquo; beginning on page S-8 of this prospectus
supplement and page 5 of the accompanying prospectus to read about factors that you should consider before making an investment
decision.</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12pt"><FONT STYLE="color: Black"><B>&nbsp;</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12pt"><FONT STYLE="color: Black">Neither the Securities
and Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined if this
prospectus supplement or the accompanying prospectus is truthful or complete. Any representation to the contrary is a criminal
offense.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" ALIGN="RIGHT" STYLE="width: 99%; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-weight: bold"><FONT STYLE="color: Black">&nbsp;</FONT></TD><TD STYLE="font-weight: bold; padding-bottom: 1pt"><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid"><FONT STYLE="color: Black">Per
    Unit</FONT></TD><TD STYLE="padding-bottom: 1pt; font-weight: bold"><FONT STYLE="color: Black">&nbsp;</FONT></TD><TD STYLE="font-weight: bold; padding-bottom: 1pt"><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid"><FONT STYLE="color: Black">Total</FONT></TD><TD STYLE="padding-bottom: 1pt; font-weight: bold"><FONT STYLE="color: Black">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,255,204)">
    <TD STYLE="width: 70%; font-weight: bold"><FONT STYLE="color: Black">Public offering price</FONT></TD><TD STYLE="width: 1%"><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="width: 1%; text-align: left"><FONT STYLE="color: Black">$</FONT></TD><TD STYLE="width: 12%; text-align: right">0.40<FONT STYLE="color: Black">0&nbsp;</FONT></TD><TD STYLE="width: 1%; text-align: left"><FONT STYLE="color: Black">&nbsp;</FONT></TD><TD STYLE="width: 1%"><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="width: 1%; text-align: left"><FONT STYLE="color: Black">$</FONT></TD><TD STYLE="width: 12%; text-align: right"><FONT STYLE="color: Black">6,000,000&nbsp;</FONT></TD><TD STYLE="width: 1%; text-align: left"><FONT STYLE="color: Black">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-weight: bold; text-align: left"><FONT STYLE="color: Black">Underwriting discount</FONT></TD><TD><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="text-align: left"><FONT STYLE="color: Black">&nbsp;</FONT></TD><TD STYLE="text-align: right">0.028<FONT STYLE="color: Black">&nbsp;</FONT></TD><TD STYLE="text-align: left"><FONT STYLE="color: Black">&nbsp;</FONT></TD><TD><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="text-align: left"><FONT STYLE="color: Black">&nbsp;</FONT></TD><TD STYLE="text-align: right">420,000<FONT STYLE="color: Black">&nbsp;</FONT></TD><TD STYLE="text-align: left"><FONT STYLE="color: Black">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,255,204)">
    <TD STYLE="font-weight: bold; text-align: left"><FONT STYLE="color: Black">Proceeds, before expenses, to us</FONT></TD><TD><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="text-align: left"><FONT STYLE="color: Black">&nbsp;</FONT></TD><TD STYLE="text-align: right">0.372<FONT STYLE="color: Black">&nbsp;</FONT></TD><TD STYLE="text-align: left"><FONT STYLE="color: Black">&nbsp;</FONT></TD><TD><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="text-align: left"><FONT STYLE="color: Black">&nbsp;</FONT></TD><TD STYLE="text-align: right">5,580,000<FONT STYLE="color: Black">&nbsp;</FONT></TD><TD STYLE="text-align: left"><FONT STYLE="color: Black">&nbsp;</FONT></TD></TR>
</TABLE><BR STYLE="clear: both"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12pt"><FONT STYLE="color: Black">The
underwriters expect to deliver the securities against payment of immediately available funds on or about April 3,
2012.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12pt">The underwriters may also exercise
its option
to
purchase
up
to
an
additional 2,250,000 shares of
our common stock and warrants to purchase up
to 2,250,000 shares of our
common stock at the public offering price per fixed combination, less the underwriting discounts and commissions, to cover
over-allotments, if any, within 45 days of the date of this prospectus supplement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black"><B>Maxim Group
LLC</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><FONT STYLE="color: Black">March
29,&nbsp;2012</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black"><B>&nbsp;</B></FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black"><B>&nbsp;</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black"><B>TABLE OF
CONTENTS </B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 89%; font-weight: bold">&nbsp;</TD>
    <TD STYLE="width: 1%; font-weight: bold; text-align: right">&nbsp;</TD>
    <TD STYLE="width: 10%; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Page</TD></TR>
<TR STYLE="vertical-align: top; background-color: rgb(204,255,204)">
    <TD STYLE="font-weight: bold; text-align: center">Prospectus Supplement</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; background-color: White">
    <TD STYLE="text-decoration: none">About this Prospectus Supplement</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-decoration: none; text-align: right">S-1</TD></TR>
<TR STYLE="vertical-align: top; background-color: rgb(204,255,204)">
    <TD STYLE="text-decoration: none">Prospectus Supplement Summary</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-decoration: none; text-align: right">S-2</TD></TR>
<TR STYLE="vertical-align: top; background-color: White">
    <TD>Risk Factors</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: right">S-8</TD></TR>
<TR STYLE="vertical-align: top; background-color: rgb(204,255,204)">
    <TD>Special Note Regarding Forward-Looking Statements</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: right">S-54</TD></TR>
<TR STYLE="vertical-align: top; background-color: White">
    <TD STYLE="text-decoration: none">Use of Proceeds</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: right">S-55</TD></TR>
<TR STYLE="vertical-align: top; background-color: rgb(204,255,204)">
    <TD STYLE="text-decoration: none">Dilution</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: right">S-56</TD></TR>
<TR STYLE="vertical-align: top; background-color: White">
    <TD STYLE="text-decoration: none">Capitalization</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: right">S-57</TD></TR>
<TR STYLE="vertical-align: top; background-color: rgb(204,255,204)">
    <TD>Description of Securities We are Offering</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: right">S-59</TD></TR>
<TR STYLE="vertical-align: top; background-color: White">
    <TD>Description of Capital Stock</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: right">S-63</TD></TR>
<TR STYLE="vertical-align: top; background-color: rgb(204,255,204)">
    <TD>Underwriting</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: right">S-88</TD></TR>
<TR STYLE="vertical-align: top; background-color: White">
    <TD STYLE="text-decoration: none">Legal Matters</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: right">S-91</TD></TR>
<TR STYLE="vertical-align: top; background-color: rgb(204,255,204)">
    <TD STYLE="text-decoration: none">Experts</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: right">S-91</TD></TR>
<TR STYLE="vertical-align: top; background-color: White">
    <TD STYLE="text-decoration: none">Where You Can Find Additional Information</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: right">S-91</TD></TR>
<TR STYLE="vertical-align: top; background-color: rgb(204,255,204)">
    <TD STYLE="text-decoration: none">Incorporation of Certain Documents by Reference</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: right">S-91</TD></TR>
<TR STYLE="vertical-align: top; background-color: White">
    <TD STYLE="font-weight: bold; text-align: center">Prospectus</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; background-color: rgb(204,255,204)">
    <TD STYLE="text-decoration: none">About this Prospectus</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-decoration: none; text-align: right">1</TD></TR>
<TR STYLE="vertical-align: top; background-color: White">
    <TD STYLE="text-decoration: none">NeoStem, Inc.</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-decoration: none; text-align: right">2</TD></TR>
<TR STYLE="vertical-align: top; background-color: rgb(204,255,204)">
    <TD STYLE="text-decoration: none">Risk Factors</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-decoration: none; text-align: right">5</TD></TR>
<TR STYLE="vertical-align: top; background-color: White">
    <TD STYLE="text-decoration: none">Special Note Regarding Forward-Looking Information</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-decoration: none; text-align: right">5</TD></TR>
<TR STYLE="vertical-align: top; background-color: rgb(204,255,204)">
    <TD STYLE="text-decoration: none">Use of Proceeds</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-decoration: none; text-align: right">5</TD></TR>
<TR STYLE="vertical-align: top; background-color: White">
    <TD STYLE="text-decoration: none">The Securities We May Offer</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-decoration: none; text-align: right">6</TD></TR>
<TR STYLE="vertical-align: top; background-color: rgb(204,255,204)">
    <TD STYLE="text-decoration: none">Description of Capital Stock</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-decoration: none; text-align: right">7</TD></TR>
<TR STYLE="vertical-align: top; background-color: White">
    <TD STYLE="text-decoration: none">Description of Debt Securities</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-decoration: none; text-align: right">29</TD></TR>
<TR STYLE="vertical-align: top; background-color: rgb(204,255,204)">
    <TD STYLE="text-decoration: none">Description of Warrants</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-decoration: none; text-align: right">38</TD></TR>
<TR STYLE="vertical-align: top; background-color: White">
    <TD STYLE="text-decoration: none">Description of Units</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-decoration: none; text-align: right">40</TD></TR>
<TR STYLE="vertical-align: top; background-color: rgb(204,255,204)">
    <TD STYLE="text-decoration: none">Plan of Distribution</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-decoration: none; text-align: right">41</TD></TR>
<TR STYLE="vertical-align: top; background-color: White">
    <TD STYLE="text-decoration: none">Legal Matters</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-decoration: none; text-align: right">43</TD></TR>
<TR STYLE="vertical-align: top; background-color: rgb(204,255,204)">
    <TD STYLE="text-decoration: none">Experts</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-decoration: none; text-align: right">43</TD></TR>
<TR STYLE="vertical-align: top; background-color: White">
    <TD STYLE="text-decoration: none">Incorporation of Certain Documents by Reference</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-decoration: none; text-align: right">43</TD></TR>
<TR STYLE="vertical-align: top; background-color: rgb(204,255,204)">
    <TD STYLE="text-decoration: none">Where You Can Find More Information</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-decoration: none; text-align: right">44</TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black"><B>ABOUT THIS
PROSPECTUS SUPPLEMENT </B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><FONT STYLE="color: Black">This document
is in two parts. The first part is this prospectus supplement, which describes the specific terms of the offering and also adds
to and updates information contained in the accompanying prospectus and the documents incorporated by reference into this prospectus
supplement and the accompanying prospectus. The second part, the accompanying prospectus dated June 13, 2011, including the documents
incorporated by reference, provides more general information. Generally, when we refer to this prospectus, we are referring to
both parts of this document combined. To the extent there is a conflict between the information contained in this prospectus supplement,
on the one hand, and the information contained in the accompanying prospectus or in any document incorporated by reference that
was filed with the Securities and Exchange Commission, or SEC, before the date of this prospectus supplement, on the other hand,
you should rely on the information in this prospectus supplement. If any statement in one of these documents is inconsistent with
a statement in another document having a later date &mdash; for example, a document incorporated by reference in the accompanying
prospectus &mdash; the statement in the document having the later date modifies or supersedes the earlier statement. You should
read this prospectus supplement and the accompanying prospectus, including the information incorporated by reference and any free
writing prospectus that we have authorized for use in connection with this offering, in their entirety before making an investment
decision.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><FONT STYLE="color: Black">You should rely
only on the information contained or incorporated by reference in this prospectus supplement and the accompanying prospectus,
along with the information contained in any free writing prospectus that we have authorized for use in connection with this offering.
If the description of the offering varies between this prospectus supplement and the accompanying prospectus, you should rely
on the information in this prospectus supplement. We have not authorized anyone to provide you with different or additional information.
You should assume that the information appearing in this prospectus supplement, the accompanying prospectus, the documents incorporated
by reference in this prospectus supplement and the accompanying prospectus, and in any free writing prospectus that we have authorized
for use in connection with this offering is accurate only as of the respective dates of those documents. Our business, financial
condition, results of operations and prospects may have changed since those dates.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><FONT STYLE="color: Black">We further note
that the representations, warranties and covenants made by us in any agreement that is filed as an exhibit to any document that
is incorporated by reference in this prospectus supplement or the accompanying prospectus were made solely for the benefit of
the parties to such agreement, including, in some cases, for the purpose of allocating risk among the parties to such agreements,
and should not be deemed to be a representation, warranty or covenant to you. Moreover, such representations, warranties and covenants
were accurate only as of the date when made; therefore, such representations, warranties and covenants should not be relied on
as accurate representations of the current state of our affairs.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">Unless we have
indicated otherwise, or the context otherwise requires, references in this prospectus supplement and the accompanying prospectus
to &ldquo;NeoStem,&rdquo; the &ldquo;Company,&rdquo; &ldquo;we,&rdquo; &ldquo;us&rdquo; and &ldquo;our&rdquo; refer to NeoStem,
Inc. and its subsidiaries.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black"><B>&nbsp;</B></FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black"><B>&nbsp;</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black"><B>PROSPECTUS
SUPPLEMENT SUMMARY </B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black"><I>&nbsp;</I></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><FONT STYLE="color: Black"><I>This summary
highlights certain information about us, this offering and information appearing elsewhere in this prospectus supplement, in the
accompanying prospectus and in the documents we incorporate by reference. This summary is not complete and does not contain all
of the information that you should consider before making an investment decision. To fully understand this offering and its consequences
to you, you should read this entire prospectus supplement and the accompanying prospectus carefully, including the factors described
under the headings &ldquo;Risk Factors&rdquo; in this prospectus supplement beginning on page S-8 and page 5 of the accompanying
prospectus, together with any free writing prospectus we have authorized for use in connection with this offering and the financial
statements and all other information incorporated by reference in this prospectus supplement and the accompanying prospectus.
When used in this prospectus supplement and the accompanying prospectus, except where the context otherwise requires, the terms
&ldquo;NeoStem,&rdquo; &ldquo;we,&rdquo; &ldquo;us&rdquo; and &ldquo;our&rdquo; refer to NeoStem, Inc. and its subsidiaries.</I></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black"><B>&nbsp;</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black"><B>About NeoStem</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><FONT STYLE="color: Black">NeoStem, Inc.
(&ldquo;we,&rdquo; &ldquo;NeoStem&rdquo; or the &ldquo;Company&rdquo;) continues to develop and build on its core capabilities
in cell therapy to capitalize on the paradigm shift that we see occurring in medicine. In particular, we anticipate that cell
therapy will have a large role in the fight against chronic disease and in lessening the economic burden that these diseases pose
to modern society. Our January 2011 acquisition of Progenitor Cell Therapy, LLC (&ldquo;PCT&rdquo;) provides NeoStem with a foundation
in both manufacturing and regulatory affairs expertise. We believe, this expertise, coupled with our existing research capabilities
and collaborations will allow us to achieve our mission of becoming a premier cell therapy company. Our PCT subsidiary&rsquo;s
manufacturing base is one of the few current Good Manufacturing Practices (&ldquo;cGMP&rdquo;) facilities available for contracting
in the burgeoning cell therapy industry. Amorcyte, LLC (&ldquo;Amorcyte&rdquo;), which we acquired in October 2011, is developing
a cell therapy for the treatment of cardiovascular disease. Amorcyte&rsquo;s lead compound, AMR-001, represents NeoStem&rsquo;s
most clinically advanced therapeutic and has commenced enrollment for a Phase 2 trial to investigate AMR-001&rsquo;s efficacy
in preserving heart function after a heart attack. We also expect to begin a Phase 1 clinical trial by 2013 to investigate AMR-001&rsquo;s
utility in arresting the progression of congestive heart failure and the associated comorbidities of that disease. Athelos Corporation
(&ldquo;Athelos&rdquo;), which is approximately 80%-owned by our subsidiary, PCT, is engaged in collaboration with Becton-Dickinson
that is exploring the earlier stage clinical development of a T-cell therapy for autoimmune conditions. In addition, our pre-clinical
assets include our VSEL<SUP>TM</SUP> Technology platform as well as our MSC (mesenchymal stem cells) product candidate for regenerative
medicine. NeoStem&rsquo;s origins are in adult stem cell research and the collection and storage of adult stem cells. We believe
that as new therapeutics are developed utilizing one&rsquo;s own stored cells (autologous), the market penetration rate for the
collection and storage business will rise sharply from its current low single digits percentage level. NeoStem is now ideally
positioned to be an integrated leader in the cell therapy industry. We have strong basic research capabilities, manufacturing
facilities on both the east and west coast of the United States, the support of regulatory and logistical expertise and the experience
of a decade of clinical practice.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><FONT STYLE="color: Black">In 2011, we
operated our business in three reportable segments: (i) Cell Therapy &ndash; United States; (ii) Regenerative Medicine &ndash;
China; and (iii) Pharmaceutical Manufacturing &ndash; China. We are pursuing the divestiture of the majority of our China operations
and anticipate they will have been exited by the close of 2012.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B>&nbsp;</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black"><B>CELL THERAPY-UNITED
STATES</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B>&nbsp;</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B><U>Cell Therapy &ndash; Services
</U></B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B>&nbsp;</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B>PCT </B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><FONT STYLE="color: Black">We acquired
our PCT subsidiary in January 2011. PCT is engaged in a broad range of services in the cell therapy market for the treatment of
human disease.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><FONT STYLE="color: Black">&nbsp;</FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><FONT STYLE="color: Black">Founded by
Andrew L. Pecora, M.D. and Robert A. Preti, Ph.D., PCT is an internationally recognized cell therapy services and development
company that represents a business for &ldquo;as needed&rdquo; development and manufacturing services for the emerging cell therapy
industry from clinical trials through eventual commercialization. With its cell therapy manufacturing facilities and team of professionals,
PCT offers a platform that can facilitate the preclinical and clinical development and commercialization of cellular therapies
for clients throughout the world. Dr. Preti now serves as PCT&rsquo;s President and Chief Scientific Officer and Dr. Pecora as
its part-time Chief Medical Officer. Dr. Pecora also serves as Chief Medical Officer of NeoStem (effective August 17, 2011). </FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><FONT STYLE="color: Black">PCT is engaged
in a broad range of services in the cell therapy market for the treatment of human disease. PCT offers cGMP compliant cell transportation,
manufacturing, storage, and distribution services and supporting clinical trial design, product process development, logistics,
regulatory and quality systems development services. Through its network of contacts throughout the cell therapy industry, PCT
is able to identify early stage development opportunities in the cell therapy field and opportunistically develop these cell therapies
through proof of concept. From that point, products can be further developed and ultimately commercialized through NeoStem&rsquo;s
developing commercial structure. PCT&rsquo;s expertise in the cell therapy arena includes cell-based therapeutic vaccines (with
applications in oncology), other cell therapeutics, and regenerative medicine. From this platform, we hope to develop cell-based
therapeutics. In addition to using PCT&rsquo;s facilities and expertise to develop Amorcyte&rsquo;s product candidates, as well
as our MSC and VSEL<SUP>TM</SUP> technologies, we may develop internally, or through partnerships, other allogeneic (cells from
a third-party donor) or autologous (cells from oneself) therapeutic technologies.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><FONT STYLE="color: Black">PCT is accredited
by the Foundation for Accreditation of Cell Therapies (&ldquo;FACT&rdquo;).</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B>&nbsp;</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B>Cell Collection, Processing and
Storage </B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><FONT STYLE="color: Black">In the United
States, through NeoStem Family Storage, LLC, a wholly-owned subsidiary of PCT, we offer &ldquo;Family Banking&rdquo; of stem cells,
which services include collection, processing and storage of cells for newborns as well as adults. This enables healthy individuals
to donate and store their stem cells for future personal therapeutic use, as may be needed. We have established a network of adult
stem cell collection centers in the U.S. and for our cord blood business distribution channel through hospitals and obstetrician
practices with a current focus on the New York and New Jersey metropolitan areas. With our acquisition of PCT, we acquired the
expertise associated with cGMP, the highest Food and Drug Administration (&ldquo;FDA&rdquo;) standard, for stem cell banking.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B>&nbsp;</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B><U>Cell Therapy &mdash; Development
</U></B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B>&nbsp;</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B>Amorcyte </B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><FONT STYLE="color: Black">We acquired
our Amorcyte subsidiary in October 2011. Amorcyte is a clinical stage therapeutics company pursuing cell-based therapies for cardiovascular
diseases. Amorcyte&rsquo;s most advanced product candidate is AMR-001, a chemotactic hematopoietic stem cell product comprised
of autologous bone marrow (&ldquo;BM&rdquo;) derived CD34+/CXCR4+ cells selected to treat damaged heart muscle following acute
myocardial infarction (&ldquo;AMI&rdquo;). AMR-001 is being evaluated to determine its effect on myocardial perfusion (blood flow)
and ability to prevent subsequent major adverse cardiac events following a significant AMI by preserving heart muscle tissue.
AMR-001 is intended to increase microvascular blood flow in the myocardium (heart muscle) via neoangiogenesis (development and
formation of new blood vessels), thereby reversing post-heart attack induced ischemia (restriction of blood supply) and rescuing
tissue from hibernation and preventing eventual cell death (apoptosis). AMR-001 is injected 5 to 11 days post-stent placement
(the repair phase) into the peri-infarct zone (that is, the living tissue on the periphery of the dead tissue), to restore perfusion
surrounding the site of the heart attack.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><FONT STYLE="color: Black">Prior to its
acquisition by NeoStem, Inc., Amorcyte completed a Phase 1 trial of AMR-001 in patients with damaged heart muscle following AMI
and in January 2012, we commenced enrollment of a Phase 2 trial to investigate AMR-001&rsquo;s ability to preserve heart function
after a heart attack. We believe that Amorcyte&rsquo;s Phase 1 study was the first stem cell trial to show dose-related, significant
improvement over standard of care following AMI. The lack of myocardial perfusion remains a significant cause of morbidity and
mortality in the United States and world-wide. Current interventions or medications have limited ability to prevent progressive
myocardial cell apoptosis leading to cardiac deterioration and downstream major adverse cardiac events (&ldquo;MACE&rdquo;). We
also believe that there are applications for AMR-001 in congestive heart failure, and we expect to begin a Phase 1 clinical trial
of AMR-001 for this indication by 2013.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><FONT STYLE="color: Black">&nbsp;</FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><FONT STYLE="color: Black">Just as it
did for Amorcyte&rsquo;s Phase 1 trial, PCT will offer its expertise in cell therapy and core process development providing a
cost advantage for AMR-001 manufacturing for the Phase 2 trial.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><FONT STYLE="color: Black">In September
2010, the U.S. Patent Office granted Amorcyte U.S. Patent 7,794,705, protecting this therapeutic compound and method of treatment.
In January 2012, the U.S. Patent Office granted Amorcyte U.S. Patent 8,088,370, expanding the protection of AMR-001 to include
treatment of all vascular injury caused by vascular insufficiency, not just AMI.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B>Other Stem Cell Research </B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><FONT STYLE="color: Black">We conduct
other research and development activities on our own and in combination with academic, government and industry collaborators.
These activities have been buttressed by our PCT acquisition with its cell therapeutic development expertise and facilities. For
example, through Athelos, an 80% owned subsidiary, we are pursuing a novel regulatory T-cell (&rdquo;T-reg&rdquo;) therapy for
restoring normal immune responses by enhancing T cell balance and function. This early clinical work provides potential applications
in graft vs. host disease, solid organ rejection and autoimmune diseases such as asthma and diabetes. To date, government grants
have provided funding for a portion of this program. In addition, our pre-clinical program is based on VSEL<SUP>TM</SUP> Technology
licensed from the University of Louisville. VSEL<SUP>TM</SUP> (very small embryonic-like) stem cells have been shown to have characteristics
generally found in embryonic stem cells without the potentially dangerous attributes of those cells. Our research efforts with
VSEL<SUP>TM</SUP> stem cells target osteoporosis and bone regeneration, macular degeneration and glaucoma and chronic wound healing.
To date, The Department of Defense has provided funding for a significant portion of this program.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B><U>Regenerative Medicine &mdash;
China </U></B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><FONT STYLE="color: Black">In 2009, we
began certain adult stem cell initiatives in the People&rsquo;s Republic of China (&ldquo;China&rdquo; or &ldquo;PRC&rdquo;) including:
(i) constructing a stem cell research and development laboratory and processing and manufacturing facility in Beijing (the &ldquo;Beijing
facility&rdquo;), (ii) establishing relationships with hospitals to provide stem cell-based therapies, and (iii) obtaining product
licenses covering certain adult stem cell therapeutics focused on regenerative medicine.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><FONT STYLE="color: Black">In December
2011, China&rsquo;s Ministry of Health announced its intention to more tightly regulate stem cell clinical trials and stem cell
therapeutic treatments in the PRC. Additionally, we operate our regenerative medicine business in China through a wholly foreign
owned entity (&ldquo;WFOE&rdquo;) and variable interest entities (&rdquo;VIEs&rdquo;). While often foreign companies use structures
similar to the ones pursuant to which we have operated our regenerative medicine business in the PRC, and while such arrangements
are not uncommon in connection with business operations of foreign companies in China in industry sectors in which foreign direct
investments are limited or prohibited, recently there has been greater scrutiny by the business community of the VIE structure.
Accordingly, the Company has determined to take steps to restrict, and expects to ultimately eliminate, its regenerative medicine
business in the PRC.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><FONT STYLE="color: Black">Our Beijing
Facility is located at the Life Science Innovation Center, Life Science Park, Zhongguancum, Beijing. It has been designed for
comprehensive cell manufacturing, collection, processing and storage that can enable the PCT business model to launch in the PRC
should the opportunity be presented. With the upcoming expiration of this lease in May 2012, the Company is considering its options
with respect to extending the lease to allow for manufacturing of cell therapies, which will depend in part upon guidance from
the PRC Ministry of Health with respect to regulations applicable to stem cell clinical research and applications.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B><U>Pharmaceutical Manufacturing
&mdash; China </U></B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><FONT STYLE="color: Black">We have a 51%
ownership interest in Suzhou Erye Pharmaceutical Company Ltd. (&ldquo;Erye&rdquo;). Erye was founded more than 50 years ago and
represents an established, vertically-integrated pharmaceutical business. Historically, Erye has concentrated its efforts on manufacturing
and distributing of generic antibiotic products. It has received more than 160 production certificates from the State Food and
Drug Administration of China, or SFDA, covering both antibiotic prescription drugs and active pharmaceutical intermediates (APIs).
Our current senior executive management team at Erye, Mr. Shi Mingsheng, Chairman, and Madame Zhang Jian, General Manager, joined
Erye in 1998 and in conjunction with others, bought it from the PRC government in 2003.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><FONT STYLE="color: Black">&nbsp;</FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><FONT STYLE="color: Black">As part of
our plan to focus our business on the cell therapy industry, we are pursuing strategic alternatives with respect to Erye. In June
2011 we engaged a financial advisor to lead the effort to pursue the possible divestiture of our 51% interest in Erye. Marketing
efforts have led to a few nonbinding letters of intent. However, in addition to the factors set forth herein, it is too early
to determine whether these or other proposals will lead to definitive agreements. See the discussion set forth below under the
Risk Factors &ldquo;We are pursuing a significant change in the nature of our business&rdquo; and &ldquo;We may not be able to
materially enhance our liquidity through a sale of our interest in Erye&rdquo;.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B>&nbsp;</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black"><B>NeoStem Corporate
Information </B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">Our principal
executive offices are located at 420 Lexington Avenue, Suite 450, New York, New York 10170, and our telephone number is (212)
584-4180. Our Common Stock is currently traded on the NYSE Amex under the symbol &ldquo;NBS.&rdquo; We maintain a corporate website
at <I>www.neostem.com</I>. The contents of our website are not incorporated by reference into this prospectus and should not be
considered to be a part of this prospectus or relied upon in connection herewith.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">NeoStem, Inc.
was incorporated under the laws of the State of Delaware in September 1980 under the name Fidelity Medical Services, Inc. and
commenced operations in the adult stem cell collection, processing and storage services business in January 2006. Unless otherwise
stated, all references to &ldquo;us,&rdquo; &ldquo;our,&rdquo; &ldquo;NeoStem,&rdquo; &ldquo;we,&rdquo; the &ldquo;Company&rdquo;
and similar designations refer to NeoStem, Inc.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">This prospectus
supplement, the accompanying prospectus and the information incorporated by reference includes trademarks, service marks and trade
names owned by us or other companies. All trademarks, service marks and trade names included or incorporated by reference into
this prospectus supplement or the accompanying prospectus are the property of their respective owners.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black"><B>&nbsp;</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black"><B>The Offering</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 35%"><FONT STYLE="color: Black">Common stock offered by us</FONT></TD>
    <TD STYLE="width: 5%"></TD>
    <TD STYLE="width: 60%; padding-left: 27pt; text-align: left; text-indent: -0.36in"><FONT STYLE="color: Black">15,000,000 shares</FONT> <SUP>(1)</SUP></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD><FONT STYLE="color: Black">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="color: Black">Warrants offered by us</FONT></TD>
    <TD><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="padding-left: -0.6in"><FONT STYLE="color: Black">Warrants to purchase up to 15,000,000 shares of our common
    stock <SUP>(2)</SUP> becoming exercisable six months after issuance. This prospectus supplement also relates to the offering of the
    shares of our common stock issuable upon exercise of the warrants.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD><FONT STYLE="color: Black">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="color: Black">Common stock to be outstanding after this offering</FONT></TD>
    <TD><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD STYLE="text-indent: 0in"><FONT STYLE="color: Black">129,765,778 shares (assuming none of the warrants issued in this
    offering are     exercised)<SUP>(3)(4)</SUP></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD><FONT STYLE="color: Black">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="color: Black">Risk Factors</FONT></TD>
    <TD><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD><FONT STYLE="color: Black">Our business and an investment in our securities involve a high degree of risk. &nbsp;See &ldquo;Risk
    Factors&rdquo; and other information included or incorporated into this prospectus supplement and the accompanying prospectus
    for a discussion of the factors you should carefully consider before deciding to invest in our securities.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD><FONT STYLE="color: Black">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="color: Black">Use of proceeds</FONT></TD>
    <TD><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD><FONT STYLE="color: Black">We currently intend to use the net proceeds of this offering for working capital, including
    research and development of cell therapeutic product candidates, expansion of business units, strategic transactions and other
    general corporate purposes, as more particularly described in the section entitled &ldquo;Use of Proceeds.&rdquo;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD><FONT STYLE="color: Black">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="color: Black">Listing</FONT></TD>
    <TD><FONT STYLE="color: Black">&nbsp;</FONT></TD>
    <TD><FONT STYLE="color: Black">Our common stock is listed on the NYSE Amex under the trading symbol &ldquo;NBS.&rdquo; There
    is no established public trading market for the offered warrants and we do not expect a market to develop. In addition, we
    do not intend to apply for listing of the warrants on any national securities exchange.</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<HR ALIGN="LEFT" NOSHADE SIZE="1" STYLE="color: Black; width: 10%; margin-top: 3pt; margin-bottom: 3pt">
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">                                                                                                                                          <TR STYLE="vertical-align: top">
<TD>&nbsp;</TD><TD>(1)</TD><TD STYLE="text-indent: -0.48in">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;17,250,000
                           shares if the                            underwriters exercise the over-allotment option in full.&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD>&nbsp;</TD><TD>&nbsp;</TD><TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD>&nbsp;</TD><TD>(2)</TD><TD>Warrants to purchase up to 17,250,000 shares
                           of our common stock if the underwriters exercise the over-allotment option in full.</TD></TR>
<TR STYLE="vertical-align: top">
<TD>&nbsp;</TD><TD>&nbsp;</TD><TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 15.1pt"><FONT STYLE="color: Black">(3)</FONT></TD><TD><FONT STYLE="color: Black">The number of shares of common stock
                                                            to be outstanding immediately after this offering as shown above is
                                                            based on 114,765,778 shares of common stock outstanding as of the
                                                            close of business on March 23, 2012. This number excludes, as of the
                                                            close of business on March 23, 2012:</FONT></TD></TR>                                                                                                                 <TR STYLE="vertical-align: top">
<TD>&nbsp;</TD><TD>&nbsp;</TD><TD>&nbsp;</TD></TR>
</TABLE>

<P STYLE="margin: 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 18.7pt"><FONT STYLE="font-family: Symbol; color: Black">&middot;</FONT></TD><TD><FONT STYLE="color: Black">options
                                                                                                               representing the
                                                                                                               right to purchase
                                                                                                               a total of 21,413,957
                                                                                                               shares of common
                                                                                                               stock at a weighted
                                                                                                               average exercise
                                                                                                               price of $1.48
                                                                                                               per share;</FONT></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 18.7pt"><FONT STYLE="font-family: Symbol; color: Black">&middot;</FONT></TD><TD><FONT STYLE="color: Black">5,510,336
                                                                                                               shares of common
                                                                                                               stock which were
                                                                                                               reserved for future
                                                                                                               equity awards that
                                                                                                               may be granted
                                                                                                               in the future under
                                                                                                               our equity incentive
                                                                                                               plans;</FONT></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 33.8pt; text-indent: -18.7pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 18.7pt"><FONT STYLE="font-family: Symbol; color: Black">&middot;</FONT></TD><TD><FONT STYLE="color: Black">warrants
                                                                                                               representing the
                                                                                                               right to purchase
                                                                                                               a total of 37,546,071
                                                                                                               shares of common
                                                                                                               stock at a weighted
                                                                                                               average exercise
                                                                                                               price of $2.35
                                                                                                               per share;</FONT></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 33.8pt; text-indent: -18.7pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 18.7pt"><FONT STYLE="font-family: Symbol; color: Black">&middot;</FONT></TD><TD><FONT STYLE="color: Black">up
                                                                                                               to 4,092,768 shares
                                                                                                               of common stock
                                                                                                               which may become
                                                                                                               issuable as &ldquo;Contingent
                                                                                                               Shares&rdquo; upon
                                                                                                               achievement of
                                                                                                               specified business
                                                                                                               milestones pursuant
                                                                                                               to the Amorcyte
                                                                                                               Merger Agreement;</FONT></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 33.8pt; text-indent: -18.7pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 18.7pt"><FONT STYLE="font-family: Symbol; color: Black">&middot;</FONT></TD><TD><FONT STYLE="color: Black">10,000
                                                                                                               shares of common
                                                                                                               stock issuable
                                                                                                               upon conversion
                                                                                                               of our outstanding
                                                                                                               Series B Convertible
                                                                                                               Redeemable Preferred
                                                                                                               Stock;</FONT></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 33.8pt; text-indent: -18.7pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 18.7pt"><FONT STYLE="font-family: Symbol; color: Black">&middot;</FONT></TD><TD><FONT STYLE="color: Black">any
                                                                                                               shares of common
                                                                                                               stock issued on
                                                                                                               conversion or redemption
                                                                                                               of our outstanding
                                                                                                               Series E 7% Senior
                                                                                                               Convertible Preferred
                                                                                                               Stock, and any
                                                                                                               shares of common
                                                                                                               stock issued in
                                                                                                               connection with
                                                                                                               dividend payments
                                                                                                               in respect of such
                                                                                                               preferred stock;</FONT></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 33.8pt; text-indent: -18.7pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 18.7pt"><FONT STYLE="font-family: Symbol; color: Black">&middot;</FONT></TD><TD><FONT STYLE="color: Black">any
                                                                                                               shares of our common
                                                                                                               stock that we may
                                                                                                               issue from time
                                                                                                               to time in connection
                                                                                                               with draw-downs
                                                                                                               pursuant to our
                                                                                                               Purchase Agreement
                                                                                                               with Aspire Capital
                                                                                                               Fund, LLC; and</FONT></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 33.8pt; text-indent: -18.7pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 18.7pt"><FONT STYLE="font-family: Symbol; color: Black">&middot;</FONT></TD><TD><FONT STYLE="color: Black">any
                                                                                                               warrants issued
                                                                                                               in this offering.</FONT></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B>&nbsp;</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B>&nbsp;</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B></B></FONT></P>

<P STYLE="margin: 0"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">
<TR STYLE="vertical-align: top">
<TD STYLE="width: 0">&nbsp;</TD><TD STYLE="width: 15.1pt">(4)</TD><TD>This number excludes the underwriters&rsquo; over-allotment option.</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B>&nbsp;</B></FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black"><B>&nbsp;</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black"><B>RISK FACTORS</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black"><I>&nbsp;</I></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black"><I>Investing
in our securities involves a high degree of risk. You should consider the following risk factors and the risk factors contained
in the accompanying prospectus, as well as other information contained or incorporated by reference in this prospectus supplement
and the accompanying prospectus, and in any free writing prospectus that we have authorized for use in connection with this offering,
before making an investment decision. If any of these risks occur, our business, financial condition, results of operations and
future prospects would likely be materially and adversely affected. In these circumstances, the market price of our common stock
would likely decline and you may lose all or part of your investment. Share information set forth in these risk factors is as
of the dates set forth herein and unless otherwise indicated, does not give effect to the issuance of the securities in connection
with this offering.</I></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black"><B>&nbsp;</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black"><B>RISKS RELATED
TO THIS OFFERING AND OUR SECURITIES </B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B><I>&nbsp;</I></B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B><I>Even after taking into account
the net proceeds of this offering, we anticipate that we will need substantial additional financing in the future to continue
our operations. If we are unable to raise additional capital as needed, we may be forced to delay, reduce or eliminate one or
more of our product development programs, cell therapy initiatives or commercialization efforts. </I></B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">Even after
taking into account the net proceeds of this offering, we anticipate that we will require additional capital to fund our current
operating plan, including our existing U.S.-based cell therapy operations (such as clinical trials of AMR-001, development of
our VSEL<SUP>TM</SUP> technology and a T-cell therapeutic, our stem cell collection and storage business, and our cell manufacturing
and processing operations).</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">Our research
and development expenses have increased with the addition to our Company of our Amorcyte subsidiary, particularly as the Phase
2 clinical trial enrolls with respect to AMR-001. AMR-001 is in the development stage and will require significant investment
before it can be commercialized. We anticipate that AMR-001 will not be commercially available for a number of years, if ever.
Even if we raise additional capital in the event that Amorcyte&rsquo;s Phase 2 clinical trial of AMR-001 produces positive results,
it is anticipated that it will be necessary to enter into one or more collaboration agreements with one or more third parties
to conduct and fund additional clinical trials, including larger, potentially pivotal Phase 3 clinical trials. If we are not able
to enter into collaboration agreements on terms that are acceptable to us, we will need to raise additional capital to fund these
trials or otherwise delay or abandon the trials. In addition, subject to obtaining regulatory approval of any present or future
Amorcyte product candidate, we expect to incur significant commercialization expenses for product sales and marketing.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt"><FONT STYLE="color: Black">Our future
capital requirements will depend on many factors, including:</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 12.25pt"></TD><TD STYLE="width: 15.65pt"><FONT STYLE="font-family: Symbol; color: Black">&middot;</FONT></TD><TD><FONT STYLE="color: Black">The
                                                                                                                 scope, progress
                                                                                                                 and results of
                                                                                                                 our historic
                                                                                                                 cell therapy
                                                                                                                 research, development,
                                                                                                                 processing and
                                                                                                                 manufacturing
                                                                                                                 programs (including
                                                                                                                 any revenues
                                                                                                                 generated by
                                                                                                                 our subsidiary
                                                                                                                 PCT) and our
                                                                                                                 adult and cord
                                                                                                                 blood stem cell
                                                                                                                 collection and
                                                                                                                 storage business;</FONT></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27.9pt; text-indent: -15.65pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 12.25pt"></TD><TD STYLE="width: 15.65pt"><FONT STYLE="font-family: Symbol; color: Black">&middot;</FONT></TD><TD><FONT STYLE="color: Black">the
                                                                                                                 scope, progress,
                                                                                                                 results, costs,
                                                                                                                 timing and outcomes
                                                                                                                 of the clinical
                                                                                                                 trials of AMR-001
                                                                                                                 and any other
                                                                                                                 product candidates;</FONT></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27.9pt; text-indent: -15.65pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 12.25pt"></TD><TD STYLE="width: 15.65pt"><FONT STYLE="font-family: Symbol; color: Black">&middot;</FONT></TD><TD><FONT STYLE="color: Black">the
                                                                                                                 scope, progress
                                                                                                                 and results of
                                                                                                                 other development
                                                                                                                 programs being
                                                                                                                 conducted by
                                                                                                                 our Amorcyte
                                                                                                                 subsidiary;</FONT></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27.9pt; text-indent: -15.65pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 12.25pt"></TD><TD STYLE="width: 15.65pt"><FONT STYLE="font-family: Symbol; color: Black">&middot;</FONT></TD><TD><FONT STYLE="color: Black">the
                                                                                                                 timing of entering
                                                                                                                 into, and the
                                                                                                                 terms of, any
                                                                                                                 collaboration
                                                                                                                 agreements with
                                                                                                                 one or more third
                                                                                                                 parties for one
                                                                                                                 or more product
                                                                                                                 candidates;</FONT></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27.9pt; text-indent: -15.65pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 12.25pt"></TD><TD STYLE="width: 15.65pt"><FONT STYLE="font-family: Symbol; color: Black">&middot;</FONT></TD><TD><FONT STYLE="color: Black">the
                                                                                                                 timing of and
                                                                                                                 the costs involved
                                                                                                                 in obtaining
                                                                                                                 regulatory approvals
                                                                                                                 for our product
                                                                                                                 candidates, a
                                                                                                                 process which
                                                                                                                 could be particularly
                                                                                                                 lengthy or complex
                                                                                                                 given the FDA&rsquo;s
                                                                                                                 limited experience
                                                                                                                 with marketing
                                                                                                                 approval for
                                                                                                                 cell therapy
                                                                                                                 products;</FONT></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27.9pt; text-indent: -15.65pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 12.25pt"></TD><TD STYLE="width: 15.65pt"><FONT STYLE="font-family: Symbol; color: Black">&middot;</FONT></TD><TD><FONT STYLE="color: Black">the
                                                                                                                 costs of operating,
                                                                                                                 expanding and
                                                                                                                 enhancing our
                                                                                                                 manufacturing
                                                                                                                 facilities and
                                                                                                                 capabilities
                                                                                                                 to support our
                                                                                                                 clinical activities
                                                                                                                 and, if any product
                                                                                                                 candidates are
                                                                                                                 approved, our
                                                                                                                 commercialization
                                                                                                                 activities;</FONT></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27.9pt; text-indent: -15.65pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

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<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 12.25pt"></TD><TD STYLE="width: 15.65pt"><FONT STYLE="font-family: Symbol; color: Black">&middot;</FONT></TD><TD><FONT STYLE="color: Black">the
                                                                                                                 costs of maintaining,
                                                                                                                 expanding and
                                                                                                                 protecting our
                                                                                                                 intellectual
                                                                                                                 property portfolio,
                                                                                                                 including potential
                                                                                                                 litigation costs
                                                                                                                 and liabilities;</FONT></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27.9pt; text-indent: -15.65pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 12.25pt"></TD><TD STYLE="width: 15.65pt"><FONT STYLE="font-family: Symbol; color: Black">&middot;</FONT></TD><TD><FONT STYLE="color: Black">revenues
                                                                                                                 received from
                                                                                                                 sales of our
                                                                                                                 product candidates,
                                                                                                                 if approved by
                                                                                                                 the FDA; and</FONT></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27.9pt; text-indent: -15.65pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 12.25pt"></TD><TD STYLE="width: 15.85pt"><FONT STYLE="font-family: Symbol; color: Black">&middot;</FONT></TD><TD><FONT STYLE="color: Black">if
                                                                                                                 and when there
                                                                                                                 is a divestiture
                                                                                                                 of Erye.</FONT></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">We would likely
seek such funding through public or private financings or some combination of the two. We may also raise capital by selling shares
of our Common Stock to Aspire Capital pursuant to the terms of our Purchase Agreement with Aspire Capital, as described below.
We may also seek funding through collaborative arrangements if we determine them to be necessary or appropriate. Additional funding
may not be available to us on acceptable terms, or at all. If we obtain capital through collaborative arrangements, these arrangements
could require us to relinquish rights to the combined company&rsquo;s technology or product candidates and could result in our
receiving only a portion of the revenues associated with the partnered product. If we raise capital through the sale of equity,
or securities convertible into equity, it would result in dilution to our then existing stockholders. Issuances of our securities
in connection with this offering will, and any future capital raise may, additionally cause antidilution adjustments to our outstanding
Series E 7% Senior Convertible Preferred Stock (the &ldquo;Series E Preferred Stock&rdquo; or the &ldquo;Series E Preferred Shares&rdquo;)
and to the warrants issued in connection therewith. If we raise additional capital through the incurrence of indebtedness, the
documents governing the terms of such debt would likely contain terms restricting our business activities, and holders of debt
instruments would have rights and privileges senior to those of our equity investors. In addition, servicing the interest and
principal repayment obligations under debt facilities could divert funds that would otherwise be available to support research
and development, clinical or commercialization activities.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">Our cash requirements
may vary materially from those now planned because of expenses relating to marketing, advertising, sales, distribution, research
and development and regulatory affairs (including the expenses related to clinical trials), as well as the costs of maintaining,
expanding and protecting our intellectual property portfolio, including potential litigation costs and liabilities. See also the
discussion below under the caption &ldquo;Erye may require additional lines of credit and bank loans.&rdquo; Additional financing
may not be available when needed or may not be available on terms acceptable to us. Our inability to obtain necessary capital
or financing to fund these needs could adversely affect our business, results of operations and financial condition.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B><I>&nbsp;</I></B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B><I>The market price and trading
volume of our Common Stock has been and may continue to be volatile and issuances of large amounts of shares of our Common Stock
could cause the market price of our Common Stock to decline. </I></B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">As of March
23, 2012, there were 114,765,778 shares of our Common Stock outstanding. In 2011, our Common Stock traded as low as $0.43 and
as high as $2.10, and in 2010 traded as low as $1.10 and as high as $3.50. In addition to our low stock trading volume, some of
the other factors which may contribute to our stock&rsquo;s price volatility include the issuance of a significant number of shares
of our Common Stock or securities convertible into Common Stock in a short period of time, announcements of government regulation,
new products or services introduced by us or by our competition, the status of our clinical trials, healthcare legislation, trends
in health insurance, litigation, fluctuations in operating results, our success in commercializing our business, market conditions
for cell therapy stocks or healthcare stocks in general as well as economic recession. We cannot assure you that the market price
of our shares of Common Stock will not fluctuate or decline significantly in the future. Some of the factors that could negatively
affect our share price or result in fluctuations in the price or trading volume of our shares of Common Stock include those set
forth under &ldquo;Risk Factors&rdquo; and &ldquo;Special Note Regarding Forward-Looking Statements&rdquo; and in the information
incorporated and deemed to be incorporated by reference herein.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black"><B><I>&nbsp;</I></B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B><I>Any adverse development relating
to any of our product candidates, such as a significant clinical trial failure, could substantially depress our stock price and
prevent us from raising additional capital.</I></B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B><I>&nbsp;</I></B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">Of particular
note, our Company's development will be significantly dependent on our product candidates, and on the status and results of our
clinical trials. Any clinical, regulatory or other development that significantly delays or prevents us from completing any of
our trials, any material safety issue or adverse side effect to any study participant in any of these trials, or the failure of
these trials to show the results expected would likely depress our stock price significantly and could prevent us from raising
the substantial additional capital our Company will need to further develop our product candidates and technologies. Moreover,
any material adverse occurrence in early-phase clinical trials could substantially impair our ability to initiate additional clinical
trials to test our product candidates, whether for new indications or otherwise. This, in turn, could adversely impact our ability
to raise additional capital and pursue our planned research and development efforts.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B><I>The nature of the business
of our Amorcyte subsidiary could subject the trading prices of our Common Stock to additional volatility. </I></B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">The stock market
in general and the market for biotechnology companies in particular have experienced extreme volatility that has often been unrelated
to the operating performance of particular companies. While the market price of our Common Stock has been historically volatile,
the clinical trials and additional development activities being undertaken through our Amorcyte subsidiary may contribute to additional
volatility of the market price of our Common Stock, as investors react to the results of these clinical trials of product candidates
and those of our competitors. In addition to the foregoing, factors that could contribute to enhanced volatility of our stock
price include:</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 12.4pt"></TD><TD STYLE="width: 15.5pt"><FONT STYLE="font-family: Symbol; color: Black">&middot;</FONT></TD><TD><FONT STYLE="color: Black">regulatory
                                                                                                               or legal developments
                                                                                                               in the United States
                                                                                                               and foreign countries;</FONT></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27.9pt; text-indent: -15.5pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 12.4pt"></TD><TD STYLE="width: 15.5pt"><FONT STYLE="font-family: Symbol; color: Black">&middot;</FONT></TD><TD><FONT STYLE="color: Black">variations
                                                                                                               in our financial
                                                                                                               results or those
                                                                                                               of companies that
                                                                                                               are perceived to
                                                                                                               be similar to us;</FONT></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27.9pt; text-indent: -15.5pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 12.4pt"></TD><TD STYLE="width: 15.5pt"><FONT STYLE="font-family: Symbol; color: Black">&middot;</FONT></TD><TD><FONT STYLE="color: Black">changes
                                                                                                               in the structure
                                                                                                               of healthcare payment
                                                                                                               systems;</FONT></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27.9pt; text-indent: -15.5pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 12.4pt"></TD><TD STYLE="width: 15.5pt"><FONT STYLE="font-family: Symbol; color: Black">&middot;</FONT></TD><TD><FONT STYLE="color: Black">announcements
                                                                                                               by the Company
                                                                                                               of significant
                                                                                                               acquisitions, strategic
                                                                                                               partnerships, joint
                                                                                                               ventures or capital
                                                                                                               commitments;</FONT></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27.9pt; text-indent: -15.5pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 12.4pt"></TD><TD STYLE="width: 15.5pt"><FONT STYLE="font-family: Symbol; color: Black">&middot;</FONT></TD><TD><FONT STYLE="color: Black">market
                                                                                                               conditions in the
                                                                                                               pharmaceutical
                                                                                                               and biotechnology
                                                                                                               sectors and issuance
                                                                                                               of securities analysts&rsquo;
                                                                                                               reports or recommendations;</FONT></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27.9pt; text-indent: -15.5pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 12.4pt"></TD><TD STYLE="width: 15.5pt"><FONT STYLE="font-family: Symbol; color: Black">&middot;</FONT></TD><TD><FONT STYLE="color: Black">sales
                                                                                                               of substantial
                                                                                                               amounts of our
                                                                                                               Common Stock by
                                                                                                               current stockholders;</FONT></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27.9pt; text-indent: -15.5pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 12.4pt"></TD><TD STYLE="width: 15.5pt"><FONT STYLE="font-family: Symbol; color: Black">&middot;</FONT></TD><TD><FONT STYLE="color: Black">sales
                                                                                                               of our securities
                                                                                                               by insiders and
                                                                                                               large stockholders;</FONT></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27.9pt; text-indent: -15.5pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 12.4pt"></TD><TD STYLE="width: 15.5pt"><FONT STYLE="font-family: Symbol; color: Black">&middot;</FONT></TD><TD><FONT STYLE="color: Black">additions
                                                                                                               or departures of
                                                                                                               key personnel;</FONT></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27.9pt; text-indent: -15.5pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 12.4pt"></TD><TD STYLE="width: 15.5pt"><FONT STYLE="font-family: Symbol; color: Black">&middot;</FONT></TD><TD><FONT STYLE="color: Black">intellectual
                                                                                                               property, product
                                                                                                               liability or other
                                                                                                               litigation against
                                                                                                               us;</FONT></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27.9pt; text-indent: -15.5pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 12.4pt"></TD><TD STYLE="width: 15.5pt"><FONT STYLE="font-family: Symbol; color: Black">&middot;</FONT></TD><TD><FONT STYLE="color: Black">expiration
                                                                                                               or termination
                                                                                                               of our potential
                                                                                                               relationships with
                                                                                                               collaborators;
                                                                                                               and</FONT></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 27.9pt; text-indent: -15.5pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 12.4pt"></TD><TD STYLE="width: 15.5pt"><FONT STYLE="font-family: Symbol; color: Black">&middot;</FONT></TD><TD><FONT STYLE="color: Black">the
                                                                                                               other factors described
                                                                                                               in this &ldquo;Risk
                                                                                                               Factors&rdquo;
                                                                                                               section.</FONT></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">In addition,
in the past stockholders have initiated class action lawsuits against biotechnology and pharmaceutical companies following periods
of volatility in the market prices of these companies&rsquo; stock. Such litigation, if instituted against our Company, could
cause us to incur substantial costs and divert management&rsquo;s attention and resources.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B><I>Management will have broad
discretion as to the use of the proceeds from this offering, and we may not use the proceeds effectively. </I></B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">Our management
will have broad discretion in the application of the net proceeds from this offering and could spend the proceeds in ways that
do not improve our results of operations or enhance the value of our Common Stock. Our failure to apply these funds effectively
could have a material adverse effect on our business, delay the development of our product candidates and cause the price of our
Common Stock to decline.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B><I>If you purchase the securities
sold in this offering, you will experience immediate dilution in your investment. You will experience further dilution upon the
issuance of Common Stock upon the conversion or in connection with redemption or dividend payments under our Series E Preferred
Shares, if we issue additional equity securities in future fundraising transactions and if shares of our Common Stock underlying
our significant number of outstanding warrants and options are purchased by the holders thereof. </I></B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><FONT STYLE="color: Black">The
portion of the public offering price per unit in this offering attributable to our Common Stock exceeds the net tangible book
value per share of our Common Stock outstanding prior to this offering. Assuming we sell 15,000,000 units in this offering at
a public offering price of $0.40 per unit, after deducting the estimated underwriting discount and estimated offering
expenses payable by us, you will experience immediate dilution of approximately $0.13 per share (or
immediate dilution of approximately $0.13 per share if the underwriters exercise their
over-allotment option in full to purchase 2,250,000 additional units in this offering), representing the difference between
our as adjusted net tangible book value per share as of December 31, 2011 after giving effect to this offering and the public
offering price. See the section entitled &ldquo;Dilution&rdquo; below for a more detailed illustration of the dilution you
would incur if you participate in this offering.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">The issuance
of Common Stock as mandatory redemption payments, dividend payments or upon conversion of some or all of our Series E Preferred
Shares issued in November 2010 will dilute the ownership interests of our existing holders of our shares of Common Stock (as of
March 23, 2012, 5,486,969 Series E Preferred shares were outstanding, convertible into an aggregate of 3,345,713 shares of our
Common Stock, subject to weighted average antidilution adjustment, including in connection with this offering). We are permitted
to make each monthly mandatory redemption payment in shares of our Common Stock (at a discounted formula price), cash, or a combination
of the two, subject to the terms governing our Series E Preferred Shares. In the past, we have elected to pay a portion (if not
all) of each mandatory redemption payment in shares of our Common Stock, and may continue to do so. Although the dollar amount
of such redemption payments are known, to the extent paid in shares of our Common Stock, the number of shares to be issued in
connection with such redemption payments fluctuates based on our stock price. Any sales or perceived sales in the public market
of our shares of Common Stock issuable upon such mandatory redemption payments or upon conversion could adversely affect prevailing
market prices of our shares of Common Stock. The issuance of Common Stock upon conversion of the Series E Preferred Shares or
upon such redemption payments may also have the effect of reducing our net income per share. In addition, the existence of the
Series E Preferred Shares may encourage short selling by market participants because the conversion of the Series E Preferred
Shares or the existence of the redemption payments could depress the market price of our shares of Common Stock. The number of
shares issuable upon conversion of the Series E Preferred Shares is subject to weighted average antidilution adjustment, including
in connection with this offering.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">If in the future
we issue additional Common Stock, or securities convertible into or exchangeable or exercisable for Common Stock, our stockholders,
including investors who purchase securities offered under this prospectus supplement, will experience additional dilution, and
any such issuances may result in downward pressure on the price of our Common Stock.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">In addition,
we have a significant number of outstanding securities convertible into, or allowing the purchase of our Common Stock.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">Investors will
be subject to increased dilution upon conversion of our outstanding Series B preferred stock and upon the exercise of outstanding
stock options and warrants. There were 114,765,778 shares of our Common Stock outstanding as of March 23, 2012. As of that date,
Series B preferred stock outstanding could be converted into 10,000 shares of our Common Stock and stock options and warrants
outstanding represented an additional 58,960,028 shares of our Common Stock that could be issued in the future. The number of
shares issuable upon exercise of warrants issued with the Series E Preferred Stock are subject to weighted average antidilution
adjustment, including in connection with this offering. Most of the outstanding shares of our Common Stock, as well as the vast
majority of the shares of our Common Stock that may be issued under our outstanding options and warrants, are not restricted from
trading or have the contractual right to be registered. Also, the issuance of additional shares as a result of such conversion
or purchase, or their subsequent sale, could adversely affect the price of our Common Stock.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">Any significant
increase in the number of shares offered for sale could cause the supply of our Common Stock available for purchase in the market
to exceed the purchase demand for our Common Stock. Such supply in excess of demand could cause the market price of our Common
Stock to decline.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B><I>&nbsp;</I></B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B><I>Any sales of our Common Stock
to Aspire Capital pursuant to our Purchase Agreement may cause substantial dilution to our existing stockholders and the sale
of the shares of Common Stock acquired by Aspire Capital could cause the price of our Common Stock to decline. </I></B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">On September
28, 2011, we entered into a Common Stock Purchase Agreement (the &quot;Purchase Agreement&quot;) with Aspire Capital Fund, LLC
(&quot;Aspire Capital&quot;). Pursuant to the Purchase Agreement, we have a right to sell to Aspire Capital up to a maximum of
100,000 shares of our Common Stock per day, which total may be increased by mutual agreement up to an additional 1,000,000 shares
per day. In addition, under certain circumstances we also have the right to sell to Aspire Capital an amount of stock equal to
up to 30% of the aggregate shares of our Common Stock traded on the NYSE Amex on the next business day, subject to a maximum number
of shares determined by us. However, we may only effect sales of shares of our Common Stock to Aspire Capital pursuant to the
Purchase Agreement (up to a maximum of $20 million in the aggregate) on a business day on which the closing sale price of our
Common Stock is not less than 75% of the closing sale price of our Common Stock (rounded down to the nearest penny) on the business
day immediately preceding the date the Purchase Agreement was executed. The extent to which we rely on Aspire Capital as a source
of funding will depend on a number of factors, including the prevailing market price of our Common Stock and the extent to which
we are able and desire to secure working capital from other sources. The aggregate number of shares that we can sell to Aspire
Capital under the Purchase Agreement may in no case exceed 15,282,502 shares of our Common Stock (plus the 990,099 Commitment
Shares previously issued), unless shareholder approval is obtained to issue more. The number of shares ultimately offered for
sale to Aspire Capital under the Purchase Agreement is dependent upon the number of shares we elect to sell to Aspire Capital,
if any, under the Purchase Agreement. Depending upon market liquidity at the time, sales of shares of our Common Stock under the
Purchase Agreement may cause the trading price of our Common Stock to decline.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">Aspire Capital
may ultimately purchase all, some or none of the $20.0 million of Common Stock that we may sell to Aspire Capital pursuant to
the Purchase Agreement. After Aspire Capital acquires any shares under the Purchase Agreement, it may sell all, some or none of
those shares. Sales to Aspire Capital by us pursuant to the Purchase Agreement may result in substantial dilution to the interests
of other holders of our Common Stock. The sale of a substantial number of shares of our Common Stock to Aspire Capital, or anticipation
of such sales, could make it more difficult for us to sell equity or equity-related securities in the future at a time and at
a price that we might otherwise wish to effect sales. However, we have the right to control the timing and amount of any sales
of our shares to Aspire Capital and the Purchase Agreement may be terminated by us at any time at our discretion without any cost
to us.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B><I>&nbsp;</I></B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B><I>Future sales of a significant
number of our shares of Common Stock in the public markets, or the perception that such sales could occur, could depress the market
price of our shares of Common Stock. </I></B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">Sales of a
substantial number of our shares of Common Stock in the public markets, or the perception that such sales could occur, could depress
the market price of our shares of Common Stock and impair our ability to raise capital through the sale of additional equity securities.
It is anticipated that the holders of our Series E Preferred Shares will be selling any shares of Common Stock issued to them
as mandatory redemption shares on each mandatory redemption date. A substantial number of shares of Common Stock are issuable
in this offering and we cannot predict if and when the investors in this offering may sell such shares in the public markets.
In addition, a substantial number of shares of Common Stock are being offered by the Selling Stockholders under our effective
Registration Statement on Form S-3 (File No. 333-173853) and we cannot predict if and when the Selling Stockholders may sell such
shares of Common Stock in the public markets. As of January 20, 2012, one-half of the base stock consideration issued in connection
with the PCT Merger had been released from escrow and these shares are now freely tradable (an aggregate of 5,300,000 shares of
our Common Stock), with the remaining one-half of the base stock consideration scheduled to be released from escrow on January
20, 2013. We cannot predict if and when following this escrow release the recipients of the PCT Merger consideration may sell
such shares of Common Stock in the public markets. Additionally, a substantial number of shares of Common Stock may come into
the public markets as a result of the Amorcyte Merger: (i) at the closing, 5,843,483 shares of Common Stock were placed in escrow
as the &ldquo;Base Stock Consideration&rdquo;, for eventual distribution to the former stockholders of Amorcyte (with the first
release from escrow, consisting of 20% of the Base Stock Consideration, to be effected in April 2012), and (ii) up to 4,092,768
shares of our Common Stock may become issuable to the former Amorcyte stockholders as &ldquo;Contingent Shares&rdquo; if certain
business milestones are achieved. We cannot predict if and when (following, as applicable, release of the Base Stock Consideration
from escrow, or issuance of Contingent Shares if the relevant milestones are achieved) the recipients of the Amorcyte Merger consideration
may sell such shares of Common Stock in the public markets. We cannot predict the number of the above-described shares that might
be sold nor the effect that future sales of our shares of Common Stock would have on the market price of our shares of Common
Stock.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B><I>Our outstanding options and
warrants may negatively affect our ability to raise additional capital. </I></B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">At March 23,
2012, we had approximately 58,960,028 stock options and warrants outstanding. Holders of our outstanding options and warrants
are given the opportunity to profit from a rise in the market price of our Common Stock. As long as these options and warrants
are outstanding, the terms on which we could obtain additional capital may be adversely affected. The holders of these options
and warrants might be expected to exercise them at a time when we would, in all likelihood, be able to obtain any needed capital
by a new offering of securities on terms more favorable than those provided by these options and warrants.</FONT></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><I>&nbsp;</I></FONT></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><I>There is no public market
for the warrants to purchase common stock in this offering. </I></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><FONT STYLE="color: Black">There is no established
public trading market for the warrants being offered in this offering, and we do not expect a market to develop. In addition,
we do not intend to apply for listing the warrants on any national securities exchange, including NYSE Amex. Without an active
market, the liquidity of the warrants will be limited.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B><I>Failure to maintain effective
internal control over financial reporting in accordance with Section 404 of the Sarbanes-Oxley Act could have a material adverse
effect on our business and stock price. </I></B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B><I>&nbsp;</I></B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">We have concluded
that as of December 31, 2011 we have a material weakness in our internal control relating to our financial reporting of Erye.
Specifically, the Company has determined the accounting staff at Erye does not have sufficient qualified accounting and finance
personnel. If we fail to (1) fully remediate the material weakness identified, or (2) we fail to maintain the adequacy of internal
control over our financial reporting, we may not be able to ensure that we can conclude on an ongoing basis that we have effective
internal control over financial reporting in accordance with Section 404 of the Sarbanes-Oxley Act, as such standards are modified,
supplemented or amended from time to time.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">As private
companies, PCT and Amorcyte were not subject to the requirements of Section 404 of the Sarbanes-Oxley Act. Now that the PCT Merger
and the Amorcyte Merger have been consummated, we expect to continue to devote management time and other resources to ensure that
the combined company complies with the requirements of Section 404. During the course of testing our disclosure controls and procedures
and internal control over financial reporting, we may identify and disclose material weaknesses or significant deficiencies in
internal control over financial reporting (which may or may not be related to PCT or Amorcyte) that will have to be remedied.
Implementing any appropriate changes to our internal control may require specific compliance training of our directors, officers
and employees, entail substantial costs in order to modify our existing accounting systems, and take a significant period of time
to complete. Such changes may not, however, be effective in maintaining the adequacy of our internal control over financial reporting,
and any failure to maintain that adequacy or inability to produce accurate financial statements on a timely basis could result
in our financial statements being unreliable, increase our operating costs and materially impair our ability to operate our business.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">Failure to
achieve and maintain effective internal control over financial reporting could result in a loss of investor confidence in our
financial reports and could have a material adverse effect on our stock price. Additionally, failure to maintain effective internal
control over our financial reporting could result in government investigation or sanctions by regulatory authorities.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B><I>Actual and beneficial ownership
of large quantities of our Common Stock by our executive officers and directors may substantially reduce the influence of other
stockholders. </I></B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B><I>&nbsp;</I></B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">As of March
23, 2012, our executive officers and directors collectively owned 33,741,251 shares of our Common Stock, representing approximately
29.4% of our outstanding Common Stock. As of such date, our executive officers and directors collectively beneficially owned 47,544,079
shares of our Common Stock. These beneficial holdings represent approximately 37.0% of our Common Stock. As a result, such persons
may have the ability to exercise enhanced control over the approval process for actions that require stockholder approval, including:
the election of our directors and the approval of mergers, sales of assets or other significant corporate transactions or other
matters submitted for stockholder approval. Because of the beneficial ownership position of these persons, other stockholders
may have less influence over matters submitted for stockholder approval. Furthermore, at certain times the interests of our substantial
stockholders may conflict with the interests of our other stockholders.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B><I>Some of our directors and
officers have positions of responsibility with other entities, and therefore have loyalties and fiduciary obligations to both
our company and such other entities. These dual positions subject such persons to conflicts of interest in related party transactions
which may cause such related party transactions to have consequences to our company that are less favorable than those which we
could have attained in comparable transactions with unaffiliated entities. </I></B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B><I>&nbsp;</I></B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">Eric H.C. Wei,
a member of our Board of Directors, is also the Managing Partner of RimAsia Capital Partners, L.P., or RimAsia. RimAsia, a substantial
stockholder of our company, beneficially owns approximately 22.4% of our Common Stock as of March 23, 2012. Mr. Shi Mingsheng
(the Chairman of the Board of Erye, and who became a director of our company in March 2010) and Madam Zhang Jian (our Vice President
of Pharmaceutical Operations and the General Manager of Erye), together with certain other persons, have shared voting and dispositive
power over the shares of our Common Stock held by Fullbright Finance Limited, or Fullbright. Fullbright,together with Mr. Shi,
and Madam Zhang, beneficially owns approximately 4.7% of our Common Stock as of March 23, 2012. These relationships create, or,
at a minimum, appear to create potential conflicts of interest when members of our company&rsquo;s senior management are faced
with decisions that could have different implications for our company and the other entities with which our directors or officers
are associated.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">Although our
company has established procedures designed to ensure that material related party transactions are fair to the company, no assurance
can be given as to how potentially conflicted board members or officers will evaluate their fiduciary duties to our company and
to other entities that they may owe fiduciary duties, respectively, or how such individuals will act in such circumstances. Furthermore,
the appearance of conflicts, even if such conflicts ultimately do not harm our company, might adversely affect the public&rsquo;s
perception of our business, as well as its relationship with its existing customers, licensors, licensees and service providers
and its ability to enter into new relationships in the future.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B><I>We may not have the cash necessary
to redeem the Series E Preferred Shares. </I></B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B><I>&nbsp;</I></B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">We have the
obligation to make monthly redemption payments on the Series E Preferred Shares, which mandatory redemption payments may be made
at our option in cash or in shares of our Common Stock at a discounted formula price, except that our right to make payment in
shares of Common Stock is dependent upon our satisfying certain Equity Conditions (defined in the certificate of designations
for the Series E Preferred Stock) and is also subject to certain Dollar Volume Limitations (as defined). If we cannot satisfy
the Equity Conditions, or if our trading prices and volume are such that we do not meet the Dollar Volume Limitations necessary
for us to be able to make all or such portion of the monthly mandatory redemption payments as we desire in stock, we may be forced
to make all (or a greater portion than we desire) of such monthly payments in cash. We may not have sufficient cash resources
at the applicable time to make those cash payments, or to make such cash payments in full. Further, any failure to pay any amounts
due to the holders of the Series E Preferred Shares, as well as certain other Trigger Events (as defined in the certificate of
designations), including without limitation certain change in control transactions, our failure to timely deliver shares, our
suspension of trading, and breaches of certain representations, warranties and covenants that are not timely cured, where a cure
period is permitted, would permit the holders of our Preferred Shares to compel repurchase of such Series E Preferred Shares at
a price per share equal to the sum of the liquidation preference plus accrued dividends plus the then applicable prepayment premium
(10% if the repurchase occurs more than 12 months after the initial issuance date). If we are required to repurchase the Series
E Preferred Shares in cash prior to maturity, no assurance can be given that we would have the cash or financial resources available
to us to make such a payment, and such an acceleration could have a material adverse effect on our business and financial condition
and may impair our ability to continue in business as a going concern.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B><I>The Series E Preferred Shares
are senior obligations of ours, and rank prior to our Common Stock with respect to dividends, distributions and payments upon
liquidation. </I></B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B><I>&nbsp;</I></B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">The rights
of the holders of the Series E Preferred Shares rank senior to the obligations to holders of our Common Stock. Upon our liquidation,
the holders of Series E Preferred Shares are entitled to receive a liquidation preference of $1.00 per share, plus all accrued
but unpaid dividends at the rate of 7% per annum prior and in preference to any distribution to the holders of any other class
of our equity securities. Further, no dividends can be paid without the consent of the holders of a majority of the outstanding
Series E Preferred Shares, and the holders of Series E Preferred Shares, as well as the holders of the warrants which were issued
to the purchasers of Series E Preferred Shares, have the right to participate in any payment of dividends or other distributions
made to the holders of our Common Stock to the same extent as if they had converted the Series E Preferred Shares or exercised
the warrants. The existence of such a senior security could have an adverse effect on the value of our Common Stock.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B><I>Holders of the Series E Preferred
Shares have rights that may restrict our ability to operate our business. </I></B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B><I>&nbsp;</I></B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">Under the securities
purchase agreement pursuant to which the Series E Preferred Shares were sold, we are subject to certain covenants that limit our
ability to create new series of preferred stock, other than series junior to the Series E Preferred Shares. We are also limited,
with certain exceptions, in our ability and the ability of our subsidiaries (other than Erye) to incur debt and to pledge our
assets. Such restrictions may have an adverse effect on our ability to operate our business while the Series E Preferred Shares
are outstanding.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B>&nbsp;</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="color: Black"><B>RISKS RELATED
TO OUR FINANCIAL CONDITION </B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B><I>&nbsp;</I></B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B><I>We are a company with a limited
operating history and have incurred substantial losses and negative cash flow from operations in the past, and expect to continue
to incur losses and negative cash flow for the near term. </I></B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">We are a company
with a limited operating history, limited capital, and limited sources of revenue. Since our inception in 1980, we have incurred
net losses of approximately $143.1 million through December 31, 2011. We incurred net losses attributable to common shareholders
of approximately $47.8 million for the year ended December 31, 2011 and approximately $23.5 million for the year ended December
31, 2010, and we expect to incur additional operating losses and negative cash flow in the future. The revenues from our United
States Cell Therapy segment are not sufficient to cover costs attributable to that business. We expect to incur losses and negative
cash flow for the foreseeable future as a result of development activities associated with our product candidate AMR-001 (including
clinical trials), our VSEL<SUP>TM</SUP> Technology, a T-cell therapeutic and other research and development efforts to advance
cell therapeutics. We also expect to continue to incur significant expenses related to sales, marketing, general and administrative
and product research and development in connection with the development of our business.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">Although Erye,
a Chinese pharmaceutical company in which we acquired a 51% interest in October 2009, had revenues of approximately $63.4 million
for the year ended December 31, 2011, and approximately $69.6 million for the year ended December 31, 2010, it has only a limited
history of earnings. Pursuant to the October 2009 joint venture agreement that governs the ownership and management of Erye, or
the Joint Venture Agreement, for the three-year period commencing on the first day of the first fiscal quarter after the Joint
Venture Agreement became effective distributions are made as follows: (i) 49% of undistributed profits, after tax, will be distributed
to Suzhou Erye Economy and Trading Co. Ltd., or EET, which owns the remaining 49% of Erye, and loaned back to Erye for use in
connection with its construction of and relocation to the new Erye facility (to be repaid gradually after construction is completed);
(ii) 45% of the net profit after tax due to the Company will be provided to Erye as part of the new facility construction fund,
which will be characterized as paid-in capital for our 51% interest in Erye; and (iii) only 6% of the net profit will be distributed
to us directly for our operating expenses. As a result, we will not be able to supplement our cash flow fully from the income
expected to be generated by Erye in the short term. We are pursuing strategic alternatives with respect to our interest in Erye.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">PCT became
a wholly-owned subsidiary of NeoStem on January 19, 2011, upon the closing of the PCT Merger. PCT has not generated any significant
amount of revenue nor been profitable in any quarter since inception.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">We consummated
our acquisition of Amorcyte on October 17, 2011. Our Amorcyte subsidiary has no product revenue and to date has not received regulatory
approval to commercialize any of its products under development. Amorcyte has not completed development of any of its product
candidates. Because of the numerous risks associated with drug and biologics development, we are unable to predict whether the
development efforts of our Amorcyte subsidiary will be successful. In January 2012, we commenced enrollment of Amorcyte&rsquo;s
Phase 2 PreSERVE clinical trial. The trial is expected to cost approximately $14 million over the first two years and anticipated
to cost up to approximately $18 million over a five year period, inclusive of manufacturing costs.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B><I>&nbsp;</I></B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B><I>While our recent acquisition
of Amorcyte will further our strategy of focusing our business on cell therapies, the development and marketing of cell therapies
is a new business direction for us. </I></B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">Beginning with
our January 2011 acquisition of PCT, we began to shift our business plan to focus on capturing the paradigm shift to cell therapies.
It is anticipated that our recent acquisition of Amorcyte will help to further our expansion into the cell therapy field. However,
we have limited experience in the areas of cell therapy development and marketing of cell therapy products, and in the related
regulatory issues and processes. While the founders of PCT, Dr. Andrew Pecora and Dr. Robert Preti, will continue to provide services
in connection with development activities, we can provide no assurances that our management will successfully oversee Amorcyte&rsquo;s
or our other clinical development activities and integrate these businesses into the NeoStem business.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B><I>We are heavily dependent on
the successful development and commercialization of AMR-001, and if we encounter delays or difficulties in the development of
this product candidate, our business would be harmed.</I></B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12pt"><FONT STYLE="color: Black">We are heavily
dependent upon the successful development of AMR-001 for cardiovascular disease. Our business could be materially harmed if we
encounter difficulties in the development of this product candidate, such as:</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 12.25pt"></TD><TD STYLE="width: 20.9pt"><FONT STYLE="font-family: Symbol"><B>&middot;</B></FONT></TD><TD>delays in the ability to manufacture the product in quantities or in a form that is suitable for any required clinical trials;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 18.7pt; text-indent: -6.7pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 12.25pt"></TD><TD STYLE="width: 20.9pt"><FONT STYLE="font-family: Symbol"><B>&middot;</B></FONT></TD><TD>delays in the design, enrollment, implementation or completion of required clinical trials;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 18.7pt; text-indent: -6.7pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 12.25pt"></TD><TD STYLE="width: 20.9pt"><FONT STYLE="font-family: Symbol"><B>&middot;</B></FONT></TD><TD>an inability to follow our current development strategy for obtaining regulatory approval from the FDA because of changes in
the regulatory approval process;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 18.7pt; text-indent: -6.7pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 12.25pt"></TD><TD STYLE="width: 20.9pt"><FONT STYLE="font-family: Symbol"><B>&middot;</B></FONT></TD><TD>less than desired or complete lack of efficacy or safety in clinical trials; and</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 18.7pt; text-indent: -6.7pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 12.25pt"></TD><TD STYLE="width: 20.9pt"><FONT STYLE="font-family: Symbol"><B>&middot;</B></FONT></TD><TD>intellectual property constraints that prevent us from making, using, or commercializing the product candidate.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B><I>We are pursuing a significant
change in the nature of our business. </I></B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">As part of
our plan to focus our business on capturing the paradigm shift to cell therapies following our January 2011 acquisition of PCT,
we are pursuing strategic alternatives with respect to our 51% interest in Erye. We plan to devote our resources and management
efforts to cell therapy manufacturing and development, and other related activities, including adult stem cell collection and
storage. We believe that if we were to monetize Erye, we would have additional capital needed to pursue the development of cell
therapies. To that end, in June 2011, we engaged a financial advisor to lead the effort to pursue the possible divesture of our
51% interest in Erye. Marketing efforts to date have led only to a few nonbinding letters of intent. However, in addition to the
factors set forth below, it is too early to determine whether these or other proposals will lead to definitive agreements.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">Any sale of
our interest would be subject to a right of first refusal held by EET pursuant to the terms of the Joint Venture Agreement between
a subsidiary of ours and EET. EET owns the remaining 49% interest in Erye. A number of issues have arisen between EET and NeoStem
with respect to the operation and financing of Erye. For instance, while EET is required to lend back to Erye dividends received
by it to finance Erye&rsquo;s move to and construction of its new facilities, Erye has recently reported to us that such arrangement
is no longer tax efficient in light of the ratio of Erye&rsquo;s shareholder loans to its registered capital. In connection with
exploring ways to remedy the additional tax burden caused by the level of shareholder loans and in preparing for a sale process,
other issues have also surfaced, including the issue of our and Erye's needing to obtain all Chinese regulatory approvals (and
associated registrations) required to reflect the legal title of our interest in Erye as being held by the proper entity within
our group which is its current beneficial owner as that term is used under U.S. law. The Company believes that we have now determined
what government approvals (and associated registrations) will need to be issued by the Suzhou Municipal Bureau of Foreign Investment
and Commerce and the Suzhou Administration for Industry and Commerce to remediate these deficiencies and the Company has had counsel
in China prepare these filings. The Company&rsquo;s management believes these regulatory deficiencies can be remediated and should
not delay a possible divestiture of the Company&rsquo;s interests in Erye that is currently under evaluation. However, the Company
requires the cooperation of the officers of Erye, as to which no assurance can be given, and we may be compelled to seek to replace
these officers or to commence legal action to obtain the required consents or otherwise move forward with requisite filings. In
addition, even if the filings are made, no assurance can be given that any unremediated regulatory deficiencies would not have
an adverse effect on the operating results and liquidity of Erye and our Company and will not impede or delay efforts to divest
our interest in Erye. Also, the remediation process is expected to trigger certain tax liabilities and penalties; however, the
ultimate liability will be based on discussions with the relevant Chinese authorities. The Company cannot reasonably assess the
exposure as of December 31, 2011.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B><I>We may not be able to materially
enhance our liquidity through a sale of our interest in Erye.</I></B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">We have not
yet determined to sell our interest in Erye, and will not do so until we can assess the level of interest generated, the potential
price and transaction terms we might be offered and any regulatory impediments to a transaction. The challenging nature of the
current China pharmaceutical market makes it a difficult time for us to be pursuing a divestiture of our 51% ownership interest
in Erye, and we expect that any sale of this interest will result in our not recouping our original investment. The process to
divest Erye has led to our interests becoming unaligned with those of the 49% shareholder, as it from time to time has indicated
a desire to be a buyer, and this has led to strained relations between the parties. A sale of our interest in Erye, if a sale
can be consummated, would have a material effect on the business, results of operations and balance sheet. Factors that may impede
a sale may include, but not be limited to, (i) EET&rsquo;s right of first refusal and the significant time and money that exercise
of such right could cause a potential purchaser, (ii) the need for any purchaser to negotiate a new Joint Venture Agreement and
a shareholder loan repayment schedule with EET if EET does not wish to either sell its interest or exercise its right of first
refusal, (iii) recent regulatory changes in China which reduce prices that may be charged for certain of Erye&rsquo;s products
and limit use of antibiotics, (iv) recent disappointing financial performance by Erye resulting at least in part from such regulatory
changes, including a decrease in revenues in 2011, and a net loss for fourth quarter 2011, (v) tax or regulatory issues affecting
Erye, including those described above and other tax increases described in our filings which will adversely affect Erye going
forward, (vi) availability of financing for a potential purchaser, and (vii) other factors typical of any sale process. There
can be no assurance that any sale of our Erye interest will be made, or will be made at a price that provides material additional
capital for our cell therapy development efforts.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B><I>&nbsp;</I></B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="color: Black"><B><I>Erye may require additional
lines of credit and bank loans. </I></B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><FONT STYLE="color: Black">Due to a number
of factors including tightening of monetary policy in China, government-imposed pricing constraints on certain of its products,
the additional expenses described above, and constraints on certain bank accounts arising from the <I>Welman</I> litigation described
in Item 3 of our Annual Report on Form 10-K for the fiscal year ended December 31, 2011 under the caption &ldquo;Legal Proceedings&rdquo;,
Erye has experienced cash flow constraints and may consider seeking additional bank loans. In connection with the <I>Welman</I>
litigation, as of December 31, 2011, approximately 15,656,000 RMB (approximately $2,460,000) of cash had been frozen in six Erye
bank accounts. No assurances can be given that it will be able to secure additional credit on satisfactory terms, or at all.</FONT></P>



<P STYLE="margin: 0"><FONT STYLE="color: Black">&nbsp;</FONT></P>

<P STYLE="margin: 0"></P>

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<P STYLE="margin: 0"></P>
<P STYLE="margin: 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>RISKS RELATED TO CELL THERAPY&nbsp;&mdash;&nbsp;UNITED
STATES</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><U>Risks Related to the Cell Therapy Industry, Clinical Development
and Commercialization</U></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>Cell therapy is still a developing field and a significant
global market for our services has yet to emerge. Our cellular therapy candidates are based on novel cell technologies that are
inherently risky and may not be understood or accepted by the marketplace.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Cell therapy is still a developing area
of research, with few cell therapy products approved for clinical use. At the PCT level, the current market and current contracts
principally consist of providing manufacturing of cell and tissue-based therapeutic products in clinical trials and processing
of stem cell products for transplantation programs. Our Amorcyte and Athelos subsidiaries are involved in developing cell-based
therapies: Amorcyte for cardiovascular indications, and Athelos for T-cell therapy for restoring normal immune responses. Our access
to these markets will depend on the progress of our development activities, particularly with respect to Amorcyte, for which the
Phase 2 clinical trial for AMR-001 is now enrolling, as well as subsequent trials. We also provide services related to the collection
and storage of umbilical cord blood units and adult stem cells. There currently is no significant global market for stem cell processing
or their collection and storage, nor is there any guarantee that such markets will develop in the near future, or at all. Major
medical institutions currently do not generally recommend private storage, and we believe that the medical community is supportive
of the public cord blood collective system. Patients can donate their cord blood to the system without charge. The market for cell
and tissue-based therapies is early-stage, substantially research oriented, and financially speculative. Very few companies have
been successful in their efforts to develop and commercialize a stem cell product. Stem cell products in general may be susceptible
to various risks, including undesirable and unintended side effects, unintended immune system responses, inadequate therapeutic
efficacy, or other characteristics that may prevent or limit their approval or commercial use. The demand for stem cell processing
and the number of people who may use cell or tissue-based therapies is difficult to forecast. As there are no real experts who
can forecast this market with accuracy, there is limited data from which the future use of our services may be forecasted. Our
success is dependent on the establishment of a large global market for our products and services and our ability to capture a share
of this market.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Our development efforts including our Phase
2 trial of AMR-001, are susceptible to the risks of failure inherent in the development and commercialization of therapeutic products
based on new technologies. The novel nature of cellular therapeutics creates significant challenges with regards to product development
and optimization, manufacturing, government regulation, third-party reimbursement and market acceptance. For example, the United
States FDA has relatively limited experience regulating therapies based on cells, and there are few approved treatments utilizing
cell therapy.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Even if we successfully develop and obtain
regulatory approval for AMR-001 or any future cellular therapeutic product candidates, the market may not understand or accept
them, which could adversely affect future sales. The degree of market acceptance of any such product candidates will depend on
a number of factors, including:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 0.17in">&nbsp;</TD>
    <TD STYLE="width: 0.2in">&bull;</TD>
    <TD>the clinical safety and effectiveness of the product candidates, the availability of alternative treatments and the perceived advantages of the particular product candidates over alternative treatments;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>the relative convenience and ease of administration of the product candidates;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>our ability to separate the product candidates from the ethical and political controversies associated with stem cell product candidates derived from human embryonic or fetal tissue;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>ethical concerns that may arise regarding our commercial use of stem cells, including adult stem cells, in the manufacture of the product candidates;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 0.17in; padding-left: 0.1in; text-indent: -0.1in">&nbsp;</TD>
    <TD STYLE="width: 0.2in">&bull;</TD>
    <TD>the frequency and severity of adverse events or other undesirable side effects involving the product candidates or the products or product candidates of others that are cell-based; and</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-left: 0.1in; text-indent: -0.1in">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">the cost of the products, the reimbursement policies of government
        and third-party payors and our ability to obtain sufficient third-party coverage or reimbursement.</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>Our drug product candidates subject us to additional extensive
regulatory scrutiny. If we are not able to obtain the necessary regulatory approvals for AMR-001 or future product candidates,
we may not be able to continue our business operations, and our Company may be materially and adversely affected. </I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Our drug product candidates, and the activities
associated with their development and commercialization, including their testing, manufacture, safety, efficacy, recordkeeping,
labeling, storage, approval, advertising, promotion, sale and distribution, are subject to comprehensive regulation by the FDA
and other regulatory agencies in the United States and by comparable authorities in states and in other countries. Our failure
to obtain regulatory approval for a product candidate would prevent us from commercializing the product candidate. We have not
received regulatory approval to market any product candidate in any jurisdiction. Securing FDA approval typically requires the
submission of extensive preclinical and clinical data and supporting information to the FDA for each therapeutic indication to
establish the product candidate&rsquo;s safety and efficacy. Securing FDA approval also requires the submission of information
about the product manufacturing process to, and inspection of manufacturing facilities by, the FDA. AMR-001 and any other potential
future products of ours may not be effective, may be only moderately effective or may prove to have undesirable or unintended side
effects, toxicities or other characteristics that may preclude the obtaining of regulatory approval or may prevent or limit commercial
use.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">The process of obtaining FDA and other
regulatory approvals is expensive, often takes many years, if approval is obtained at all, and can vary substantially based upon
a variety of factors, including the type, complexity and novelty of the product candidates involved and challenges by competitors.
Because all of its product candidates are based on its CD34+ stem cell technology, any adverse events in our Amorcyte subsidiary&rsquo;s
clinical trials of one of its product candidates could negatively affect the clinical trials and approval process for Amorcyte&rsquo;s
other product candidates. Changes in regulatory approval policies during the development period, changes in or the enactment of
additional statutes or regulations, or changes in regulatory review for each submitted product application, may cause delays in
the approval or rejection of an application or may make it easier for our competitors to gain regulatory approval to enter the
marketplace. The FDA has substantial discretion in the approval process and may refuse to accept any application or may decide
that Amorcyte&rsquo;s data are insufficient for approval and require additional preclinical, clinical or other studies. In addition,
varying agency interpretations of the data obtained from preclinical and clinical testing could delay, limit or prevent regulatory
approval of a product candidate. Any regulatory approval we ultimately obtain may be limited or subject to restrictions or post-approval
commitments that render the approved product not commercially viable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Any of the following factors, among others,
may cause regulatory approval for our drug product candidates to be delayed, limited or denied:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 0.17in">&nbsp;</TD>
    <TD STYLE="width: 0.2in">&bull;</TD>
    <TD>the product candidates require significant clinical testing to demonstrate safety and effectiveness before applications for marketing approval can be filed with the FDA;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>data obtained from preclinical and nonclinical animal testing and clinical trials can be interpreted in different ways, and the FDA may not agree with our respective interpretations or may require us to conduct additional testing;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>it may take many years to complete the testing of product candidates, and failure can occur at any stage of the process;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>negative or inconclusive results or the occurrence of serious or unexpected adverse events during a clinical trial could cause us to delay or terminate development efforts for a product candidate; and</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>FDA may require expansion of the size and scope of the clinical trials.</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Any difficulties that we encounter in obtaining
regulatory approval would have a substantial adverse impact on our ability to generate product sales, and could make any search
for a collaborative partner more difficult.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>Our VSEL<SUP>TM</SUP> Technology and our</I></B> <B><I>other
research and development activities using cells in therapeutic indications present additional risks. </I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Our research and development activities
relating to our VSEL<SUP>TM</SUP> Technology and other populations of adult stem cells also pose additional risks related to requirements
for preclinical and clinical testing by regulatory authorities including the FDA, to demonstrate the safety and efficacy of the
underlying therapy. The development of new drugs and therapies is often a long, expensive and difficult process and most attempts
fail. Our VSEL<SUP>TM</SUP> Technology is in the very early stages of development and will require many steps, tests and processes
before we will be able to commence clinical testing in humans. There can be no assurance that a biologics license application,
or BLA, with the FDA will not be required for our VSEL<SUP>TM</SUP> Technology or our other stem cell technologies. The approval
process for a BLA can take years, require human clinical trials and cost several million dollars. There also can be no assurance
that we independently, or through collaborations, will successfully develop, commercialize or market our VSEL<SUP>TM</SUP> Technology
or other stem cells for any therapeutic indication. Should we fail to develop our VSEL<SUP>TM</SUP> Technology or other adult stem
cell technologies pursued by us, our business prospects, operating results and financial condition will be materially and adversely
affected.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>If clinical trials of our product candidate AMR-001 or
any future product candidates fail to demonstrate safety and efficacy to the satisfaction of the FDA or do not otherwise produce
positive results, we may incur additional costs or experience delays in completing, or ultimately be unable to complete, the development
and commercialization of such product candidates. </I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Before obtaining regulatory approval for
the sale of AMR-001 or any other product candidate, we must conduct, at our own expense, extensive clinical trials to demonstrate
the safety and efficacy of the product candidates in humans. Clinical testing is expensive, difficult to design and implement,
can take many years to complete and is uncertain as to outcome. A failure of one or more clinical trials conducted by our Amorcyte
subsidiary or on its behalf can occur at any stage of testing. We may experience numerous unforeseen events during, or as a result
of, clinical trials that could delay or prevent our ability to receive regulatory approval or commercialize our product candidates,
including the following:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 0.17in">&nbsp;</TD>
    <TD STYLE="width: 0.2in">&bull;</TD>
    <TD>regulators or institutional review boards may not authorize us or our investigators to commence a clinical trial or conduct a clinical trial at a prospective trial site;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>clinical trials of product candidates may produce negative or inconclusive results, and we may decide, or regulators may require us, to conduct additional clinical trials or abandon product development programs that we expect to be pursuing;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>the number of patients required for clinical trials of product candidates may be larger than we anticipate, enrollment in these clinical trials may be slower than we anticipate, or participants may drop out of these clinical trials at a higher rate than we anticipate;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>third party contractors may fail to comply with regulatory requirements or meet their contractual obligations to us in a timely manner or at all;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>we might have to suspend or terminate clinical trials of our product candidates for various reasons, including a finding that the participants are being exposed to unacceptable health risks;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>regulators or institutional review boards may require that we or our investigators suspend or terminate clinical research for various reasons, including noncompliance with regulatory requirements;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>the cost of clinical trials of our product candidates may be greater than anticipated;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>we may be subject to a more complex regulatory process, since cell-based therapies are relatively new and regulatory agencies have less experience with them than with traditional pharmaceutical products;</TD></TR>
</TABLE>

<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="margin: 0"></P>

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<P STYLE="margin: 0"></P>

<P STYLE="margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 0.17in">&nbsp;</TD>
    <TD STYLE="width: 0.2in">&bull;</TD>
    <TD>the supply or quality of our product candidates or other materials necessary to conduct clinical trials of these product candidates may be insufficient or inadequate; and</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>our product candidates may have undesirable side effects or other unexpected characteristics, causing us or our investigators to halt or terminate the trials.</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">During Amorcyte&rsquo;s Phase 1 trial of
AMR-001, serious adverse events in the treatment group were not significantly different in number compared to the control group.
However, serious adverse events during the Phase 1 trial that occurred included one treatment group subject death from ventricular
fibrillation soon after cell infusion. The ventricular fibrillation was attributed to recurrent myocardial infarction from stent
thrombosis preceding cell infusion. This subject&rsquo;s death resulted in a clinical hold during the Phase 1 trial. The hold was
removed upon FDA&rsquo;s review of the complete documentation on the patient and changes to enrollment procedures for additional
subjects that was submitted by Amorcyte. Another treatment group subject was withdrawn because of acute stent thrombosis before
cell infusion. One control subject and two additional treatment subjects experienced in-stent restenosis. One treatment subject
experienced worsening of congestive heart failure.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">There can be no assurance that similar
or other events will not occur in future clinical trials of our Amorcyte subsidiary's product candidates that could give rise to
safety concerns, particularly in light of the impaired heart function of patients who will be the target subject population of
Amorcyte's future planned clinical trials.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">If we are required to conduct additional
clinical trials or other testing of AMR-001 beyond those that we currently contemplate, or if we are required to conduct additional
trials or testing of future product candidates beyond what we currently anticipate, or if we are unable to successfully complete
clinical trials of our product candidates or other testing, if the results of these trials or tests are not positive or are only
modestly positive, or if there are safety concerns, we may:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 0.17in">&nbsp;</TD>
    <TD STYLE="width: 0.2in">&bull;</TD>
    <TD>be delayed in obtaining marketing approval for AMR-001 (or any future product candidate);</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>not be able to obtain marketing approval;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>obtain approval for indications that are not as broad as intended;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>have the product removed from the market after obtaining marketing approval;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>be subject to additional post-marketing testing requirements; or</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>be subject to restrictions on how the product is distributed or used.</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Our product development costs will also
increase if we experience delays in testing or approvals. We cannot predict whether any clinical trials will begin as planned,
will need to be restructured or will be completed on schedule, or at all. Significant clinical trial delays also could shorten
any periods during which we may have the exclusive right to commercialize product candidates or allow our competitors to bring
products to market before we do and impair our ability to commercialize our product candidates and may harm our business and results
of operations.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>The initiation of a pivotal Phase 3 clinical trial for
AMR-001 will require the validation and establishment of manufacturing controls that may delay product development. </I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">We initiated a Phase 2 clinical trial of
AMR-001, enrolling our first patient in January 2012, and we are targeting enrolling approximately 160 patients over the course
of a year or so.<B> </B>If the results of the Phase 2 clinical trial are positive and support Phase 3 development, we intend to
initiate and complete one or more pivotal Phase 3 clinical trials before seeking regulatory approval to commercialize AMR-001.
Our Amorcyte subsidiary is required to have certain validated and established manufacturing controls with respect to AMR-001 related
to its safety, purity and potency when administered to patients. Manufacturing control issues will need to be addressed and resolved
with the FDA if we seek to initiate a Phase 3 clinical trial of AMR-001. Specifically, we must develop a potency assay for AMR-001
and lot release specifications that correlate with AMR-001 activity or clinical response. We may not be successful in our efforts
to address these chemistry, manufacturing and controls, or CMC, issues for AMR-001 in a manner satisfactory to the FDA. If we cannot
initiate, or if we are delayed in initiating, a pivotal Phase 3 clinical program of AMR-001 as a result of our failure to satisfy
the FDA&rsquo;s CMC concerns or otherwise, the timing of our regulatory submission for commercialization of AMR-001 could be delayed,
or we may not be able to seek regulatory approval to commercialize AMR-001 at all.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>Development of Amorcyte's AMR-001 is subject to uncertainty
because the CD34+ cells are derived from human bone marrow, a source material that is inherently variable. </I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">The number of CD34+/CXCR4+-cells and the
composition of the CD34+ cell population from bone marrow vary from patient to patient. These cells are the basis of our product
candidate AMR-001. Such variability in composition could adversely affect our ability to manufacture these product candidates derived
from a patient&rsquo;s bone marrow or to establish and meet acceptable specifications for release of the product candidate for
use in a clinical trial or, if approved, for treatment of a particular patient. As a consequence, the development and regulatory
approval process for these product candidates could be delayed or may never be completed.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>The results of preclinical studies may not correlate with
the results of human clinical trials. In addition, early stage clinical trial results do not ensure success in later stage clinical
trials, and interim trial results are not necessarily predictive of final trial results. </I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">To date, we have not completed the development
of any products through regulatory approval. While Amorcyte and others have analyzed the potential of AMR-001 in preclinical studies
with animals, the potential efficacy of AMR-001 in humans has only been evaluated in a Phase 1 clinical trial. The results of preclinical
studies in animals may not be predictive of results in a clinical trial. Likewise, the outcomes of early clinical trials may not
be predictive of the success of later clinical trials. The safety and efficacy data from our Phase 2 clinical trial of AMR-001
may be less favorable than the data observed in the Phase 1 clinical trial of this product candidate, which was based on small
numbers of patients. There can be no assurances that the clinical trials of any product candidate will ultimately be successful.
New information regarding the safety and efficacy of such product candidate may be less favorable than the data observed to date.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>We may experience delays in enrolling patients in our
clinical trials, which could delay or prevent the receipt of necessary regulatory approvals. </I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">We may not be able to initiate or continue
clinical trials of AMR-001 (or other product candidates) if we are unable to locate and enroll a sufficient number of eligible
patients to participate in the clinical trials required by the FDA or other regulatory authorities. We may also be unable to engage
a sufficient number of clinical trial sites to conduct our trials. The challenge of enrolling patients will become more difficult
if we are required by the FDA or a similar regulatory agency outside the United States to conduct a trial on a larger population
than we currently anticipate. In that event, we might be required to seek patients to participate in our trials from Europe or
other foreign jurisdictions, which could raise regulatory uncertainties and increase clinical trial costs. Moreover, because our
PCT subsidiary does not currently have FDA registered manufacturing facilities operating outside of the United States, our ability
to conduct trials outside of the U.S. may be constrained by our ability to transport trial materials to foreign destinations within
the expiry period of such materials unless we commence operation outside of the United States.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">We and our investigators may also face
challenges in enrolling patients to participate in our clinical trials due to the novelty of our cell-based therapies. Some patients
may have concerns regarding cell therapy that may negatively affect their perception of therapies under development and their decision
to enroll in the trials. Furthermore, patients suffering from diseases within target indications may enroll in competing clinical
trials, which could negatively affect our ability to complete enrollment of our trials.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Additional factors that may affect our
ability to enroll patients in clinical trials include:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 0.17in">&nbsp;</TD>
    <TD STYLE="width: 0.2in">&bull;</TD>
    <TD>the size of the patient population;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>patients&rsquo; willingness to receive a placebo or other inactive control on the control arm of a clinical study;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>the distance between patients and clinical test sites; and</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>the eligibility criteria for the trial.</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Enrollment delays in clinical trials may
result in increased development costs for product candidates, and inability to enroll a sufficient number of patients for any current
or future clinical trials would result in significant delays or may require one or more clinical trials to be abandoned altogether.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>The cell sorting system we are using in the Phase 2 clinical
trial of AMR-001 is owned by an unaffiliated third party. </I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">The essential cell sorting system that
we are using in our Phase 2 clinical trial of AMR-001 is being provided to us by the unaffiliated third party that owns the system.
Any lack of continued availability of the system, for any reason, would have a material adverse effect on our AMR-001 product development
and commercialization efforts. Although there are other available systems in the marketplace, we have not evaluated their costs
or safety and effectiveness, or whether AMR-001 would be compatible with such systems. Moreover, if the system becomes unavailable
during or after Phase 2, we would need to demonstrate that the Phase 2 data obtained with this system are still relevant to future
trials using cells sorted with other systems.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>We may also use other third-party collaborators to help
us develop or commercialize AMR-001 or future product candidates, and our ability to commercialize such candidates may be impaired
or delayed if collaborations are unsuccessful. </I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">We may in the future selectively pursue
strategic collaborations for the development and commercialization of AMR-001 or other product candidates and for the international
development and commercialization of such product candidates. For example, we anticipate that we might need to enter into a collaboration
agreement with a third party to conduct and fund one or more pivotal Phase 3 clinical trials of AMR-001. In addition, we may not
be able to commercialize AMR-001 successfully without entering into an arrangement with a third party to provide an approved method
of administration.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">There can be no assurance that we will
be able to identify suitable collaborators or negotiate collaboration agreements on terms that are acceptable to us, or at all.
In any future third-party collaboration, we would be dependent upon the success of the collaborators in performing their responsibilities
and their continued cooperation. Such collaborators may not cooperate or perform their obligations under their agreements with
us. We cannot control the amount and timing of our collaborators&rsquo; resources that will be devoted to performing their responsibilities
under their agreements with us. Collaborators may choose to pursue alternative technologies in preference to those being developed
in collaboration with us. The development and commercialization of product candidates will be delayed if collaborators fail to
conduct their responsibilities in a timely manner or in accordance with applicable regulatory requirements or if they breach or
terminate their collaboration agreements. Disputes with collaborators could also result in product development delays, decreased
revenues and litigation expenses.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>If the potential of AMR-001 or our other cell therapy
product candidates to address the indications that we are pursuing is not realized, or if we are unable to demonstrate in clinical
trials that AMR-001 or any other cell therapeutic is safe and effective for the indications pursued, the value of our technology
and development programs could be significantly reduced. Contractual arrangements between our Company and any licensors or collaborators
may require us to pay royalties or make other payments in connection with the successful development of a product candidate. For
example, even if we successfully commercialize AMR-001, we will have to pay a portion of any AMR-001 revenues to the former stockholders
of Amorcyte as an earn out.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">We are currently exploring in clinical
development, the potential of Amorcyte&rsquo;s AMR-001 to address certain targeted cardiovascular indications, and the potential
of Athelos&rsquo; T-reg therapy for restoring normal immune responses. This technology is still in early stages of discovery and
development, and our Amorcyte subsidiary has not proven in clinical trials that its product candidate will be safe and effective
for the indications for which it intends to seek approval. Our Athelos subsidiary&rsquo;s T-reg therapeutic for autoimmune disorders
is in earlier stages of clinical development. These and other cell therapy product candidates we may pursue are susceptible to
various risks, including undesirable and unintended side effects, inadequate therapeutic efficacy or other characteristics that
may prevent or limit their marketing approval or commercial use. For example, our Amorcyte subsidiary has not treated a sufficient
number of patients to allow us to evaluate the most frequent or most serious adverse events that could occur with AMR-001. Any
undesirable side effects that might be caused by AMR-001 (or future cell therapy product candidates) could interrupt, delay or
halt clinical trials and could result in the denial of regulatory approval by the FDA or other regulatory authorities for any or
all targeted indications. We could also be required to change the manner in which a product candidate is administered, which could
require that additional clinical trials be conducted. If the potential of AMR-001, Athelos&rsquo; T-reg therapeutic, or any other
cell therapeutic product candidate of ours is not realized, whether as a result of unintended consequences or otherwise, the value
of our technology and development programs could be significantly reduced.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Even if we obtain all applicable regulatory
approvals and successfully commercialize one or more of our cell therapy candidates, contractual arrangements between our Company
and a licensor, collaborator or other third party, as applicable, in connection with the respective product, may require that we
make royalty or other payments to the respective third party, and as a result our Company would not receive all of the revenue
derived from commercial sales of the respective product. For example, the Amorcyte Merger Agreement requires us to pay certain
earn out payments following the first commercial sale of AMR-001 for the benefit of the former stockholders of Amorcyte, generally
equal to 10% of net sales (or 30% of any sublicensing fees, royalties and milestone fees or profit sharing payments, in the event
we license or otherwise grant an unaffiliated third party the right to commercialize or otherwise exploit AMR-001), less NeoStem&rsquo;s
out-of-pocket clinical development costs not previously paid or reimbursed and other expenses. Also, the license agreements relating
to the T-reg therapeutics being developed by Athelos include obligations to pay royalties on net sales of licensed products, maintenance
fees and milestone fees upon events such as initiation of clinical trial stages, license application filings and regulatory approvals.
Where such an agreement applies, the payment by us of the applicable royalties and other fees mean that our Company does not receive
all of the revenue upon a successful commercialization of the respective product candidate.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>We have a very limited history of conducting our own research
and development activities. </I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">To support our own research and development activities for our
VSEL<SUP>TM</SUP> Technology, in September 2009 we signed a lease for approximately 8,000 square feet of office and laboratory
space in Cambridge, Massachusetts that has served as our research and development headquarters. The Company is assessing its need
for the Cambridge facility going forward given the acquisition of PCT with its Allendale, NJ and Mountain View, CA facilities which
could accommodate this work. In May 2011 we sublet a portion of our Cambridge facility to another life science company. To pursue
our current business strategy, we must have in place appropriate research capabilities, either on our own or through relationships
with third parties. There can be no assurance that we will be successful in these efforts. Our additional research and development
capacity also will require adequate sources of funding. There can be no assurance that any of these development efforts will produce
a successful product or technology. Our failure to develop new products would have a material adverse effect on our business, operating
results and financial condition.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>Even if we are successful in developing a therapeutic
application using our cell technologies, we still may be unsuccessful in creating a commercially viable and profitable business.
</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">The commercial viability of our stem cell
technologies may depend on our ability to successfully isolate and expand the number of stem cells collected through adult stem
cell collection processes in order to achieve a therapeutically-viable dose. Today, the number of very small embryonic-like stem
cells that can be isolated from the peripheral blood of an adult donor is relatively small and this volume of cells may not be
sufficient for therapeutic applications. <FONT STYLE="color: windowtext">Cell expansion processes may thus prove to be a</FONT><FONT STYLE="color: red">
</FONT>critical component of our adult stem cell collection, processing and storage services <FONT STYLE="color: windowtext">as
it relates </FONT>to the VSEL<SUP>TM</SUP> Technology and other potential cell technologies. There are many biotechnology laboratories
attempting to develop cell expansion technology, but to date<FONT STYLE="color: red">,</FONT>&nbsp;cell expansion techniques remain
very inefficient. There can be no assurance that such technology will be effective or available at all. The <FONT STYLE="color: windowtext">unavailability</FONT>
of cost effective and reliable expansion technologies could severely limit the commercial opportunities of our VSEL<SUP>TM</SUP>
Technology program and other potential&nbsp;cell technologies and limit our business prospects, which could have a material adverse
effect on our business, operating results and financial condition.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Moreover, stem cell collection techniques
are rapidly developing and could undergo significant change in the future. Such rapid technological development could result in
our technologies becoming obsolete. Successful biotechnology development in general is highly uncertain and is dependent on numerous
factors, many of which are beyond our control. While our AMR-001 product candidate, our Athelos program and our VSEL<SUP>TM</SUP>
Technology&nbsp;appear promising, such technologies may fail to be successfully commercialized for numerous reasons, including,
but not limited to, competing technologies for the same indication. There can be no assurance that we will be able to develop a
commercially successful therapeutic application for this technology or other potential stem cell technologies.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>Technological and medical developments or improvements
in conventional therapies could render the use of cell therapy and our services and planned products obsolete. </I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Advances in other treatment methods or
in disease prevention techniques could significantly reduce or entirely eliminate the need for our cell therapy services, planned
products and therapeutic efforts. There is no assurance that cell therapies will achieve the degree of success envisioned by us
in the treatment of disease. Nor is there any assurance that new technological improvements or techniques will not render obsolete
the processes currently used by us, the need for our services or our planned products. Additionally, technological or medical developments
may materially alter the commercial viability of our technology or services, and require us to incur significant costs to replace
or modify equipment in which we have a substantial investment. We are focused on cell therapy, and if this field is substantially
unsuccessful, this could jeopardize our success or future results. The occurrence of any of these factors may have a material adverse
effect on our business, operating results and financial condition.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>Cell therapies may not be successfully developed by us
or others, and in such case, demand for the ancillary services that we provide (such as cell processing and manufacturing, adult
stem cell collection, and processing and storage) may never develop. </I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">The value of our development programs,
as well as the value of the ancillary supporting services that we provide (such as our stem cell collection, processing and storage
business, or the processing and manufacturing services offered by our PCT subsidiary), could be significantly impaired, and our
ability to become profitable and continue our business could be materially and adversely affected, if cell therapies under development
by us or by others to treat disease are not proven effective, demonstrate unacceptable risks or side effects or, where required,
fail to receive regulatory approval. The therapeutic application of cells to treat serious diseases is currently being explored
by a number of companies. Cells collected and used for the same individual are referred to as autologous cells and those collected
from an individual who is not the user of the cells are referred to as allogeneic cells. To our knowledge, the only allowed therapeutic
uses of stem cells in the U.S., other than in connection with clinical trials, involves hematopoietic stem cell transplants to
treat certain types of blood-based cancers (hematopoietic stem cells are the stem cells from which all blood cells are made) and
adult autologous cultured cartilage cells for implantation for the repair of symptomatic cartilage defects of the femoral condyle
(the distal end of the femur). No other stem cell therapeutic products have received regulatory approval for sale in the U.S. While
stem cell-based therapy has been reported to be susceptible to various risks, including some undesirable side effects and immune
system responses, these problems have been primarily associated with allogeneic use. Inadequate therapeutic efficacy also is a
risk that may prevent or limit approval or commercial use of adult stem cells, whether for autologous use or allogeneic use. In
addition, the time and cost necessary to complete the clinical development and to obtain regulatory approval of new therapies using
stems cells are expected to be significant. If a market for underlying cell therapies never materializes, the market for ancillary
and supporting services would also suffer.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>The demand for PCT&rsquo;s services depends in part on
our customers&rsquo; research and development and marketing efforts. Our business, financial condition and results of operations
may be harmed if our customers spend less on, or are less successful in, these activities. </I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Many of PCT&rsquo;s customers are engaged
in research, development, production and marketing. The amount of customer spending on research, development, production and marketing
has a large impact on our revenues and profitability, particularly the amount customers choose to spend on outsourcing. Customers
determine the amounts that they will spend based upon, among other things, available resources and their need to develop new products,
which, in turn, is dependent upon a number of factors, including their competitors&rsquo; research, development and production
initiatives, and the anticipated reimbursement scenarios for specific products and therapeutic areas. In addition, consolidation
in the industries in which our customers operate may have an impact on such spending as customers integrate acquired operations,
including research and development departments and their budgets. Our customers finance their research and development spending
from private and public sources. A reduction in spending by our customers could have a material adverse effect on our business,
financial condition and results of operations. If our customers are not successful in attaining or retaining product sales due
to market conditions, reimbursement issues or other factors, our results of operations may be materially impacted. Further, the
nature and duration of PCT&rsquo;s contracts with customers, which may be subject to repeated renegotiation and amendments which
change the objectives of our work and the milestones which determine when revenues are received by us, can yield varying revenues
and profits, which may have an adverse effect on our revenues.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>Adverse outcomes or limitations of our stem cell or cord
blood collection and storage services, or a failure in the performance of the cryopreservation storage facility or systems of our
service providers, could harm our reputation and business. </I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Customers may experience adverse outcomes
or encounter limitations in connection with our stem cell or cord blood collection and storage services. For example, when stem
cells are collected from a customer for storage, there is the possibility of an infection acquired from the apheresis process,
which is the process of extracting stem cells from a patient&rsquo;s whole blood, which is an integral part of our collection process.
Both our stem cell and cord blood collection and storage services may be subject to additional limitations, including (i) collection
of insufficient quantities of stem cells for therapeutic applications; (ii) failure of the equipment supporting our cryopreservation
storage service to function properly and thus maintain a supply of usable adult stem cells; and (iii) specimen damage, including
contamination or loss in transit to us. Should any of these events occur, our reputation could be harmed, our operations could
be adversely affected and litigation could be filed against us. Our systems and operations are vulnerable to damage or interruption
from fire, flood, equipment failure, break-ins, tornadoes and similar events for which we do not have redundant systems or a formal
disaster recovery plan. We may not carry sufficient business interruption insurance and/or liability insurance to compensate for
losses and claims that might arise in the event of such an interruption. Any claim of adverse side effects or limitations or material
disruption in our ability to maintain continued uninterrupted storage systems could have a material adverse effect on our business,
operating results and financial condition.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">In addition, the value of our cord blood
storage services is related to the higher success rate of autologous cord blood transplants over unrelated ones. If medical research
discovers new and more effective medical procedures that make allogeneic cord blood transplants safer and more effective, the clinical
advantage of storing a child&rsquo;s umbilical cord blood for his or her own future therapeutic use may significantly decline.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>We have limited manufacturing capabilities. In the event
of regulatory approval of a commercial application of AMR-001, we may not be able to manufacture AMR-001 (or any other product
that may be approved) in compliance with evolving regulatory standards or in quantities sufficient for commercial sale. </I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">We believe that we can provide services
and produce materials for clinical trials and for human use at our existing facilities, which we believe are compliant with FDA
requirements for cGMP, and cGTP. We also believe that we have sufficient capacity to meet expected near term demand. However, we
may need to, depending on demand, expand our manufacturing capabilities for cell therapy services and products in the future. In
2007, PCT acquired an additional facility in Allendale, New Jersey, which became a cGMP compliant facility in 2010. The demand
for our services and products could, at times, exceed existing manufacturing capacity. If we do not meet rising demand for products
and services on a timely basis or are not able to maintain cGMP compliance standards, then our clients and potential clients may
elect to obtain the products and services from competitors, which could materially and adversely affect our revenues.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Components of therapeutic products approved
for commercial sale or used in late-stage clinical trials must be manufactured in accordance with cGMP. Manufacturers of cell-based
product candidates such as AMR-001 also must comply with the cGTP. In addition, therapeutic products may be required to modify
their manufacturing process from time to time in response to FDA requests. Manufacture of live cellular-based products is complex
and subjects companies to significant regulatory burdens that may change over time. We may encounter difficulties in the production
of our product candidates due to our limited manufacturing experience. Although Amorcyte's cell processing services are provided
&quot;in-house&quot; through its sister subsidiary PCT, we may not have sufficient manufacturing capacity to meet any commercial
demand that might develop should AMR-001 demonstrate efficacy, receive necessary approvals and be cleared for commercialization.
These difficulties could reduce sales of our products, if any are approved for marketing, increase costs or cause production delays,
any of which could damage the reputation and diminish potential profitability.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">We expect that we would need to significantly
expand our manufacturing capabilities to meet potential demand for commercial production of product candidates that might attain
regulatory approval. Such expansion would require additional regulatory approvals. We may also encounter difficulties in the commercial-scale
manufacture that may be required following any regulatory approval. PCT is currently developing new processes and is in discussions
with other companies to develop new instruments to improve manufacturing efficiency. Improving the speed and efficiency of our
manufacturing process including cell sorters and other instruments PCT uses in connection with AMR-001production is a key element
of our business plan. We cannot provide assurances that we will be able to develop process enhancements that are acceptable to
the FDA, on a timely basis, on commercially reasonable terms, or at all. If we fail to develop these improvements, we could face
significantly higher capital expenditures than we anticipate in connection with AMR-001 development, increased facility and personnel
costs and other increased operating expenses. We may need to demonstrate that product candidates manufactured using new processes
or instruments are comparable to the product candidates used in clinical trials. Depending on the type and degree of differences,
we may be required to conduct additional studies or clinical trials to demonstrate comparability.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">In addition, some changes in manufacturing
processes or procedures, including a change in the location where a product candidate is manufactured, generally require FDA or
foreign regulatory authority review and approval prior to implementation. We may need to conduct additional preclinical studies
and clinical trials to support approval of any such changes for Amorcyte. Furthermore, this review process could be costly and
time-consuming and could delay or prevent the commercialization of product candidates.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>If our processing and storage facilities are damaged or
destroyed, our business, clinical trials, programs, and prospects could be negatively affected and could adversely affect our value.
</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">We process and store adult autologous stem
cells from our network of U.S. adult stem cell collection centers and the umbilical cord blood of customers of NeoStem Family Storage,
LLC at PCT&rsquo;s facility in Allendale, New Jersey, and may do so at PCT&rsquo;s Mountain View, California, facility in the future.
We also process and store cellular therapy products for clinical trials at PCT&rsquo;s facility in Allendale, New Jersey, and may
do so at PCT&rsquo;s Mountain View, California, facility. If these facilities or the equipment in these facilities was to be significantly
damaged or destroyed, we could suffer a loss of some or all of the stored adult autologous stem cells, cord blood units, and cellular
therapy products. Depending on the extent of loss, such an event could reduce the ability of us, NeoStem Family Storage, LLC, and
PCT to provide stem cells when requested, could expose us, NeoStem Family Storage, LLC, and PCT to significant liability from our
customers, and could affect the ability to continue to provide adult autologous stem cells and umbilical cord blood preservation
services and manufacturing of cellular therapy services and products. While we believe that we have insured against losses from
damage to or destruction of our facilities consistent with typical industry practices, if we have underestimated our insurance
needs, we may not have sufficient insurance to cover losses beyond the limits on its policies. Such events could have a material
adverse effect on our value.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Furthermore, AMR-001 for our Amorcyte subsidiary's
clinical trials is produced by PCT at PCT&rsquo;s facilities. Because PCT serves as Amorcyte&rsquo;s exclusive provider of all
cell processing services (including production of AMR-001 for clinical trials), Amorcyte relies on PCT&rsquo;s Allendale or Mountain
View facilities and on the continuing suitability of PCT&rsquo;s facility to provide necessary services. If PCT&rsquo;s Allendale
or Mountain View facilities (or the equipment therein) are significantly damaged or destroyed, Amorcyte will likely experience
significant disruptions to the manufacturing capacity for AMR-001, which capacity might not be quickly or inexpensively replaced.
In such a situation, we may be required to negotiate agreements with third parties for cell processing services, which would likely
increase our operating costs. In the event of a temporary or protracted loss of PCT&rsquo;s facility or equipment, it is possible
that Amorcyte might not be able to transfer manufacturing to a third party. Even if Amorcyte could transfer manufacturing to a
third party, the shift would likely be expensive and time-consuming, particularly since the new facility would need to comply with
the necessary regulatory requirements and Amorcyte would need FDA approval before selling any products manufactured at that facility.
Such an event could delay clinical trials or, if any Amorcyte product candidates are approved by the FDA, reduce sales of such
products.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>We have a limited marketing staff and budget. </I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">The degree of market acceptance of our
products and services depends upon a number of factors, including the strength of our sales and marketing support. If our marketing
is not effective, our ability to generate revenues could be significantly impaired. Due to capital constraints, our marketing and
sales activities have been somewhat limited and thus we may not be able to make our services known to a sufficient number of potential
customers and partners. Limitations in our marketing and sales activities, and the failure to attract enough customers, will affect
our ability to operate profitably.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>For any other product candidate that receives marketing
approval from the FDA, we would need either to hire a sales force with expertise in biologic products or to contract with a third
party to provide a sales force to meet its needs. </I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">We have no experience in the selling, marketing
or distribution of biologic products. To achieve commercial success for any product that might be approved in the future for marketing,
we would be required either to develop a sales and marketing organization or to outsource these functions to third parties.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">We may be unable to establish marketing,
sales and distribution capabilities necessary to commercialize and gain market acceptance for any of its product candidates and
to be competitive. In addition, co-promotion or other marketing arrangements with third parties to commercialize product candidates
could significantly limit the revenues derived from such product candidates, and these third parties may fail to commercialize
the product candidates successfully.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>The market for services related to the collection, preservation
and expansion of cells has become increasingly competitive. Our competitors may have greater resources or capabilities or better
technologies than do we, or may succeed in developing better service than do we and we may not be successful in competing with
them. Additionally, the product development initiatives of our Amorcyte subsidiary face substantial competition, which may result
in others discovering, developing or commercializing products before or more successfully than we do. </I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">The biotechnology and life science industries
are highly competitive. They include multinational biotechnology and life science, pharmaceutical and chemical companies, academic
and scientific institutions, governmental agencies, and public and private research organizations. Many of these companies or entities
have significantly greater financial and technical resources and production and marketing capabilities than do we. The biotechnology
and life science industries are characterized by extensive research and development, and rapid technological progress. Competitors
may successfully develop services or products superior or less expensive than cell therapy services or products, rendering our
services less valuable or marketable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Historically, in the U.S. we have faced
competition from other established operators of stem cell preservation businesses and providers of stem cell storage services.
Today, there is an established and growing market for cord blood stem cell banking. We are aware of at least one other company
with established stem cell banking services that processes and stores stem cells collected from adipose, or fat, tissue. This type
of stem cell banking requires harvesting fat by a liposuction procedure. Embryonic stem cells represent yet another alternative
to pre-donated and stored adult stem cells. As techniques for expanding stem cells improve, thereby allowing therapeutic doses,
the use of embryonic stem cells and other collection techniques of adult stem cells could increase and compete with our services.
We are also aware that other technologies are being developed, for example, to turn skin cells into cells that behave like embryonic
stem cells or to harvest stem cells from the pulp of baby teeth. While these and other approaches remain in early stages of development,
they may one day be competitive.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">In addition, cord blood banks such as ViaCord,
a Perkin Elmer company, or LifebankUSA, a Celgene company, easily could enter the field of adult stem cell collection because of
their processing labs, storage facilities and customer lists. We estimate that, combined, there are approximately 75 cord blood
banks in the U.S., approximately 36 of which are private autologous banks, meaning that the donor and recipient are the same, and
approximately 39 of which are public allogeneic banks, meaning that the donor and recipient are not the same. Hospitals that have
transplant centers to serve cancer patients may elect to provide some or all of the services that we provide. According to the
National Marrow Donor Program, there are approximately 52 hospitals in the U.S. with stem cell transplant centers. These competitors
may have better experience and access to greater financial resources than do we. In addition, other established companies may enter
our markets and compete with us. There can be no assurance that we will be able to compete successfully.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">NeoStem Family Storage, LLC will also have
to compete with the national, public cord blood banking program, which has the support of the medical community and which receives
federal funding. In this regard, NeoStem Family Storage, LLC also competes with public cord blood banks such as the New York Blood
Center (National Cord Blood Program), University of Colorado Cord Blood Bank, Milan Cord Blood Bank, Dusseldorf Cord Blood Bank,
and other public cord blood banks around the world. Public cord blood banks provide families with the option of donating their
cord blood for public use at no cost. The Stem Cell Therapeutic Act provides financing for a national system of public cord blood
banks in the United States to encourage cord blood donations from an ethnically diverse population. In addition, many states are
evaluating the feasibility of establishing cord blood repositories for transplantation purposes. An increase in the number and
diversity of publicly available cord blood units from public banks would increase the probability of finding suitably matched cells
for a family member, which may result in a decrease in the demand for private cord blood banking. If the science of human leukocyte
antigens, or HLA, typing advances, then unrelated cord blood transplantation may become safer and more efficacious, similarly reducing
the clinical advantage of related cord blood transplantation. Such events could negatively affect our business and revenues.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">The cell therapy industry is subject to
rapid and intense technological change. Our cell therapy development programs face, and will continue to face, intense competition
from pharmaceutical, biopharmaceutical and biotechnology companies, as well as numerous academic and research institutions and
governmental agencies engaged in drug discovery activities or funding, both in the United States and abroad. Some of these competitors
are pursuing the development of drugs and other therapies that target the same diseases and conditions that we are targeting with
our product candidates, including AMR-001.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Amorcyte&rsquo;s product candidate generally
targets patients without other revascularization options. Therefore, we do not believe that Amorcyte will compete directly with
pharmaceutical therapies being developed to treat less severe stages of our target indications. However, to the extent that therapies
are developed that reverse the progression of the ischemic damage or improve blood flow to damaged tissue, they could have the
effect of reducing demand for Amorcyte's product candidate. In addition, because Amorcyte&rsquo;s product candidate may require
the removal of bone marrow from the patient, potential competing products that do not require this invasive procedure may have
a competitive advantage against Amorcyte products in terms of patient appeal. New pharmaceutical agents or devices that improve
the repair of cardiac injury after a heart attack, with the result that fewer patients develop ischemic heart failure, would also
represent a competitive threat for AMR-001. Furthermore, cell-based therapies, such as skeletal myoblasts, bone marrow-derived
stem cells and adipose cells are being pursued by companies such as Aastrom Biosciences, Inc., Angioblast Systems, Inc., Athersys,
Inc., Pluristem Therapeutics, Inc., ReNeuron Group, Stemedica Cell Technologies Inc. and Bioheart, Inc. Some other companies, such
as Cytori and Miltenyi, are developing devices to facilitate the production of therapeutic cell populations by clinicians for the
treatment of Amorcyte&rsquo;s target indications. Such devices may be approved by the FDA under a less rigorous regulatory process,
and less extensive clinical testing and manufacturing controls than Amorcyte is required to pursue for AMR-001. Development and
approval of such a device on the basis of this more limited dataset may take less time than development of AMR-001 and substantially
affect our ability to market an Amorcyte product candidate if approved.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">As a general matter, our Company may also
face competition in the future from other companies that are researching and developing cell therapies. We are aware of many companies
working in this area. Many of the companies competing against us have financial and other resources substantially greater than
ours. In addition, many of these competitors have significantly greater experience in testing pharmaceutical and other therapeutic
products, obtaining FDA and other regulatory approvals of products, and marketing and selling those products. If we obtain necessary
regulatory approval and commences significant commercial sales of any products, we will also be competing with respect to manufacturing
efficiency and marketing capabilities, areas in which we have limited or no commercial-scale experience. Mergers and acquisitions
in the pharmaceutical and biotechnology industries may result in even more resources being concentrated by our competitors. Competition
may increase further as a result of advances made in the commercial applicability of our technologies and greater availability
of capital for investment in these fields.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">As a result, competitors of ours may:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 0.17in">&nbsp;</TD>
    <TD STYLE="width: 0.2in">&bull;</TD>
    <TD>develop products that are safer or more effective than ours;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>obtain FDA and other regulatory approvals or reach the market with their products more rapidly than we can, reducing the potential sales of our product candidates;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>develop new or improved technologies and scientific advances;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>obtain patent protection that could impact our ability to market our product candidates;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>devote greater resources to market or sell their products;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>initiate or withstand substantial price competition more successfully than we can;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>recruit skilled scientific workers from the limited pool of available talent; and</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>take advantage of acquisition or other opportunities more readily than we can.</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>Building market acceptance of our U.S. autologous adult
stem cell collection, processing and storage services, may be more costly and take longer than we expect. </I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">The success of our U.S. autologous adult
stem cell business depends on continuing and growing market acceptance of our collection, processing and storage services as well
as cell therapy generally. Increasing the awareness and demand for our services requires expenditures for marketing and education
of consumers and medical practitioners who, under present law, must order stem cell collection and treatment on behalf of a potential
customer. The time and expense required to educate and to build awareness of our services and their potential benefits, and about
cell therapy in general, could significantly delay market acceptance and our ultimate profitability. The successful commercialization
of our services will also require that we satisfactorily address the concerns of medical practitioners in order to avoid resistance
to recommendations for our services and ultimately reach our potential consumers. No assurances can be given that our business
plan and marketing efforts will be successful, that we will be able to commercialize our services, or that there will be market
or clinical acceptance of our services by potential customers or physicians, respectively, sufficient to generate any material
revenues for us. To date, only a minimal number of collections have been performed at the collection centers in our network.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>There is a scarcity of experienced professionals in the
field of cell therapy and we may not be able to retain key officers or employees or hire new key officers or employees needed to
implement our business strategy and develop our products and businesses. If we are unable to retain or hire key officers or employees,
we may be unable to continue to grow this business or to implement our business strategy, and our business may be materially and
adversely affected. </I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Given the specialized nature of cell therapy
and the fact that it is a young field, there is an inherent scarcity of experienced personnel in the field. The Company is substantially
dependent on the skills and efforts of current senior management for their management and operations, as well as for the implementation
of their business strategy. As a result of the difficulty in locating qualified new management, the loss or incapacity of existing
members of management or unavailability of qualified management or as replacements for management who resign or are terminated
could adversely affect the Company&rsquo;s operations. The future success of the Company also depends upon our ability to attract
and retain additional qualified personnel (including medical, scientific, technical, commercial, business and administrative personnel)
necessary to support our anticipated growth, develop our business, perform our contractual obligations to third parties and maintain
appropriate licensure, on acceptable terms. For instance, we expect to hire a Vice President of Clinical Development and Regulatory
Affairs. There can be no assurance that we will be successful in attracting or retaining personnel required by us to continue to
grow our operations. The loss of a key employee, the failure of a key employee to perform in his or her current position or our
inability to attract and retain skilled employees, as needed, could result in our inability to continue to grow our business or
to implement our business strategy, or may have a material adverse effect on our business, financial condition and operating results.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>Current cell therapy products have a limited biologic
shelf life as a result of which there are constraints on transit times between the time stem cells are extracted from a patient
and the time that a processed product leaves our facility and arrives for re-infusion in the patient. Thus, our current business
model has to assume that, in order to effectively provide many of our services in a market, we need to have a suitable facility
that can provide timely service in such market. This could add significantly to our capital requirements and be a limiting factor
on our future growth and profitability. </I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Current cell therapy products have a limited
shelf life, in certain instances limited to less than 12 hours. Thus, there are constraints on transit times between the time the
cell product is extracted from a patient and the product arrives at one of our facilities for processing, as well as constraints
on the time that a processed product leaves our facility and arrives for re-infusion in the patient. Therefore, cell therapy facilities
need to be located in major population centers in which patients of the cell therapy products are likely to be located and within
close proximity of major airports from which they can be timely delivered. Building new facilities requires significant commitments
of time and capital, which we may not have available in a timely manner. Even if such new facilities are established, there may
be challenges to ensuring that they are compliant with cGMP, other FDA requirements, and/or applicable state or local regulatory
requirements. We cannot be certain that we would be able to recoup the costs of establishing a facility and attaining regulatory
compliances in a given market. Thus, the limited biologic shelf life of cell therapy products is a hindrance on the rate at which
we can expand our cell processing and manufacturing services into new geographic markets and requires significant capital risk
by us, which we may or may not be able to recover.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>Commercially available transportation systems are not
set up for shipment of biological or other perishable goods and may not be able to meet the demands of the emerging cell therapy
market. To succeed, the large-scale commercialization of cell therapy products will need to overcome the present weaknesses of
the major air carriers. </I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Weaknesses in our existing transportation
carriers include the lack of a true point-to-point chain of control, non-controlled X-ray and inspection, no guarantee of package
orientation, handling or storage conditions and in many cases no standard, documented and tracked operating procedures. While reliable
ground carriers with experience in the transport of blood products already exist in major metropolitan areas of the country, air
carriers meeting such needs are limited. We evaluated the major domestic express carriers, and concluded that even their highest-level
services are inadequate to meet the sector&rsquo;s needs. However, we identified and validated only one specialty air carrier as
a transportation partner, which specializes in shipping medical products, including whole blood and blood products, tissue for
transplantation, and diagnostic specimens. There are presently few alternative sources for the safe transportation of cell therapy
products. If this carrier should cease its medical shipping operations or otherwise be unable to properly meet our transportation
needs, the lack of access to safe and effective transportation options could adversely affect our business.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>We may be subject to significant product liability claims
and litigation, including potential exposure from the use of our Amorcyte subsidiary&rsquo;s product candidates in human subjects,
and our insurance may be inadequate to cover claims that may arise. </I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Our business exposes us to potential product
liability risks inherent in the testing, processing and marketing of cell therapy products. Such liability claims may be expensive
to defend and result in large judgments against us. We face an inherent risk of product liability exposure related to the testing
of AMR-001 and any future product candidates in human clinical trials and will face an even greater risk if we commercially sell
any products that we may develop following requisite approvals therefor. No product candidate has been widely used over an extended
period of time, and therefore safety data is limited. Cell therapy companies derive the raw materials for manufacturing of product
candidates from human cell sources, and therefore the manufacturing process and handling requirements are extensive, which increases
the risk of quality failures and subsequent product liability claims. We presently have product liability insurance limited to
$5 million per incident and $5 million in annual aggregate. In connection with the launch of our Phase 2 clinical trial of AMR-001,
a clinical trial endorsement was added to our product liability policy, including Amorcyte as an additional insured.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">We will need to increase our insurance
coverage when we begin commercializing product candidates, if ever. If and when any product enters the commercialization phase,
we may not be able to obtain or maintain product liability insurance on acceptable terms with adequate coverage or at all. If we
are unable to obtain and maintain adequate insurance, or if claims against us substantially exceed our coverage, then our financial
position could be significantly impaired.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Whether or not we are ultimately successful
in any product liability litigation that may arise, such litigation could consume substantial amounts of our financial and managerial
resources and could result in:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 0.17in">&nbsp;</TD>
    <TD STYLE="width: 0.2in">&bull;</TD>
    <TD>decreased demand for any products or product candidates we may develop;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>significant awards against us;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>substantial litigation costs;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>injury to our reputation; and</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>withdrawal of clinical trial participants.</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12pt">We also maintain errors and omissions, directors
and officers, workers&rsquo; compensation and other insurance appropriate to our business activities. If we were to be subject
to a claim in excess of this coverage or to a claim not covered by our insurance and the claim succeeded, we would be required
to pay the claim from our own limited resources, which could have a material adverse effect on our financial condition, results
of operations and business. Additionally, liability or alleged liability could harm our business by diverting the attention and
resources of our management and damaging our reputation and that of our subsidiaries.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="text-transform: uppercase"><B>Risks
Related to Government Regulation</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>We operate in a highly regulated environment and may be
unable to comply with applicable federal and state regulations, registrations and approvals or the standards of private accrediting
entities. Failure to comply with applicable licensure, registration, certification, and accreditation standards may result in loss
of licensure, certification or accreditation or other government enforcement actions. </I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Facilities engaged in the recovery, processing,
storage, labeling, packaging or distribution of any HCT/Ps, or the screening or testing of a donor, are required to register with
the FDA. Any third party retained by us to process our samples must be similarly registered with the FDA and comply with HCT/P
regulations. We and any third-party processors are also required to comply with FDA&rsquo;s cGTP regulations. If we, or any third-party
processors, fail to register or update registration information in a timely way, or fail to comply with cGTP regulations, we will
be out of compliance with FDA regulations which could adversely affect our business. Adverse events or other considerations in
the field of stem cell therapy that may occur could result in greater governmental regulation of our business, creating increased
expenses for our stem cell collection and storage services.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Our manufacture of certain cellular therapy
products for ourselves or on behalf of our customers triggers additional FDA requirements applicable to HCT/Ps, or products comprised
of HCT/Ps, which are regulated as a drug, biological product, or medical device. FDA or cGMP, are federal regulations that govern
the manufacture, processing, packaging and holding of cell therapy products regulated as drugs. FDA&rsquo;s Quality System Regulation,
or QSR, similarly govern the manufacture, processing, packaging and holding of cell therapy products regulated as medical devices.
We must comply with cGMP or QSR requirements including quality control, quality assurance and the maintenance of records and documentation
for certain products. We may be unable to comply with these cGMP or QSR requirements and with other FDA, state and foreign regulatory
requirements. These requirements may change over time and we or third-party manufacturers may be unable to comply with the revised
requirements.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">We also are subject to state and federal
laws regulating the proper disposal of biohazardous materials. Although we believe we are currently in compliance with all such
applicable laws, a violation of such laws, or the future enactment of more stringent laws or regulations, could subject us to liability
for noncompliance and may require us to incur significant costs.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Some states impose additional regulation
and oversight on clinical laboratories and stem cell laboratories operating within their borders and impose regulatory compliance
obligations on out-of-state laboratories providing services to their residents. Many of the states in which we, our strategic partners
or members of our collection network, engage in collection, processing or storage activities have licensing requirements with which
we must comply. Additionally, there may be state regulations affecting the use of HCT/Ps that would affect our business. Certain
licensing requirements require employment of medical directors and others with certain training and technical backgrounds and there
can be no assurance that such individuals can be retained or will remain retained or that the cost of retaining such individuals
will not materially and adversely affect our ability to market or perform our services or our ability to do so profitably. There
can be no assurance that we, our strategic partners or members of our collection center network, will be able to obtain or maintain
any necessary licenses required to conduct business in any states or that the cost of compliance will not materially and adversely
affect our ability to market or perform our services or our ability to do so profitably.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Currently, PCT is licensed as a blood bank
with respect to its activities in New Jersey, as a tissue bank with respect to its activities in New York and as a drug manufacturer
with respect to its facility in California. We believe that PCT and NeoStem Family Storage, LLC are in material compliance with
current federal, state, and local stem cell laboratory licensure requirements. However, the licensing requirements in the states
where we are currently licensed may change, and PCT and/or NeoStem Family Storage, LLC may become subject to the additional licensing,
registration and/or compliance requirements of other states, local governments and/or the federal government as PCT and/or NeoStem
Family Storage, LLC expands its network and as new regulations are implemented. If we fail to comply with the various licensure
requirements, certification and accreditation standards to which we are subject, we may be subject to a loss of licensure, certification,
or accreditation that could adversely affect them.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Additionally, certain private entities
have promulgated standards for certification, accreditation and licensing of cord blood businesses that may apply to our operations.
These organizations include, but may not be limited to, AABB, formerly the American Association of Blood Banks, the Foundation
for the Accreditation of Cellular Therapy (FACT), and the American Association of Tissue Banks (AATB). While our compliance with
the standards of these organizations currently are voluntary, in some cases compliance with such standards may be necessary for
a cord blood business to be accepted and competitive in the marketplace. Compliance with these standards and obtaining the applicable
accreditation, certification, or license from such private organizations can be costly and time-consuming. These accreditation,
certification, or license requirements may also change and new standards may be developed. If we fail to comply with applicable
standards, or fail to obtain or maintain applicable accreditations, certifications, or licenses, our business may be adversely
affected.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">There can be no assurance that we will
be able, or will have the resources, to continue to comply with regulations that govern our operations currently, or that we will
be able to comply with any new regulations that may govern our operations, or that the cost of compliance will not materially and
adversely affect our ability to market or perform our services or our ability to do so profitably. Failure to comply with these
requirements may result in fines and civil or criminal penalties, suspension of production, suspension or delay in product approval,
product seizure or recall, or withdrawal of product approval. If the safety of any materials supplied by third parties is compromised
due to their failure to adhere to applicable laws or for other reasons, we may not be able to obtain regulatory approval for, or
successfully commercialize, product candidates that we may develop.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>Our adult stem cell collection, processing and storage
business was not contemplated by many existing laws and regulations, and our ongoing compliance, therefore, is subject to interpretation
and risk. </I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Our adult stem cell collection, processing
and storage service is not a medical treatment, although it involves medical procedures. Our stem cell-related business is relatively
new and is not addressed by many of the regulations applicable to our field. As a result, there is often considerable uncertainty
as to the applicability of regulatory requirements. Although we have devoted significant resources to ensuring compliance with
those laws that we believe to be applicable, it is possible that regulators may disagree with our interpretations, prompting additional
compliance requirements or even enforcement actions.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">We believe that the adult stem cells collected,
processed and stored through our collection services are properly classified under the FDA&rsquo;s human cells, tissues and cellular-
and tissue-based products, or HCT/P, regulatory paradigm but should not be classified as a medical device, biologic or drug. There
can be no assurance that the FDA will not classify the adult stem cells collected, processed and stored through our collection
services as a medical device, biologic or drug. Any such classification could have adverse consequences for us and make it more
difficult or expensive for us to conduct our business by requiring regulatory clearance, approval and/or compliance with additional
regulatory requirements.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">The costs of compliance with such additional
requirements or such enforcement may have a material adverse effect on our operations or may require restructuring of our operations
or impair our ability to operate profitably.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>If we or any of our investigators are not able to conduct
the clinical trials of our product candidates in accordance with regulations and accepted standards, and on schedule, regulatory
approval by the FDA and other regulatory authorities may be delayed or denied. </I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">To obtain marketing approvals for our product
candidates in the United States, we must, among other requirements, complete adequate and well-controlled clinical trials sufficient
to demonstrate to the FDA that the product candidate is safe and effective, for each indication for which approval is sought. Several
factors could prevent completion or cause significant delay of these trials, including an inability to enroll the required number
of patients. Negative or inconclusive results from, or serious adverse events during, a clinical trial could cause the clinical
trial to be repeated or a development program to be terminated, even if other studies or trials relating to the program are successful.
A serious adverse event is an event that results in significant medical consequences, such as hospitalization, disability or death,
and must be reported to the FDA. We cannot predict whether safety concerns regarding our product candidates will or will not develop.
The FDA can place a clinical trial on hold if, among other reasons, it finds that patients enrolled in the trial are or would be
exposed to an unreasonable and significant risk of illness or injury. If safety concerns develop, we may, or the FDA or an institutional
review board may require us to, stop the affected trials before completion.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">One subject in the AMR-001 Phase 1 study
died from ventricular fibrillation soon after infusion of the product candidate AMR-001. The ventricular fibrillation was attributed
to recurrent myocardial infarction from stent thrombosis preceding AMR-001 infusion. This subject&rsquo;s death resulted in a clinical
hold during the Phase 1 trial. The hold was removed upon FDA&rsquo;s review of the complete documentation on the patient and changes
to the enrollment process that were submitted by Amorcyte.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">The completion of our clinical trials may
be delayed or terminated for many reasons, including if:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 0.17in">&nbsp;</TD>
    <TD STYLE="width: 0.2in">&bull;</TD>
    <TD>the FDA or other regulatory authority does not grant permission to proceed and places the trial on clinical hold;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>subjects do not enroll in our clinical trials at the rate expected;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>subjects experience an unacceptable rate or severity of adverse side effects;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>third-party clinical investigators do not perform the clinical trials on the anticipated schedule or consistent with the clinical trial protocol, good clinical practices required by the FDA and other regulatory requirements, or other third parties do not perform data collection and analysis in a timely or accurate manner;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>inspections of clinical trial sites by the FDA or by institutional review boards of research institutions participating in the clinical trials, reveal regulatory violations that require the sponsor of the trial to undertake corrective action, suspend or terminate one or more sites, or prohibit use of some or all of the data in support of marketing applications; or</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>the FDA or one or more institutional review boards suspends or terminates the trial at an investigational site, or precludes enrollment of additional subjects.</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Our development costs will increase if
there are material delays in our clinical trials, or if we are required to modify, suspend, terminate or repeat a clinical trial.
If we are unable to conduct our clinical trials properly and on schedule, marketing approval may be delayed or denied by the FDA.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>Any product for which we obtain marketing approval will
be subject to extensive ongoing regulatory requirements, and we may be subject to penalties if we fail to comply with regulatory
requirements or if we experience unanticipated problems with our products, when and if any of them are approved. </I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Products for which we obtain marketing
approval, if any, including the manufacturing processes, post-approval clinical data, adverse event reporting, labeling, advertising
and promotional activities for such product, will be subject to continual requirements of and review by, the FDA and comparable
regulatory authorities. These requirements include submissions of safety and other post-marketing information and reports, registration
requirements, cGMP and cGTP requirements relating to quality control, quality assurance and corresponding maintenance of records
and documents, requirements relating to product labeling, advertising and promotion, and recordkeeping. Even if a product candidate
receives regulatory approval, the approval may be subject to additional limitations on the indicated uses for which the product
may be marketed or to other conditions of approval. In addition, approval may contain requirements for costly post-marketing testing
and surveillance to monitor the safety or efficacy of the product. Discovery after approval of previously unknown problems with
a product, manufacturer or manufacturing process, or failure to comply with regulatory requirements, may result in actions such
as:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 0.17in">&nbsp;</TD>
    <TD STYLE="width: 0.2in">&bull;</TD>
    <TD>changes in product manufacturing processes;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>restrictions on product marketing;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>restrictions on product distribution;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>requirements to conduct post-marketing clinical trials;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-left: 0.1in; text-indent: -0.1in">&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>warning letters;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-left: 0.1in; text-indent: -0.1in">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>withdrawal of a product from the market;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>refusal to approve pending applications or supplements to approved applications that we submit;</TD></TR>
</TABLE>

<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="margin: 0"></P>

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<P STYLE="margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 0.17in">&nbsp;</TD>
    <TD STYLE="width: 0.2in">&bull;</TD>
    <TD>recall of products;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>fines, restitution or disgorgement of profits or revenue;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>suspension or withdrawal of regulatory approvals;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>refusal to permit the import or export of our products;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>product seizure;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>injunctions; or</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>imposition of civil or criminal penalties.</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>Failure to obtain regulatory approval in international
jurisdictions would prevent us from marketing products abroad. </I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">We may in the future seek to market AMR-001
or other product candidates outside the United States. In order to market such product candidates in the European Union and many
other jurisdictions, we must submit clinical data concerning our product candidates and obtain separate regulatory approvals and
comply with numerous and varying regulatory requirements. The approval procedure varies among countries and can involve additional
testing. The time required to obtain approval from foreign regulators may be longer than the time required to obtain FDA approval.
The regulatory approval process outside the United States may include all of the risks associated with obtaining FDA approval.
In addition, in many countries outside the United States, it is required that the product candidate be approved for reimbursement
before it can be approved for sale in that country. In some cases this may include approval of the intended price to be charged
for the product, if approved. We may not obtain approvals from regulatory authorities outside the United States on a timely basis,
or at all. Approval by the FDA does not ensure approval by regulatory authorities in other countries or jurisdictions, and approval
by one regulatory authority outside the United States does not ensure approval by regulatory authorities in other countries or
jurisdictions or by the FDA, but a failure or delay in obtaining regulatory approval in one country may negatively affect the regulatory
process in other countries. We may not be able to file for regulatory approvals and may not receive necessary approvals to commercialize
any products in any market and therefore may not be able to generate sufficient revenues to support our business.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>Our business involves the use of hazardous materials that
could expose our Company to environmental and other liability. </I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Our PCT facility located in Allendale,
New Jersey is subject to various local, state and federal laws and regulations relating to safe working conditions, laboratory
and manufacturing practices and the use and disposal of hazardous or potentially hazardous substances, including chemicals, micro-organisms
and various radioactive compounds used in connection with Amorcyte&rsquo;s research and development activities. In the United States,
these laws include the Occupational Safety and Health Act, the Toxic Test Substances Control Act and the Resource Conservation
and Recovery Act. No assurances can be given that accidental contamination or injury to employees, service providers and third
parties from hazardous materials will not occur. We do not have insurance to cover claims arising from our use and disposal of
these hazardous substances. Our insurance program does not include environmental coverage.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>Any regulatory exclusivity that we may obtain upon approval
of AMR-001 or any other product candidates may not adequately protect our future products; accordingly, others could compete against
us more directly. </I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Our success will depend in part on our
ability to obtain and maintain the regulatory exclusivity provided by the Public Health Service Act upon approval by the FDA of
a biologics license application, or BLA, for Amorcyte product candidates or other product candidates, if any. This regulatory exclusivity
is new, involves complex legal and factual questions and will likely be the subject of much litigation, and court decisions may
introduce uncertainty in the enforceability or scope of regulatory exclusivity provided to an approved biologic product. Therefore,
enforceability or scope of any regulatory exclusivity for an approved biologic product in the United States cannot be predicted
with certainty, and may not provide sufficient protection against competitors.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>The Health Insurance Portability and Accountability Act
of 1996, or HIPAA, requires that our business comply with state and federal privacy laws which increase the cost and administrative
burden of providing stem cell banking services. </I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">We are subject to state and federal privacy
laws related to the protection of our customers&rsquo; personal health information and state and federal laws related to the security
of such personal health information and other personal data to which we would have access through the provision of our services.
We are obligated to comply with privacy and security standards adopted under HIPAA, as amended by the Health Information Technology
for Economic and Clinical Health Act of 2009 (the &ldquo;HITECH Act&rdquo;). As a result of the HITECH Act, our compliance burden
has increased, and we will be subject to audit and enforcement by the federal government and, in some cases, enforcement by state
authorities. We may also be obligated to publicly disclose wrongful disclosures or losses of personal health information. We may
be required to spend substantial amounts of time and money to comply with these requirements, any regulations and licensing requirements,
as well as any future legislative and regulatory initiatives. Failure by us or our business partners to comply with these or other
applicable regulatory requirements or any delay in compliance may result in, among other things, injunctions, operating restrictions,
and civil fines and criminal prosecution and have a material adverse effect on the marketing and sales of our services and our
ability to operate profitably or at all.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>We, our strategic partners and our customers conduct business
in a heavily regulated industry. If we or one or more of our strategic partners or customers fail to comply with applicable current
and future laws and government regulations, our business and financial results could be adversely affected. </I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">The healthcare industry is one of the most
highly regulated industries in the United States. The federal government, individual state and local governments and private accreditation
organizations all oversee and monitor the activities of individuals and businesses engaged in the delivery of health care products
and services. Current laws, rules and regulations that could directly or indirectly affect our ability and the ability of our strategic
partners and customers to operate each of their businesses could include, without limitation, the following:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 0.17in">&nbsp;</TD>
    <TD STYLE="width: 0.2in">&bull;</TD>
    <TD>State and local licensure, registration and regulation of laboratories, the collection, processing and storage of human cells and tissue and cord blood, and the development and manufacture of pharmaceuticals and biologics;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>The federal Clinical Laboratory Improvement Amendments;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>Laws and regulations administered by the FDA, including the Federal Food, Drug, and Cosmetic Act and related laws and regulations;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>The Public Health Service Act and related laws and regulations;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>Laws and regulations administered by the United States Department of Health and Human Services, including the Office for Human Research Protections;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>State laws and regulations governing human subject research;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>Occupational Safety and Health requirements;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>State and local laws and regulations dealing with the handling and disposal of medical waste;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>The federal Medicare and Medicaid Anti-Kickback Law and similar state laws and regulations;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>Federal and state coverage and reimbursement laws and regulations, including laws and regulations administered by the Centers for Medicare &amp; Medicaid Services;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&bull;</TD>
    <TD>The federal Health Insurance Portability and Accountability Act of 1996 (&ldquo;HIPAA&rdquo;), including the amendments included in the American Recovery and Reinvestment Act of 2009, commonly known as the HITECH Act, and regulations promulgated thereunder;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>
<P STYLE="margin: 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD>The federal physician self-referral prohibition, commonly known as the Stark Law, and state equivalents of the Stark Law;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD>State funding decisions on stem cell research and the development of cellular therapies; and</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD>The Intermediate Sanctions rules of the IRS providing for potential financial sanctions with respect to &ldquo;Excess Benefit
Transactions&rdquo; with HUMC or other tax-exempt organizations.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">In addition, as we expand into other parts
of the world, we will need to comply with the applicable laws and regulations in such foreign jurisdictions. We have not yet thoroughly
explored the requirements or feasibility of such compliance. It is possible that we may not be permitted to expand our business
into one or more foreign jurisdictions.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">Although we intend to conduct our business
in compliance with applicable laws and regulations and believe that we are in material compliance with applicable governmental
healthcare laws and regulations, the laws and regulations affecting our business and relationships are complex, and many aspects
of such relationships have not been the subject of judicial or regulatory interpretation. Furthermore, the cell therapy industry
is the topic of significant government interest, and thus the laws and regulations applicable to us and our strategic partners
and customers and to their business are subject to frequent change and/or reinterpretation and there can be no assurance that the
laws and regulations applicable to us and our strategic partners and customers will not be amended or interpreted in a manner that
adversely affects our business, financial condition, or operating results. For example, the federal government could issue tighter
restrictions on private cord blood banking that prevents NeoStem Family Storage, LLC from collecting cord blood for private banking.
While we are not aware of any such developments or that any court or federal or state government is reviewing our operations, it
is possible that such a review could result in a determination that would have a material adverse effect on our business, financial
condition and operating results. Thus, there can be no assurance that we and our strategic partners and customers will be able
to maintain compliance with all such healthcare laws and regulations. Failure to comply with such healthcare laws and regulations,
as well as the costs associated with such compliance or with enforcement of such healthcare laws and regulations, may have a material
adverse effect on our operations or may require restructuring of our operations or impair our ability to operate profitably.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>It is uncertain to what extent the government, private
health insurers and third-party payors will approve coverage or provide reimbursement for the therapies and products to which our
services relate. Availability for such reimbursement may be further limited by an increasing uninsured population and reductions
in Medicare and Medicaid funding in the United States.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">To the extent that the health care provider
customers cannot obtain coverage or reimbursement for our therapies and products, they may elect not to provide such therapies
and products to their patients and, thus, may not need our services. Further, as cost containment pressures are increasing in the
health care industry, government and private payors adopt strategies designed to limit the amount of reimbursement paid to health
care providers. Such cost containment measures may include:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD>Reducing reimbursement rates;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD>Challenging the prices charged for medical products and services;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD>Limiting services covered;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD>Decreasing utilization of services;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD>Negotiating prospective or discounted contract pricing;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD>Adopting capitation strategies; and</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD>Seeking competitive bids.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Similarly, the trend toward managed health
care and bundled pricing for health care services in the United States, which may accelerate under the health reform legislation
approved by Congress on March 23, 2010 and thereafter signed into law (&ldquo;Health Reform&rdquo;), could significantly influence
the purchase of healthcare services and products, resulting in lower prices and reduced demand for our therapeutic products under
development.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">We may receive a portion of our revenues
from services rendered to patients enrolled in federal health care programs, such as Medicare, and we may also directly or indirectly
receive revenues from federal health care programs. Federal health care programs are subject to changes in coverage and reimbursement
rules and procedures, including retroactive rate adjustments. These contingencies could materially decrease the range of services
covered by such programs or the reimbursement rates paid directly or indirectly for our products and services. To the extent that
any health care reform favors the reimbursement of other therapies over our therapeutic products under development, such reform
could affect our ability to sell our services, which may have a material adverse effect on our revenues.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">The limitation on reimbursement available
from private and government payors may reduce the demand for, or the price of, our services, which could have a material adverse
effect on our revenues. Additional legislation or regulation relating to the health care industry or third-party coverage and reimbursement
may be enacted in the future which could adversely affect the revenues generated from the sale of our products and services.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">Furthermore, there has been a trend in
recent years towards reductions in overall funding for Medicare and Medicaid. There has also been an increase in the number of
people who do not have any form of health care coverage in recent years and who are not eligible for or enrolled in Medicare, Medicaid
or other governmental programs. The extent to which the reforms brought about under Health Reform may be successful in reducing
the number of such uninsured is unclear, and the reduced funding of governmental programs and increase in uninsured populations
could have a negative impact on the demand for our services to the extent they relate to products and services which are reimbursed
by government and private payors.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>Health care companies have been the subjects of federal
and state investigations, and we could become subject to investigations in the future.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Both federal and state government agencies
have heightened civil and criminal enforcement efforts. There are numerous ongoing investigations of health care companies, as
well as their executives and managers. In addition, amendments to the Federal False Claims Act, including under Health Reform,
have made it easier for private parties to bring &ldquo;<I>qui tam</I>&rdquo; (whistleblower) lawsuits against companies under
which the whistleblower may be entitled to receive a percentage of any money paid to the government. The Federal False Claims Act
provides, in part, that an action can be brought against any person or entity that has knowingly presented, or caused to be presented,
a false or fraudulent request for payment from the federal government, or who has made a false statement or used a false record
to get a claim approved. The government has taken the position that claims presented in violation of the federal anti-kickback
law, Stark Law or other healthcare-related laws, including laws enforced by the FDA, may be considered a violation of the Federal
False Claims Act. Penalties include substantial fines for each false claim, plus three times the amount of damages that the federal
government sustained because of the act of that person or entity and/or exclusion from the Medicare program. In addition, a majority
of states have adopted similar state whistleblower and false claims provisions.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">We are not aware of any government investigations
involving any of our facilities or management. While management believes that we are in material compliance with applicable governmental
healthcare laws and regulations, any future investigations of our business or executives could cause us to incur substantial costs,
and result in significant liabilities or penalties, as well as damage to our reputation.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>Unintended consequences of recently adopted health reform
legislation in the U.S. may adversely affect our business.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">The healthcare industry is undergoing
fundamental changes resulting from political, economic and regulatory influences. In the U.S., comprehensive programs are under
consideration that seek to, among other things, increase access to healthcare for the uninsured and control the escalation of healthcare
expenditures within the economy. On March 23, 2010, health reform legislation was approved by Congress and has been signed into
law. While we do not believe this legislation will have a direct impact on our business, the legislation has only recently been
enacted and requires the adoption of implementing regulations, which may have unintended consequences or indirectly impact our
business. For instance, the scope and implications of the recent amendments pursuant to the Fraud Enforcement and Recovery Act
of 2009 (&ldquo;FERA&rdquo;), have yet to be fully determined or adjudicated and as a result it is difficult to predict how future
enforcement initiatives may impact our business. Also, in some instances our clients may be health insurers that will be subject
to limitations on their administrative expenses and new federal review of &ldquo;unreasonable&rdquo; rate increases which could
impact the prices they pay for our services. If the legislation causes such unintended consequences or indirect impact, it could
have a material adverse effect on our business, financial condition and results of operations.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>Legislation regarding the establishment and funding of
public cord blood collection and storage may adversely affect the business of NeoStem Family Storage, LLC.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">The Stem Cell Therapeutic and Research
Act of 2005 established requirements for a national donor bank of cord blood and for a national network for matching cord blood
to patients. The federal government has entered into contracts with the National Marrow Donor Program (NMDP) to carry out the provisions
of this legislation. Under these contracts, the NMDP acts as the nation&rsquo;s Cord Blood Coordinating Center and actively recruits
parents for cord blood donations. The NMDP also administers the National Cord Blood Inventory (NCBI), which has a goal of collecting
150,000 cord blood units that may be used for patients throughout the United States. The legislation also authorized federal funding
to support its goals and requirements. Parents may opt to donate their newborn&rsquo;s cord blood to the public registry and to
use the public registry if stem cells from cord blood are needed for treatment purposes. In this regard, an important advantage
of the national, public cord blood collection system is that it costs nothing for patients to donate their cord blood. This national,
public cord blood registry has also been widely accepted and supported by the medical community, so physicians and others in the
health care community may be less willing to use or recommend a private cord blood facility when public collection is available.
Additionally, major medical organizations, including the American Academy of Pediatrics (AAP), the American Medical Association
(AMA), the American College of Obstetricians and Gynecologists (ACOG), and the American Society of Blood and Marrow Transplantation
(ASBMT) do not recommend private storage, except in very limited instances. Further, we believe that the medical community is currently
supportive of public cord blood donation and the national cord blood registry that is administered by the National Marrow Donor
Program. For these reasons, a significant number of patients may choose to use to donate their cord blood to the national, public
cord registry instead of privately banking cord blood. The medical community could also issue stronger recommendations and opinions
that favor the use of the national registry. Therefore, the existence and proliferation of the national registry may adversely
affect our business.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>Our success in developing future therapeutics will depend
in part on establishing and maintaining effective strategic partnerships and collaborations, which may impose restrictions on our
business and subject us to additional regulation.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">A key aspect of our business strategy is
to establish strategic relationships in order to gain access to critical supplies, to expand or complement our research and development
or commercialization capabilities, and to reduce the cost of research and development. There can be no assurance that we will enter
into such relationships, that the arrangements will be on favorable terms or that such relationships will be successful. If any
of our research partners terminate their relationship with us or fail to perform their obligations in a timely manner, our research
and development activities or commercialization of our services may be substantially impaired or delayed.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">Relationships with licensed professionals
such as physicians may be subject to state and federal laws restricting the referral of business, prohibiting certain payments
to physicians, or otherwise limiting such collaborations. If our services become approved for reimbursement by government or private
insurers, we could be subject to additional regulation and perhaps additional limitations on our ability to structure relationships
with physicians. Additionally, state regulators may impose restrictions on the business activities and relationships of licensed
physicians or other licensed professionals. For example, many states restrict or prohibit the employment of licensed physicians
by for-profit corporations, or the &ldquo;corporate practice of medicine.&rdquo; If we fail to structure our relationships with
physicians in accordance with applicable laws or other regulatory requirements, it could have a material adverse effect on our
business. Even if we do enter into these arrangements, we may not be able to maintain these relationships or establish new ones
in the future on acceptable terms.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="text-transform: uppercase"><B>Risks
Related to Our Intellectual Property</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>There is significant uncertainty about the validity and
permissible scope of patents in the biotechnological industry and we may not be able to obtain patent protection. If our patent
position does not adequately protect our product candidates or any future products, others could compete against us more directly,
which would harm our businesses.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">We own or hold exclusive rights to over
30 issued patents and over 80 pending patent applications. In January 2012, the U.S. Patent Office granted Amorcyte U.S. Patent
No. 8,088,370 which expands the breadth of AMR-001 protection to include all treatments of vascular injury caused by vascular insufficiency.
Given the nature of our therapeutic programs, our patents and patent applications cover certain methods of isolating, storing and
using stem cells, including very small embryonic stem cells, as well as compositions and methods relating to T regulatory cells.
There can be no assurance that the patent applications to which we hold rights will result in the issuance of patents, or that
any patents issued or licensed to us will not be challenged and held to be invalid or of a scope of coverage that is different
from what we believe the patent&rsquo;s scope to be. Our success will depend, in part, on whether we can: obtain patents to protect
our own products and technologies; obtain licenses to use the technologies of third parties if necessary, which may be protected
by patents; and protect our trade secrets and know-how. Our inability to obtain and rely upon patents essential to our business
may have a material adverse effect on our business, operating results and financial condition.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Our ability to successfully commercialize
AMR-001, or any other product candidate, depends in large part on our ability to obtain and maintain patent protection for our
product candidates. Issued patents may be challenged by third parties, resulting in patents being invalidated, rendered unenforceable,
narrowed in scope, or enabling a third party to circumvent any such issued patents. The patent position of biotechnology companies
is generally highly uncertain, involves complex legal and factual questions and has been the subject of much litigation and recent
court decisions introducing uncertainty in the strength of patents owned by biotechnology companies. The legal systems of some
foreign countries do not favor the aggressive enforcement of patents, and the laws of foreign countries may not protect our rights
to the same extent as the laws of the United States. Therefore, any patents that we own or license may not provide sufficient protection
against competitors.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">The claims of the issued patents, and the
claims of any patents which may issue in the future and be owned by or licensed to us, may not confer on us significant commercial
protection against competing products. Also, any pending patent applications may not issue, and we may not receive any additional
patents. The patents might not contain claims that are sufficiently broad to prevent others from utilizing the covered technologies.
For instance, patents relating to our AMR-001 product candidate are limited to an isolated and nonexpanded population of autologous
mononuclear cells enriched for CD34<SUP>+</SUP> cells, which further contains a subpopulation of potent CD34<SUP>+</SUP>/CXCR4<SUP>+</SUP>
cells that have CXCR4-mediated chemotactic activity. Products that do not contain enriched CD34<SUP>+</SUP>/CXCR4<SUP>+</SUP> cells,
or which contain populations of cells that derive efficacy from a different mechanism of action, may not infringe the existing
AMR-001 patents.<B> </B>Consequently, our competitors may independently develop competing products that do not infringe our patents
or other intellectual property. To the extent a competitor can develop similar products using a different chemistry, these patents
will not prevent others from directly competing with us.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Because of the extensive time required
for development, testing and regulatory review of a potential product, it is possible that, before any product candidate can be
commercialized, any related patent may expire or remain in force for only a short period following commercialization of such product
candidate, thereby reducing any advantages of the patent. For instance, one of the patents issued to our Amorcyte subsidiary relating
to its technology will expire in 2028, subject to extension of the patent term for regulatory delay for any approved product for
which Amorcyte is eligible. To the extent our product candidates based on that technology are not commercialized significantly
ahead of this date, or to the extent we have no other patent protection on such product candidates, those product candidates would
not be protected by patents beyond 2028 and we would then rely solely on other forms of exclusivity, such as regulatory exclusivity
provided by the Federal Food, Drug and Cosmetic Act, which may provide less protection of our competitive position.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">Similar considerations apply in any other
country where we are prosecuting patents, have been issued patents, or have licensed patents or patent applications relating to
its technology. The laws of foreign countries may not protect intellectual property rights to the same extent as do laws of the
United States.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>We may be unable to protect our intellectual property
from infringement by third parties. We may become involved in lawsuits to protect or enforce patents (including the patents of
potential collaborators or licensors), which could be expensive and time consuming.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">Despite our efforts to protect our intellectual
property, third parties may infringe or misappropriate our intellectual property, including infringement of patents held by, or
the patents of the respective potential collaborators or licensors of, our Amorcyte subsidiary. Our competitors may also independently
develop similar technology, duplicate our processes or services or design around our intellectual property rights. We may have
to litigate to enforce and protect our intellectual property rights to determine their scope, validity or enforceability. Intellectual
property litigation is costly, time-consuming, diverts the attention of management and technical personnel and could result in
substantial uncertainty regarding our future viability. The loss of intellectual property protection or the inability to secure
or enforce intellectual property protection would limit our ability to develop or market our services in the future. This would
also likely have an adverse effect on the revenues generated by any sale or license of such intellectual property. Furthermore,
any public announcements related to such litigation or regulatory proceedings could adversely affect the price of our Common Stock.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">As a result of any infringement of our
intellectual property, we may be required to file infringement claims to counter infringement or unauthorized use. The cost of
any patent litigation or other proceeding, even if resolved in our favor, could be substantial. Some of our competitors may be
able to sustain the costs of such litigation or proceedings more effectively than we can because of their substantially greater
financial resources. Patent litigation and other proceedings may also absorb significant management time. In addition, in an infringement
proceeding, a court may decide that a patent is not valid or is unenforceable, or may refuse to stop the other party from using
the technology at issue on the grounds that patents used by us do not cover our technology. An adverse determination of any litigation
or defense proceedings could put one or more of such patents at risk of being invalidated or interpreted narrowly and could put
patent applications at risk of not issuing. Our Amorcyte subsidiary is aware of several companies that are employing stem cell
sorting technology in their research and product development efforts. If these companies commercialize products that use cell sorting
technology similar to Amorcyte&rsquo;s, there can be no assurance that we would have a basis for initiating patent infringement
proceedings or that if initiated we would prevail in such proceedings.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Interference proceedings conducted within
the U.S. Patent and Trademark Office may be necessary to determine the priority of inventions with respect to our patent applications
or those of our Amorcyte subsidiary&rsquo;s potential collaborators or licensors. Litigation or interference proceedings may fail
and, even if successful, may result in substantial costs and distraction to our management. We may not be able, alone or with its
potential collaborators and licensors, to prevent misappropriation of our proprietary rights, particularly in countries where the
laws may not protect such rights as fully as in the United States.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">Furthermore, because of the substantial
amount of discovery required in connection with intellectual property litigation, there is a risk that some of our confidential
information could be compromised by disclosure during this type of litigation. In addition, during the course of this kind of litigation,
there could be public announcements of the results of hearings, motions or other interim proceedings or developments.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>Third parties may claim that we infringe on their intellectual
property.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">We may be subject to costly litigation
in the event our technology is claimed to infringe upon the proprietary rights of others. Third parties may have, or may eventually
be issued, patents that would be infringed by our technology. Any of these third parties could make a claim of infringement against
us with respect to our technology. We may also be subject to claims by third parties for breach of copyright, trademark or license
usage rights. Litigation and patent interference proceedings could result in substantial expense to us and significant diversion
of efforts by our technical and management personnel. An adverse determination in any such proceeding or in patent litigation could
subject us to significant liabilities to third parties or require us to seek licenses from third parties. Such licenses may not
be available on acceptable terms or at all. Adverse determinations in a judicial or administrative proceeding or failure to obtain
necessary licenses could prevent us from commercializing our products, which would have a material adverse affect on our business,
operating results and financial condition.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">The research, development and commercialization
activities conducted through our new Amorcyte subsidiary, including any product candidates resulting from these activities, may
infringe or be claimed to infringe patents or other proprietary rights owned by third parties and to which Amorcyte does not hold
licenses or other rights. There may be applications that have been filed but not published that, when issued, could be asserted
against Amorcyte. These third parties could bring claims against Amorcyte that would cause us to incur substantial expenses and,
if successful, could cause us to pay substantial damages. Further, if a patent infringement suit were brought against Amorcyte,
we could be forced to stop or delay research, development, manufacturing or sales of the product or product candidate that is the
subject of the suit.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Our Amorcyte subsidiary has not conducted
an exhaustive search or analysis of third-party patent rights to determine whether its research, development or commercialization
activities, including any product candidates resulting from these activities, may infringe or be alleged to infringe any third-party
patent rights.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">As a result of intellectual property infringement
claims, or in order to avoid potential claims, Amorcyte may choose, or be required, to seek a license from the third party. These
licenses may not be available on acceptable terms, or at all. Even if Amorcyte is able to obtain a license, the license would likely
obligate the licensee to pay license fees or royalties or both, and the rights granted to the licensee might be nonexclusive, which
could result in competitors gaining access to the same intellectual property. Ultimately, we could be prevented from commercializing
a product, or be forced to cease some aspect of our business operations, if, as a result of actual or threatened patent infringement
claims, we are unable to enter into licenses on acceptable terms. All of the issues described above could also affect potential
collaborators to the extent our Amorcyte subsidiary has any collaborations then in place, which would also affect the success of
the collaboration and therefore the success of our Company as a whole.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">There has been substantial litigation and
other proceedings regarding patent and other intellectual property rights in the pharmaceutical and biotechnology industries. In
addition to infringement claims, we may become a party to other patent litigation and other proceedings, including interference
or reexamination proceedings declared by the U.S. Patent and Trademark Office and opposition proceedings in the European Patent
Office, regarding intellectual property rights with respect to its product candidates and technology. Uncertainties resulting from
the initiation and continuation of patent litigation or other proceedings could have a material adverse effect on our ability to
compete in the marketplace.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>We may be unable to maintain our licenses, patents or
other intellectual property and could lose important protections that are material to continuing our operations and growth and
our ability to achieve profitability.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">Certain of our license agreements require
us to pay license fees, royalties and milestone payments and fees for patent filings and applications. Obtaining and maintaining
patent protection and licensing rights also depends, in part, on our ability to pay the applicable filing and maintenance fees.
Our failure to meet financial obligations under our license agreements in a timely manner or our non-payment or delay in payment
of our patent fees, could result in the loss of some or all of our rights to proprietary technology or the inability to secure
or enforce intellectual property protection. Additionally, our license agreements require us to meet certain diligence obligations
in the development of the licensed products. Our failure to meet these diligence obligations under our license agreements could
result in the loss of some or all of our rights under the license agreements. The loss of any or all of our intellectual property
rights could materially limit our ability to develop and/or market our services, which would materially and adversely affect our
business, operating results and financial condition.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>If we are unable to protect the confidentiality of our
proprietary information and know-how, our competitive position would be impaired.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">A significant amount of our technology,
especially regarding manufacturing processes, is unpatented and is maintained as trade secrets. The background technologies used
in the development of our cell therapeutics are known in the scientific community, and it is possible to duplicate the methods
that we use to create our product candidates. In an effort to protect these trade secrets, we require our employees, consultants
and contractors to execute confidentiality agreements. These agreements require that all confidential information developed by
the individual or made known to the individual by us during the course of the relationship be kept confidential and not disclosed
to third parties. These agreements, however, may not provide us with adequate protection against improper use or disclosure of
confidential information, and these agreements may be breached. Adequate remedies may not exist in the event of unauthorized use
or disclosure of confidential information. A breach of confidentiality could affect our competitive position. In addition, in some
situations, these agreements may conflict with, or be subject to, the rights of third parties with whom employees, consultants,
collaborators or advisors have previous employment or consulting relationships. Also, others may independently develop substantially
equivalent proprietary information and techniques or otherwise gain access to our trade secrets. The disclosure of our trade secrets
would impair our Company&rsquo;s competitive position.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>Our Amorcyte subsidiary relies on its ability to stop
others from competing by enforcing its patents; however, some jurisdictions may require patent holders to grant licenses to third
parties. Such compulsory licenses could be extended to include Amorcyte&rsquo;s product candidates including AMR-001, which may
limit our potential revenue opportunities.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Many countries, including some countries
in Europe, have compulsory licensing laws under which a patent owner may be compelled to grant licenses to third parties. In addition,
most countries limit the enforceability of patents against government agencies or government contractors. In these countries, the
patent owner may be limited to monetary relief and may be unable to enjoin infringement, which could materially diminish the value
of the patent. Compulsory licensing of life-saving products is also becoming increasingly popular in developing countries, either
through direct legislation or international initiatives. Such compulsory licenses could be extended to our Amorcyte subsidiary&rsquo;s
respective product candidates, which may limit our potential revenue opportunities, including with respect to any future revenues
which may result from AMR-001.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>Changes to U.S. Patent Law may have a material adverse
effect on our intellectual property rights.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">The Leahy-Smith America Invents Act (AIA),
which was signed into law on September 16, 2011, significantly changes United States patent law. It may take some time to establish
what the law means, since regulations that will govern how the new law is implemented have not yet been established, and since
the law has not yet been implemented, it has not yet been interpreted by the lower courts, and reviewed by either the Federal Circuit
Court of Appeals or the Supreme Court, a process that will take years. The first major change is that AIA switches the U.S. patent
system from a &ldquo;first to invent&rdquo; system to a &ldquo;first to file&rdquo; system. Once the first to file system is in
effect, there is a risk that another company may independently develop identical or similar patents at approximately the same time,
and be awarded the patents instead of us. Once &ldquo;first to file&rdquo; is implemented, there will no longer be a need to determine
who is the inventor of an invention. As a result, for the second major change, AIA abolishes interference proceedings, and establishes
derivation proceedings to replace interference proceedings in all cases in which the time period for instituting an interference
proceeding has not lapsed where an inventor named in an earlier application derived the claimed invention from a named inventor.
Once derivation proceedings are in effect, there is a risk that the inventorship of any pending patent application can be challenged
for reasons of derivation. The third major change is that AIA establishes post-grant opposition proceedings that will apply to
patent applications filed after &ldquo;first to file&rdquo; becomes effective. Post-grant opposition will enable a person who is
not the patent owner to initiate proceedings in the Patent office within 9 months after the grant of a patent that can result in
cancellation of a patent as invalid. Therefore there is a risk that any of our patents once granted after the effective date of
these provisions of the new law (March 16, 2013) may be subject to post-grant opposition, which will increase uncertainty on the
validity of any newly granted patent or can ultimately result in cancellation of the patent.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>RISKS RELATED TO DOING BUSINESS IN CHINA</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>Our operations are subject to risks associated with emerging
markets.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">The Chinese economy is not well established
and is only recently emerging and growing as a significant market for consumer goods and services. Accordingly, there is no assurance
that the market will continue to grow. Perceived risks associated with investing in China, or a general disruption in the development
of China&rsquo;s markets could materially and adversely affect the business, operating results and financial condition of Erye
and us.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>A significant portion of our assets are currently located
in the PRC, and investors may not be able to enforce federal securities laws or their other legal rights.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">A substantial portion of our assets are
located in the PRC. As a result, it may be difficult for investors in the U.S. to enforce their legal rights, to effect service
of process upon certain of our directors or officers or to enforce judgments of U.S. courts predicated upon civil liabilities and
criminal penalties against our directors and officers located outside of the U.S.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>The PRC government has the ability to exercise significant
influence and control over our operations in China.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">In recent years, the PRC government has
implemented measures for economic reform, the reduction of state ownership of productive assets and the establishment of corporate
governance practices in business enterprises. However, many productive assets in China are still owned by the PRC government. In
addition, the government continues to play a significant role in regulating industrial development by imposing business regulations.
It also exercises significant control over the country&rsquo;s economic growth through the allocation of resources, controlling
payment of foreign currency-denominated obligations, setting monetary policy and providing preferential treatment to particular
industries or companies.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">There can be no assurance that China&rsquo;s
economic, political or legal systems will not develop in a way that becomes detrimental to our business, results of operations
and financial condition. Our activities may be materially and adversely affected by changes in China&rsquo;s economic and social
conditions and by changes in the policies of the government, such as measures to control inflation, changes in the rates or method
of taxation and the imposition of additional restrictions on currency conversion.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Additional factors that we may experience
in connection with having operations in China that may adversely affect our business and results of operations include:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD>our inability to enforce or obtain a remedy under any material agreements;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD>PRC restrictions on foreign investment that could impair our ability to conduct our business or acquire or contract with other
entities in the future;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD>restrictions on currency exchange that may limit our ability to use cash flow most effectively or to repatriate our investment;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD>fluctuations in currency values;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD>cultural, language and managerial differences that may reduce our overall performance; and</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD>political instability in China.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.25in">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.25in"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>Cultural, language and managerial differences may adversely
affect our overall performance.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">We have experienced difficulties in assimilating
cultural, language and managerial differences with our subsidiaries in China. Personnel issues have developed in consolidating
management teams from different cultural backgrounds. In addition, language translation issues from time to time have caused miscommunications.
These factors make the management of our operations in China more difficult. Difficulties in coordinating the efforts of our U.S.-based
management team with our China-based management team may cause our business, operating results and financial condition to be materially
and adversely affected.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>We may not be able to enforce our rights in China.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">China&rsquo;s legal and judicial system
may negatively impact foreign investors. The legal system in China is evolving rapidly, and enforcement of laws is inconsistent.
It may be impossible to obtain swift and equitable enforcement of laws or enforcement of the judgment of one court by a court of
another jurisdiction. China&rsquo;s legal system is based on civil law or written statutes and a decision by one judge does not
set a legal precedent that must be followed by judges in other cases. In addition, the interpretation of Chinese laws may vary
to reflect domestic political changes.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">There are substantial uncertainties regarding
the interpretation and application to our business of PRC laws and regulations, since many of the rules and regulations that companies
face in China are not made public. The effectiveness of newly enacted laws, regulations or amendments may be delayed, resulting
in detrimental reliance by foreign investors. New laws and regulations that apply to future businesses may be applied retroactively
to existing businesses. We cannot predict what effect the interpretation of existing or new PRC laws or regulations may have on
our business.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">The laws of China are likely to govern
many of our material agreements, including, without limitation the Joint Venture Agreement. We cannot assure you that we will be
able to enforce our interests or our material agreements or that expected remedies will be available. The inability to enforce
or obtain a remedy under any of our future agreements may have a material adverse impact on our operations.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>Our businesses in China are subject to government regulation
that limit or prohibit direct foreign investment, limiting our ability to control these businesses, and making future pursuit of
these businesses inadvisable.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">The PRC government has imposed regulations
in various industries, including medical research and the stem cell business, that limit foreign investors&rsquo; equity ownership
or prohibit foreign investments altogether in companies that operate in such industries. As a result, our ability to control our
existing China-based business historically was limited.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">If the relevant Chinese authorities find
us or any business combination to be in violation of any laws or regulations, they would have broad discretion in dealing with
such violation, including, without limitation: (i) levying fines; (ii) revoking our business and other licenses; (iii) requiring
that we restructure our ownership or operations; and (iv) requiring that we discontinue any portion or all of our business.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">In December 2011, China&rsquo;s Ministry
of Health announced its intention to more tightly regulate stem cell clinical trials and the use of stem cell therapeutic treatments
in the PRC. As a result of this and the factors noted above, the Company has determined to take steps to restrict, and expects
to ultimately eliminate, its regenerative medicine business in the PRC.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><B><I>&nbsp;</I></B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>Early termination of cooperative relationship with local
hospitals due to tightened and uncertain regulatory environment may subject us to damages for the hospitals' direct and indirect
losses; we may suffer other costs related to our winding down of our China regenerative medicine activities.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">On December 16, 2011, the SFDA and Ministry
of Health (&ldquo;MOH&rdquo;) jointly issued a notice to halt unproven stem-cell clinical trials and suspend new application for
stem-cell clinical trials until July 1, 2012. This ban has significantly added risk associated with our operation in China.&nbsp;
Given the nature and extent of such notice as well as recent tightening in Chinese government&rsquo;s scrutiny of VIE structures
in the prohibited business sectors, we are seeking to unilaterally terminate our cooperative agreements with local hospitals on
cell-based therapies prior to the end of their term.&nbsp; In the event of a claim of default by the hospitals, we may be liable
for damages for those hospitals&rsquo; direct and indirect losses resulting from our early termination of the cooperative agreements.
Although the cooperative agreements provide that either side may terminate the agreements due to a force majeure event that includes
adverse changes in government regulations directly affecting the performance of these agreements, the hospitals might claim that
the aforesaid change and uncertainty of the regulatory environment does not constitute a force majeure event. In such event, we
may need to litigate whether we had legitimate grounds to early terminate the agreements, which would be subject to the determination
in a Chinese venue. We could also be exposed to other costs associated with the winding down of our PRC regenerative medicine business
such as employee severance costs.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>We may suffer losses if we cannot utilize our assets in
China.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12pt">The Company&rsquo;s Beijing laboratory facility
was originally intended for stem cell research and development, but has been equipped to provide comprehensive cell manufacturing,
collection, processing and storage capabilities to enable the PCT business model to launch in the PRC and provide cells for clinical
trials. The lease for this facility expires in May 2012 and the Company is considering its options with respect to extending this
lease to allow for manufacturing for clinical trials in Asia. If the Company does not determine to renew the lease due to limitations
on its utility under the new regulatory initiatives in China or otherwise, the Company may incur certain expenses in connection
with returning the premises to the landlord.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>The PRC government does not permit direct foreign investment
in stem cell research and development businesses. Accordingly, we operate these businesses through local companies with which we
have contractual relationships but in which we do not have controlling equity ownership.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">PRC regulations prevent foreign companies
from directly engaging in stem cell-related research, development and commercial applications in China. Therefore, to perform these
activities, we operate our current stem cell-related business in China through domestic variable interest entities, or VIEs: Tianjin
Niou Bio-Technology Ltd., or Tianjin Neo Bio-Technology, and Beijing Ruijieao Bio-Technology Ltd., or Beijing Ruijieao, each a
Chinese domestic company controlled by the Chinese employees of NeoStem (China), Inc., our wholly foreign-owned entity, or the
WFOE, through various business agreements, referred to, collectively, as the VIE documents. Tianjin Neo-Biotechnology conducts
operations formerly conducted by another Company VIE, Qingdao Neo Biotechnology. We control these companies and operate these businesses
through contractual arrangements with the companies and their individual owners, but we have no direct equity ownership or control
over these companies. Our contractual arrangements may not be as effective in providing control over these entities as direct ownership.
For example, the VIEs could fail to take actions required for our business or fail to conduct business in the manner we desire
despite their contractual obligation to do so. These companies are able to transact business with parties not affiliated with us.
If these companies fail to perform under their agreements with us, we may have to rely on legal remedies under PRC law, which may
not be effective. In addition, we cannot be certain that the individual equity owners of the VIEs would always act in our best
interests, especially if they have no other relationship with us.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">Although other foreign companies have used
WFOEs and VIE structures similar to ours and such arrangements are not uncommon in connection with business operations of foreign
companies in China in industry sectors in which foreign direct investments are limited or prohibited, recently there has been greater
scrutiny by the business community of the VIE structure and, additionally, the application of a VIE structure to control companies
in a sector in which foreign direct investment is specifically prohibited carries increased risks.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">For example, if our structure is deemed
in violation of PRC law, the PRC government could revoke the business license of the WFOE, require us to discontinue or restrict
our operations, restrict our right to collect revenues, require us to restructure our business, corporate structure or operations,
impose additional conditions or requirements with which we may not be able to comply, impose restrictions on our business operations
or on our customers, or take other regulatory or enforcement actions against us. We may also encounter difficulties in enforcing
related contracts. Any of these events could materially and adversely affect our business, operating results and financial condition.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In addition, the Ministry of Commerce,
or the MOFCOM, promulgated the <I>Rules of Ministry of Commerce on Implementation of Security Review System of Mergers and Acquisitions
of Domestic Enterprises by Foreign Investors</I> in August&nbsp;2011, or the MOFCOM Security Review Rules, to implement the <I>Notice
of the General Office of the State Council on Establishing the Security Review System for Mergers and Acquisitions of Domestic
Enterprises by Foreign Investors</I> promulgated on February&nbsp;3, 2011, or Circular No.&nbsp;6. The MOFCOM Security Review Rules
came into effect on September&nbsp;1, 2011 and replaced the <I>Interim Provisions of the Ministry of Commerce on Matters Relating
to the Implementation of the Security Review System for Mergers and Acquisitions of Domestic Enterprises by Foreign Investors</I>
promulgated by MOFCOM in March 2011. According to these circulars and rules, a security review is required for mergers and acquisitions
by foreign investors having <I>&quot;national defense and security&quot;</I> concerns and mergers and acquisitions by which foreign
investors may acquire the <I>&quot;de facto control&quot;</I> of domestic enterprises having <I>&quot;national security&quot;</I>
concerns. In addition, when deciding whether a specific merger or acquisition of a domestic enterprise by foreign investors is
subject to the security review, the MOFCOM will look into the substance and actual impact of the transaction. The MOFCOM Security
Review Rules further prohibit foreign investors from bypassing the security review requirement by structuring transactions through
proxies, trusts, indirect investments, leases, loans, control through contractual arrangements or offshore transactions. There
is no explicit provision or official interpretation stating that our business falls into the scope subject to the security review,
and there is no requirement for foreign investors in those mergers and acquisitions transactions already completed prior to the
promulgation of Circular No.&nbsp;6 to submit such transactions to MOFCOM for security review. The enactment of the MOFCOM National
Security Review Rules specifically prohibits circumvention of the rules through VIE arrangement in the area of foreign investment
in business of national security concern.&nbsp;&nbsp;Although we believe that our business, judging from its scale, should not
cause any concern for national security review at its current state, there is no assurance that MOFCOM would not apply the same
concept of anti-circumvention in the future to foreign investment in prohibited areas through VIE structure, the same way that
our investment in China was structured.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>For so long as we own an interest in Erye, we expect to
rely, in part, on dividends paid by Erye to supply cash flow for our U.S. business, and statutory or contractual restrictions may
limit their ability to pay dividends to us.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">For so long as we own an interest in Erye,
we intend to rely partly on dividends paid to us under the October 2009 Joint Venture Agreement, attributable to our 51% ownership
interest in Erye, to meet our future cash needs. Pursuant to the Joint Venture Agreement that governs the ownership and management
of Erye, for the three-year period commencing on the first day of the first fiscal quarter after the Joint Venture Agreement became
effective distributions are made as follows: (i) 49% of undistributed profits (after tax) will be distributed to EET and loaned
back to Erye for use in connection with its construction of the new Erye facility (to be repaid gradually after construction is
completed); (ii) 45% of the net profit after tax will be provided to Erye as part of the new facility construction fund, which
will be characterized as paid-in capital for our 51% interest in Erye; and (iii) only 6% of the net profit will be distributed
to us directly for our operating expenses.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">The payment of dividends by entities organized
under PRC law to non-PRC entities is subject to limitations. Regulations in the PRC currently permit payment of dividends Erye
only out of accumulated distributable earnings, if any, as determined in accordance with accounting standards and regulations in
China. Moreover, Erye is required to appropriate from PRC GAAP profit after tax to other non-distributable reserve funds. These
reserve funds include one or more of the following: (i) a general reserve, (ii) an enterprise expansion fund and (iii) a staff
bonus and welfare fund. Subject to certain cumulative limits (i.e., 50% of the registered capital of relevant company), the general
reserve fund requires annual appropriation at 10% of after tax profit (as determined under accounting principles generally accepted
in the PRC at each year-end); the appropriation to the other funds are at the discretion of Erye. In addition, if Erye incurs additional
debt on its own behalf to finance the building of the new facility in the future, the instruments governing the debt may restrict
Erye&rsquo;s or the joint venture&rsquo;s ability to pay dividends or make other distributions to us. This may diminish the cash
flow we receive from Erye&rsquo;s operations, which would have a material adverse effect on our business, operating results and
financial condition.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>Restrictions on currency exchange may limit our ability
to utilize our cash flow effectively.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Our interests in China will be subject
to China&rsquo;s rules and regulations on currency conversion. In particular, the initial capitalization and operating expenses
of the VIEs are funded by our WFOE. In China, the State Administration for Foreign Exchange, or the SAFE, regulates the conversion
of the Chinese Renminbi into foreign currencies and the conversion of foreign currencies into Chinese Renminbi. Currently, foreign
investment enterprises are required to apply to the SAFE for Foreign Exchange Registration Certificates, or IC Cards of Enterprises
with Foreign Investment. Foreign investment enterprises holding such registration certificates, which must be renewed annually,
are allowed to open foreign currency accounts including a &ldquo;basic account&rdquo; and &ldquo;capital account.&rdquo; Currency
translation within the scope of the &ldquo;basic account,&rdquo; such as remittance of foreign currencies for payment of dividends,
can be effected without requiring the approval of the SAFE. However, conversion of currency in the &ldquo;capital account,&rdquo;
including capital items such as direct investments, loans, and securities, require approval of the SAFE. According to the <I>Notice
of the General Affairs Department of the State Administration of Foreign Exchange on the Relevant Operating Issues Concerning the
Improvement of the Administration of Payment and Settlement of Foreign Currency Capital of Foreign-invested Enterprises</I> promulgated
on August 29, 2008, or the SAFE Notice 142, to apply to a bank for settlement of foreign currency capital, a foreign invested enterprise
shall submit the documents certifying the uses of the RMB funds from the settlement of foreign currency capital and a detailed
checklist on use of the RMB funds from the last settlement of foreign currency capital. It is stipulated that only if the funds
for the settlement of foreign currency capital are of an amount not more than US$50,000 and are to be used for enterprise reserve,
the above documents may be exempted by the bank. This SAFE Notice 142, along with the recent practice of Chinese banks of restricting
foreign currency conversion for fear of &ldquo;hot money&rdquo; going into China, limits and may continue to limit our ability
to channel funds to the VIE entities for their operation. There can be no assurance that the PRC regulatory authorities will not
impose further restrictions on the convertibility of the Chinese currency. Future restrictions on currency exchanges may limit
our ability to use our cash flow for the distribution of dividends to our stockholders or to fund operations we may have outside
of China, which could materially adversely affect our business and operating results.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>Fluctuations in the value of the Renminbi relative to
the U.S. dollar could affect our operating results.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">We prepare our financial statements in
U.S. dollars, while our underlying businesses operate in two currencies, U.S. dollars and Chinese Renminbi. It is anticipated that
our Chinese operations will conduct their operations primarily in Renminbi and our U.S. operations will conduct their operations
in dollars. At the present time, we do not expect to have significant cross currency transactions that will be at risk to foreign
currency exchange rates. Nevertheless, the conversion of financial information using a functional currency of Renminbi will be
subject to risks related to foreign currency exchange rate fluctuations. The value of Renminbi against the U.S. dollar and other
currencies may fluctuate and is affected by, among other things, changes in China&rsquo;s political and economic conditions and
supply and demand in local markets. As we have significant operations in China, and will rely principally on revenues earned in
China, any significant revaluation of the Renminbi could materially and adversely affect our financial results. For example, to
the extent that we need to convert U.S. dollars we receive from an offering of our securities into Renminbi for our operations,
appreciation of the Renminbi against the U.S. dollar could have a material adverse effect on our business, financial condition
and results of operations.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">Beginning in July of 2005, the PRC government
changed its policy of pegging the value of Renminbi to the U.S. dollar. Under the new policy, the value of the Renminbi has fluctuated
within a narrow and managed band against a basket of certain foreign currencies. However, the Chinese government has come under
increasing U.S. and international pressure to revalue the Renminbi or to permit it to trade in a wider band, which many observers
believe would lead to substantial appreciation of the Renminbi against the U.S. dollar and other major currencies. There can be
no assurance that Renminbi will be stable against the U.S. dollar. On June 19, 2010 the central bank of China announced that it
will gradually modify its monetary policy and make the Renminbi&rsquo;s exchange rate more flexible and allow the Renminbi to appreciate
in value in line with its economic strength.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>Erye&rsquo;s manufacturing operations in China may be
adversely affected by changes in PRC government policies regarding ownership of assets and allocation of resources to various industries
and companies.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">While the PRC government has implemented
economic and market reforms, a substantial portion of productive assets in China are still owned by the PRC government. The PRC
government also exercises significant control over China&rsquo;s economic growth through the allocation of resources, controlling
payment of foreign currency and providing preferential treatment to particular industries or companies. Should the PRC government
change its policies regarding economic growth and private ownership of manufacturing and other assets of Erye, we may lose rights
to certain business assets and our business, operating results and financial condition may be materially harmed.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>China&rsquo;s State Food and Drug Administration&rsquo;s
regulations may limit our ability to develop, license, manufacture and market our products and services.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Some or all of our operations in China
will be subject to oversight and regulation by the PRC&rsquo;s State Food and Drug Administration (&ldquo;SFDA&rdquo;). Government
regulations, among other things, cover the inspection of and controls over testing, manufacturing, safety and environmental considerations,
efficacy, labeling, advertising, promotion, record keeping and sale and distribution of pharmaceutical products. Such government
regulations may increase our costs and prevent or delay the licensing, manufacturing and marketing of any of our products or services.
In the event we seek to license, manufacture, sell or distribute new products or services, we likely will need approvals from certain
government agencies such as the SFDA. The future growth and profitability of any operations in China would be contingent on obtaining
the requisite approvals. There can be no assurance that we will obtain such approvals.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">In 2004, the SFDA implemented new guidelines for the licensing
of pharmaceutical products. All existing manufacturers with licenses were required to apply for the Good Manufacturing Practices,
or cGMP, certifications. Erye has received the requisite certifications. However, should Erye fail to maintain its cGMP certifications
or fail to obtain cGMP and other certifications for its new production facilities, this would have a material adverse effect on
Erye&rsquo;s and our business, results of operations and financial condition.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12pt">According to <I>Good Manufacturing Practices
for Pharmaceutical Products (revised edition 2010)</I>, or the New GMP Rules promulgated by the Ministry of Health of the PRC on
January 17, 2011 which became effective on March 1, 2011, all the newly constructed manufacturing facilities of drug manufacture
enterprises in China shall comply with the requirements of the New GMP Rules, which are stricter than the original GMP standards.
Therefore, should Erye fail to maintain its cGMP certifications in accordance with the New GMP Rules for its new production facilities,
this would have a material adverse effect on Erye&rsquo;s and our business, results of operations and financial condition.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">In addition, delays, product recalls or
failures to receive approval may be encountered based upon additional government regulation, legislative changes, administrative
action or changes in governmental policy and interpretation applicable to the Chinese pharmaceutical industry. Our pharmaceutical
activities also may subject us to government regulations with respect to product prices and other marketing and promotional related
activities. Government regulations may substantially increase our costs for developing, licensing, manufacturing and marketing
any products or services, which could have a material adverse effect on our business, operating results and financial condition.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">The SFDA and other regulatory authorities
in China have implemented a series of new punitive and stringent measures regarding the pharmaceuticals industry to redress certain
past misconducts in the industry and certain deficiencies in public health reform policies. Given the nature and extent of such
new enforcement measures, the aggressive manner in which such enforcement is being conducted and the fact that newly-constituted
local level branches are encouraged to issue such punishments and fines, there is the possibility of large scale and significant
penalties being levied on manufacturers. These new measures may include fines, restriction and suspension of operations and marketing
and other unspecified penalties. This new regulatory environment has added significantly to the risks of our businesses in China
and may have a material adverse effect on our business, operating results and financial condition.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>Changes to PRC policies regarding drug pricing have had
a material adverse effect on Erye&rsquo;s and our results of operations and financial condition and may continue to do so.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Erye&rsquo;s financial performance is heavily
dependent on government pricing policies and procedures, which are subject to change. The <I>Rules on Introduction of Suzhou&rsquo;s
Local Enterprises Produced Drugs into Suzhou&rsquo;s Local Medical Insurance Drugs Catalogue</I>, which was promulgated in 2006,
may soon cease to be effective. The cancellation of such Rules would likely reduce Erye&rsquo;s sales and profits. On March 2,
2011, the National Development and Reform Commission issued price cuts for drugs covered by national medical insurance which substantially
impacts two of Erye&rsquo;s drugs. It is anticipated that the price of Piperacillin Sodium Sulbactum Sodium will decrease by 50%
and the price of Ligustrazine Phosphate will be cut by 75%; in 2011 the price reduction experienced by Erye on these products was
approximately 24%. In 2011 Piperacillin Sodium Sulbactum Sodium accounted for approximately 5% of sales and Ligustrazine Phosphate
accounted for approximately 1% of sales. These policies regarding drug pricing and the resulting price reductions experienced by
Erye will likely negatively affect the offers presented to us in connection with the divestiture of our 51% interest in Erye that
we are pursuing.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>PRC policies limiting the use of antibiotics may have
a material adverse effect on Erye&rsquo;s and our results of operations and financial condition.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Recently, the PRC Ministry of Health issued,
for public comment, a draft policy &ldquo;Administrative Measures on Clinical Use of Antibiotics&rdquo; to curb their overuse.
The proposed guidelines set forth three categories of antibiotics, which include (1) restricted, (2) non-restricted, and (3) special-use
only. According to the October 12, 2011 China Healthcare report published by Deutsche Bank, AG (the &ldquo;China Healthcare report&rdquo;),
it has been projected that the limitation of antibiotic usage in China will reduce the historical compound annual growth rate which
has been approximately 20%. According to the China Healthcare report, it has been estimated that China&rsquo;s population consumes
about ten times the global per capita average of antibiotics. These regulations have not been finalized but issuance of a draft
policy has created uncertainty on the part of distributors and has reduced purchases by distributors and in part has contributed
to sales reductions in 2011. This draft policy regarding antibiotic use and the uncertainty that has been created will likely negatively
affect the offers that have been presented to us.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>Erye&rsquo;s production is concentrated in a small number
of production lines and Erye is operating in a new facility.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Erye began transferring its operations to
its new manufacturing facility in January 2010. The construction of this facility is substantially complete. The relocation and
new production lines have been completed and have received cGMP certification. To date Erye has received the following SFDA cGMP
certifications:</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>solvent crystallization sterile penicillin</TD></TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>freeze dried raw sterile penicillin</TD></TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>penicillin</TD></TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>cephalosporin powder for injection</TD></TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>freeze dried powder for injection</TD></TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-family: Symbol">&middot;</FONT></TD><TD>its capsule line.&nbsp;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.75in; text-indent: -0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Erye&rsquo;s production is concentrated in a small number of
production lines. Any interruptions in production with respect to those lines will have a material adverse effect on Erye&rsquo;s
business and ours.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>In China, we may conduct research and development activities
related to cell therapy in cooperation with a domestic Chinese company. If these activities are regarded by PRC government authorities
as &ldquo;human genetic resources research and development activities,&rdquo; additional approvals by PRC government authorities
will be required.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Our research and development activities
in cell therapy in China may be conducted in cooperation with Beijing Ruijieao Biotechnology Ltd. Pursuant to the <I>Interim Measures
for the Administration of Human Genetic Resources</I>, or the Measures, that took effect on June 10, 1998, China maintains a reporting
and registration system on important pedigrees and genetic resources in specified regions. All entities and individuals involved
in sampling, collecting, researching, developing, trading or exporting human genetic resources or taking such resources outside
China must abide by the Measures. &ldquo;Human genetic resources&rdquo; refers to genetic materials such as human organs, tissues,
cells, blood specimens, preparations or any type of recombinant DNA constructs, which contain human genome, genes or gene products
as well as to the information related to such genetic materials.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">It is possible that our research and development
activities conducted by the Lab in cooperation with us in China may be regarded by PRC government authorities as human genetic
resources research and development activities, and thus will be subject to approval by PRC government authorities. The sharing
of patents or other corresponding intellectual property rights derived from such research and development operations is also subject
to various restrictions and approval requirements established under the Measures.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">With regard to the ownership of intellectual
property rights derived from human genetic resources research and development, the Measures provide that the China-based research
and development institution shall have priority access to information about the human genetic resources within China, particularly
the important pedigrees and genetic resources in the specified regions and the relevant data, information and specimens and any
transfer of such human genetic resources to other institutions shall be prohibited without obtaining corresponding approval from
the Human Genetic Resource Administration Office of China, among other governmental authorities or agencies. No foreign collaborating
institution or individual that has access to the above-mentioned information may publicize, publish, apply for patent rights or
disclose it by any other means without obtaining government approval. In a collaborative research and development project involving
human genetic resources of China between any Chinese and foreign institutions, intellectual property rights shall be allocated
according to the following principles: (i) patent rights shall be jointly applied for by both parties and the resulting patent
rights shall be owned by both parties if an achievement resulting from the collaboration is patentable; (ii) either party has the
right to exploit such patent separately or jointly in its own country, subject to the terms of the collaboration; however, the
transfer of such patent to any third party or authorizing any third party to implement such patent shall be carried out upon agreement
of both parties, and the benefits obtained thereof shall be shared in accordance with their respective contributions; and (iii)
the right of utilizing, transferring and sharing any other scientific achievement resulted from the collaboration shall be specified
in the collaborative contract or agreement signed by both parties. Both parties are equally entitled to make use of the achievement
which is not specified in the collaborative contract or agreement; however, the transfer of such achievement to any third party
shall be carried out upon agreement of both parties, and the benefits obtained thereof shall be shared in accordance with their
respective contributions.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">If the research and development operations
conducted by the Lab in cooperation with us in China are regarded by PRC government authorities as human genetic resources research
and development activities, we may be required to obtain approval from PRC governmental authorities to continue such operations
and the Measures may adversely affect our rights to intellectual property developed from such operations. Our inability to access
intellectual property, or our inability to obtain required approvals on a timely basis, or at all, could materially and adversely
affect our operations in China, and our operating results and financial condition.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"><B><I>Some of the laws and regulations
governing our business in China are vague and subject to risks of interpretation.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Some of the PRC laws and regulations governing
our business operations in China are vague and their official interpretation and enforcement may involve substantial uncertainty.
These include, but are not limited to, laws and regulations governing our business and the enforcement and performance of our contractual
arrangements in the event of the imposition of statutory liens, death, bankruptcy and criminal proceedings. Despite their uncertainty,
we will be required to comply.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">New laws and regulations that affect existing
and proposed businesses may be applied retroactively. Accordingly, the effectiveness of newly enacted laws, regulations or amendments
may not be clear. We cannot predict what effect the interpretation of existing or new PRC laws or regulations may have on our business.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">In addition, pursuant to China&rsquo;s Administrative Measures
on the Foreign Investment in Commercial Sector, foreign enterprises are permitted to establish or invest in wholly foreign-owned
enterprises or joint ventures that engage in wholesale or retail sales of pharmaceuticals in China subject to the implementation
of relevant regulations. However, no specific regulations in this regard have been promulgated to date, which creates uncertainty.
If specific regulations are not promulgated, or if any promulgated regulations contain clauses that cause an adverse impact to
our operations in China, then our business, operating results and financial condition could be materially and adversely affected.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>The laws and regulations governing the therapeutic use
of stem cells in China are evolving. New PRC laws and regulations may impose conditions or requirements which could materially
and adversely affect our business.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">As the stem cell therapy industry is at
an early stage of development in China, new laws and regulations may be adopted in the future to address new issues that arise
from time to time. As a result, substantial uncertainties exist regarding the interpretation and implementation of current and
any future PRC laws and regulations applicable to the stem cell therapy industry. There is no way to predict the content or scope
of future Chinese stem cell regulation. There can be no assurance that the PRC government authorities will not issue new laws or
regulations that impose conditions or requirements with which we cannot comply. Noncompliance could materially and adversely affect
our business, results of operations and financial condition.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">On December 16, 2011, China&rsquo;s Ministry
of Health announced its intention to more tightly regulate stem cell clinical trials and stem cell therapeutic treatments in the
PRC. The Ministry of Health ordered an immediate halt to &ldquo;unapproved stem cell clinical trials and applications,&rdquo; and
put applications for new stem cell trials on hold until July 1, 2012. For those clinical trials for stem cell products already
approved by the SFDA, the Clinical Trial Approval Instructions and the Good Clinical Practice, or GCP, shall be strictly followed,
with unwarranted changes to the approved clinical trial protocol and profit-seeking activities strictly forbidden. As a result
of this and other factors, the Company has determined to take steps to restrict, and expects to ultimately eliminate, its regenerative
medicine business in the PRC. We are currently investigating the potential impact of the Ministry of Health&rsquo;s announcement,
as well as other regulatory initiatives and regulations in China, on potential PRC-based operations through our Beijing Facility.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>We may be subject to fines and legal sanctions imposed
by the SAFE or other PRC government authorities if we or our PRC employees fail to comply with recent PRC regulations relating
to employee stock options granted by offshore listed companies to PRC citizens.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">On April 6, 2007, the SAFE issued
the &ldquo;<I>Operating Procedures for Administration of Domestic Individuals Participating in the Employee Stock Ownership
Plan or Stock Option Plan of An Overseas Listed Company</I>,&rdquo; referred to as Circular 78. It is not clear whether
Circular 78 covers all forms of equity compensation plans or only those which provide for the granting of stock options. For
any plans which are so covered and are adopted by a non-PRC listed company after April 6, 2007, Circular 78 requires all
participants who are PRC citizens to register with and obtain approvals from the SAFE prior to their participation in the
plan. In addition, Circular 78 also requires PRC citizens to register with the SAFE and make the necessary applications and
filings if they participated in an overseas listed company&rsquo;s covered equity compensation plan prior to April 6, 2007.
The 2009 Non-U.S. Plan authorizes the grant of certain equity awards to our officers, directors and employees, some of whom
are PRC citizens. Circular 78 may require our officers, directors and employees who receive option grants and are PRC
citizens to register with the SAFE. We believe that the registration and approval requirements contemplated in Circular 78
will be burdensome and time consuming. If it is determined that any of our equity compensation plans are subject to Circular
78, failure to comply with such provisions may subject us and participants of our equity incentive plan who are PRC citizens
to fines and legal sanctions and prevent us from being able to grant equity compensation to our PRC employees. In that case,
our ability to compensate our officers, directors and employees through equity compensation would be hindered and our
business operations may be adversely affected.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>Failure to comply with the U.S. Foreign Corrupt Practices
Act could subject us to penalties and other adverse consequences.</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">We are subject to the U.S. Foreign Corrupt
Practices Act, which generally prohibits U.S. companies from engaging in bribery or other prohibited payments to foreign officials
for the purpose of obtaining or retaining business. Foreign companies, including some that may compete with us, are not subject
to these prohibitions. Corruption, extortion, bribery, pay-offs, theft and other fraudulent practices occur from time-to-time in
the PRC. There can be no assurance, however, that our employees or other agents will not engage in such conduct for which we might
be held responsible. If our employees or other agents are found to have engaged in such practices, we could suffer severe penalties
and other consequences that may have a material adverse effect on our business, financial condition and results of operations.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SPECIAL NOTE REGARDING FORWARD-LOOKING
STATEMENTS</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">This prospectus supplement, the accompanying
prospectus and the documents incorporated by reference herein or therein contain forward-looking statements within the meaning
of Section 27A of the Securities Act of 1933, as amended (the &ldquo;Securities Act&rdquo;), and Section 21E of the Securities
Exchange Act of 1934, as amended (the &ldquo;Exchange Act&rdquo;), which are subject to a number of risks and uncertainties. All
statements, other than statements of historical facts, that we include in this prospectus, any prospectus supplement, and in the
documents we incorporate by reference in this prospectus, may be deemed forward-looking statements for purposes of the Securities
Act and the Exchange Act. We use the words &ldquo;anticipate,&rdquo; &ldquo;believe,&rdquo; &ldquo;estimate,&rdquo; &ldquo;expect,&rdquo;
&ldquo;intend,&rdquo; &ldquo;may,&rdquo; &ldquo;plan,&rdquo; &ldquo;project,&rdquo; &ldquo;will,&rdquo; &ldquo;would&rdquo; and
similar expressions to identify forward-looking statements, although not all forward-looking statements contain these identifying
words. We cannot guarantee that we actually will achieve the plans, intentions or expectations disclosed in our forward-looking
statements and, accordingly, you should not place undue reliance on our forward-looking statements. There are a number of important
factors that could cause actual results or events to differ materially from the forward-looking statements that we make, including
the Risk Factors above and the factors included in the documents we incorporate by reference in this prospectus. You should read
these factors and the other cautionary statements made in the documents we incorporate by reference as being applicable to all
related forward-looking statements wherever they appear in this prospectus, any prospectus supplement, and any document incorporated
by reference. We caution you that we do not undertake any obligation to update forward-looking statements made by us.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 12.4pt"><B>USE OF PROCEEDS</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">We estimate that the net proceeds
from the sale of 15,000,000 units that we are offering, excluding the proceeds, if any, from the exercise of the warrants
issued in this offering, will be approximately $ 5,297,000 (or approximately $6,134,000  if the underwriters
exercise their over-allotment option in full), after deducting the estimated underwriting discount and estimated offering
expenses payable by us.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">We currently intend to use the net proceeds
of this offering for working capital, including research and development of cell therapeutic product candidates, expansion of business
units, strategic transactions and other general corporate purposes. As of the date of this prospectus supplement and except as
explicitly set forth herein, we cannot specify with certainty all of the particular uses of the proceeds from this offering. Accordingly,
we will retain broad discretion over the use of such proceeds. Pending use of the net proceeds of this offering as described above,
we intend to invest the net proceeds in short-term interest-bearing investment grade instruments.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 12.4pt"><B>DILUTION</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Our net tangible book value as of December
31, 2011 was approximately $28.4 million, or $0.26 per share of common stock. Net tangible book value per share of common stock
is calculated by subtracting our total liabilities from our total tangible assets, which is total assets less intangible assets,
and dividing this amount by the number of shares of common stock outstanding.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">After giving effect to our sale
of 15,000,000 units in this public offering at a public offering price of $0.40 per unit (but excluding
the exercise of any warrants issued in this offering), after deducting the estimated underwriting discount and estimated
offering expenses payable by us, our as adjusted net tangible book value as of December 31, 2011 would have been
approximately $33.7 million, or $0.27 per share. This
represents an immediate increase in net tangible book value of $0.01 per share to existing stockholders
and immediate dilution in net tangible book value of $0.13&nbsp;per share to new investors participating in
this offering at the public offering price. The following table illustrates this dilution on a per share basis:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" ALIGN="CENTER" STYLE="width: 85%; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: bottom; background-color: rgb(204,255,204)">
    <TD STYLE="width: 77%">Public offering price per unit</TD><TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%; text-align: left"></TD><TD STYLE="width: 9%; text-align: right"></TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%; text-align: left">$</TD>
    <TD STYLE="width: 9%; text-align: right">0.40</TD><TD STYLE="width: 1%; text-align: left"></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="padding-left: 0.25in">Historical net tangible book value per share as of December 31, 2011</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">$</TD><TD STYLE="text-align: right">0.26</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,255,204)">
    <TD STYLE="text-align: left; padding-bottom: 1pt; padding-left: 0.25in">Increase per share attributable to investors participating in this offering</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">$</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">0.01</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD><TD STYLE="padding-bottom: 1pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left; padding-bottom: 1pt">As adjusted net tangible book value per share after this offering</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="text-align: left"></TD><TD STYLE="text-align: right"></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">$</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: right">0.27</TD><TD STYLE="padding-bottom: 1pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,255,204)">
    <TD STYLE="text-align: left; padding-bottom: 2.5pt">Dilution per share to investors participating in this offering</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="text-align: left"></TD><TD STYLE="text-align: right"></TD>
    <TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; text-align: left">$</TD>
    <TD STYLE="border-bottom: Black 2.5pt double; text-align: right">0.13</TD><TD STYLE="padding-bottom: 2.5pt; text-align: left">&nbsp;</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12pt"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">If the underwriters exercise
their over-allotment option in full to purchase 2,250,000 additional units in this offering, our pro forma net tangible book
value as of December 31, 2011 would be approximately
$34.5&nbsp;million, or
$0.27 per share, the increase in the pro forma net tangible book value to existing stockholders would be
$0.01&nbsp;per share and the pro forma dilution to new investors participating in this offering would be
$0.13&nbsp;per share.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12pt">The above discussion and table are based
on 109,329,587 shares of common stock outstanding as of the close of business on December 31, 2011. This number excludes, as of
the close of business on December 31, 2011, the warrants offered hereby and the shares of our common stock issuable upon exercise
of the warrants offered hereby and also excludes:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD>options representing the right to purchase a total of 17,143,505 shares of common stock at a weighted average exercise price
of $1.71 per share;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD>10,825,422 shares of common stock which were reserved for future equity awards that may be granted in the future under our
equity incentive plans;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD>warrants representing the right to purchase a total of 37,389,825 shares of common stock at a weighted average exercise price
of $2.35 per share;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD>10,000 shares of common stock issuable upon conversion of our outstanding Series B Convertible Redeemable Preferred Stock;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD>any shares of common stock issued on conversion or redemption of our outstanding Series E 7% Senior Convertible Preferred Stock,
and any shares of common stock issued in connection with dividend payments in respect of such preferred stock; and</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD>any shares of our common stock that we may issue from time to time in connection with draw-downs pursuant to our Purchase Agreement
with Aspire Capital Fund, LLC.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>CAPITALIZATION</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.25pt">The following table sets forth our capitalization
as of December 31, 2011:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.2in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD>on an actual basis, without giving effect to this offering and the use of net proceeds as discussed in &ldquo;Use of Proceeds&rdquo;;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.2in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD>on an as adjusted basis to reflect this offering (but excluding the exercise of any warrants issued in this offering) and the
use of net proceeds as discussed in &ldquo;Use of Proceeds&rdquo;.</TD></TR></TABLE>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">This capitalization table should be read
in conjunction with management&rsquo;s discussion and analysis of results of operations and our consolidated financial statements
and related notes included in our annual report on Form 10-K for the year ended December 31, 2011, and the other financial information
included and incorporated by reference in this prospectus supplement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" ALIGN="CENTER" STYLE="width: 97%; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="6" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">(thousands)<BR> As of December 31, 2011</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD><TD STYLE="font-weight: bold">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-weight: bold; text-align: center">&nbsp;</TD><TD STYLE="font-weight: bold">&nbsp;</TD><TD STYLE="font-weight: bold">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-weight: bold; text-align: center">Pro Forma,</TD><TD STYLE="font-weight: bold">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Actual</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">As Adjusted</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,255,204)">
    <TD STYLE="width: 74%; text-align: left; padding-bottom: 2.5pt; text-indent: -0.1in; padding-left: 0.1in">Cash and Cash Equivalents</TD><TD STYLE="width: 1%; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="width: 1%; border-bottom: Black 2.5pt double; text-align: left">$</TD><TD STYLE="width: 10%; border-bottom: Black 2.5pt double; text-align: right">12,745.4</TD><TD STYLE="width: 1%; padding-bottom: 2.5pt; text-align: left">&nbsp;</TD><TD STYLE="width: 1%; padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="width: 1%; border-bottom: Black 2.5pt double; text-align: left">$</TD><TD STYLE="width: 10%; border-bottom: Black 2.5pt double; text-align: right">18,042.4</TD><TD STYLE="width: 1%; padding-bottom: 2.5pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-indent: -0.1in; padding-left: 0.1in">Debt:</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,255,204)">
    <TD STYLE="text-align: left; text-indent: 0; padding-left: 0.12in">Amounts due related party</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">20,862.7</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">20,862.7</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left; text-indent: -0.1in; padding-left: 0.1in">Redeemable convertible Series E 7% preferred stock 6,662,748 shares issued and outstanding actual and pro forma, as adjusted</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">4,811.3</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">4,811.3</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,255,204)">
    <TD STYLE="text-align: left; text-indent: -0.1in; padding-left: 0.1in">Shareholders&rsquo; equity:</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left; text-indent: -0.1in; padding-left: 0.1in">Preferred stock, par value $0.01, 20,000,000 shares authorized, 10,000 shares of Series B convertible redeemable preferred stock issued and outstanding actual and pro forma, as adjusted</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.1</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.1</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,255,204)">
    <TD STYLE="text-align: left; text-indent: -0.1in; padding-left: 0.1in">Common stock, par value $0.001, 500,000,000 shares
    authorized, 109,329,587 shares issued and outstanding, actual and 124,329,587 shares issued and outstanding, pro forma, as
    adjusted<SUP>(1)</SUP></TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">109.3</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">124.3</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left; text-indent: -0.1in; padding-left: 0.1in">Additional paid in capital</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">200,858.6</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">206,140.6</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,255,204)">
    <TD STYLE="text-align: left; text-indent: -0.1in; padding-left: 0.1in">Accumulated other comprehensive income</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">4,152.3</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">4,152.3</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left; padding-bottom: 1pt; text-indent: -0.1in; padding-left: 0.1in">Accumulated deficit</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">(143,094.9</TD><TD STYLE="padding-bottom: 1pt; text-align: left">)</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">(143,094.9</TD><TD STYLE="padding-bottom: 1pt; text-align: left">)</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,255,204)">
    <TD STYLE="text-align: left; padding-bottom: 1pt; text-indent: -0.1in; padding-left: 0.1in">Total shareholders&rsquo; equity</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">62,025.6</TD><TD STYLE="padding-bottom: 1pt; text-align: left">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt; text-align: left; border-bottom: Black 1pt solid">&nbsp;</TD><TD STYLE="padding-bottom: 1pt; text-align: right; border-bottom: Black 1pt solid">67,322.6</TD><TD STYLE="padding-bottom: 1pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left; text-indent: -0.1in; padding-left: 0.1in; padding-bottom: 2.5pt">Total capitalization</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="text-align: left; border-bottom: Black 2.5pt double">$</TD><TD STYLE="text-align: right; border-bottom: Black 2.5pt double">87,699.4</TD><TD STYLE="text-align: left; padding-bottom: 2.5pt">&nbsp;</TD><TD STYLE="padding-bottom: 2.5pt">&nbsp;</TD>
    <TD STYLE="text-align: left; border-bottom: Black 2.5pt double">$</TD><TD STYLE="text-align: right; border-bottom: Black 2.5pt double">&nbsp;&nbsp;&nbsp;92,996.6</TD><TD STYLE="text-align: left; padding-bottom: 2.5pt">&nbsp;</TD></TR>
</TABLE>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 2%"></TD><TD STYLE="width: 2%">(1)</TD><TD STYLE="width: 96%">Outstanding shares of common stock as of December 31, 2011 excludes the warrants offered hereby and the shares of our common
stock issuable upon exercise of the warrants offered hereby, and also excludes:</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 4%"></TD><TD STYLE="width: 4%">&bull;</TD><TD STYLE="width: 92%">options representing the right to purchase a total of 17,143,505 shares of common stock at a weighted average exercise price
of $1.71 per share;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.4in; text-align: center; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 4%"></TD><TD STYLE="width: 4%">&bull;</TD><TD STYLE="width: 92%">10,825,422 shares of common stock which were reserved for future equity awards that may be granted in the future under our
equity incentive plans;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.4in; text-indent: -0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.4in; text-indent: -0.25in"></P>

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<TD STYLE="width: 4%"></TD><TD STYLE="width: 4%">&bull;</TD><TD STYLE="width: 92%">warrants representing the right to purchase a total of 37,389,825 shares of common stock at a weighted average exercise price
of $2.35 per share;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.4in; text-align: center; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 4%"></TD><TD STYLE="width: 4%">&bull;</TD><TD STYLE="width: 92%">10,000 shares of common stock issuable upon conversion of our outstanding Series B Convertible Redeemable Preferred Stock;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.4in; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 4%"></TD><TD STYLE="width: 4%">&bull;</TD><TD STYLE="width: 92%">any shares of common stock issued on conversion or redemption of our outstanding Series E 7% Senior Convertible Preferred Stock,
and any shares of common stock issued in connection with dividend payments in respect of such preferred stock;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.4in; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 4%"></TD><TD STYLE="width: 4%">&bull;</TD><TD STYLE="width: 92%">any shares of our common stock that we may issue from time to time in connection with draw-downs pursuant to our Purchase Agreement
with Aspire Capital Fund, LLC.; and</TD></TR>                                        <TR STYLE="vertical-align: top">
<TD>&nbsp;</TD><TD>&nbsp;</TD><TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD>&nbsp;</TD><TD>&bull;</TD><TD>the underwriters&rsquo; over-allotment option.</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">DESCRIPTION OF SECURITIES WE ARE OFFERING</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15.1pt">We are offering:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 33.85pt; text-align: center; text-indent: -0.25in"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.2in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD>15,000,000 shares of our common stock; and</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.45in; text-align: center; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.2in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD>15,000,000 warrants to purchase one share of our common stock and the shares of common stock issuable upon the exercise
                                                                   of                                                                    such
                                                                   warrants.</TD></TR></TABLE>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 33.85pt; text-align: center; text-indent: -0.25in"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The common stock and warrants will be
sold in units, with each unit consisting of one share of common stock and a warrant to purchase one share of our common
stock. Units will not be issued or certificated. The shares of common stock and warrants are immediately separable and will
be issued separately. The shares of common stock issuable from time to time upon exercise of the warrants, if any, are also
being offered pursuant to this prospectus supplement and the accompanying prospectus.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Common Stock</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The material terms and provisions of our
common stock and each other class of our securities which qualifies or limits our common stock are described under the caption
&ldquo;Description of Capital Stock&rdquo; starting on page S-63 of this prospectus supplement.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I>&nbsp;</I></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Warrants</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The material terms and provisions of the
warrants being offered pursuant to this prospectus supplement and the accompanying prospectus are summarized below.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><B>Term; Exercise Price
and Exercisability.</B>&nbsp;&nbsp;The warrants to be issued in this offering represent the rights to purchase up to an
aggregate of 15,000,000 shares of our common stock (excluding the underwriters&rsquo; over-allotment option). Each warrant
will have an exercise price of $0.51 per share, will become exercisable six months after issuance (the &ldquo;Initial
Exercise Date&rdquo;) (or such earlier date as may be hereafter designated by the Company) and will expire five years from
the date of issuance. The number of warrant shares that may be acquired by any holder upon any exercise of the warrant will
be limited to the extent necessary to insure that, following such exercise (or other issuance), the total number of shares of
common stock then beneficially owned by such holder and its affiliates and any other persons whose beneficial ownership of
common stock would be aggregated with the holder&rsquo;s for purposes of Section 13(d) of the Securities Exchange Act of
1934, as amended, does not exceed 4.99% of the total number of issued and outstanding shares of common stock (including for
such purpose the shares of common stock issuable upon such exercise), or beneficial ownership limitation. The holder may
elect to change this beneficial ownership limitation from 4.99% to 9.99% of the total number of issued and outstanding shares
of common stock (including for such purpose the shares of common stock issuable upon such exercise) upon providing us with
not less than 61 days&rsquo; prior written notice.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><B>Manner of
Exercise.</B>&nbsp;&nbsp;Holders of the warrants may exercise their warrants to purchase shares of our common stock at any
time on or after the Initial Exercise Date and on or before the expiration date by delivering (i) notice of exercise,
appropriately completed and duly signed, and (ii) payment of the exercise price by wire transfer or cashier&rsquo;s check
drawn on a United States bank, for the number of shares with respect to which the warrant is being exercised. Warrants may be
exercised in whole or in part, but only for full shares of common stock. We provide certain buy-in rights to a holder if we
fail to deliver the shares of common stock underlying the warrants by the date on which delivery
of the warrant shares is required by the warrant. The buy-in rights apply if after the day on which delivery
of the warrant shares is required by the warrant, the holder purchases (in an open market transaction or otherwise) shares
of our common stock to deliver in satisfaction of a sale by the holder of the warrant shares that the holder anticipated
receiving from us upon exercise of the warrant. In such event, we will:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD>pay in cash to the holder the amount equal to the excess (if any) of the buy-in price (including brokerage commissions, if
any) over the product of (A) the number of warrant shares that we were required to deliver to the holder in connection with the
exercise at issue, times (B) the price at which the sell order giving rise to holder&rsquo;s purchase obligation was executed;
and</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: center; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD>at the election of holder, either (A) reinstate the portion of the warrant as to such number of shares of common stock for
which such exercise was not honored, or (B) deliver to the holder such number of shares
of common stock that would have been issued had we timely complied with our exercise and delivery obligations.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">If the holder of a warrant desires to exercise
its warrant and there is no effective registration statement registering,
or no current prospectus available for, the issuance of the shares of common stock underlying the warrants, in lieu of
exercising its warrant by payment of a wire transfer or cashier&rsquo;s check, the holder may elect to receive shares equal to
the value of such holder&rsquo;s warrant by surrender of the warrant to us, together with a properly endorsed notice of exercise.
The number of shares to be issued would be determined by a formula based on the total number of shares with respect to which the
warrant is being exercised, the volume weighted average price for the shares of our common stock on the trading day immediately
prior to the date of exercise and the applicable exercise price of the warrants.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The shares of common stock issuable on exercise
of the warrants will be, when issued and paid for in accordance with the warrants, duly authorized, validly issued and fully paid
and non-assessable. We will authorize and reserve at least that number of shares of common stock equal to the number of shares
of common stock issuable upon exercise of all outstanding warrants.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><B>Call
Provision.</B>&nbsp;&nbsp;Subject to certain exceptions, while the warrants are outstanding and following the Initial
Exercise Date, if the volume weighted average price of a share of our common stock for each of 10 consecutive Trading Days (the
&ldquo;Measurement Period,&rdquo; which 10 consecutive Trading Day period shall not have commenced until after the Initial
Exercise Date) exceeds $1.53&nbsp;(subject to adjustment), then we may, within 1 Trading Day of the end of such Measurement
Period, upon notice, call for cancellation of all or any portion of the warrants (a &ldquo;Call&rdquo;) for consideration
equal to $0.001 per Share. Our right to Call the warrants shall be exercised ratably among the holders based on each
holder&rsquo;s initial purchase of warrants from us.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><B>Fundamental
Transaction.</B>&nbsp;&nbsp;If, at any time while the warrants are outstanding, (1) we consolidate or merge with or
into another corporation, (2) we sell, lease, license, assign, transfer, convey or otherwise dispose of all or substantially
all of our assets for consideration which is distributed to the holders of all our Common Stock, (3) any purchase offer,
tender offer or exchange offer (whether by us or another individual or entity) is completed pursuant to which holders of our
common stock are permitted to sell, tender or exchange their shares for other securities, cash or property and has been
accepted by the holders of 50% or more of our outstanding common stock,  (4) we effect any reclassification or
recapitalization of our common stock or any compulsory share exchange pursuant to which our common stock is converted into or
exchanged for other securities, cash or property or (5) we consummate a stock or share purchase agreement or other business
combination (including, without limitation,a reorganization, recapitalization, spin-off or scheme of arrangement) with
another individual, entity or group whereby such other individual, entity or group acquires more than 50% of our outstanding
stock (or the occurrence of any analogous proceeding) affecting our company (each, a &ldquo;Fundamental Transaction&rdquo;),
then upon any subsequent exercise of the warrants, the holders thereof will have the right to receive the same amount and
kind of securities, as it would have been entitled to receive upon the occurrence of such Fundamental Transaction if it had
been, immediately prior to such Fundamental Transaction, the holder of the number of warrant shares then issuable upon
exercise of the warrant, and any additional consideration payable as part of the Fundamental Transaction; <I>provided,
however,</I> that in the event of a Fundamental Transaction that is (1) an all cash transaction, (2) a &ldquo;Rule 13e-3
transaction&rdquo; as defined in Rule 13e-3 under the Exchange Act, or (3) a Fundamental Transaction (other than as described
solely in clause (5) above) involving a person or entity not traded on a national securities exchange, including, but not
limited to, the New York Stock Exchange, the NYSE Amex, the Nasdaq Global Select Market, the Nasdaq Global Market, or the
Nasdaq Capital Market, we or any Successor Entity (as defined below) shall, at the holder&rsquo;s option, exercisable at any
time concurrently with, or within 30 days after, the consummation of the Fundamental Transaction, purchase the warrant from
the holder by paying to the holder an amount of cash equal to the Black Scholes Value (as defined in the warrant) of the
remaining unexercised portion of the warrant on the date of the consummation of such Fundamental Transaction, and we shall
cause any successor entity in a Fundamental Transaction in which we are not the survivor (the &ldquo;Successor Entity&rdquo;)
to assume in writing all of our obligations under the warrant prior to such Fundamental Transaction and shall, at the option
of the holder, deliver to the holder in exchange for the warrant a security of the Successor Entity evidenced by a written
instrument substantially similar in form and substance to the warrants which is exercisable for a corresponding number of
shares of capital stock of such Successor Entity (or its parent entity) equivalent to the shares of common stock acquirable
and receivable upon exercise of the warrants (without regard to any limitations on the exercise of the warrant) prior to such
Fundamental Transaction, and with an exercise price which applies the exercise price under the warrant to such shares of
capital stock (but taking into account the relative value of the shares of common stock pursuant to such Fundamental
Transaction and the value of such shares of capital stock, such number of shares of capital stock and such exercise price
being for the purpose of protecting the economic value of the warrant immediately prior to the consummation of such
Fundamental Transaction), and which is reasonably satisfactory in form and substance to the holder.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><B>Certain Adjustments.</B>&nbsp;&nbsp;The
exercise price and the number of shares of common stock purchasable upon the exercise of the warrants are subject to adjustment
upon the occurrence of specific events, including stock dividends, stock splits, combinations and reclassifications of our common
stock. Additionally, the exercise price of the warrants issued to the investors is subject to certain adjustments if we (i) issue
rights, options or warrants to all holders of common stock (and not to the warrant holder) entitling them to subscribe for or purchase
shares of common stock at a price per share less than the volume weighted average price (the &ldquo;VWAP&rdquo;) of the common
stock on the record date for the determination of stockholders entitled to receive such rights, options or warrants, or (ii) distribute
to all holders of common stock (and not to the warrant holder) evidences of our indebtedness or assets (including cash and cash
dividends) or rights or warrants to purchase any security.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><B>Delivery of
Warrant Shares.</B>&nbsp;&nbsp;Upon the holder&rsquo;s exercise of a warrant, we will promptly, but in no event later than
three business days after the exercise date (referred to as the &ldquo;exercise share delivery date&rdquo;), issue and
deliver, or cause to be issued and delivered,  the shares of common stock issuable upon exercise of the warrant. If the
holder provides the necessary information to us, we will issue and deliver the shares electronically through The Depository
Trust Corporation through its Deposit Withdrawal Agent Commission System (DWAC) or another established clearing corporation
performing similar functions.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15.1pt"><B>Notice of Corporate Action.</B>&nbsp;&nbsp;We
will provide prior notice to holders of the warrants in advance of certain record or effective dates (as specified below) in connection
with the following corporate events, to provide the holders of the warrants with the opportunity to exercise their warrants and
hold common stock:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.2in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD>if we declare a dividend (or any other distribution in whatever form) on our common stock;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.45in; text-align: center; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.2in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD>if we declare a special nonrecurring cash dividend on or a redemption of common stock;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.45in; text-align: center; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.2in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD>if we authorize the granting to all holders of our common stock rights or warrants to subscribe for or purchase any shares
of capital stock of any class or of any rights;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.45in; text-align: center; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.2in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD>if the approval of any of our stockholders shall be required in connection with any reclassification of our common stock, any
consolidation or merger to which our company is a party, any sale or transfer of all or substantially all of our assets, or any
compulsory share exchange whereby our common stock is converted into other securities, cash or property; or</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.45in; text-align: center; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.2in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD>if we authorize the voluntary or involuntary liquidation or winding up of the affairs of the Company,</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.45in; text-indent: -0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">then, in each case, we will mail to the holders of the warrants
a notice stating:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.45in; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.2in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD>the date on which a record is to be taken for the purpose of such dividend, distribution, redemption, rights or warrants, or
if a record is not to be taken, the date as of which the holders of our common stock of record to be entitled to such dividend,
distributions, redemption, rights or warrants are to be determined, or</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.15in; text-align: center; text-indent: 0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.2in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD>the date on which such reclassification, consolidation, merger, sale, transfer or share exchange is expected to become effective
or close, and the date as of which it is expected that holders of record of our common stock will be entitled to exchange their
shares of common stock for securities, cash or other property deliverable upon such reclassification, consolidation, merger, sale,
transfer or share exchange.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Subject to applicable law, the holder will be provided a reasonable
opportunity to exercise the warrant prior to the effective date of the event triggering such notice. No holders of the warrants
will possess any rights as a stockholder under those warrants until the holder exercises those warrants.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><B>Transferability.</B>&nbsp;&nbsp;The warrants
may be transferred independent of the common stock they were issued with, on a form of assignment, subject to all applicable laws.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><B>Fractional Shares.</B>&nbsp;&nbsp;No fractional
shares or scrip representing fractional shares shall be issued upon the exercise of the warrants. As to any fraction of a share
which the holder would otherwise be entitled to purchase upon such exercise, we will, at our election, either pay a cash adjustment
in respect of such final fraction in an amount equal to such fraction multiplied by the exercise price or round up to the next
whole share.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><B>Exchange Listing.</B>&nbsp;&nbsp;We do
not plan on making an application to list the warrants on the NYSE Amex or any other national securities exchange or recognized
trading system. The common stock underlying the warrants is listed on the NYSE Amex.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The description of the warrants contained
herein does not purport to be complete and is qualified in its entirety by reference to the form of warrant, which will be filed
as an exhibit to a Current Report on Form 8-K to be filed with the SEC by us in connection with this offering.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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    <!-- Field: /Page -->

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">DESCRIPTION OF CAPITAL STOCK</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The following is a summary of all material
characteristics of our capital stock as set forth in our certificate of incorporation and bylaws, and our outstanding warrants.
The summary does not purport to be complete and is qualified in its entirety by reference to our certificate of incorporation and
bylaws and the Class A warrants, the Class D warrants, the warrants issued in our November 2010 Common Stock Offering and in our
November 2010 Preferred Stock Offering, the warrants issued in connection with the PCT Merger and the Amorcyte Merger, the Series
NA Warrants and the Certificate of Designations relating to our Series E 7% Senior Convertible Preferred Stock themselves, all
of which are incorporated by reference as exhibits to the registration statement of which this prospectus is a part, and to the
provisions of the General Corporation Law of the State of Delaware, as amended.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Common Stock</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">We are authorized to issue 500,000,000 shares
of common stock, par value $0.001 per share (&ldquo;Common Stock&rdquo;). Holders of our Common Stock are entitled to one vote
per share in the election of directors and on all other matter on which stockholders are entitled or permitted to vote. Holders
of our Common Stock are not entitled to cumulative voting rights. Therefore, holders of a majority of the shares voting for the
election of directors can elect all of the directors. Subject to the terms of any outstanding series of preferred stock, the holders
of our Common Stock are entitled to dividends in the amounts and at times as may be declared by the Board of Directors out of funds
legally available. Upon liquidation or dissolution, holders of our Common Stock are entitled to share ratably in all net assets
available for distribution to stockholders after payment of any liquidation preferences to holders of our preferred stock. Holders
of our Common Stock have no redemption, conversion or preemptive rights.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">As of March 23, 2012, we had 114,765,778
shares of Common Stock issued and outstanding, exclusive of existing convertible preferred stock, options and warrants and the
shares and warrants to be issued in this offering.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Preferred Stock</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">We are authorized to issue up to 20,000,000
shares of preferred stock, par value $0.01 per share, with such designations, rights, and preferences as may be determined from
time to time by our Board of Directors. Accordingly, our Board of Directors is empowered, without stockholder approval, to issue
preferred stock with dividend, liquidation, conversion, voting, or other rights that could adversely affect the voting power or
other rights of the holders of our Common Stock. The issuance of preferred stock could have the effect of restricting dividends
on our Common Stock, diluting the voting power of our Common Stock, impairing the liquidation rights of our Common Stock, or delaying
or preventing a change in control of our company, all without further action by our stockholders.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">As of March 23, 2012, there were:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.2in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD>10,000 shares of our Series B Convertible Redeemable Preferred Stock, $0.01 par value per share (&ldquo;Series B Preferred
Stock&rdquo;), issued and outstanding; and</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.45in; text-align: center; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.2in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD>5,486,969 shares of our Series E 7% Senior Convertible Preferred Stock, $0.01 par value per share (the &ldquo;Series E Preferred
Stock,&rdquo; or the &ldquo;Series E Preferred Shares&rdquo;), issued and outstanding.</TD></TR></TABLE>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.45in; text-indent: -0.25in"><I>&nbsp;</I></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I>Series B Preferred Stock </I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The Series B Preferred Stock ranks pari passu
with our Common Stock with respect to the payment of dividends and to the distribution of assets upon liquidation, dissolution
or winding up.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">So long as any shares of the Series B Preferred
Stock are outstanding, no dividend shall be declared or paid or set aside for payment or other distribution declared or made upon
our Common Stock or upon any other stock ranking junior to, or on a parity with, the Series B Preferred Stock as to dividends or
upon liquidation, dissolution or winding up, unless, in the case of our preferred stock, the same dividend is declared, paid or
set aside for payment on all outstanding shares of the Series B Preferred Stock or in the case of our Common Stock, ten times such
dividend per share is declared, paid or set aside for payment on each outstanding share of the Series B Preferred Stock.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Except as otherwise provided by law, each
share of the Series B Preferred Stock has the same voting rights as ten shares of our Common Stock and the holders of the Series
B Preferred Stock and the Common Stock shall vote together as one class on all matters.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The holder of any share of Series B Preferred
Stock has the right, at such holder&rsquo;s option, to convert such share into one fully paid and non-assessable share of our Common
Stock, subject to adjustment.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">In the event of any voluntary or involuntary
dissolution, liquidation or winding up of our Company, after any distribution of assets is made to the holders of any other class
or series of stock that ranks prior to the Series B Preferred Stock in respect of distributions upon the liquidation of our company,
the holder of each share of Series B Preferred Stock then outstanding shall be entitled to be paid out of our assets available
for distribution to our stockholders, an amount on a pari passu basis equal to ten times the amount per share distributed to the
holders of our Common Stock. After payment of the full amount of the distribution to which they are entitled, the holders of shares
of the Series B Preferred Stock will not be entitled to any further participation in any distribution of assets by the corporation.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Shares of Series B Preferred Stock issued
and reacquired by us shall have the status of authorized and unissued shares of preferred stock, undesignated as to series, subject
to later issuance.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Holders of shares of Series B Preferred Stock
are not entitled to any preemptive or subscription rights in respect of any securities of the corporation.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I>&nbsp;</I></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I>Series E 7% Senior Convertible Preferred Stock </I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>General.</I>&nbsp;&nbsp;We are authorized
to issue up to 20,000,000 shares of preferred stock, par value $0.01 per share, with such designations, rights and preferences
as may be determined from time to time by our Board of Directors, without further stockholder approval. Accordingly, our Board
of Directors has created out of the authorized and unissued shares of our preferred stock a series of preferred stock designated
as the Series E 7% Senior Convertible Preferred Stock. As of March 23, 2012, there were 5,486,969 shares of Series E 7% Senior
Convertible Preferred Stock, par value $0.01 per share (the &ldquo;Series E Preferred Stock,&rdquo; or the &ldquo;Series E Preferred
Shares&rdquo;) issued and outstanding.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The following is a brief description of the
terms of our Series E Preferred Stock. The description of the Series E Preferred Stock contained herein does not purport to be
complete and is qualified in its entirety by reference to the Certificate of Designations for the Series E Preferred Stock.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Dividends.</I>&nbsp;&nbsp;Holders of Series
E Preferred Stock shall be entitled to receive dividends payable in cash (or, at our option, in shares of our Common Stock if the
Equity Conditions are satisfied) on the Liquidation Preference (as defined below) of such Series E Preferred Share at the per share
rate of seven percent (7%) per annum, which shall be cumulative. Dividends on the Series E Preferred Shares shall commence accruing
on the Initial Issuance Date and shall be computed on the basis of a 360-day year of twelve 30-day months. Dividends shall be payable
in arrears on each Mandatory Redemption Date. &ldquo;Mandatory Redemption Date&rdquo; is defined in the certificate of designations
as March 19, 2011, and the 19th day of each calendar month thereafter (or the next trading day thereafter) and ending on and including
May 20, 2013 (the &ldquo;Maturity Date&rdquo;). The Maturity Date will be deemed to be a Mandatory Redemption Date.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>&nbsp;</I></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Liquidation Preference.</I>&nbsp;&nbsp;In
the event of any liquidation, dissolution or winding up of our company, either voluntary or involuntary (a &ldquo;Liquidation Event&rdquo;),
the holders of the Series E Preferred Shares shall be entitled to receive, out of our assets available for distribution to stockholders
(&ldquo;Liquidation Funds&rdquo;), prior and in preference to any distribution of any of our assets to the holders of any other
class or series of equity securities, the amount of one dollar ($1.00) per share plus all accrued but unpaid dividends (the &ldquo;Liquidation
Preference&rdquo;). After payment of the full amount of the Liquidation Preference, in the case of a Liquidation Event, the holders
will not be entitled to any further participation in any distribution of our assets; provided that the foregoing shall not affect
any rights which holders may have with respect to any requirement that our company repurchase the Series E Preferred Shares or
for any right to monetary damages. All the preferential amounts to be paid to the holders of the Series E Preferred Shares shall
be paid or set apart for payment before the payment or setting apart for payment of any amount for, or the distribution of any
Liquidation Funds of our company to the holders of shares of other classes or series of our preferred stock junior in rank to the
Series E Preferred Shares in connection with a Liquidation Event.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-weight: normal"><I>Mandatory Monthly Redemption.</I></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><FONT STYLE="font-weight: normal"><I>&nbsp;</I></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><FONT STYLE="font-weight: normal">The certificate
of designations provides that &ldquo;Mandatory Redemption Shares&rdquo; means, with respect to (a) any Mandatory Redemption Date
(other than the Maturity Date) an amount equal to 1/27th of the Series E Preferred Shares initially issued pursuant to the stock
purchase agreement (regardless of whether any holder has converted any Series E Preferred Shares or we have optionally redeemed
any Series E Preferred Shares) and (b) the Maturity Date, all outstanding Series E Preferred Shares. On each applicable Mandatory
Redemption Date, we shall redeem the Mandatory Redemption Shares at an aggregate redemption price equal to the sum of (x) the product
of (A) the Liquidation Preference and (B) the number of Mandatory Redemption Shares required to be redeemed on such Mandatory Redemption
Date plus (y) any and all accrued but unpaid dividends on all of the outstanding Series E Preferred Shares (the &ldquo;Mandatory
Redemption Price&rdquo;). The Mandatory Redemption Price shall be payable, at our option, in cash or shares of our Common Stock
or any combination of cash and shares of our Common Stock, provided, however, that no portion of the Mandatory Redemption Price
may be paid in shares of our Common Stock unless the Equity Conditions are satisfied or waived by the holders of a majority of
the Series E Preferred Shares (the &ldquo;Required Holders&rdquo;) in writing prior to delivery of the applicable Mandatory Redemption
Notice (as defined below); provided, further, however, that the portion of the applicable Mandatory Redemption Price that we elect
to pay in shares of our Common Stock (if any) shall not exceed the Dollar Volume Limitation (unless waived by the Required Holders
in writing). </FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">On a date not less than twenty-two (22) trading
days, but in no event more than twenty-five (25) trading days, prior to each Mandatory Redemption Date (the &ldquo;Mandatory Redemption
Notice Date&rdquo;), we shall deliver a written notice (a &ldquo;Mandatory Redemption Notice&rdquo;) to the holders, which shall
either: (i) confirm that the entire applicable Mandatory Redemption Price shall be paid in cash; or (ii) (A) state that we elect
to pay all or a portion of the Mandatory Redemption Price in shares of our Common Stock, (B) specify the portion that we elect
to pay in cash (expressed in dollars) (such amount, the &ldquo;Cash Payment Amount&rdquo;) and the portion that we elect to pay
in shares of our Common Stock (expressed in dollars) (such portion a &ldquo;Stock Payment Amount&rdquo;), which amounts when added
together must equal the applicable Mandatory Redemption Price, (C) certify that the Equity Conditions (as defined below) are then
satisfied (or waived by the Required Holders), (D) state the Dollar Volume Limitation (expressed in dollars) and certify that the
Stock Payment Amount does not exceed such Dollar Volume Limitation and (E) certify that the Maximum Share Amount (as defined below)
has not been exceeded. If (x) we do not timely deliver a Mandatory Redemption Notice or (y) the Equity Conditions are not satisfied
(unless waived by the Required Holders), then we shall be deemed to have delivered, a Mandatory Redemption Notice electing to pay
the entire Mandatory Redemption Price in cash. The certificate of designations provides that &ldquo;Dollar Volume Limitation&rdquo;
means fifteen percent (15%) of the aggregate dollar trading volume of our Common Stock on the NYSE Amex Equities (or other applicable
trading market) over the twenty-two (22) consecutive trading day period ending on the trading day immediately preceding the date
of the Mandatory Redemption Notice or Optional Redemption Notice, as applicable. The term &ldquo;dollar trading volume&rdquo; for
any trading day shall be determined by multiplying the Daily VWAP by the volume as reported on Bloomberg for such trading day.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The term &ldquo;Equity Conditions&rdquo;
means each of the following: (i) on each day during the Equity Conditions Measuring Period, all shares of our Common Stock to be
issued on the applicable Mandatory Redemption Date (or such other date on or event for which the Equity Conditions are required
to be satisfied) shall be eligible for resale by the holder without restriction and without need for additional registration under
any applicable federal or state securities laws, and we shall have no knowledge of any fact that would cause any shares of Common
Stock not to be so eligible for resale by the holder without restriction and without need for additional registration under any
applicable federal or state securities laws; (ii) on each day during the Equity Conditions Measuring Period, the shares of Common
Stock are designated for listing on a trading market and shall not have been suspended from trading on such trading market nor
shall delisting or suspension by such exchange or market have been threatened or pending in writing by such exchange nor shall
there be any Securities and Exchange Commission or judicial stop trade order or trading suspension stop order; (iii) any shares
of our Common Stock to be issued in connection with the applicable Mandatory Redemption Date (or such other date on or event for
which the Equity Conditions are required to be satisfied) may be issued in full without violating the rules or regulations of the
trading market or any applicable laws; (iv) on each day during the Equity Conditions Measuring Period, there shall not have occurred
and be continuing, unless waived by the holder, either (A) a Trigger Event (as defined below) or (B) an event that with the passage
of time or giving of notice would constitute a Trigger Event; (v) on each day during the Equity Conditions Measuring Period, we
have not provided any holder with any non-public information; (vi) on each day during the Equity Conditions Measuring Period, neither
the registration statement of which the prospectus supplement pertaining to our senior convertible preferred stock offering is
a part nor the prospectus nor such prospectus supplement contains any untrue statement of a material fact or omits to state a material
fact necessary in order to make the statements made therein, in the light of the circumstances under which they were made, not
misleading and such registration statement, prospectus and such prospectus supplement comply with all applicable securities laws
as to form and substance (unless the issuable shares of Common Stock may be sold without restriction); (vii) our transfer agent
for the shares of our Common Stock is participating in the Depository Trust Company (&ldquo;DTC&rdquo;) Fast Automated Securities
Transfer Program; and (viii) all shares of our Common Stock to be issued in connection with the applicable Mandatory Redemption
Date (or such other date on or event for which the Equity Conditions are required to be satisfied) are duly authorized and will
be validly issued, fully paid and non-assessable upon issuance, free and clear of all liens, claims or encumbrances, and the issuance
thereof will not require any further approvals of our board of directors or stockholders. &ldquo;Equity Conditions Measuring Period&rdquo;
means the period beginning twenty (20) trading days prior to the applicable Mandatory Redemption Date (or such other date on or
event for which the Equity Conditions are required to be satisfied) and ending on and including such Mandatory Redemption Date.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">To the extent that we elect (or are required)
to pay all or any portion of the applicable Mandatory Redemption Price in shares of our Common Stock, the applicable Stock Payment
Amount will be paid as follows:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.2in"></TD><TD STYLE="width: 0.25in">(A)</TD><TD>twenty-one (21) trading days prior to the applicable Mandatory Redemption Date (the &ldquo;First Advance Date&rdquo;), we shall
deliver to the holders a number of shares of our Common Stock determined by dividing (x) the Stock Payment Amount for such Mandatory
Redemption Date by (y) ninety-two percent (92%) of the Daily VWAP on the trading day immediately preceding such Advance Date (the
&ldquo;First Advance Shares&rdquo;);</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.45in; text-align: center; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.2in"></TD><TD STYLE="width: 0.25in">(B)</TD><TD>eleven (11) trading days prior to the applicable Mandatory Redemption Date (the &ldquo;Second Advance Date&rdquo; and together
with the First Advance Date, the &ldquo;Advance Dates&rdquo; and each, an &ldquo;Advance Date&rdquo;), we shall deliver to the
holders a number of shares of our Common Stock equal to the positive difference (if any) between (x) the quotient of (1) the Stock
Payment Amount and (2) the average of the five lowest Daily VWAPs during the first (10) ten trading days of the applicable Stock
Payment Pricing Period and (y) the number of First Advance Shares delivered to the holders in connection with such Mandatory Redemption
Date (the &ldquo;Second Advance Shares&rdquo; and together with the First Advance Shares, the &ldquo;Advance Shares&rdquo;); and</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.45in; text-align: center; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.2in"></TD><TD STYLE="width: 0.25in">(C)</TD><TD>not later than three (3) trading days after the applicable Mandatory Redemption Date, we shall deliver an additional number
of shares of our Common Stock (the &ldquo;True-Up Shares&rdquo;), if any, to the holders equal to the positive difference between
(a) the Stock Payment Amount divided by the Stock Payment Price for such Mandatory Redemption Date and (b) the Advance Shares;
provided; however, that if clause (b) exceeds clause (a), then each holder shall return its pro rata portion of such excess number
of shares of our Common Stock to us, and such excess shares shall immediately be deemed cancelled effective as of the True Up.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&ldquo;Daily VWAP&rdquo; means, for any date,
(i) the daily volume weighted average price of our Common Stock for such date on the NYSE Amex Equities as reported by Bloomberg;
(ii) if our Common Stock is not then listed on the NYSE Amex Equities, the daily volume weighted average price of our Common Stock
for such date on such other trading market where our Common Stock is then listed as reported by Bloomberg; (iii) if the foregoing
do not apply, the volume weighted average price of our Common Stock in the over-the-counter market on the electronic bulletin board
for our Common Stock as reported by Bloomberg, or, if no volume weighted average price is reported for such security by Bloomberg,
the highest bid as reported on the &ldquo;pink sheets&rdquo; at the close of trading; or (iv) in all other cases, the fair market
value of a share of our Common Stock as determined by an independent appraiser selected in good faith by the Required Holders and
reasonably acceptable to us.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">To the extent that we elect to pay all or
any portion of the applicable Mandatory Redemption Price in shares of our Common Stock:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.2in"></TD><TD STYLE="width: 0.25in">(A)</TD><TD>to the extent that the aggregate number of Advance Shares or True-Up Shares to be delivered to a holder in respect of any individual
Stock Payment Amount would cause such holder to exceed the Beneficial Ownership Limitation (as defined below under &ldquo;Ownership
Cap&rdquo;), then, (I) the holder shall provide written notice to us that such delivery of all or a portion of the Advance Shares
or True-Up Shares would cause such holder to exceed the Beneficial Ownership Limitation, and (II) in addition to delivery of the
number of Advance Shares or True-Up Shares that would not cause such holder to exceed the Beneficial Ownership Limitation, we shall
pay to such holder in lieu of such number of Advance Shares or True-Up Shares that would cause such holder to exceed the Beneficial
Ownership Limitation (such excess number of shares, the &ldquo;Excess Shares&rdquo;), not more than the later of three (3) trading
days after the Mandatory Redemption Date or ten (10) trading days after the date of such holder&rsquo;s written notice, an amount
in cash equal to the portion of the Stock Payment Amount that would otherwise be payable in respect of the Excess Shares;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.45in; text-align: center; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.2in"></TD><TD STYLE="width: 0.25in">(B)</TD><TD>to the extent that such Stock Payment Amount, when aggregated with any shares of our Common Stock already issued in respect
of all of the Series E Preferred Shares, would cause the Maximum Share Amount to be exceeded, then that portion of such Stock Payment
Amount that would not exceed the Maximum Share Amount shall be delivered to the holders hereunder in shares of our Common Stock
as provided above, ratably based on the holders&rsquo; relative ownership of the outstanding Series E Preferred Shares, and we
shall pay to the holders, not more than three (3) trading days after the Mandatory Redemption Date, an amount in cash equal to
the Stock Replacement Payment in lieu of any portion of such Stock Payment Amount that would cause the Maximum Share Amount to
be exceeded;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.2in"></TD><TD STYLE="width: 0.25in">(C)</TD><TD>if the Equity Conditions are neither (x) satisfied nor (y) waived, on the trading day immediately preceding the First Advance
Date and/or on the First Advance Date, or if the Daily VWAP cannot be determined on the trading day immediately preceding the First
Advance Date, or if we fail to deliver the First Advance Shares to the holders on the First Advance Date, then the holder may,
at its options upon written notice to us, require us to pay to such holder, not later than three (3) trading days after the Mandatory
Redemption Date, an amount of cash equal to the Stock Replacement Payment in lieu of such Stock Payment Amount; or</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.45in; text-align: center; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.2in"></TD><TD STYLE="width: 0.25in">(D)</TD><TD>if subsequent to the delivery of the First Advance Shares (A) the Equity Conditions are neither (x) satisfied nor (y) waived
in accordance with the terms hereof, as applicable, on any day of the Stock Payment Pricing Period or (B) if the Daily VWAP cannot
be determined on any day of the Stock Payment Pricing Period, then each holder may, at its option, elect in a written notice to
us to redeliver all or any portion of the Advance Shares to us and we will pay to such holder, not later than three (3) trading
days after the Mandatory Redemption Date, an amount of cash equal to the Stock Replacement Payment in lieu of such portion of the
Stock Payment Amount for which such holder has elected in writing to redeliver Advance Shares to us.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The &ldquo;Stock Replacement Payment&rdquo;
shall be determined according to the following formula:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">SRP = (X/Y) * S</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">For the purposes of the foregoing formula:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">SRP = Stock Replacement Payment</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">X = the average Daily VWAP of the shares
of our Common Stock for the applicable Stock Payment Pricing Period</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Y = the Stock Payment Price for the applicable
Stock Payment Pricing Period</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">S = the Stock Payment Amount (or, (A) in
the case that either or both of Maximum Share Amount and/or Beneficial Ownership Limitation is exceeded as provided above, only
that portion of such Stock Payment Amount that would exceed the Maximum Share Amount and/or Beneficial Ownership Limitation, as
applicable, and/or (B) that portion of the Stock Payment Amount for which the holder has elected in its written notice to redeliver
Advance Shares to us).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Any shares of our Common Stock required to
be delivered by us to a holder shall be credited to such holder&rsquo;s or its designee&rsquo;s balance account with DTC through
its Deposit/Withdrawal at Custodian system (&ldquo;DWAC&rdquo;).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Each mandatory redemption (and the related
payment of the Mandatory Redemption Price) shall be made pro rata among the holders based on each holder&rsquo;s relative percentage
ownership of the outstanding Series E Preferred Shares.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Notwithstanding the delivery of a Mandatory
Redemption Notice, the holder may deliver a Conversion Notice with respect to all or any portion of the specific Mandatory Redemption
Shares to be redeemed on the applicable Mandatory Redemption Date at any time prior to such Mandatory Redemption Date. Any Advance
Shares delivered to such holder in connection with such Mandatory Redemption Date shall count towards the number of shares of our
Common Stock that we will be obligated to deliver on the applicable Share Delivery Date (as defined below), and to the extent that
the Advance Shares exceeds the number of shares of our Common Stock that we would be required to deliver on the applicable Share
Delivery Date, the holder shall return such excess to us.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Each and every time that we sell any shares
of our Common Stock pursuant to any Equity Line, we shall immediately deliver a written notice to each holder (an &ldquo;Equity
Line Draw Notice&rdquo;), which Equity Line Draw Notice shall state the aggregate purchase price for such shares of our Common
Stock (the &ldquo;Equity Line Aggregate Purchase Price&rdquo;). Each holder may, at its option, by delivering a written notice
to us, require us to pay the Mandatory Redemption Price (or the appropriate portion thereof) on the next succeeding Mandatory Redemption
Date (or to the extent that the date of such Equity Line Draw notice is subsequent to the date of the Mandatory Redemption Notice
for such Mandatory Redemption Date, then the next succeeding Mandatory Redemption Date) in shares of our Common Stock in an amount
equal to its pro rata portion of the Equity Line Aggregate Purchase Price. To the extent that the Equity Line Aggregate Purchase
Price exceeds the aggregate amount of the entire Mandatory Redemption Price for such Mandatory Redemption Date, then on each succeeding
Mandatory Redemption Date the holder may, at its option, by delivering a written notice to us, require us to pay its pro rata portion
of the applicable Mandatory Redemption Price in shares of our Common Stock until we have made aggregate payments in shares of our
Common Stock equal to its pro rata portion of the entire Equity Line Aggregate Purchase Price. Notwithstanding anything to the
contrary, all payments of Mandatory Redemption Price made in shares of our Common Stock shall be subject the requirement to make
the appropriate Stock Replacement Payment if applicable. Pro rata portion for a holder is the number of Series E Preferred Shares
then held by such holder divided by the aggregate number of outstanding Series E Preferred Shares.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Optional Redemption.</I>&nbsp;&nbsp;We
may, at our option, redeem the Series E Preferred Shares, at any time and from time to time, in whole or in part (but not less
than 1,000,000 Series E Preferred Shares at any one time) for an amount equal to (a) the liquidation preference per Series E Preferred
Share plus any accrued and unpaid dividends through the optional redemption date (the &ldquo;Base Redemption Price&rdquo;) plus
(b) (i) if such prepayment occurs on or before the twelve month anniversary of the closing, an amount equal to 15% of the Base
Redemption Price or (ii) if such prepayment occurs at any time after the twelve month anniversary of the closing date, an amount
equal to 10% of the Base Redemption Price (the additional amount under clause (b) being referred to as the &ldquo;Additional Redemption
Price&rdquo;). The Base Redemption Price will be paid in cash and the Additional Redemption Price will be paid in cash or, at our
option and provided (w) the Equity Conditions are satisfied (unless waived by the Required Holders), (x) the portion of the Additional
Redemption Price to be paid in shares of our Common Stock does not exceed the Dollar Volume Limitation (unless waived by the Required
Holders), (y) the Maximum Share Amount is not exceeded and (z) the Daily VWAP is available on the trading day immediately preceding
the First Optional Redemption Advance Date and on each day of the Stock Payment Pricing Period, in shares of our Common Stock.&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">We will deliver written notice of optional
redemption to the holders 30 trading days prior to the date we set for such optional redemption, which may not be a Mandatory Redemption
Date or any day of a Stock Payment Pricing Period with respect to any mandatory redemption date. Each holder may submit a conversion
notice for the specific Series E Preferred Shares to be redeemed at any time prior to the optional redemption date. The optional
redemption notice will specify the number of Series E Preferred Shares to be redeemed and what portion of the Additional Redemption
Price will be paid in shares of our Common Stock (expressed in dollars), what portion of the Additional Redemption Price will be
paid in cash (expressed in dollars) and (A) certify that the Equity Conditions are satisfied, (B) state the Dollar Volume Limitation
(expressed in dollars) and certify that the portion of the Additional Redemption Price to be paid in shares of our Common Stock
does not exceeded such Dollar Volume Limitation and (C) certify that the Maximum Share Amount has not been exceeded. The optional
redemption notice will be irrevocable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">To the extent that any portion of the Additional
Redemption Price will be paid in shares of our Common Stock, 21 trading days prior to the optional redemption date (the &ldquo;First
Optional Redemption Advance Date&rdquo;), we will advance to the holders a number of shares of our Common Stock determined by dividing
(x) that portion of the Additional Redemption Price to be paid in shares of our Common Stock by (y) 92% of the Daily VWAP on the
trading day immediately preceding the First Optional Redemption Advance Date (the &ldquo;First Optional Redemption Advance Shares&rdquo;).
In addition, 11 trading days prior to the applicable optional redemption date (the &ldquo;Second Optional Redemption Advance Date&rdquo;
and together with the First Optional Redemption Advance Date, the &ldquo;Optional Redemption Advance Dates&rdquo; and each, an
&ldquo;Optional Redemption Advance Date&rdquo;), we will advance to the holders an additional number of shares of our Common Stock
equal to the positive difference (if any) between (x) the quotient of (1) the portion of the Additional Redemption Price to be
paid in shares of our Common Stock and (2) the average of the five lowest Daily VWAPs during the first 10 trading days of the applicable
Stock Payment Pricing Period and (y) the number of First Optional Redemption Advance Shares delivered to the holders in connection
with such optional redemption date (the &ldquo;Second Optional Redemption Advance Shares&rdquo; and together with the First Optional
Redemption Advance Shares, the &ldquo;Optional Redemption Advance Shares&rdquo;). Not later than three trading days after the optional
redemption date, we will deliver an additional number of shares of our Common Stock, if any, to the holder equal to the positive
difference between (1) that portion of the Additional Redemption Price to be paid in shares of our Common Stock divided by the
Stock Payment Price and (2) the Optional Redemption Advance Shares. If clause (2) of the immediately preceding sentence exceeds
clause (1) of the immediately preceding sentence, then each holder shall return to us its pro rata portion of such excess number
of shares of our Common Stock. No holder shall have any liability to us to the extent that any Optional Redemption Advance Shares
that are returned to us pursuant to the immediately preceding sentence decrease in value following the applicable Optional Redemption
Advance Date.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Optional Conversion by the Holders.</I>&nbsp;&nbsp;Each
holder of the Series E Preferred Shares shall have the right at any time and from time to time, at the option of such holder, to
convert all or any portion of the Series E Preferred Shares held by such holder, for such number shares of our Common Stock, free
and clear of any liens, claims or encumbrances, as is determined by dividing (i) the Liquidation Preference times the number of
Series E Preferred Shares being converted, by (ii) the Conversion Price (as defined below) in effect on the Conversion Date (as
defined below). Immediately following such conversion, the persons entitled to receive the shares of our Common Stock upon the
conversion of Series E Preferred Shares shall be treated for all purposes as having become the owners of such shares of our Common
Stock, subject to the rights provided herein to holders. Pursuant to the certificate of designations, the initial &ldquo;Conversion
Price&rdquo; was $2.0004, subject to adjustment as provided therein. As of March 23, 2012, the adjusted Conversion Price was $1.64,
and will be further adjusted as a result of this offering. The Conversion Price is subject to further adjustment in accordance
with the terms of the certificate of designations.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The Conversion Price is subject to adjustment
under the following circumstances:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.2in"></TD><TD STYLE="width: 0.25in">(i)</TD><TD>in the event we effect a stock split or combination of our outstanding Common Stock, then the conversion price then in effect
will be proportionately decreased or increased, as applicable.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.45in; text-align: center; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.2in"></TD><TD STYLE="width: 0.25in">(ii)</TD><TD>in the event we make, issue or set a record date for the determination of holders of our Common Stock entitled to receive a
dividend or other distribution payable in shares of our Common Stock, then the conversion price shall be decreased by multiplying
the conversion price then in effect by a fraction equal to: (a) the total number of shares of our Common Stock issued and outstanding
immediately prior to such issuance or the close of business on such record date divided by (b) the total number of shares our Common
Stock issued and outstanding immediately prior to such issuance or the close of business on such record date plus the number of
shares of our Common Stock issuable in payment of such dividend or distribution.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.45in; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.2in"></TD><TD STYLE="width: 0.25in">(iii)</TD><TD>in the event we make, issue or set a record date for the determination of holders of our Common Stock entitled to receive a
dividend or other distribution payable in securities or property other than shares of our Common Stock, then an appropriate revision
shall be made to conversion price then in effect such that the holders of the Series E Preferred Shares shall receive upon conversion
thereof, in addition to the shares of our Common Stock to which the holders would be entitled, the number of securities or other
property that they would have received had such holders converted their Series E Preferred Shares into shares of our Common Stock
on the date of such event.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.45in; text-align: center; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.2in"></TD><TD STYLE="width: 0.25in">(iv)</TD><TD>in the event we issue or sell shares of our Common Stock (other than as provided above in connection with a stock split or
combination or the payment of certain dividends and distributions) at a price per share less than the Conversion Price, or without
consideration, the Conversion Price then in effect upon each such issuance shall be adjusted by multiplying the Conversion Price
by a fraction equal to: (a) the total number of shares of our Common Stock issued and outstanding immediately prior to such issuance
plus the number of shares of our Common Stock which the aggregate consideration for the total number of such additional shares
of our Common Stock so issued would purchase at a price per share equal to the Conversion Price then in effect divided by (b) the
number of shares of our Common Stock outstanding immediately after the issuance of such additional shares.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.45in; text-align: center; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.2in"></TD><TD STYLE="width: 0.25in">(v)</TD><TD>in the event we shall issue or sell any rights, warrants or options to purchase or other securities convertible into or exchangeable
or exercisable for, directly or indirectly, any shares of our Common Stock or securities convertible into or exchangeable or exercisable
for, directly or indirectly, shares of our Common Stock or common stock equivalents and the price per share at which such additional
shares of our Common Stock may be issued pursuant to any such common stock equivalent shall be less than the Conversion Price then
in effect, or if after the issuance of any common stock equivalents, the price per share at for which such additional shares of
our Common Stock may be issued pursuant to any such common stock equivalent is thereafter amended or adjusted such that the price
as so amended or adjusted shall be less than the Conversion Price then in effect, then the conversion price then in effect upon
each such issuance or adjustment shall be adjusted by multiplying the conversion price by a fraction equal to: (a) the total number
of shares of our Common Stock issued and outstanding immediately prior to such issuance plus the number of shares of our Common
Stock which the aggregate consideration for the total number of such additional shares of our Common Stock so issued would purchase
at a price per share equal to the conversion price then in effect divided by (b) the number of shares of our Common Stock outstanding
immediately after the issuance of such additional shares.</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Notwithstanding the foregoing, the Conversion
Price will not be adjusted for the sale or issuance of &ldquo;Excluded Securities,&rdquo; which are defined in the certificate
of designations as the following: (a) shares of our Common Stock or common stock equivalents issued pursuant to a stock option
plan that has been approved by our Board of Directors and our stockholders, pursuant to which our securities may be issued only
to a person eligible for award under such plan, (b) shares of our Common Stock or common stock equivalents issued to employees
or consultants (including in connection with investor relations activities) for compensatory purposes, (c) shares of our Common
Stock or common stock equivalents issued upon the exercise or conversion of common stock equivalents outstanding on the closing
date for the offering of the Series E Preferred Stock, (d) shares of our Common Stock or common stock equivalents issued to investors
in our common stock offering that was conducted concurrently with the offering of Series E Preferred Stock, (e) shares of our Common
Stock or common stock equivalents issued in the PCT Merger, (f) shares of our Common Stock or common stock equivalents issued in
the offering of the Series E Preferred Stock, including pursuant to the certificate of designations or upon exercise of the warrants
offered in connection with the Series E Preferred Stock, and (g) shares of our Common Stock or common stock equivalents issued
or deemed to be issued in connection with any acquisition by our company, whether through a merger, an acquisition of stock or
an acquisition of assets, or a license, of any business, product, assets or technologies, or any strategic partnership, strategic
investment or joint venture involving any technology or product, or any other transaction the primary purpose of which is not to
raise capital; provided however, that the number of shares of our Common Stock which may be issued pursuant to this clause (g)
in any transaction or series of related transactions shall not exceed 33% of the number of shares of our Common Stock outstanding
immediately prior to any such transaction.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">In case of any reorganization or any reclassification
of our capital stock or any consolidation or merger of our company with or into any other corporation or corporations or a sale
or transfer of all or substantially all of our assets to any other person or a &ldquo;going private&rdquo; transaction under Rule
13e-3 promulgated pursuant to the Securities Exchange Act of 1934 (the &ldquo;Exchange Act&rdquo;), as amended, then, as part of
such reorganization, consolidation, merger, or transfer if the holders of shares of our Common Stock receive any publicly traded
securities as part or all of the consideration for such reorganization, reclassification, consolidation, merger or sale, then it
shall be a condition precedent of any such event or transaction that provision shall be made such that each Series E Preferred
Share shall thereafter be convertible into such new securities at a conversion price and pricing formula which places the holders
of Series E Preferred Shares in an economically equivalent position as they would have been if not for such event. The foregoing
does not limit the right that holders of the Series E Preferred Shares have to require us to repurchase the Series E Preferred
Shares. See &ldquo;Mandatory Repurchase By Us&rdquo; below.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Reservation of Shares Issuable Upon Conversion.</I>&nbsp;&nbsp;We
shall at all times reserve and keep available out of our authorized but unissued shares of our Common Stock, solely for the purposes
of effecting the conversion and/or redemption of the Series E Preferred Shares, an number of shares of our Common Stock equal to
200% of the number of shares issuable upon conversion of the Series E Preferred Shares at the conversion price then in effect.
If at any time while any of the Series E Preferred Shares remain outstanding we do not have a sufficient number of authorized and
unreserved shares of our Common Stock to satisfy such obligation to reserve for issuance upon conversion and/or redemption of the
Series E Preferred Shares, then we shall promptly take all action necessary to increase the number of authorized shares of our
Common Stock to an amount sufficient to allow us to satisfy such obligation to reserve for issuance upon conversion and/or redemption
of the Series E Preferred Shares. Without limiting the generality of the foregoing sentence, as soon as practicable after the date
on which we fail to have a sufficient number of authorized but unissued shares of our Common Stock available to satisfy such obligation,
but in no event later than sixty (60) days (or the lesser of (i) ninety (90) days if the proxy statement is reviewed by the staff
of the Securities and Exchange Commission or (ii) ten (10) days after the staff of the SEC indicated that it has no further comments
to such proxy statement) after the occurrence of such failure, we shall hold a meeting of our stockholders for the approval of
an increase in the number of authorized shares of our Common Stock. In connection with such meeting, we shall provide each stockholder
with a proxy statement and shall use our reasonable best efforts to solicit our stockholders&rsquo; approval of such increase in
authorized shares of our Common Stock and to cause our board of directors to recommend to the stockholders that they approve such
proposal.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"></P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Fractional Shares.</I>&nbsp;&nbsp;No fractional
shares shall be issued upon the conversion of any Series E Preferred Shares. All shares of our Common Stock (including fractions
thereof) issuable upon conversion of more than one Series E Preferred Share by a holder thereof and all Series E Preferred Shares
issuable upon the purchase thereof shall be aggregated for purposes of determining whether the conversion and/or purchase would
result in the issuance of any fractional share. If, after the aforementioned aggregation, the conversion and/or purchase would
result in the issuance of a fraction of a share of our Common Stock, we shall, in lieu of issuing any fractional share, either
round up the number of shares to the next highest whole number or, at our option, pay the holder otherwise entitled to such fraction
a sum in cash equal to the fair market value of such fraction on the conversion date (as determined in good faith by our Board
of Directors).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Failure to Redeliver.</I>&nbsp;&nbsp;If
any holder fails to re-deliver shares of our Common Stock to us within ten (10) trading days of being required to do so in connection
with a Mandatory Redemption or an optional redemption by us, then, unless such shares of Common Stock have been called by us, we
may, at our option, redeem a number of Series E Preferred Shares having a Liquidation Preference equal in value to the product
of (x) such number of shares of our Common Stock and (y) the Stock Payment Price for such Mandatory Redemption Date or Optional
Redemption Date, the case may be, in lieu of requiring such holder to return such shares of Common Stock.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Mandatory Repurchase by Us.</I>&nbsp;&nbsp;Each
holder of Series E Preferred Shares shall have the unilateral option and right to compel us to repurchase for cash any or all of
such holder&rsquo;s Series E Preferred Shares within three days of a written notice requiring such repurchase (provided that no
written notice shall be required for if any of the events described in clauses (v) and (vi) below occur and demand for repurchase
shall be deemed automatically made upon the occurrence of any of those events), at a price per Series E Preferred Share equal to
the sum of (a) the liquidation preference plus (b) any and all accrued and unpaid dividends on the Series E Preferred Shares (the
sum of (a) and (b), the &ldquo;Base Mandatory Repurchase Price&rdquo;) plus (c) (i) if such demand for repurchase occurs on or
before the twelve month anniversary of the closing date, an amount equal to 15% of the Base Mandatory Repurchase Price, or (ii)
if such demand for repurchase occurs at any time after the twelve month anniversary of the closing date, an amount equal to 10%
of the Base Mandatory Repurchase Price, if any of the following events shall have occurred or are continuing:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.2in"></TD><TD STYLE="width: 0.25in">(i)</TD><TD>A Change in Control Transaction (as defined below);</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.45in; text-align: center; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.2in"></TD><TD STYLE="width: 0.25in">(ii)</TD><TD>A &ldquo;going private&rdquo; transaction under SEC rules;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.45in; text-align: center; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.2in"></TD><TD STYLE="width: 0.25in">(iii)</TD><TD>A tender offer by our company under SEC Rule 13e-4;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.45in; text-align: center; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.2in"></TD><TD STYLE="width: 0.25in">(iv)</TD><TD>the suspension from trading or the failure of our Common Stock to be listed on a trading market for a period of five consecutive
trading days or for more than an aggregate of 10 trading days in any 365-day period;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.45in; text-align: center; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.2in"></TD><TD STYLE="width: 0.25in">(v)</TD><TD>the entry by a competent court of (i) a decree or order for relief pertaining to our company or any of our subsidiaries under
any applicable federal or state bankruptcy, insolvency, reorganization or other similar law or (ii) a decree or order adjudging
our company or any of our subsidiaries as bankrupt or insolvent or (iii) appointing a custodian, receiver, trustee or other similar
official for our company or any of our subsidiaries or of any substantial part of our property, or ordering the liquidation of
our company&rsquo;s affairs, and the continuance of any such decree or order for a period of 60 consecutive days;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.45in; text-align: center; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.2in"></TD><TD STYLE="width: 0.25in">(vi)</TD><TD>the commencement by our company or any of our subsidiaries of a voluntary case or proceeding under any applicable federal or
state bankruptcy, insolvency, reorganization or other similar law, or the consent by us to the entry of a decree or order for relief
in an involuntary case or proceeding under any applicable federal or state bankruptcy, insolvency, reorganization or other similar
law or to the commencement of any bankruptcy or insolvency case or proceeding against our company, or the consent by us to the
appointment of or taking possession by a custodian, receiver, trustee or other similar official of our company or of any substantial
part of our property, or the making by us of an assignment for the benefit of creditors, or the admission by our company in writing
of its inability to pay its debts generally as they become due;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.45in; text-align: center; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.2in"></TD><TD STYLE="width: 0.25in">(vii)</TD><TD>following an Authorized Share Failure (as defined), our failure to receive stockholder approval to approve the required increase
in the number of shares of our Common Stock within five days after the Meeting Outside Date (as defined); or</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.45in; text-align: center; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.2in"></TD><TD STYLE="width: 0.25in">(viii)</TD><TD>our failure to deliver shares of our Common Stock on any Share Delivery Date, Advance Date, mandatory redemption date or optional
redemption date, if such failure continues for two (2) trading days after the date that delivery of shares of Common Stock is due;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.45in; text-align: center; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.2in"></TD><TD STYLE="width: 0.25in">(ix)</TD><TD>our failure to pay any amounts when and as due pursuant to the certificate of designations or any other document relating to
the issuance of the Series E Preferred Shares, if such failure continues for two (2) trading days after the date that such payment
is due;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.45in; text-align: center; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.2in"></TD><TD STYLE="width: 0.25in">(x)</TD><TD>our breach of certain covenants contained in the certificate of designations and the stock purchase agreement;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.45in; text-align: center; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.2in"></TD><TD STYLE="width: 0.25in">(xi)</TD><TD>our company or any of its subsidiaries shall (A) default in any payment of any amount or amounts of principal of or interest
on any indebtedness the aggregate principal amount of which indebtedness is in excess of $1,000,000 or (B) default in the observance
or performance of any other agreement or condition relating to any such indebtedness, or any other event shall occur or condition
exist, as a result of which the holder or holders or beneficiary or beneficiaries of such indebtedness or a trustee on their behalf
have declared such indebtedness to be due prior to its stated maturity;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.45in; text-indent: -0.25in">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.45in; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.2in"></TD><TD STYLE="width: 0.25in">(xii)</TD><TD>the effectiveness of the registration statement pertaining to the Series E Preferred Shares or the ability to use the applicable
prospectus supplement and the prospectus lapses for any reason and continues for a period of 10 consecutive days or for more than
an aggregate of 20 days in any 365-day period;</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.45in; text-align: center; text-indent: -0.25in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.2in"></TD><TD STYLE="width: 0.25in">(xiii)</TD><TD>we breach any representation, warranty, covenant or other term or condition of the certificate of designations, the stock purchase
agreement or the warrant to be issued with the Series E Preferred Shares, except to the extent that such breach would not have
a material adverse effect (as defined in the stock purchase agreement), and except in the case of a breach of a covenant which
is curable, only if such breach remains uncured for a period of at least 10 calendar days (the events described in clauses (v),
(vi), (viii), (ix), (x), (xi), (xii) and (xiii) are collectively referred to as the &ldquo;Trigger Events&rdquo; and each, as a
&ldquo;Trigger Event&rdquo;).</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">A &ldquo;Change in Control Transaction&rdquo;
will be deemed to exist if (i) there occurs any consolidation or merger of our company with or into any other corporation or other
entity or person (whether or not our company is the surviving corporation), or any other corporate reorganization or transaction
or series of related transactions in which in excess of 50% of the voting power in our company is transferred through a merger,
consolidation, tender offer or similar transaction, (ii) any person, together with its affiliates and associates, beneficially
owns or is deemed to beneficially own (as described in Rule 13d-3 under the Exchange Act without regard to the 60-day exercise
period) in excess of 50% of the voting power in our company (provided, however, that if any person is immediately prior to the
closing date a beneficial owner of 40% or more of our Common Stock, it shall not be deemed to be a Change of Control Transaction
if such person increases its beneficial ownership percentage by not more than 10 percentage points), (iii) there is a replacement
of more than one-half of the members of our board of directors which is not approved by those individuals who are members of our
board on the date thereof, in one or a series of related transactions or (iv) a sale or transfer of all or substantially all of
our assets, determined on a consolidated basis; provided, however, that a Change in Control Transaction will not be deemed to have
occurred pursuant to clause (iv) if such sale or transfer is the sale or transfer of not more than one business segment during
the period from the closing of the offering of the Series E Preferred Shares (November 19, 2010) through the Maturity Date and
we remain a publicly traded corporation and if, on the effective date of the sale or transfer described therein, we deposit funds
in the escrow account (as defined in the stock purchase agreement) such that the balance in the escrow account after such deposit
is the lesser of $5 million or 100% of the aggregate liquidation preference of the outstanding Series E Preferred Shares.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Ownership Cap.</I>&nbsp;&nbsp;Notwithstanding
anything to the contrary set forth herein, at no time may we issue to a holder, shares of our Common Stock if the number of shares
of our Common Stock to be issued pursuant to such issuance would exceed, when aggregated with all other shares of our Common Stock
beneficially owned by such holder at such time (as determined in accordance with relevant Exchange Act rules), the number of shares
of our Common Stock that would result in the holder beneficially owning (as determined in accordance with relevant Exchange Act
rules) more than 4.9% (the &ldquo;Beneficial Ownership Limitation&rdquo;) of our then issued and outstanding Common Stock. Each
holder shall have the right (with respect to itself only) to waive such ownership cap upon not less than sixty-five (65) days&rsquo;
prior notice to us. Notwithstanding the foregoing, the holder shall have the right to: (A) at any time and from time to time immediately
reduce the Beneficial Ownership Limitation and (B) (subject to waiver) at any time and from time to time, increase the Beneficial
Ownership Limitation immediately in the event of the announcement as pending or planned of a Change in Control Transaction.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Participation.</I>&nbsp;&nbsp;The holders
of the Series E Preferred Shares shall be entitled to such dividends paid and distributions made to the holders of shares of our
Common Stock to the same extent as if such holders of the Series E Preferred Shares had converted the Series E Preferred Shares
into shares of our Common Stock (without regard to any limitations on conversion herein or elsewhere) and had held such shares
of Common Stock on the record date for such dividends and distributions.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Voting Rights.</I>&nbsp;&nbsp;Except as
expressly provided in the certificate of designations, holders of the Series E Preferred Shares shall not have any voting rights.
So long as any Series E Preferred Shares are outstanding, in addition to any other vote or consent of our stockholders required
by law or by our amended and restated certificate of incorporation and except where the vote or written consent of holders of a
greater than number of shares is required by law or by another provision of our amended and restated certificate of incorporation,
the affirmative vote, at a meeting duly called for such purpose or the written consent without a meeting, of the holders of at
least a majority of the Series E Preferred Shares then outstanding, voting together as a single class, shall be required before
we may: (a) amend or repeal any provision of, or add any provision to, the certificate of designations governing the Series E Preferred
Shares, our amended and restated certificate of incorporation or bylaws, or file any articles of amendment, certificate of designations,
preferences, limitations and relative rights of any series of preferred stock, if any such action would adversely alter or change
the preferences, rights, privileges or powers of, or restrictions provided for the benefit of the Series E Preferred Shares, regardless
of whether any such action shall be by means of amendment to our certificate of incorporation or by merger, consolidation or otherwise;
(b) increase or decrease (other than by conversion) the authorized number of Series E Preferred Shares (we may increase or decrease
our number of authorized shares of undesignated &ldquo;blank check&rdquo; preferred stock); (c) create or authorize (by reclassification
or otherwise) any new class or series of shares that has a preference over or is on a parity with the Series E Preferred Shares
with respect to dividends or the distribution of assets on a Liquidation Event; (c) purchase, repurchase or redeem any shares of
our Common Stock or other shares of our capital stock; (e) pay dividends or make any other distribution on our Common Stock or
other capital stock; (f) whether or not prohibited by the terms of the Series E Preferred Shares, circumvent a right of the Series
E Preferred Shares.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Ranking.</I>&nbsp;&nbsp;The Series E Preferred
Shares shall rank senior to our Common Stock and any other class or series of our stock now existing or hereinafter authorized
over which the Series E Preferred Shares has preference or priority in the payment of dividends or in the distribution of assets
on any voluntary or involuntary dissolution or winding up of our affairs. Without the prior written consent of the Required Holders,
we may not authorize or issue additional or other capital stock that is of senior or pari-passu rank to the Series E Preferred
Shares in respect of preferences as to dividends and other distributions, amortization and redemption payments and payments upon
a liquidation event without the prior express written consent of the holders of a majority of the Series E Preferred Shares. We
may issue preferred stock that is junior in rank to the Series E Preferred Shares in respect of the preferences as to dividends
and other distributions, amortization and redemption payments and payments upon a liquidation event, provided, that the maturity
date (or any other date requiring redemption, repayment or any other payment, including without limitation, dividends) of any such
junior preferred shares is not on or before ninety-one (91) days after the maturity date for the Series E Preferred Shares.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Options</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">As of March 23, 2012, we had outstanding
options to purchase an aggregate of 21,413,957 shares of our Common Stock with exercise prices ranging from $0.52 to $15.00 per
share, with an approximate weighted average exercise price of $1.48 per share. The shares of our Common Stock underlying all such
options are (or prior to exercise will be) registered with the SEC.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Warrants</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">As of March 23, 2012, we had outstanding
warrants to purchase an aggregate of 37,546,071 shares of our Common Stock with exercise prices ranging from $0.56 to $7.00, with
an approximate weighted average exercise price of $2.35 per share. The shares of Common Stock underlying the vast majority of such
warrants have been registered for resale.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I>&nbsp;</I></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I>Class A Warrants </I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>General.</I>&nbsp;&nbsp;Each Class A warrant
entitles the holder to purchase one share of our Common Stock at an exercise price per share of $6.00. The exercise price per share
of each Class A warrant is subject to adjustment upon the occurrence of certain events as provided in the Class A warrant certificate
and summarized below. The Class A warrants may be exercised at any time until July 16, 2012, which is the expiration date, unless
redeemed. The Class A warrants which have not previously been exercised will expire on the expiration date. A Class A warrant holder
will not be deemed to be a holder of the underlying Common Stock for any purpose until the Class A warrant has been properly exercised.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Redemption.</I>&nbsp;&nbsp;In the event
our Common Stock is trading at a price equal to or exceeding the redemption threshold of $8.00 per share for 20 consecutive trading
days, we have the option to call the Class A warrants. If the holders of the Class A warrants have not exercised the Class A warrants
within 30 days of the written notice to call, we may redeem the Class A warrants at $0.001 per warrant. We will send the written
notice of call by first class mail to Class A warrant holders at their last known addresses appearing on the registration records
maintained by the transfer agent for the Class A warrants. No other form of notice by publication or otherwise will be required.
If we call any Class A warrants for redemption, they will be exercisable until the close of business on the business day next preceding
the specified redemption date.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Exercise.</I>&nbsp;&nbsp;A Class A warrant
holder may exercise our Class A warrants only if an appropriate registration statement is then in effect with the SEC and if the
shares of our Common Stock underlying the Class A warrants are qualified for sale under the securities laws of the state in which
the holder resides.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Adjustments of Exercise Price.</I>&nbsp;&nbsp;The
exercise price and redemption price of the Class A warrants are subject to adjustment in specified circumstances, including in
the event we declare any stock dividend to stockholders or effect any split or reverse split with respect to our Common Stock after
the issuance thereof. Therefore, if we effect any stock split or reverse split with respect to our Common Stock, the exercise price
in effect immediately prior to such stock split or reverse split will be proportionately reduced or increased, respectively. Any
adjustment of the exercise price will also result in an adjustment of the number of shares purchasable upon exercise of a Class
A warrant or, if we elect, an adjustment of the number of Class A warrants outstanding. The Class A warrants do not contain provisions
protecting against dilution resulting from the sale of additional shares of our Common Stock for less than the exercise price of
the Class A warrants or the current market price of our Common Stock.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>No Voting and Dividend Rights.</I>&nbsp;&nbsp;Until
exercised, the Class A warrants will have no voting, dividend or other stockholder rights.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I>&nbsp;</I></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I>Class D Warrants </I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Each Class D warrant entitles the holder
to purchase one share of our Common Stock at an exercise price per share of $2.50. The exercise price per share of each Class D
warrant is subject to adjustment upon the occurrence of certain events as provided in the Class D warrant certificate and summarized
below. The Class D warrants may be exercised at any time during their five year term, or eight year term in the case of a Class
D warrant to purchase an aggregate of 4,000,000 shares held by RimAsia Capital Partners, L.P., a Cayman Islands exempted limited
partnership and an affiliate of NeoStem (&ldquo;RimAsia&rdquo;), unless redeemed. The Class D warrants which have not been previously
exercised will expire at the expiration date. A Class D warrant holder will not be deemed to be a holder of the underlying Common
Stock for any purpose until the Class D warrant is exercised.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">In the event our Common Stock is trading
at a per share price equal to or exceeding the redemption threshold of $3.50, or $5.00 in the case of the Class D warrant held
by RimAsia, for twenty consecutive trading days, we have the option to call the Class D warrants. If the holders of Class D warrants
have not exercised the Class D Warrants within 30 days of the written notice to call, we may redeem the Class D warrants at $0.001
per warrant. We will send the written notice of call by first class mail to Class D warrant holders at their last known addresses
appearing on the registration records maintained by the transfer agent of the Class D warrants. No other form of notice by publication
or otherwise will be required. If we call any Class D Warrants for redemption, they will be exercisable until close of business
on the business day next preceding the specified redemption date.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The exercise price and redemption price of
the Class D warrants are subject to adjustment in specified circumstances, including in the event we declare any stock dividend
to stockholders or effect any split or reverse split with respect to our Common Stock after the issuance thereof. Therefore, if
we effect any stock split or reverse split with respect to our Common Stock, the exercise price in effect immediately prior to
such stock split or reverse split will be proportionately reduced or increased, respectively. Any adjustment of the exercise price
will also result in an adjustment of the number of shares purchasable upon exercise of a Class D warrant or, if we elect, an adjustment
of the number of Class D warrants outstanding. The Class D warrants do not contain provisions protecting against dilution resulting
from the sale of additional shares of our Common Stock for less than the exercise price of the Class D warrants or the current
market price of our Common Stock.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Until exercised, the Class D warrants will
have no voting, dividend or other stockholder rights.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I>&nbsp;</I></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I>Warrants Issued in Our November 2010 Common Stock Offering
</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">On November 19, 2010, in connection with
a public offering of our Common Stock and certain warrants, we issued (i) 6,337,980 shares of our Common Stock and (ii) warrants
to purchase up to 3,168,993 shares of our Common Stock (the &ldquo;November 2010 Common Stock Offering&rdquo;). The material terms
and provisions of the warrants issued in connection with our November 2010 Common Stock Offering are summarized below.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Term; Exercise Price and Exercisability.</I>&nbsp;&nbsp;The
warrants issued in our November 2010 Common Stock Offering represent the rights to purchase up to an aggregate of 3,168,993 shares
of our Common Stock. Each warrant has exercise price of $1.85 per share, becoming exercisable six months after issuance and expiring
five years from the date of issuance. The number of warrant shares that may be acquired by any holder upon any exercise of the
warrant will be limited to the extent necessary to insure that, following such exercise (or other issuance), the total number of
shares of our Common Stock then beneficially owned by such holder and its affiliates and any other persons whose beneficial ownership
of common stock would be aggregated with the holder&rsquo;s for purposes of Section 13(d) of the Securities Exchange Act of 1934,
as amended, does not exceed 4.99% of the total number of issued and outstanding shares of our Common Stock (including for such
purpose the shares of our Common Stock issuable upon such exercise), which is referred to as the &ldquo;beneficial ownership limitation.&rdquo;
The holder may elect to change this beneficial ownership limitation from 4.99% to 9.99% of the total number of issued and outstanding
shares of our Common Stock (including for such purpose the shares of our Common Stock issuable upon such exercise) upon providing
us with not less than 61 days&rsquo; prior written notice.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Call Provision.</I>&nbsp;&nbsp;Subject
to certain exceptions, while the warrants are outstanding, if the volume weighted average price of a share of our Common Stock
for each of 20 consecutive Trading Days (the &ldquo;Measurement Period,&rdquo; which 20 consecutive Trading Day period shall not
have commenced until after the Initial Exercise Date) exceeds $3.70 (subject to adjustment), (i) the average daily volume for such
Measurement Period exceeds $100,000 per Trading Day (subject to adjustment) and (ii) the holder is not in possession of any information
that constitutes, or might constitute, material non-public information which was provided by us, then we may, within 1 Trading
Day of the end of such Measurement Period, upon notice, call for cancellation of all or any portion of the warrants (a &ldquo;Call&rdquo;)
for consideration equal to $0.001 per share. Our right to Call the warrants shall be exercised ratably among the holders based
on each holder&rsquo;s initial purchase of warrants from us.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Fundamental Transaction.</I>&nbsp;&nbsp;If,
at any time while the warrants are outstanding, (1) we consolidate or merge with or into another corporation, (2) we sell, lease,
license, assign, transfer, convey or otherwise dispose of all or substantially all of our assets, (3) any purchase offer, tender
offer or exchange offer (whether by us or another individual or entity) is completed pursuant to which holders of our Common Stock
are permitted to sell, tender or exchange their shares for other securities, cash or property and has been accepted by the holders
of 50% or more of our outstanding Common Stock or (4) we effect any reclassification or recapitalization of our Common Stock or
any compulsory share exchange pursuant to which our Common Stock is converted into or exchanged for other securities, cash or property
(each, a &ldquo;Fundamental Transaction&rdquo;), then upon any subsequent exercise of the warrants, each holder thereof will have
the right to receive the same amount and kind of securities, as it would have been entitled to receive upon the occurrence of such
Fundamental Transaction if it had been, immediately prior to such Fundamental Transaction, the holder of the number of warrant
shares then issuable upon exercise of the warrant, and any additional consideration payable as part of the Fundamental Transaction;
<I>provided, however</I>, that in the event of a change of control transaction (as defined in the warrant) other than one in which
the successor entity is a publicly traded corporation whose stock is listed or quoted for trading on the New York Stock Exchange,
NASDAQ markets or the NYSE Amex and results in the warrants being exercisable for publicly traded common stock of such successor
entity, at the request of a holder of a warrant delivered before the 90th calendar day after consummation of such change of control
transaction, we (or the successor entity) will purchase the warrant by paying to the holder, cash in an amount equal to the Black
Scholes value, as described in the warrant, of the remaining unexercised portion of the warrant on the date of consummation of
such change of control transaction.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>



<P STYLE="margin: 0"></P>
<P STYLE="margin: 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Certain Adjustments.</I>&nbsp;&nbsp;The
exercise price and the number of shares of our Common Stock purchasable upon the exercise of the warrants are subject to adjustment
upon the occurrence of specific events, including stock dividends, stock splits, combinations and reclassifications of our Common
Stock. Additionally, the exercise price of the warrants issued to the investors is subject to certain adjustments if we (i) issue
rights, options or warrants to all holders of our Common Stock (and not to the warrant holder) entitling them to subscribe for
or purchase shares of our Common Stock at a price per share less than the volume weighted average price (the &ldquo;VWAP&rdquo;)
of our Common Stock on the record date for the determination of stockholders entitled to receive such rights, options or warrants,
or (ii) distribute to all holders of our Common Stock (and not to the warrant holder) evidences of our indebtedness or assets (including
cash and cash dividends) or rights or warrants to purchase any security.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Fractional Shares.</I>&nbsp;&nbsp;No fractional
shares or scrip representing fractional shares shall be issued upon the exercise of the warrants. As to any fraction of a share
which the holder would otherwise be entitled to purchase upon such exercise, we will, at our election, either pay a cash adjustment
in respect of such final fraction in an amount equal to such fraction multiplied by the exercise price or round up to the next
whole share.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Exchange Listing.</I>&nbsp;&nbsp;We do
not plan on making an application to list the warrants on the NYSE Amex or any other national securities exchange or recognized
trading system. Our Common Stock underlying the warrants is listed on the NYSE Amex.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The description of the warrants contained
herein does not purport to be complete and is qualified in its entirety by reference to the form of warrant, which was filed as
Exhibit 4.1 to our Current Report on Form 8-K filed with the SEC on November 16, 2010 in connection with the November 2010 Common
Stock Offering.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I>&nbsp;</I></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I>Warrants Issued in Our November 2010 Preferred Stock
Offering </I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">On November 19, 2010, in connection with
a registered direct placement of certain preferred stock, warrants and Common Stock, we issued (i) 10,582,011 shares of our Series
E Preferred Stock, (ii) warrants to purchase up to 1,322,486 shares of our Common Stock (subject to adjustment) and (iii) 164,418
shares of our Common Stock (the &ldquo;November 2010 Preferred Stock Offering&rdquo;). The material terms and provisions of the
warrants issued in connection with our November 2010 Preferred Stock Offering are summarized below.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Term; Exercise Price and Exercisability.</I>&nbsp;&nbsp;As
of March 23, 2012, the warrants issued in our November 2010 Preferred Stock Offering represent the rights to purchase up to an
aggregate of 1,484,171 shares of our Common Stock (as adjusted). Each warrant has an exercise price of $1.86 per share (as adjusted),
and will expire three years from the date of issuance. The number of warrant shares that may be acquired by any holder upon any
exercise of the warrant will be limited to the extent necessary to insure that, following such exercise, the total number of shares
of our Common Stock then beneficially owned by such holder and its affiliates and any other persons whose beneficial ownership
of our Common Stock would be aggregated with the holder&rsquo;s for purposes of Section 13(d) of the Securities Exchange Act of
1934, as amended, does not exceed 4.9% of the then issued and outstanding shares of our Common Stock (including for such purpose
the shares of our Common Stock issuable upon such exercise), which is referred to as the &ldquo;beneficial ownership limitation.&rdquo;
However, in the event of the announcement of a Change in Control Transaction (as defined in the certificate of designations with
respect to the Series E Preferred Stock), the holder will have the right to (A) at any time and from time to time immediately reduce
the beneficial ownership limitation and (B) (subject to waiver) at any time and from time to time, increase the beneficial ownership
limitation immediately.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>&nbsp;</I></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Exercise Elected by Us.</I>&nbsp;&nbsp;Subject
to certain exceptions, while the warrants are outstanding, if the daily volume weighted average price (the &ldquo;Daily VWAP&rdquo;)
of a share of our Common Stock for each of 20 trading days out of 30 consecutive trading days (the &ldquo;Trigger Period&rdquo;)
has remained at least 100% above the exercise price, then we may, subject to certain conditions, require the holder to exercise
the warrant in full upon not less than 10 business days prior written notice (the &ldquo;Mandatory Notice Period&rdquo;). Notwithstanding
such a notice, the holder may exercise the warrant at any time during the Mandatory Notice Period. Our right to require the exercise
of the warrants is subject to the following additional conditions: (i) during each trading day of the Trigger Period and during
each trading day of the Mandatory Notice Period, the Equity Conditions (as defined below) shall be satisfied; and (ii) the Daily
VWAP of our Common Stock has remained at or above 100% of the exercise price during all trading days in the Mandatory Notice Period.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&ldquo;Equity Conditions&rdquo; means each
of the following: (i) on each day of the Trigger Period and on each day of the Mandatory Notice Period, all warrants shares shall
be eligible for resale by the holder without restriction and without need for additional registration under any applicable federal
or state securities laws and we shall have no knowledge of any fact that would cause any warrant shares not to be so eligible for
resale by the holder without restriction and without the need for additional registration under any applicable federal or state
securities laws; (ii) on each day during the Trigger Period and the Mandatory Notice Period, our Common Stock is designated for
listing on a Trading Market (as defined in the certificate of designations with respect to the Series E Preferred Stock) and shall
not have been suspended from trading on such Trading Market nor shall delisting or suspension by such exchange or market have been
threatened or pending in writing by such Trading Market nor shall there be any Securities and Exchange Commission or judicial stop
trade order or trading suspension stop order; (iii) any warrant shares may be issued in full without violating the rules or regulations
of the Trading Market or any applicable laws; (iv) on each day during the Trigger Period and the Mandatory Notice Period, there
shall not have occurred and be continuing, unless waived by the holder, either (A) a Trigger Event (as defined in the certificate
of designations with respect to the Series E Preferred Stock) or (B) an event that with the passage of time or giving of notice
would constitute a Trigger Event; (v) on each day during the Trigger Period and the Mandatory Notice Period, we have not provided
the holder with any non-public information; (vi) on each day during the Trigger Period and the Mandatory Notice Period, neither
the registration statement, the prospectus supplement nor the prospectus applicable to the November 2010 Preferred Stock Offering
contains any untrue statement of a material fact or omits to state a material fact necessary in order to make the statements made
therein, in light of the circumstances under which they were made not misleading, and the prospectus supplement and the prospectus
comply with all applicable securities laws as to form and substance, (vii) the transfer agent for our Common Stock is participating
in the Depository Trust Company (&ldquo;DTC&rdquo;) Fast Automated Securities Transfer Program; and (viii) all warrants shares
are duly authorized and will be validly issued, fully paid and non-assessable upon issuance, free and clear of all liens, claims
or encumbrances, and the issuance of the warrant shares will not require any further approvals of our Board of Directors or stockholders.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Certain Adjustments.</I>&nbsp;&nbsp;The
exercise price and the number of shares of Common Stock purchasable upon the exercise of the warrants are subject to adjustment
upon the occurrence of specific events, including stock dividends, stock splits, combinations and reclassifications of our Common
Stock. Additionally, the exercise price of the warrants is subject to certain weighted average adjustments if NeoStem issues or
sells any additional shares of Common Stock or common stock equivalents at a price per share less than the exercise price then
in effect, or without consideration, the exercise price then in effect will be adjusted. Notwithstanding the foregoing, there will
be no adjustment to the exercise price with respect to the sale or issuance of certain Excluded Securities, as defined in the certificate
of designations with respect to the Series E Preferred Stock. See &ldquo;Series E 7% Senior Convertible Preferred Stock &mdash;
Optional Conversion by the Holders.&rdquo; As of March 23, 2012, (i) the exercise price of the warrants had been adjusted to $1.86
(and will be further adjusted as a result of this offering), and (ii) the number of shares of Common Stock purchasable upon the
exercise of the warrants had been adjusted (in the aggregate) to 1,484,171 shares of Common Stock (and will be further adjusted
as a result of this offering).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Fractional Shares.</I>&nbsp;&nbsp;No fractional
shares or scrip representing fractional shares shall be issued upon the exercise of the warrants. As to any fraction of a share
which the holder would otherwise be entitled to purchase upon such exercise, we will, at our election, either pay a cash adjustment
in respect of such final fraction in an amount equal to such fraction multiplied by the exercise price or round up to the next
whole share.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>&nbsp;</I></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Exchange Listing.</I>&nbsp;&nbsp;We do
not plan on making an application to list the warrants on the NYSE Amex or any other national securities exchange or recognized
trading system. Our Common Stock underlying the warrants is listed on the NYSE Amex.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The description of the warrants contained
herein does not purport to be complete and is qualified in its entirety by reference to the form of warrant, which was filed as
Exhibit 4.2 to our Current Report on Form 8-K filed with the SEC on November 16, 2010 in connection with our November 2010 Preferred
Stock Offering.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I>&nbsp;</I></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I>Warrants Issued in Connection With the PCT Merger </I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">In connection with the closing of the PCT
Merger on January 19, 2011 (and in addition to the Common Stock consideration for the PCT Merger which we deposited into an escrow
account at such time), we issued seven-year warrants to purchase an aggregate 3,000,000 shares of our Common Stock (collectively,
the &ldquo;PCT Merger Warrants&rdquo;). The PCT Merger Warrants are being delivered in book entry form to the former members of
PCT after receipt by us of an appropriate letter of transmittal from the respective former member. The PCT Merger Warrants are
divided into three series as follows: (i) warrants to purchase an aggregate 1,000,000 shares of our Common Stock at an exercise
price of $3.00 per share (the &ldquo;$3.00 Warrants&rdquo;); (ii) warrants to purchase an aggregate 1,000,000 shares of our Common
Stock at an exercise price of $5.00 per share (the &ldquo;$5.00 Warrants&rdquo;); and (iii) warrants to purchase an aggregate 1,000,000
shares of our Common Stock at an exercise price of $7.00 per share, and which will vest only if the $7.00 Warrant Condition (as
defined below) is accomplished within three years of the closing of the PCT Merger (the &ldquo;$7.00 Warrants&rdquo;). The material
terms and provisions of the PCT Merger Warrants are summarized below.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-weight: normal"><I>$3.00 Warrants and $5.00
Warrants </I></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>General.</I>&nbsp;&nbsp;Each $3.00 Warrant
and $5.00 Warrant entitles the holder to purchase one share of Common Stock at an exercise price per share of $3.00 and $5.00,
respectively. The exercise price per share of each $3.00 Warrant and $5.00 Warrant is subject to adjustment upon the occurrence
of certain events as provided in the applicable warrant certificate and summarized below. The $3.00 Warrants and $5.00 Warrants
may be exercised at any time during their seven year term, unless redeemed. The $3.00 Warrants and $5.00 Warrants which have not
been previously exercised will expire at the expiration date. Holders of the warrants will not be deemed to be a holder of the
underlying Common Stock for any purpose until such warrant is exercised. As described below, the Warrants are redeemable in certain
circumstances. Transfer of the shares issuable upon exercise of the Warrants had been restricted until the one year anniversary
of the Closing Date.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Redemption.</I>&nbsp;&nbsp;In the event
Common Stock is trading at a per share price equal to or exceeding the redemption threshold of $5.00 with respect to the $3.00
Warrant or $7.00 with respect to the $5.00 Warrant for twenty (20) out of thirty (30) consecutive trading days, NeoStem has the
option to call the applicable warrant. If the warrant holders have not exercised the warrants within 14 days of the redemption
notice, NeoStem may redeem the warrants at $0.001 per warrant. NeoStem will send the redemption notice by first class mail to warrant
holders at their last known addresses appearing on the registration records maintained by the transfer agent of the warrants. No
other form of notice by publication or otherwise will be required. If NeoStem calls any warrants for redemption, they will be exercisable
until close of business on the business day next preceding the specified redemption date. Notwithstanding the foregoing, NeoStem
may not redeem the Warrants unless (i) NeoStem waives the lock-up provisions in the applicable Warrant and (ii) the issuance of
the shares underlying the Warrants is covered by an effective registration statement or there is an effective resale registration
statement available to the holders of the Warrants with respect to the shares underlying the Warrants.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>&nbsp;</I></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Adjustments of Exercise Price.</I>&nbsp;&nbsp;The
exercise price and redemption price of the warrants are subject to adjustment in specified circumstances, including in the event
(i) there is a merger or consolidation and NeoStem is not the surviving corporation; (ii) there is subdivision, combination or
reclassification of securities, recapitalization, automatic conversion, or other similar event affecting the number or character
of outstanding shares of Common Stock; or (iii) NeoStem declares any stock dividend to stockholders or effects any split or reverse
split with respect to the Common Stock after the issuance thereof. The warrants do not contain provisions protecting against dilution
resulting from the sale of additional shares of Common Stock for less than the exercise price of the warrants or the current market
price of the Common Stock.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>No Voting and Dividend Rights.</I>&nbsp;&nbsp;Until
exercised, the holders of the warrants will have no voting, dividend or other stockholder rights.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Registration Rights.</I>&nbsp;&nbsp;NeoStem
has agreed to use its commercially reasonable efforts to maintain the effectiveness of a registration statement covering the shares
underlying the Warrants at any time that both (a) the Warrants are exercisable and (b) the exercise price of the Warrants is less
than 105% of the price at which the Common Stock is trading on the NYSE Amex (or, such other stock exchange on which the Common
Stock trades). Under certain limited circumstances, if a registration statement is not effective or a prospectus supplement is
not available during the last 20 business days prior to the expiration date of the Warrants, the exercise period of the Warrants
would be extended for a period of 20 business days following such effectiveness or availability.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-weight: normal"><I>$7.00 Warrants </I></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>General.</I>&nbsp;&nbsp;Each $7.00 Warrant
entitles the holder to purchase one share of Common Stock at an exercise price per share of $7.00. The exercise price per share
of each $7.00 Warrant is subject to adjustment upon the occurrence of certain events as provided in the $7.00 Warrant certificate
and summarized below. The $7.00 Warrants may be exercised only if the $7.00 Warrant Condition (as defined below) is satisfied and
at any time thereafter during their seven year term, unless redeemed. The $7.00 Warrants which have not been previously exercised
will expire at the expiration date. A $7.00 Warrant holder will not be deemed to be a holder of the underlying Common Stock for
any purpose until the $7.00 Warrant is exercised.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Performance Condition.</I>&nbsp;&nbsp;The
$7.00 Warrant Condition is a performance condition that provides that the $7.00 Warrants will not vest and will not become exercisable
unless PCT secures, prior to the third annual anniversary of the Closing Date, one or more material binding commercial manufacturing
contracts with one or more third parties, each on an arm&rsquo;s length basis, which commercial manufacturing contracts result
in aggregate revenues to PCT in excess of $5 million per year over a period of at least 3 years and in the reasonable judgment
of NeoStem's Board of Directors the manufacturing contracts will be profitable each year during the term of such contracts in accordance
with GAAP.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Redemption.</I>&nbsp;&nbsp;In the event
Common Stock is trading at a per share price equal to or exceeding the redemption threshold of $9.00 for twenty (20) out of thirty
(30) consecutive trading days, NeoStem has the option to call the $7.00 Warrants. If the holders of $7.00 Warrants have not exercised
the $7.00 Warrants within 14 days of the redemption notice, NeoStem may redeem the $7.00 Warrants at $0.001 per warrant. NeoStem
will send the redemption notice by first class mail to $7.00 Warrant holders at their last known addresses appearing on the registration
records maintained by the transfer agent of the $7.00 Warrants. No other form of notice by publication or otherwise will be required.
If NeoStem calls any $7.00 Warrants for redemption, they will be exercisable until close of business on the business day next preceding
the specified redemption date. Notwithstanding the foregoing, NeoStem may not redeem the $7.00 Warrants unless (i) NeoStem waives
the lock-up provisions in the applicable Warrant, (ii) the issuance of the shares of Common Stock underlying the $7.00 Warrants
is covered by an effective registration statement or there is an effective resale registration statement available to the holders
of the $7.00 Warrants with respect to such shares and (iii) the $7.00 Warrant Condition has been achieved or NeoStem waives the
$7.00 Warrant Condition concurrently with its provision of the redemption notice.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Adjustments of Exercise Price.</I>&nbsp;&nbsp;The
exercise price and redemption price of the $7.00 Warrants are subject to adjustment in specified circumstances, including in the
event (i) there is a merger or consolidation and NeoStem is not the surviving corporation; (ii) there is subdivision, combination
or reclassification of securities, recapitalization, automatic conversion, or other similar event affecting the number or character
of outstanding shares of Common Stock; or (iii) NeoStem declares any stock dividend to stockholders or effect any split or reverse
split with respect to the Common Stock after the issuance thereof. The $7.00 Warrants do not contain provisions protecting against
dilution resulting from the sale of additional shares of Common Stock for less than the exercise price of the $7.00 Warrants or
the current market price of the Common Stock.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>&nbsp;</I></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>No Voting and Dividend Rights.</I>&nbsp;&nbsp;Until
exercised, the $7.00 Warrants will have no voting, dividend or other stockholder rights.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Registration Rights.</I>&nbsp;&nbsp;NeoStem
has agreed to use its commercially reasonable efforts to maintain the effectiveness of a registration statement covering the shares
underlying the Warrants at any time that both (a) the Warrants are exercisable and (b) the exercise price of the Warrants is less
than 105% of the price at which the Common Stock is trading on the NYSE Amex (or, such other stock exchange on which the Common
Stock trades). Under certain limited circumstances, if a registration statement is not effective or a prospectus supplement is
not available during the last 20 business days prior to the expiration date of the Warrants, the exercise period of the Warrants
would be extended for a period of 20 business days following such effectiveness or availability.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The above description of the PCT Merger Warrants
does not purport to be complete and is qualified in its entirety by reference to the Warrant Agreement (with the forms of $3.00
Warrant, $5.00 Warrant and $7.00 Warrant attached thereto), which was filed as Exhibit 4.1 to our Current Report on Form 8-K dated
January 18, 2011 and filed with the SEC on January 24, 2011 in connection with the closing of the PCT Merger.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I>Series NA Warrants </I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Background.</I>&nbsp;&nbsp;On July 22,
2011, we completed an underwritten offering of 13,750,000 units, with each unit consisting of one share of our Common Stock and
a warrant to purchase 0.75 of a share of our Common Stock (each, a &ldquo;Series NA Warrant&rdquo;). The Series NA Warrants issued
in connection with the July 2011 underwritten offering cover, in the aggregate, up to 10,312,500 shares of our Common Stock. The
material terms and provisions of the Series NA Warrants are summarized below.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Warrant Agreement.</I>&nbsp;&nbsp;Pursuant
to the terms of the underwriting entered into in connection with the July 2011 offering, the Series NA Warrants may be issued through
DTC and evidenced by a &ldquo;Global Warrant&rdquo; or may be delivered in physical or other appropriate form. The Series NA Warrants
are governed by a warrant agreement (the &ldquo;Warrant Agreement&rdquo;), dated as of July 22, 2011, between us and Continental
Stock Transfer &amp; Trust Company, as our agent in respect of the Series NA Warrants. Book-entry form Series NA Warrants may be
exercised by notifying a broker who is a DTC participant prior to the expiry of such warrants and providing payment of the exercise
price for the number of shares of our Common Stock for which such warrants are being exercised. The following description of the
terms of the Warrant Agreement is subject to the detailed provisions of such Warrant Agreement, the form of which is filed as Exhibit
2.1 to our Current Report on Form 8-K dated July 19, 2011.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Term; Exercise Price and Exercisability.</I>&nbsp;&nbsp;The
Series NA Warrants represent the rights to purchase up to an aggregate of 10,312,500 shares of our Common Stock. Each warrant has
an exercise price of $1.45 per share, was immediately exercisable upon issuance, and will expire on July 18, 2016. The number of
warrant shares that may be acquired by any holder upon any exercise of the warrant will be limited to the extent necessary to insure
that, following such exercise (or other issuance), the total number of shares of our Common Stock then beneficially owned by such
holder and its affiliates and any other persons whose beneficial ownership of our Common Stock would be aggregated with the holder&rsquo;s
for purposes of Section 13(d) of the Securities Exchange Act of 1934, as amended, does not exceed 4.99% of the total number of
issued and outstanding shares of our Common Stock (including for such purpose the shares of our Common Stock issuable upon such
exercise), or beneficial ownership limitation. The holder may elect to change this beneficial ownership limitation from 4.99% to
9.99% of the total number of issued and outstanding shares of our Common Stock (including for such purpose the shares of our Common
Stock issuable upon such exercise) upon providing us with not less than 61 days&rsquo; prior written notice.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>&nbsp;</I></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Manner of Exercise.</I>&nbsp;&nbsp;Holders
of the Series NA Warrants may exercise their Series NA Warrants to purchase shares of our Common Stock on or before the expiration
date by delivering (i) notice of exercise, appropriately completed and duly signed, and (ii) if such holder is not utilizing the
cashless exercise provisions with respect to the warrants, payment of the exercise price by wire transfer or cashier&rsquo;s check
drawn on a United States bank, for the number of shares with respect to which the warrant is being exercised. Series NA Warrants
may be exercised in whole or in part, but only for full shares of our Common Stock. We provide certain buy-in rights to a holder
if we fail to deliver the shares of our Common Stock underlying the Series NA Warrants by the second trading day after the date
on which delivery of the stock certificate is required by the Series NA Warrant. The buy-in rights apply if after the second trading
day on which delivery of the stock is required by the Series NA Warrant, the holder purchases (in an open market transaction or
otherwise) shares of our Common Stock to deliver in satisfaction of a sale by the holder of the warrant shares that the holder
anticipated receiving from us upon exercise of the Series NA Warrant. In such event, we will:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-family: Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 3%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 3%; font: 10pt Symbol">&middot;</TD>
    <TD STYLE="width: 94%; font-size: 10pt">pay in cash to the holder the amount equal to the excess (if any) of the buy-in price (including brokerage commissions, if any) over the product of (A) the number of warrant shares that we were required to deliver to the holder in connection with the exercise at issue, times (B) the price at which the sell order giving rise to holder&rsquo;s purchase obligation was executed; and</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 3%">&nbsp;</TD>
    <TD STYLE="width: 3%; font-family: Symbol">&middot;</TD>
    <TD STYLE="width: 94%">at the election of holder, either (A) reinstate the portion of the Series NA Warrant as to such number of shares of our Common Stock for which such exercise was not honored, or (B) deliver to the holder such number of shares of our Common Stock that would have been exercised had we timely complied with our exercise and delivery obligations.</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">If the holder of a Series NA Warrant desires
to exercise its warrant and sell the shares issuable upon exercise of its warrant and there is no effective registration statement
registering, or no current prospectus available for, the issuance or resale of the shares of our Common Stock underlying such warrants,
in lieu of exercising its warrant by payment of a wire transfer or cashier&rsquo;s check, the holder may elect to receive shares
equal to the value of such holder&rsquo;s warrant by surrender of the warrant to us, together with a properly endorsed notice of
exercise. The number of shares to be issued would be determined by a formula based on the total number of shares with respect to
which the warrant is being exercised, the volume weighted average price for the shares of our Common Stock on the trading day immediately
prior to the date of exercise and the applicable exercise price of the Series NA Warrants.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The shares of our Common Stock issuable on
exercise of the Series NA warrants will be, when issued and paid for in accordance with the Series NA Warrants, duly authorized,
validly issued and fully paid and non-assessable. We have authorized and reserved at least that number of shares of our Common
Stock equal to the number of shares of our Common Stock issuable upon exercise of all outstanding Series NA Warrants.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Fundamental Transaction.</I>&nbsp;&nbsp;If,
at any time while the Series NA Warrants are outstanding, (1) we consolidate or merge with or into another corporation, (2) we
sell, lease, license, assign, transfer, convey or otherwise dispose of all or substantially all of our assets, (3) any purchase
offer, tender offer or exchange offer (whether by us or another individual or entity) is completed pursuant to which holders of
our Common Stock are permitted to sell, tender or exchange their shares for other securities, cash or property and has been accepted
by the holders of 50% or more of our outstanding Common Stock or (4) we effect any reclassification or recapitalization of our
Common Stock or any compulsory share exchange pursuant to which our Common Stock is converted into or exchanged for other securities,
cash or property (or the occurrence of any analogous proceeding) affecting us (each, a &ldquo;Fundamental Transaction&rdquo;),
then upon any subsequent exercise of the Series NA Warrants, the holders thereof will have the right to receive the same amount
and kind of securities, as they would have been entitled to receive upon the occurrence of such Fundamental Transaction if they
had been, immediately prior to such Fundamental Transaction, the holder of the number of warrant shares then issuable upon exercise
of the Series NA Warrant, and any additional consideration payable as part of the Fundamental Transaction; <I>provided, however</I>,
that in the event of a change of control transaction (as defined in the warrant) other than one in which the successor entity is
a publicly traded corporation whose stock is listed or quoted for trading on the New York Stock Exchange, NASDAQ markets or the
NYSE Amex and results in the Series NA Warrants being exercisable for publicly traded common stock of such successor entity, at
the request of a holder of a warrant delivered before the 90th calendar day after consummation of such change of control transaction,
we (or the successor entity) will purchase the warrant by paying to the holder, cash in an amount equal to the Black Scholes value,
as described in the warrant, of the remaining unexercised portion of the warrant on the date of consummation of such change of
control transaction.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Certain Adjustments.</I>&nbsp;&nbsp;The
exercise price and the number of shares of our Common Stock purchasable upon the exercise of the Series NA Warrants are subject
to adjustment upon the occurrence of specific events, including stock dividends (excluding payments in respect of our Series E
Preferred Stock), stock splits, combinations and reclassifications of our Common Stock. Additionally, the exercise price of the
Series NA Warrants is subject to certain adjustments if we (i) issue rights, options or warrants to all holders of our Common Stock
(and not to the warrant holder) entitling them to subscribe for or purchase shares of our Common Stock at a price per share less
than the volume weighted average price (the &ldquo;VWAP&rdquo;) of our Common Stock on the record date for the determination of
stockholders entitled to receive such rights, options or warrants, or (ii) distribute to all holders of our Common Stock (and not
to the warrant holder) evidences of our indebtedness or assets (including cash and cash dividends) or rights or warrants to purchase
any security.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Delivery of Certificates.</I>&nbsp;&nbsp;Upon
the holder&rsquo;s exercise of a Series NA Warrant, we will promptly, but in no event later than three business days after the
exercise date (referred to as the &ldquo;warrant share delivery date&rdquo;), issue and deliver, or cause to be issued and delivered,
a certificate for the shares of our Common Stock issuable upon exercise of the Series NA Warrant. In addition, we will, if the
holder provides the necessary information to us, issue and deliver the shares electronically through The Depository Trust Corporation
through its Deposit Withdrawal Agent Commission System (DWAC) or another established clearing corporation performing similar functions.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Notice of Corporate Action.</I>&nbsp;&nbsp;We
will provide prior notice to holders of the Series NA Warrants in advance of certain record or effective dates (as specified below)
in connection with the following corporate events, to provide the holders of the Series NA Warrants with the opportunity to exercise
their warrants and hold our Common Stock:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 3%">&nbsp;</TD>
    <TD STYLE="width: 3%; font-family: Symbol">&middot;</TD>
    <TD STYLE="width: 94%">if we declare a dividend (or any other distribution in whatever form) on our Common Stock;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 3%">&nbsp;</TD>
    <TD STYLE="width: 3%; font-family: Symbol">&middot;</TD>
    <TD STYLE="width: 94%">if we declare a special nonrecurring cash dividend on or a redemption of our Common Stock;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 3%">&nbsp;</TD>
    <TD STYLE="width: 3%; font-family: Symbol">&middot;</TD>
    <TD STYLE="width: 94%">if we authorize the granting to all holders of our Common Stock rights or warrants to subscribe for or purchase any shares of capital stock of any class or of any rights;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 3%">&nbsp;</TD>
    <TD STYLE="width: 3%; font-family: Symbol">&middot;</TD>
    <TD STYLE="width: 94%">if the approval of any of our stockholders shall be required in connection with any reclassification of our Common Stock, any consolidation or merger to which we are a party, any sale or transfer of all or substantially all of our assets, or any compulsory share exchange whereby our Common Stock is converted into other securities, cash or property; or</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 3%">&nbsp;</TD>
    <TD STYLE="width: 3%; font-family: Symbol">&middot;</TD>
    <TD STYLE="width: 94%">if we authorize the voluntary or involuntary liquidation or winding up of the affairs of our Company, then, in each case, we will mail to the holders of the Series NA Warrants a notice stating:</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 3%">&nbsp;</TD>
    <TD STYLE="width: 3%; font-family: Symbol">&middot;</TD>
    <TD STYLE="width: 94%">the date on which a record is to be taken for the purpose of such dividend, distribution, redemption, rights or warrants, or if a record is not to be taken, the date as of which the holders of our Common Stock of record to be entitled to such dividend, distributions, redemption, rights or warrants are to be determined, or</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 3%">&nbsp;</TD>
    <TD STYLE="width: 3%; font-family: Symbol">&middot;</TD>
    <TD STYLE="width: 94%">the date on which such reclassification, consolidation, merger, sale, transfer or share exchange is expected to become effective or close, and the date as of which it is expected that holders of record of our Common Stock will be entitled to exchange their shares of Common Stock for securities, cash or other property deliverable upon such reclassification, consolidation, merger, sale, transfer or share exchange.</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Subject to applicable law, the holder will
be provided a reasonable opportunity (which shall be not less than eight (8) calendar days notice) to exercise the Series NA Warrant
prior to the effective date of the event triggering such notice. No holders of the Series NA Warrants will possess any rights as
a stockholder under those warrants until the holder exercises those warrants.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Transferability.</I>&nbsp;&nbsp;The Series
NA Warrants may be transferred independent of the Common Stock they were issued with, on a form of assignment, subject to all applicable
laws.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>&nbsp;</I></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Fractional Shares.</I>&nbsp;&nbsp;No fractional
shares or scrip representing fractional shares shall be issued upon the exercise of the Series NA Warrants. As to any fraction
of a share which the holder would otherwise be entitled to purchase upon such exercise, we will, at our election, either pay a
cash adjustment in respect of such final fraction in an amount equal to such fraction multiplied by the exercise price or round
up to the next whole share.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Exchange Listing.</I>&nbsp;&nbsp;We do
not plan on making an application to list the Series NA Warrants on the NYSE Amex or any other national securities exchange or
recognized trading system. Our Common Stock underlying the Series NA Warrants is listed on the NYSE Amex.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The description of the Series NA Warrants
contained herein does not purport to be complete and is qualified in its entirety by reference to the Warrant Agreement and the
Form of Warrant Certificate, which are filed as Exhibit 4.1 to our Current Report on Form 8-K dated July 19, 2011.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I>Series AMO Warrants</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><B><I>General.</I></B>&nbsp;&nbsp;Upon closing
the Amorcyte Merger on October 17, 2011, as a portion of the merger consideration we issued Series AMO Warrants to purchase an
aggregate of 1,881,008 shares of our Common Stock (the &ldquo;Series AMO Warrants&rdquo;). The Series AMO Warrants are evidenced
by a &ldquo;Global Warrant&rdquo; and were delivered in book entry form to the former stockholders of Amorcyte. Each Series AMO
Warrant entitles the holder to purchase one share of our Common Stock at an exercise price of $1.466 per share. The exercise price
per share of each Warrant will be subject to adjustment upon the occurrence of certain events as provided in the form of global
warrant certificate and summarized below. The Series AMO Warrants may be exercised at any time during their seven year term, unless
redeemed; provided, however, that transfer of any shares of our Common Stock issuable upon exercise of the Series AMO Warrants
is restricted until the one year anniversary of the closing date of the Amorcyte Merger. The Series AMO Warrants which have not
been previously exercised will expire at the expiration date. A Series AMO Warrant holder will not be deemed to be a holder of
the underlying Common Stock for any purpose until the Series AMO Warrant is exercised.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><B><I>Redemption.</I></B>&nbsp;&nbsp;In the
event our Common Stock is trading at a per share price equal to or exceeding the redemption threshold of $3.466 per share for twenty
(20) out of thirty (30) consecutive trading days, we have the option to call the Series AMO Warrants. If the holders of Series
AMO Warrants have not exercised their warrants within 14 days of the redemption notice, we may redeem the Series AMO Warrants at
$0.0001 per warrant. We will send the redemption notice by first class mail to Series AMO Warrant holders at their last known addresses
appearing on the registration records maintained by the transfer agent of the Series AMO Warrants. No other form of notice by publication
or otherwise will be required. If we call any Series AMO Warrants for redemption, they will be exercisable until close of business
on the business day next preceding the specified redemption date.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><B><I>Adjustments of Exercise Price.</I></B>&nbsp;&nbsp;The
exercise price and redemption price of the Series AMO Warrants is subject to adjustment in specified circumstances, including in
the event (i) there is a merger or consolidation and we are not the surviving corporation; (ii) there is subdivision, combination
or reclassification of securities, recapitalization, automatic conversion, or other similar event affecting the number or character
of outstanding shares of our Common Stock; or (iii) we declare any stock dividend to stockholders or effect any split or reverse
split with respect to our Common Stock. The Series AMO Warrants do not contain provisions protecting against dilution resulting
from the sale of additional shares of our Common Stock for less than the exercise price of the Series AMO Warrants or the current
market price of our Common Stock.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><B><I>No Voting and Dividend Rights.</I></B>&nbsp;&nbsp;Until
exercised, the Series AMO Warrants have no voting, dividend or other stockholder rights.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><B><I>&nbsp;</I></B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><B><I>Registration Rights.</I></B>&nbsp;&nbsp;We
shall use commercially reasonable efforts to maintain the effectiveness of the Registration Statement on Form S-4 which covers
the shares of our Common Stock underlying the Series AMO Warrants or file and maintain the effectiveness of another registration
statement covering the shares of our Common Stock issuable upon exercise of the Series AMO Warrants at any time that both (a) the
Series AMO Warrants are exercisable and (b) the exercise price of the Series AMO Warrants is less than 105% of the price at which
our Common Stock is trading on the NYSE Amex (or if our Common Stock is no longer trading on the NYSE Amex, such other stock exchange
on which such shares trade). In no event will any holder of a Series AMO Warrant be entitled to receive a &ldquo;net cash settlement&rdquo;
in lieu of physical settlement in shares of our Common Stock regardless of whether we comply with our obligation described in the
preceding sentence.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The description of the Series AMO Warrants
contained herein does not purport to be complete and is qualified in its entirety by reference to the Warrant Agreement and the
Form of Global Series AMO Warrant attached thereto, which is filed as Exhibit 4.1 to our Current Report on Form 8-K dated October
17, 2011.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Anti-Takeover Effects of Certain Provisions of Delaware
Law and Our Certificate of Incorporation and Bylaws</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt; text-align: justify">Our Amended and Restated Certificate of Incorporation
and bylaws contain some provisions that could make our acquisition by means of a tender or exchange offer, a proxy contest or otherwise
more difficult. These provisions are summarized below.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Special Meetings.</I>&nbsp;&nbsp;Our bylaws
provide that special meetings of our stockholders may, unless otherwise prescribed by law, be called by our Chairman of the Board
(if any), our Board of Directors or our Chief Executive Officer and shall be held at such place, on such date and at such time
as shall be fixed by our Board of Directors or the person calling the meeting. Business transacted at any special meeting shall
be limited to matters relating to the purpose or purposes stated in the notice of the meeting.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Undesignated Preferred Stock.</I>&nbsp;&nbsp;The
ability to authorize undesignated preferred stock makes it possible for our Board of Directors to issue preferred stock with voting
or other rights or preferences that could impede the success of any attempt to acquire us. The ability to issue preferred stock
may have the effect of deferring hostile takeovers or delaying changes in control or management of our company.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Delaware Anti-Takeover Statute.</I>&nbsp;&nbsp;We
are subject to the provisions of Section 203 of the Delaware General Corporation Law regulating corporate takeovers. In general,
Section 203 prohibits a publicly held Delaware corporation from engaging in a business combination with an interested stockholder
for a period of three years following the date the person became an interested stockholder unless:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 3%">&nbsp;</TD>
    <TD STYLE="width: 3%; font-family: Symbol">&middot;</TD>
    <TD STYLE="width: 94%">prior to the date of the transaction, the board of directors of the corporation approved either the business combination or the transaction which resulted in the stockholder becoming an interested stockholder;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 3%">&nbsp;</TD>
    <TD STYLE="width: 3%; font-family: Symbol">&middot;</TD>
    <TD STYLE="width: 94%">upon completion of the transaction that resulted in the stockholder becoming an interested stockholder, the stockholder owned at least 85% of the voting stock of the corporation outstanding at the time the transaction commenced, excluding for purposes of determining the number of shares outstanding (1) shares owned by persons who are directors and also officers and (2) shares owned by employee stock plans in which employee participants do not have the right to determine confidentially whether shares held subject to the plan will be tendered in a tender or exchange offer; and</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 3%">&nbsp;</TD>
    <TD STYLE="width: 3%; font-family: Symbol">&middot;</TD>
    <TD STYLE="width: 94%">on or subsequent to the date of the transaction, the business combination is approved by the board and authorized at an annual or special meeting of stockholders, and not by written consent, by the affirmative vote of at least 66 2/3% of the outstanding voting stock which is not owned by the interested stockholder.</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Generally, a business combination includes
a merger, asset or stock sale, or other transaction resulting in a financial benefit to the interested stockholder. An interested
stockholder is a person who, together with affiliates and associates, owns or, within three years prior to the determination of
interested stockholder status, owned 15% or more of a corporation&rsquo;s outstanding voting securities. We expect the existence
of this provision to have an anti-takeover effect with respect to transactions our Board of Directors does not approve in advance.
We also anticipate that Section 203 may discourage attempted acquisitions that might result in a premium over the market price
for the shares of our Common Stock held by stockholders.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The provisions of Delaware law, our Amended
and Restated Certificate of Incorporation and our bylaws could have the effect of discouraging others from attempting hostile takeovers
and, as a consequence, they may also inhibit temporary fluctuations in the market price of our Common Stock that often result from
actual or rumored hostile takeover attempts. These provisions may also have the effect of preventing changes in our management.
It is possible that these provisions could make it more difficult to accomplish transactions that stockholders may otherwise deem
to be in their best interests.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Potential Effects of Authorized but Unissued Stock</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">We have shares of Common Stock and preferred
stock available for future issuance without stockholder approval. We may utilize these additional shares for a variety of corporate
purposes, including future public offerings to raise additional capital, to facilitate corporate acquisitions or payment as a dividend
on the capital stock.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The existence of unissued and unreserved
Common Stock and preferred stock may enable our Board of Directors to issue shares to persons friendly to current management or
to issue preferred stock with terms that could render more difficult or discourage a third-party attempt to obtain control of us
by means of a merger, tender offer, proxy contest or otherwise, thereby protecting the continuity of our management. In addition,
the Board of Directors has the discretion to determine designations, rights, preferences, privileges and restrictions, including
voting rights, dividend rights, conversion rights, redemption privileges and liquidation preferences of each series of preferred
stock, all to the fullest extent permissible under the Delaware General Corporation Law and subject to any limitations set forth
in our certificate of incorporation. The purpose of authorizing the Board of Directors to issue preferred stock and to determine
the rights and preferences applicable to such preferred stock is to eliminate delays associated with a stockholder vote on specific
issuances. The issuance of preferred stock, while providing desirable flexibility in connection with possible financings, acquisitions
and other corporate purposes, could have the effect of making it more difficult for a third party to acquire, or could discourage
a third party from acquiring, a majority of our outstanding voting stock.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Limitations of Director Liability and Indemnification of
Directors, Officers and Employees</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Section 145 of the Delaware General Corporation
Law, permits indemnification of directors, officers, agents and controlling persons of a corporation under certain conditions and
subject to certain limitations. Section 145 empowers a corporation to indemnify any person who was or is a party or is threatened
to be made a party to any threatened, pending or completed action, suit or proceeding whether civil, criminal, administrative or
investigative, by reason of the fact that he or she is or was a director, officer or agent of the corporation or another enterprise
if serving at the request of the corporation. Depending on the character of the proceeding, a corporation may indemnify against
expenses (including attorneys&rsquo; fees), judgments, fines and amounts paid in settlement actually and reasonably incurred in
connection with such action, suit or proceeding if the person indemnified acted in good faith and in a manner he or she reasonably
believed to be in or not opposed to, the best interests of the corporation, and, with respect to any criminal action or proceeding,
had no reasonable cause to believe his or her conduct was unlawful. In the case of an action by or in the right of the corporation,
no indemnification may be made with respect to any claim, issue or matter as to which such person shall have been adjudged to be
liable to the corporation unless and only to the extent that the Court of Chancery or the court in which such action or suit was
brought shall determine that despite the adjudication of liability such person is fairly and reasonably entitled to indemnity for
such expenses which the court shall deem proper. Section 145 further provides that to the extent a present or former director or
officer of a corporation has been successful in the defense of any action, suit or proceeding referred to above or in the defense
of any claim, issue or matter therein, such person shall be indemnified against expenses (including attorneys&rsquo; fees) actually
and reasonably incurred by such person in connection therewith.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Indemnification Agreements</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">We have entered into indemnification agreements
with each of our Chief Executive Officer, Chief Financial Officer, General Counsel, certain other employees and each of our directors
pursuant to which we have agreed to indemnify such party to the full extent permitted by law, subject to certain exceptions, if
such party becomes subject to an action because such party is our director, officer, employee, agent or fiduciary.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">Transfer Agent</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The transfer agent and registrar for our
Common Stock is Continental Stock Transfer &amp; Trust Company. Its address is 17 Battery Place, New York, New York, 10004 and
its telephone number is (212) 509-4000.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">NYSE Amex Listing</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Our Common Stock is traded on the NYSE Amex
under the symbol &ldquo;NBS.&rdquo; The warrants to purchase Common Stock issued to the investors in this offering are not expected
to be eligible for trading on any market.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>UNDERWRITING</B></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">We and the underwriters for the offering
named below have entered into an underwriting agreement with respect to the units being offered. Subject to the terms and conditions
of the underwriting agreement, each underwriter has severally agreed to purchase from us the number of units set forth opposite
its name below. Maxim Group LLC is the representative of the underwriters.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="font-weight: bold; border-bottom: Black 1pt solid">Underwriter</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font-weight: bold; border-bottom: Black 1pt solid; text-align: center">Number of Units</TD></TR>
<TR STYLE="vertical-align: top; background-color: rgb(204,255,204)">
    <TD STYLE="width: 62%">Maxim Group LLC</TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 35%; text-align: center">15,000,000</TD>
    <TD NOWRAP STYLE="width: 1%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; background-color: White">
    <TD STYLE="padding-left: 9pt">Total&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.25pt double">&nbsp;</TD>
    <TD STYLE="text-align: center; border-bottom: Black 2.25pt double">15,000,000</TD>
    <TD NOWRAP>&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The underwriting agreement provides that
the obligations of the underwriters are subject to certain conditions precedent and that the underwriters have agreed, severally
and not jointly, to purchase all of the units sold under the underwriting agreement if any of these units are purchased. If an
underwriter defaults, the underwriting agreement provides that the purchase commitments of the non-defaulting underwriters may
be increased or the underwriting agreement may be terminated.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">We and the underwriters have agreed to indemnify
each other against certain liabilities, including liabilities under the Securities Act. We have also agreed to contribute to payments
the underwriters may be required to make in respect of such liabilities.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The underwriters are offering the
units, subject to prior sale, when, as and if issued to and accepted by them, subject to approval of legal matters by their
counsel and other conditions specified in the underwriting agreement. The underwriters reserve the right to withdraw, cancel
or modify offers to the public and to reject orders in whole or in part. The underwriter is not required to take or pay for
the securities covered by the over-allotment option described below.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><B>Discounts and Commissions.</B> The following
table shows the public offering price, underwriting discount and proceeds, before expenses, to us.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">We estimate that the total expenses of
the offering, excluding underwriting discount, will be approximately $283,000, which includes up
to $60,000 that we have agreed to reimburse the underwriters for the fees and expenses incurred
by them in connection with the offering. These amounts are shown assuming either no exercise or full exercise of
the over-allotment option. These amounts exclude potential proceeds from the exercise of the warrants offered in combination
with the shares of our common stock.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="6" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Total</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid; vertical-align: bottom">Per Unit</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Without<br>Over-allotment</TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: center; vertical-align: bottom; border-bottom: Black 1pt solid"><B>With<BR>Over-allotment</B></TD>
    <TD STYLE="padding-bottom: 1pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; background-color: rgb(204,255,204)">
    <TD STYLE="width: 67%">Public offering price</TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%">$</TD>
    <TD STYLE="width: 8%; text-align: right">0.400</TD>
    <TD NOWRAP STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%">$</TD>
    <TD STYLE="width: 8%; text-align: right">6,000,000</TD>
    <TD NOWRAP STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%">$</TD>
    <TD STYLE="width: 8%; text-align: right">6,900,000</TD>
    <TD STYLE="width: 1%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; background-color: White">
    <TD>Underwriting discount</TD>
    <TD NOWRAP>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">0.028</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">420,000</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>$</TD>
    <TD STYLE="text-align: right">483,000</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; background-color: rgb(204,255,204)">
    <TD>Proceeds, before expenses, to us</TD>
    <TD>&nbsp;</TD>
    <TD>$</TD>
    <TD STYLE="text-align: right">0.372</TD>
    <TD NOWRAP>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>$</TD>
    <TD STYLE="text-align: right">5,580,000</TD>
    <TD NOWRAP>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>$</TD>
    <TD STYLE="text-align: right">6,417,000</TD>
    <TD>&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">I-Bankers Securities, Inc. will be
paid a financial advisory fee of $30,000 by Maxim, which amount will reduce the underwriting discount to be paid to the
underwriters.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">In compliance with guidelines of the Financial
Industry Regulatory Authority, or FINRA, the maximum consideration or discount to be received by any FINRA member or independent
broker dealer may not exceed 8% of the aggregate amount of the securities offered pursuant to this prospectus supplement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The underwriters propose to offer the units
offered by us to the public at the public offering price set forth on the cover of this prospectus supplement. If all of the units
offered by us are not sold at the public offering price, the underwriters may change the offering price and other selling terms.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><B>Option to Purchase
Additional Securities. </B>We have granted to the underwriters an option, exercisable for  45 days from the date of this
prospectus supplement, to purchase up to an aggregate of 2,250,000 additional shares of common stock and warrants to purchase
up to 2,250,000 additional shares of common stock in multiples of the fixed combination of one share and a warrant to
purchase up to one share at the public offering price, less underwriting discounts and commissions. The underwriters may
exercise this option, in whole or in part, solely for the purpose of covering over-allotments, if any, made in connection
with the offering of the securities offered by this prospectus supplement. If the over-allotment option is exercised in full,
the total offering price to the public would be $6,900,000, the total underwriter discounts and commissions would be $483,000
and the total proceeds to us, before expenses, would be $6,417,000.&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><B>Discretionary Accounts.</B> The underwriters
do not intend to confirm sales of the securities offered hereby to any accounts over which they have discretionary authority.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><B>Lock-Ups. </B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Pursuant to the Underwriting Agreement,
we have agreed during a period of  60 days after the date of the pricing of this offering, subject to certain exceptions, not
to, indirectly or directly, without the prior written consent of Maxim Group LLC on behalf of the underwriters, offer, sell,
assign, transfer, pledge, contract to sell, or otherwise dispose of, any shares of our common stock or any securities
convertible into or exercisable or exchangeable for our common stock. The exceptions include (1) our sale of common stock and
warrants in this offering, (2) our issuance of common stock, options to acquire common stock or other equity awards pursuant
to our employee benefit plans as such plans now exist, (3) our issuance of common stock pursuant to the valid exercises,
vesting or settlements of options, warrants or rights outstanding on the date of this prospectus supplement, (4) our issuance
of shares of common stock or securities convertible or exercisable into shares of common stock to consultants (including in
connection with investor relations activities), (5) our issuance of shares of common stock or securities convertible or
exercisable into shares of common stock in connection with any acquisition, strategic partnership, joint venture or
collaboration to which we are or may become a party, or the acquisition or license of any products or technology by us, but
do not include any such transaction in which we are issuing securities primarily for the purpose of raising capital or to an
entity whose primary business is investing in securities, (6) our issuance of shares of common stock or securities
convertible into or exercisable or exchangeable for common stock to holders of our Series E Preferred Stock, to the extent
permitted by our certificate of incorporation (including any certificates of designation or other amendments thereto), (7)
the contribution or sale of any shares of common stock to The Stem For Life Foundation, or (8) the issuance of restricted
securities in private placements (so long as the price per share in the private placement is not less than the per unit
purchase price paid by the underwriters in  this offering) and no registration statement for the resale of such securities is
filed before the expiration of the 60-day lock-up period; provided that, prior to the issuance of any securities pursuant to
clause (4), (5) or (7), we will cause the recipients of such securities to execute and deliver to Maxim Group LLC an
agreement to be bound by a lock-up running for 75 days from the date of the pricing of this offering. We also agree
that during the 60-day restricted period, we will take no action to release, and will not waive any of our rights to
maintain, any shares of our common stock held under (i) the escrow agreement related to certain merger consideration paid by
us in connection with the PCT acquisition and (ii) the escrow agreement related to certain merger consideration paid by us
in connection with the Amorcyte acquisition (the &ldquo;Amorcyte Escrow Agreement&rdquo;), except as may be required to
be released pursuant to the terms of the Amorcyte Escrow Agreement, which shares will not be subject to this lock-up. We
also agree that during the 60-day restricted period, other than for the sale of the common stock and warrants offered by
this prospectus supplement, we will not file any registration statement, preliminary prospectus or prospectus, or any
amendment or supplement thereto, under the Securities Act for any such transaction or which registers, or offers for sale,
our common stock or any securities convertible into or exercisable or exchangeable for common stock, except for the filing of
a registration statement(s) relating to employee benefit plans, a registration statement filed in connection with any
issuance described under clause (5) above, and as required in connection with registration statements on file with the SEC as
of the date of the Underwriting Agreement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">In addition, certain of our executive officers
and our most substantial stockholder have agreed to a 75-day lock-up from the date of the pricing of this offering with respect
to shares of our common stock (or other securities convertible into or exercisable or exchangeable for our common stock) that they
beneficially own, subject to certain exceptions. This means that, for such 75-day period, such persons may not offer, sell, assign,
transfer, pledge, contract to sell, or otherwise dispose of these securities, without the prior written consent of Maxim. The exceptions
permit, among other things and subject to restrictions, (1) if the holder is a natural person, certain transfers made as a bona
fide gifts to any member of the holder&rsquo;s immediate family, to a trust the beneficiaries of which are exclusively the holder
or members of the holder&rsquo;s immediate family or to a charity or educational institute, or by will or intestate succession
upon the death of the holder, and (2) if the holder is a corporation, partnership, limited liability company or other business
entity (a) transfers to any shareholder, partner or member of, or owner of a similar equity interest in, the holder if such transfer
is not for value, (b) transfers in connection with the sale of all or substantially all of the holder&rsquo;s capital stock, partnership
interests, membership interests or other similar equity interests, or all or substantially all of the holder&rsquo;s assets, in
any such case not undertaken for the purpose of avoiding the restrictions imposed by the &ldquo;lock-up&rdquo; agreement or (c)
to another corporation, partnership, limited liability company or other business entity so long as the transferee is an affiliate
of the holder and such transfer is not for value.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The applicable restricted period will be
automatically extended if (i) during the last 17 days of the restricted period we issue an earnings release or material news or
a material event relating to us occurs or (ii) prior to the expiration of the restricted period, we announce that we will release
earnings results during the 16-day period beginning on the last day of the restricted period, in either of which case the restrictions
described above will continue to apply until the expiration of the 18-day period beginning on the issuance of the earnings release
or the occurrence of the material news or material event.</P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><B>Electronic Offer, Sale and Distribution
of Units.</B> A prospectus supplement in electronic format may be made available on the websites maintained by one or more of the
underwriters or selling group members, if any, participating in this offering and one or more of the underwriters participating
in this offering may distribute prospectus supplements electronically. The representatives may agree to allocate a number of units
to underwriters and selling group members for sale to their online brokerage account holders. Internet distributions will be allocated
by the underwriters and selling group members that will make internet distributions on the same basis as other allocations. Other
than the prospectus supplement in electronic format, the information on these websites is not part of this prospectus supplement
or the registration statement of which this prospectus supplement forms a part, has not been approved or endorsed by us or any
underwriter in its capacity as underwriter, and should not be relied upon by investors.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 6pt; margin-left: 0in; text-indent: 0.25in; text-align: left"><B>Stabilization</B>.
To facilitate the offering, the underwriters may engage in transactions that stabilize, maintain or otherwise affect the price
of our common stock during and after the offering. Specifically, the underwriters may over-allot or otherwise create a short position
in the common stock for their own account by selling more common stock than have been sold to them by us. Short sales involve
the sale by the underwriters of a greater number of shares of common stock than they are required to purchase in this offering.
&ldquo;Naked&rdquo; short sales are sales in excess of the number sold to them by us. The underwriters must close out any naked
short position by purchasing common stock in the open market. A naked short position is more likely to be created if the underwriters
are concerned that there may be downward pressure on the price of the common stock in the open market after pricing that could
adversely affect investors who purchase in this offering.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 6pt; margin-left: 0in; text-indent: 0.25in; text-align: left">&nbsp;In
addition, the underwriters may stabilize or maintain the price of the common stock by bidding for or purchasing common stock in
the open market and may impose penalty bids. If penalty bids are imposed, selling concessions allowed to syndicate members or
other broker dealers participating in the offering are reclaimed if common stock previously distributed in the offering are repurchased,
whether in connection with stabilization transactions or otherwise. The effect of these transactions may be to stabilize or maintain
the market price of the common stock at a level above that which might otherwise prevail in the open market. The imposition of
a penalty bid may also affect the price of the common stock to the extent that it discourages resales of the common stock. The
magnitude or effect of any stabilization or other transactions is uncertain. These transactions may be effected on the NYSE Amex
or otherwise and, if commenced, may be discontinued at any time.&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><B>Other Relationships.</B> Certain of the
underwriters and their affiliates have provided, and may in the future provide, various investment banking, commercial banking
and other financial services for us and our affiliates for which they have received, and may in the future receive, customary fees.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>LEGAL MATTERS</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Lowenstein Sandler PC, Roseland, New Jersey
will pass upon the validity of the issuance of the securities offered by this prospectus supplement and the accompanying prospectus.
The underwriters are being represented in connection with this offering by Ellenoff Grossman &amp; Schole LLP, New York, New York.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>EXPERTS </B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">The consolidated financial statements as
of and for the year ended December 31, 2011, incorporated in this prospectus supplement and elsewhere in the registration statement
of which this prospectus supplement forms a part, by reference from the Company&rsquo;s Annual Report on Form 10-K for the year
ended December 31, 2011, have been audited by Grant Thornton LLP, an independent registered public accounting firm, as stated in
their report, which is incorporated herein by reference. Such consolidated financial statements have been so incorporated in reliance
upon the report of such firm given upon their authority as experts in accounting and auditing.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">The consolidated financial statements as
of and for the year ended December 31, 2010, incorporated in this prospectus supplement and elsewhere in the registration statement
of which this prospectus supplement forms a part, by reference from the Company&rsquo;s Annual Report on Form 10-K for the year
ended December 31, 2011, have been audited by Deloitte &amp; Touche LLP, an independent registered public accounting firm, as stated
in their report, which is incorporated herein by reference. Such consolidated financial statements have been so incorporated in
reliance upon the report of such firm given upon their authority as experts in accounting and auditing.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>WHERE YOU CAN FIND MORE INFORMATION </B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">This prospectus supplement is part of a
registration statement on Form S-3 that we filed with the SEC. The registration statement that contains this prospectus supplement,
including the exhibits to the registration statement, contains additional information about us and the common stock offered by
this prospectus supplement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">We file annual, quarterly and special reports,
proxy statements and other information with the SEC. You may read and copy any document we file with the SEC at the SEC&rsquo;s
Public Reference Room at 100 F Street, N.E. Washington, D.C. 20549. Please call the SEC at 1-800-SEC-0330 for further information
on the Public Reference Room. Our public filings, including reports, proxy and information statements, are also available on the
SEC&rsquo;s web site at <I>http://www.sec.gov</I>.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>INCORPORATION OF CERTAIN DOCUMENTS BY
REFERENCE </B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">The SEC allows us to &ldquo;incorporate
by reference&rdquo; the information contained in documents that we file with them, which means that we can disclose important information
to you by referring to those documents. The information incorporated by reference is considered to be part of this prospectus supplement.
Information in this prospectus supplement modifies or supersedes information incorporated by reference that we filed with the SEC
prior to the date of this prospectus supplement, and information that we file later with the SEC also will automatically update
and supersede this information.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">We incorporate by reference the documents
listed below and any documents that we file in the future with the SEC under Sections 13(a), 13(c), 14 or 15(d) of the Securities
Exchange Act of 1934, as amended, after the date of this prospectus supplement and before the completion of the offering:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 3%; font-family: Symbol">&middot;</TD>
    <TD STYLE="width: 95%">Our Annual Report on Form 10-K for the year ended December 31, 2011, filed with the SEC on March 20, 2012;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 3%; font-family: Symbol">&middot;</TD>
    <TD STYLE="width: 95%">The portions of our Definitive Proxy Statement for our 2011 Annual Meeting of Stockholders, included in our Prospectus filed with the SEC pursuant to Rule 424(b)(3) on September 16, 2011, set forth under the captions &ldquo;Other Relationships Between the Parties&rdquo;, &ldquo;Management of the Combined Company After the Amorcyte Merger&rdquo;, &ldquo;Biographical Information&rdquo;, &ldquo;NeoStem Corporate Governance&rdquo;, &ldquo;Section 16(a) Beneficial Ownership Reporting Compliance&rdquo;, &ldquo;Code of Ethics&rdquo;, &ldquo;Accounting Fees and Other Accounting Matters&rdquo;, &ldquo;NeoStem Executive Compensation&rdquo;, &ldquo;NeoStem Employment Agreements and Equity Grants&rdquo;, &ldquo;NeoStem&rsquo;s Outstanding Equity Awards at Fiscal Year-End&rdquo;, &ldquo;Equity Compensation Plan Information&rdquo;, &ldquo;NeoStem Director Compensation&rdquo;, &ldquo;Security Ownership of Certain Beneficial Owners and Management of NeoStem&rdquo; and &ldquo;Certain Relationships and Related Transactions&rdquo;;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 3%; font-family: Symbol">&middot;</TD>
    <TD STYLE="width: 95%">Our Current Reports on Form 8-K and amendments thereto dated December 8, 2011 (filed December 9,
    2011), January 4, 2012 (filed January 6, 2012), January 10, 2012 (filed January 11, 2012), January 12, 2012 (filed January
    12, 2012),  January 25, 2012 (filed January 26, 2012) and March 29, 2012 (filed March 29, 2012) (excluding any information
    deemed     furnished     pursuant     to     Item     2.02     or Item 7.01 of any such Current Report on Form 8-K); and</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 3%; font-family: Symbol">&middot;</TD>
    <TD STYLE="width: 95%">The description of our common stock set forth in the Registration Statement on Form 8-A, declared effective on August 8, 2007 (including any amendment or report filed with the SEC for the purpose of updating such description);</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">To the extent that any statement in this
prospectus supplement is inconsistent with any statement that is incorporated by reference and that was made on or before the date
of this prospectus supplement, the statement in this prospectus supplement shall supersede such incorporated statement. The incorporated
statement shall not be deemed, except as modified or superseded, to constitute a part of this prospectus supplement, the accompanying
prospectus or the registration statement. Statements contained in this prospectus supplement as to the contents of any contract
or other document are not necessarily complete and, in each instance, we refer you to the copy of each contract or document filed
as an exhibit to the registration statement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">We will furnish without charge to you,
upon written or oral request, a copy of any or all of the documents incorporated by reference, including exhibits to these documents.
You should direct any requests for documents to:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">NeoStem, Inc.<BR>
420 Lexington Avenue, Suite 450<BR>
New York, New York 10170<BR>
(212) 584-4180<BR>
Attention: Catherine M. Vaczy, Esq., Vice President and General Counsel</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 12.4pt">Exhibits to the filings will not be sent,
however, unless those exhibits have specifically been incorporated by reference in this document.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>PROSPECTUS</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>$75,000,000</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><img src="logo.jpg"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>NEOSTEM, INC.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Common Stock<BR>
Preferred Stock<BR>
Debt Securities<BR>
Warrants<BR>
Units</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">We may from time to time offer and sell common
stock, preferred stock, debt securities, warrants and units, having an aggregate offering price of up to $75,000,000. We may offer
and sell these securities separately or together in any combination. We may offer and sell these securities to or through underwriters,
directly to investors or through agents. We will specify the terms of the securities, and the names of any underwriters or agents
and their respective compensation, in supplements to this prospectus.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Our common stock is listed on the on the
NYSE Amex and traded under the symbol &ldquo;NBS.&rdquo; The closing bid price of our common stock on the NYSE Amex on June 13,
2011 was $1.48 per share.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Investing in our securities involves risks.
See &ldquo;Risk Factors&rdquo; at page <U>5</U> of this prospectus.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><B>Neither the Securities and Exchange Commission
nor any state securities commission has approved or disapproved of these securities or passed upon the accuracy or adequacy of
this prospectus. Any representation to the contrary is a criminal offense.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">This prospectus may not be used to consummate
sales of securities unless it is accompanied by a prospectus supplement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">The date of this prospectus is June 13,
2011.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>TABLE OF CONTENTS</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 90%">&nbsp;</TD>
    <TD STYLE="width: 2%; font-weight: bold; text-align: center">&nbsp;</TD>
    <TD STYLE="width: 8%; border-bottom: black 1pt solid; font-weight: bold; text-align: center"><B>Page</B></TD></TR>
<TR STYLE="vertical-align: top; background-color: rgb(204,255,204)">
    <TD>ABOUT THIS PROSPECTUS</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: right">1</TD></TR>
<TR STYLE="vertical-align: top; background-color: White">
    <TD>NEOSTEM, INC.</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: right">2</TD></TR>
<TR STYLE="vertical-align: top; background-color: rgb(204,255,204)">
    <TD>RISK FACTORS</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: right">5</TD></TR>
<TR STYLE="vertical-align: top; background-color: White">
    <TD>SPECIAL NOTE REGARDING FORWARD-LOOKING INFORMATION</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: right">5</TD></TR>
<TR STYLE="vertical-align: top; background-color: rgb(204,255,204)">
    <TD>USE OF PROCEEDS</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: right">5</TD></TR>
<TR STYLE="vertical-align: top; background-color: White">
    <TD>THE SECURITIES WE MAY OFFER</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: right">6</TD></TR>
<TR STYLE="vertical-align: top; background-color: rgb(204,255,204)">
    <TD>DESCRIPTION OF CAPITAL STOCK</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: right">7</TD></TR>
<TR STYLE="vertical-align: top; background-color: White">
    <TD>DESCRIPTION OF DEBT SECURITIES</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: right">29</TD></TR>
<TR STYLE="vertical-align: top; background-color: rgb(204,255,204)">
    <TD>DESCRIPTION OF WARRANTS</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: right">38</TD></TR>
<TR STYLE="vertical-align: top; background-color: White">
    <TD>DESCRIPTION OF UNITS</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: right">40</TD></TR>
<TR STYLE="vertical-align: top; background-color: rgb(204,255,204)">
    <TD>PLAN OF DISTRIBUTION</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: right">41</TD></TR>
<TR STYLE="vertical-align: top; background-color: White">
    <TD>LEGAL MATTERS</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: right">43</TD></TR>
<TR STYLE="vertical-align: top; background-color: rgb(204,255,204)">
    <TD>EXPERTS</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: right">43</TD></TR>
<TR STYLE="vertical-align: top; background-color: White">
    <TD>INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: right">43</TD></TR>
<TR STYLE="vertical-align: top; background-color: rgb(204,255,204)">
    <TD>WHERE YOU CAN FIND MORE INFORMATION</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD STYLE="text-align: right">44</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><B>No dealer, salesperson or other person
has been authorized to give any information or to make any representations other than those contained or incorporated by reference
in this prospectus or any accompanying prospectus supplement in connection with the offer made by this prospectus or any accompanying
prospectus supplement and, if given or made, such information or representations must not be relied upon as having been authorized
by NeoStem, Inc. or any such person. Neither the delivery of this prospectus or any accompanying prospectus supplement nor any
sale made hereunder and thereunder shall under any circumstances create an implication that there has been no change in the affairs
of NeoStem, Inc. since the date hereof. This prospectus or any accompanying prospectus supplement does not constitute an offer
or solicitation by anyone in any state in which such offer or solicitation is not authorized or in which the person making such
offer or solicitation is not qualified to do so or to anyone to whom it is unlawful to make such offer or solicitation.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>ABOUT THIS PROSPECTUS</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">This prospectus is part of a registration
statement that we filed with the Securities and Exchange Commission, using a &ldquo;shelf&rdquo; registration process. Under this
shelf process, we may sell any combination of the securities described in this prospectus in one or more offerings up to a total
dollar amount of $75,000,000. We have provided to you in this prospectus a general description of the securities we may offer.
Each time we sell securities under this shelf registration process, we will provide a prospectus supplement that will contain specific
information about the terms of the offering. We may also add, update or change in the prospectus supplement or any &ldquo;free
writing prospectus&rdquo; we may authorize to be delivered to you any of the information contained in this prospectus. To the extent
there is a conflict between the information contained in this prospectus and the prospectus supplement or any free writing prospectus
we may authorize to be delivered to you, you should rely on the information in the prospectus supplement or free writing prospectus,
as the case may be, provided that if any statement in one of these documents is inconsistent with a statement in another document
having a later date&nbsp;&mdash;&nbsp;for example, a document incorporated by reference in this prospectus or any prospectus supplement&nbsp;&mdash;&nbsp;the
statement in the document having the later date modifies or supersedes the earlier statement. This prospectus, together with the
applicable prospectus supplements and any free writing prospectus we may authorize to be delivered to you, includes all material
information relating to this offering.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">An investment in our securities involves
certain risks that should be carefully considered by prospective investors. See &ldquo;Risk Factors.&rdquo;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">You should read this prospectus and any prospectus
supplement as well as additional information described under &ldquo;Incorporation of Certain Documents by Reference&rdquo; and
&ldquo;Where You Can Find More Information&rdquo; on pages <U>43</U> and <U>44</U> , respectively.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>NEOSTEM, INC.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">NeoStem, Inc. (&ldquo;we&rdquo;, &ldquo;NeoStem&rdquo;
or the &ldquo;Company&rdquo;) continues to develop as a company in the cell therapy arena with the January 2011 completion of the
Progenitor Cell Therapy, LLC (&ldquo;PCT&rdquo;) acquisition. We view this acquisition as a foundation in achieving our strategic
mission of capturing the paradigm shift to cell therapy. While NeoStem&rsquo;s origins began in the adult stem cell research, collection
and storage service business, the PCT acquisition begins a new dimension in the Company&rsquo;s business model. NeoStem today,
with approximately 85 U.S. based employees, brings to bear significant resources to meet the basic research, manufacturing, regulatory,
clinical and logistical demands of an integrated cell therapeutics company. NeoStem is now ideally positioned in the year ahead
to transition from its origin as a service provider to a therapeutics company leveraging the intellectual capital of the Company&rsquo;s
core assets to attract world renowned clients. We perceive the advancement of cell therapeutics in Asia as another key part of
our emerging strategy given the more favorable research and regulatory environment in Asia versus Western countries. As such, we
intend to continue to build key relationships at clinical sites in China where these therapies are now being commercialized. We
see our pharmaceutical business (Suzhou Erye Pharmaceutical Company Ltd.) and stem cell service business as engines of growth to
support these initiatives.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">We operate our business in three reportable
segments: (i) Cell Therapy&nbsp;&mdash;&nbsp;United States; (ii) Regenerative Medicine&nbsp;&mdash;&nbsp;China; and (iii) Pharmaceutical
Manufacturing&nbsp;&mdash;&nbsp;China.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><U>Cell Therapy&nbsp;&mdash;&nbsp;United States</U></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>PCT Merger</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The cornerstone of our Cell Therapy business
is Progenitor Cell Therapy, LLC. On January 19, 2011 we completed our acquisition of PCT (the &ldquo;PCT Merger&rdquo;) pursuant
to the terms of an Agreement and Plan of Merger, dated September 23, 2010 (the &ldquo;PCT Merger Agreement&rdquo;). As a result
of the consummation of the PCT Merger, we acquired all of the membership interests of PCT, and PCT is now a wholly-owned subsidiary
of our Company.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">All of the membership interests of PCT outstanding
immediately prior to the effective time of the PCT Merger were converted into the right to receive, in the aggregate, (i) 10,600,000
shares of our Common Stock and (ii) 3 series of seven year warrants to purchase up to 1,000,000 shares of our Common Stock per
series (3,000,000 shares in the aggregate), at exercise prices of $3.00, $5.00 and $7.00, respectively, per share (the &ldquo;PCT
Warrants&rdquo;). The PCT Warrants are redeemable in certain circumstances. Transfer of the shares issuable upon exercise of the
PCT Warrants is restricted until the one year anniversary of the closing of the PCT Merger.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">In accordance with the PCT Merger Agreement,
we have deposited into an escrow account 10,600,000 shares of our Common Stock for eventual distribution to the former members
of PCT (subject to downward adjustment to satisfy any indemnification claims of NeoStem, all as described in the PCT Merger Agreement).
For so long as any of the 10,600,000 shares are held in escrow, such shares shall be voted by the escrow agent as directed by our
Board of Directors.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Founded by Dr. Andrew L. Pecora and Robert
A. Preti, Ph.D., PCT became an internationally recognized cell therapy services and development company. They sought to create
a business for &ldquo;as needed&rdquo; development and manufacturing services for the emerging cell therapy industry and to prepare
for eventual commercialization. With its cell therapy manufacturing facilities and team of professionals, PCT offers a platform
that can facilitate the preclinical and clinical development and commercialization of cellular therapies for clients throughout
the world. PCT offers current Good Manufacturing Practices (cGMP)-compliant cell transportation, manufacturing, storage, and distribution
services and supporting clinical trial design, product process development, logistics, regulatory and quality systems development
services. In addition, through its network of contacts throughout the cell therapy industry, PCT is able to identify early stage
development opportunities in the cell therapy field and opportunistically develop these cell therapies through proof of concept
where they can be further developed and ultimately commercialized through NeoStem&rsquo;s developing commercial structure. Dr.
Preti now serves as PCT&rsquo;s President and Dr. Pecora as part-time Chief Medical Officer of PCT. Dr. Pecora will also serve
on the board of directors of NeoStem.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">PCT is engaged in a broad range of services
in the cell therapy market for the treatment of human disease, including but not limited to contract manufacturing, product and
process development, product and regulatory consulting, and product characterization and comparability. PCT&rsquo;s expertise in
the cell therapy space, which includes therapeutic vaccines (oncology), various related cell therapeutics, cell diagnostics, and
regenerative medicine, creates a platform upon which we intend to build a therapeutics strategy. Our goal is to develop internally,
or through partnerships, allogeneic (cells from a third-party donor) or autologous (cells from oneself) cell therapeutics technologies
that, in the aggregate, will comprise the Cell Therapy&nbsp;&mdash;&nbsp;United States reportable segment.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">In addition, PCT will assume NeoStem&rsquo;s
adult stem cell business based on PCT&rsquo;s strategic advantages in meeting cGMP regulatory requirements in an industry that
is widely dispersed with a range of quality issues. We believe that PCT, as a quality leader, is ideally positioned to become a
leader in cell collection, processing and storage (cell banking) which is synergistic with NeoStem&rsquo;s roots in this business.
In addition, PCT&rsquo;s leadership in the transportation and distribution of cell therapy products is complementary to NeoStem&rsquo;s
strategic vision of working with the industry leader as the partner of choice. These efforts are being bundled together into a
new service with PCT&rsquo;s cord blood banking business into a multigenerational stem cell collection and storage plan that the
Company will call the &ldquo;Family Plan&rdquo;.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Cell Collection, Processing and Storage Business</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">In the United States, we are a provider of
adult stem cell collection, processing and storage services enabling healthy adult individuals to donate and store their stem cells
for personal therapeutic use. Similar to the banking of cord blood, pre-donating cells at a younger age helps to ensure a supply
of one&rsquo;s own stem cells should they be needed for future medical treatment. We have established a network of adult stem cell
collection centers to include ten centers throughout the country. With our acquisition of PCT, we acquired the expertise of cGMP
cord blood banking. PCT has been processing and providing storage services for a number of third-party company clients, including
Viacord and Cord Blood of America, as well as for DomaniCell, LLC, its own cord blood business. DomaniCell, a wholly owned subsidiary
of PCT, assists hospitals by providing umbilical cord blood unit collection and long-term storage services to patients for potential
future therapeutic use. DomaniCell has been providing the front-end interface and support services to hospitals and in turn employs
PCT&rsquo;s cell therapy manufacturing facilities network for the processing and long-term storage of umbilical cord blood units.
With the acquisition of PCT, we are bundling together NeoStem&rsquo;s adult stem cell collection and PCT&rsquo;s cord blood collection
offerings as a multi-generational collection and storage service called the &ldquo;Family Plan.&rdquo; Dr. Manny Alvarez, an esteemed
Obstetrician and Gynecologist and recognized television and online healthcare professional is serving exclusively as the Company&rsquo;s
spokesperson and public representative under a three year agreement, with an option to extend, under which he will promote NeoStem&rsquo;s
consumer services through endorsements, print and online marketing, and more. This offers NeoStem&rsquo;s stem cell banking products
the validation of a highly respected health news personality.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">In July 2010, we were named &ldquo;Best Stem
Cell Company, 2010,&rdquo; in the New Economy&rsquo;s Biotech Awards.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Stem Cell Research</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">NeoStem is conducting research and development
activities in its own laboratory facility. Through collaborations, we are pursuing therapeutic and potentially diagnostic applications
of adult stem cells, including applications using our own VSEL <SUP>TM</SUP> Technology (very small embryonic-like stem cells).
VSEL <SUP>TM</SUP> Technology, licensed from the University of Louisville, represents NeoStem&rsquo;s proprietary platform. We
believe VSEL <SUP>TM</SUP> Technology holds significant potential for the Company, affording us entry into the regenerative medicine
arena with a unique cell product that may, in turn, open up new areas in regenerative medicine. This research is also conducted
though funded academic research collaborations. In April 2009, we entered into a License Agreement with Vincent Falanga, M.D.,
pursuant to which we acquired a world-wide, exclusive license to certain innovative stem cell technology and applications for wound
healing. In conjunction with that license we entered into a multi-year sponsored research agreement with the Roger Williams Medical
Center in Providence, Rhode Island and Dr. Falanga&rsquo;s laboratory, funded by the Department of Defense, to study the use of
VSELs and mesenchymal cells for the treatment of chronic wounds. We have in-licensed more mature technologies that use stem cells
for regenerative applications, including rebuilding cartilage, repairing fractures and rejuvenating aging skin. Some of these products
or treatments are commercialized in Asia.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><U>Regenerative Medicine&nbsp;&mdash;&nbsp;China</U></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">We are also seeking to apply our cellular
therapies in the People&rsquo;s Republic of China (&ldquo;China&rdquo; or &ldquo;PRC&rdquo;). In 2009, we began several China-based,
adult stem cell initiatives including: (i) creating a separate China-based stem cell operation, (ii) constructing a stem cell research
and development laboratory and processing and manufacturing facility in Beijing, (iii) establishing relationships with hospitals
to provide stem cell-based therapies, and (iv) obtaining product licenses covering several adult stem cell therapeutics focused
on regenerative medicine. In 2010, we began offering stem cell banking services and certain stem cell therapies to patients in
Asia, as well as to foreigners traveling to Asia seeking medical treatments that are either unavailable or cost prohibitive in
their home countries.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">In June 2010 we launched a collaboration
with Shandong Wendeng Orthopaedic Hospital, or Wendeng Hospital, which was the first hospital in the network we are establishing
to offer orthopaedic treatments in China. In December 2010, we entered into the second hospital cooperation agreement with Shijiazhuang
Third Hospital in the provincial capital of Hebei Province. We expect to enter into a third hospital collaboration agreement in
mid-2011. In the third quarter of 2010, Weihai Municipal Price Bureau, the local authority in charge of pricing for public medical
services in China, approved the pricing for single side and bilateral arthroscopic orthopedic autologous adult stem cell based
treatment licensed by us which is being administered at Wendeng Hospital. Importantly, the Weihai Municipal Labor Bureau Medical
Insurance Office approved Wendeng Hospital&rsquo;s application for reimbursement whereby patients are eligible to receive reimbursement
for up to 80% of the cost of the orthopedic procedure under the new technology category.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Strategically, we view our efforts in China
as pioneering new pathways towards both commercialization of therapies to the largest patient populations in the world, and creating
a unique regulatory pathway for advanced proof of concept studies which may prove invaluable to the Company&rsquo;s research efforts
We intend to develop a distribution platform for cell therapy that can be used to expedite commercialization of new therapies in
China for PCT clients and to commercialize our own proprietary technologies as they emerge.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><U>Pharmaceutical Manufacturing&nbsp;&mdash;&nbsp;China</U></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">We acquired a 51% ownership interest in Suzhou
Erye Pharmaceutical Company Ltd. (&ldquo; <U>Erye</U> &rdquo;) in October 2009. Erye was founded more than 50 years ago and represents
an established, vertically-integrated pharmaceutical business. Historically, Erye has concentrated its efforts on manufacturing
and distributing of generic antibiotic products. It has received more than 160 production certificates from the State Food and
Drug Administration of China, or SFDA, covering both antibiotic prescription drugs and active pharmaceutical intermediates (APIs).
Our current senior executive management team at Erye, Mr. Shi, Chairman, and Madame Zhang, General Manager, joined Erye in 1998,
and in conjunction with others bought it from the PRC government in 2003. A majority of the drugs that Eyre manufactures are on
China&rsquo;s &ldquo;essential drug&rdquo; list, and Erye&rsquo;s new facility under construction will enable greater production.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Corporate Information</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Our principal executive offices are located
at 420 Lexington Avenue, Suite 450, New York, New York 10170, and our telephone number is (212) 584-4180. Our Common Stock is currently
traded on the NYSE Amex under the symbol &ldquo;NBS.&rdquo; We maintain a corporate website at <I>www.neostem.com</I> . The contents
of our website are not incorporated by reference into this prospectus and should not be considered to be a part of this prospectus
or relied upon in connection herewith.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">NeoStem, Inc. was incorporated under the
laws of the State of Delaware in September 1980 under the name Fidelity Medical Services, Inc. and commenced operations in the
adult stem cell collection, processing and storage services business in January 2006. Unless otherwise stated, all references to
&ldquo;us,&rdquo; &ldquo;our,&rdquo; &ldquo;NeoStem,&rdquo; &ldquo;we,&rdquo; the &ldquo;Company&rdquo; and similar designations
refer to NeoStem, Inc.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>RISK FACTORS</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Investing in our securities involves risk.
Please see the risk factors under the heading &ldquo;Risk Factors&rdquo; beginning on page 32 of our Annual Report on Form 10-K
for the year ended December 31, 2010, on file with the Securities and Exchange Commission. Before making an investment decision,
you should carefully consider these risks as well as other information we include or incorporate by reference in this prospectus
and any prospectus supplement. The risks and uncertainties we have described are not the only ones facing our company. Additional
risks and uncertainties not presently known to us or that we currently deem immaterial may also affect our business operations.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SPECIAL NOTE REGARDING FORWARD-LOOKING
INFORMATION</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">This prospectus, any prospectus supplement
and the documents we incorporate by reference in this prospectus contain forward-looking statements within the meaning of Section
27A of the Securities Act of 1933, as amended (the &ldquo;Securities Act&rdquo;), and Section 21E of the Securities Exchange Act
of 1934, as amended (the &ldquo;Exchange Act&rdquo;). All statements, other than statements of historical facts, that we include
in this prospectus, any prospectus supplement, and in the documents we incorporate by reference in this prospectus, may be deemed
forward-looking statements for purposes of the Securities Act and the Exchange Act. We use the words &ldquo;anticipate,&rdquo;
&ldquo;believe,&rdquo; &ldquo;estimate,&rdquo; &ldquo;expect,&rdquo; &ldquo;intend,&rdquo; &ldquo;may,&rdquo; &ldquo;plan,&rdquo;
&ldquo;project,&rdquo; &ldquo;will,&rdquo; &ldquo;would&rdquo; and similar expressions to identify forward-looking statements,
although not all forward-looking statements contain these identifying words. We cannot guarantee that we actually will achieve
the plans, intentions or expectations disclosed in our forward-looking statements and, accordingly, you should not place undue
reliance on our forward-looking statements. There are a number of important factors that could cause actual results or events to
differ materially from the forward-looking statements that we make, including the factors included in the documents we incorporate
by reference in this prospectus. You should read these factors and the other cautionary statements made in the documents we incorporate
by reference as being applicable to all related forward-looking statements wherever they appear in this prospectus, any prospectus
supplement, and any document incorporated by reference. We caution you that we do not undertake any obligation to update forward-looking
statements made by us.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>USE OF PROCEEDS</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Unless otherwise provided in the applicable
prospectus supplement, we intend to use the net proceeds from the sale of the securities under this prospectus for general corporate
purposes, including working capital and general corporate purposes. Although we have no present plans or intentions, we may use
a portion of the net proceeds to acquire or invest in complementary businesses. We will set forth in the prospectus supplement
our intended use for the net proceeds received from the sale of any securities. Pending the use of the net proceeds, we may use
the net proceeds to invest in investment-grade, interest-bearing securities.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>THE SECURITIES WE MAY OFFER</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The descriptions of the securities contained
in this prospectus, together with the applicable prospectus supplements, summarize all the material terms and provisions of the
various types of securities that we may offer. We will describe in the applicable prospectus supplement relating to any securities
the particular terms of the securities offered by that prospectus supplement. If we indicate in the applicable prospectus supplement,
the terms of the securities may differ from the terms we have summarized below. We will also include in the prospectus supplement
information, where applicable, about material United States federal income tax considerations relating to the securities, and the
securities exchange, if any, on which the securities will be listed.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">We may sell from time to time, in one or
more offerings:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>common stock;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>preferred stock;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>debt securities;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>warrants to purchase any of the securities listed above; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>units consisting of any combination of the securities listed above.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">In this prospectus, we refer to the common
stock, preferred stock, debt securities, warrants and units collectively as &ldquo;securities.&rdquo; The total dollar amount of
all securities that we may sell will not exceed $75,000,000.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">If we issue debt securities at a discount
from their original stated principal amount, then, for purposes of calculating the total dollar amount of all securities issued
under this prospectus, we will treat the initial offering price of the debt securities as the total original principal amount of
the debt securities.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">This prospectus may not be used to consummate
a sale of securities unless it is accompanied by a prospectus supplement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>DESCRIPTION OF CAPITAL STOCK</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The following is a summary of all material
characteristics of our capital stock as set forth in our certificate of incorporation and bylaws, and our outstanding warrants.
The summary does not purport to be complete and is qualified in its entirety by reference to our certificate of incorporation and
bylaws and the Class A warrants, the Class D warrants, the warrants issued in our November 2010 Common Stock Offering and in our
November 2010 Preferred Stock Offering, the warrants issued in connection with the PCT Merger, and the Certificate of Designations
relating to our Series E 7% Senior Convertible Preferred Stock themselves, all of which are incorporated by reference as exhibits
to the registration statement of which this prospectus is a part, and to the provisions of the General Corporation Law of the State
of Delaware, as amended.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Common Stock</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">We are authorized to issue 500,000,000 shares
of common stock, par value $0.001 per share (&ldquo;Common Stock&rdquo;). Holders of our Common Stock are entitled to one vote
per share in the election of directors and on all other matter on which stockholders are entitled or permitted to vote. Holders
of our Common Stock are not entitled to cumulative voting rights. Therefore, holders of a majority of the shares voting for the
election of directors can elect all of the directors. Subject to the terms of any outstanding series of preferred stock, the holders
of our Common Stock are entitled to dividends in the amounts and at times as may be declared by the Board of Directors out of funds
legally available. Upon liquidation or dissolution, holders of our Common Stock are entitled to share ratably in all net assets
available for distribution to stockholders after payment of any liquidation preferences to holders of our preferred stock. Holders
of our Common Stock have no redemption, conversion or preemptive rights.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">As of April 11, 2011, we had 80,024,412 shares
of Common Stock issued and outstanding, exclusive of existing options and warrants and the shares to be issued in this offering.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Preferred Stock</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">We are authorized to issue up to 20,000,000
shares of preferred stock, par value $0.01 per share, with such designations, rights, and preferences as may be determined from
time to time by our Board of Directors. Accordingly, our Board of Directors is empowered, without stockholder approval, to issue
preferred stock with dividend, liquidation, conversion, voting, or other rights that could adversely affect the voting power or
other rights of the holders of our Common Stock. The issuance of preferred stock could have the effect of restricting dividends
on our Common Stock, diluting the voting power of our Common Stock, impairing the liquidation rights of our Common Stock, or delaying
or preventing a change in control of our company, all without further action by our stockholders.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">As of April 11, 2011, there were:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>10,000 shares of our Series B Convertible Redeemable Preferred Stock, $0.01 par value per share (&ldquo;Series B Preferred
Stock&rdquo;), authorized and outstanding; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>10,582,011 shares of our Series E 7% Senior Convertible Preferred Stock, $0.01 par value per share (the &ldquo;Series E Preferred
Stock,&rdquo; or the &ldquo;Series E Preferred Shares&rdquo;), authorized and outstanding.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>Series B Preferred Stock</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The Series B Preferred Stock ranks pari passu
with our Common Stock with respect to the payment of dividends and to the distribution of assets upon liquidation, dissolution
or winding up.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">So long as any shares of the Series B Preferred
Stock are outstanding, no dividend shall be declared or paid or set aside for payment or other distribution declared or made upon
our Common Stock or upon any other stock ranking junior to, or on a parity with, the Series B Preferred Stock as to dividends or
upon liquidation, dissolution or winding up, unless, in the case of our preferred stock, the same dividend is declared, paid or
set aside for payment on all outstanding shares of the Series B Preferred Stock or in the case of our Common Stock, ten times such
dividend per share is declared, paid or set aside for payment on each outstanding share of the Series B Preferred Stock.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Except as otherwise provided by law, each
share of the Series B Preferred Stock has the same voting rights as ten shares of our Common Stock and the holders of the Series
B Preferred Stock and the Common Stock shall vote together as one class on all matters.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The holder of any share of Series B Preferred
Stock has the right, at such holder&rsquo;s option, to convert such share into one fully paid and non-assessable share of our Common
Stock, subject to adjustment.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">In the event of any voluntary or involuntary
dissolution, liquidation or winding up of our Company, after any distribution of assets is made to the holders of any other class
or series of stock that ranks prior to the Series B Preferred Stock in respect of distributions upon the liquidation of our company,
the holder of each share of Series B Preferred Stock then outstanding shall be entitled to be paid out of our assets available
for distribution to our stockholders, an amount on a pari passu basis equal to ten times the amount per share distributed to the
holders of our Common Stock. After payment of the full amount of the distribution to which they are entitled, the holders of shares
of the Series B Preferred Stock will not be entitled to any further participation in any distribution of assets by the corporation.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Shares of Series B Preferred Stock issued
and reacquired by us shall have the status of authorized and unissued shares of preferred stock, undesignated as to series, subject
to later issuance.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Holders of shares of Series B Preferred Stock
are not entitled to any preemptive or subscription rights in respect of any securities of the corporation.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>Series E 7% Senior Convertible Preferred Stock</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>General.</I> &nbsp;&nbsp;We are authorized
to issue up to 20,000,000 shares of preferred stock, par value $0.01 per share, with such designations, rights and preferences
as may be determined from time to time by our Board of Directors, without further stockholder approval. Accordingly, our Board
of Directors has created out of the authorized and unissued shares of our preferred stock a series of preferred stock designated
as the Series E 7% Senior Convertible Preferred Stock. As of April 11, 2011, there were 10,582,011 shares of Series E 7% Senior
Convertible Preferred Stock, par value $0.01 per share (the &ldquo;Series E Preferred Stock,&rdquo; or the &ldquo;Series E Preferred
Shares&rdquo;) issued and outstanding.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The following is a brief description of the
terms of our Series E Preferred Stock. The description of the Series E Preferred Stock contained herein does not purport to be
complete and is qualified in its entirety by reference to the Certificate of Designations for the Series E Preferred Stock.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Stockholder Approval.</I> &nbsp;&nbsp;We
were required to hold a special meeting of our stockholders as soon as practicable after the closing of our senior convertible
preferred stock offering (which closed on November 19, 2010) for the purpose of approving the issuance in full of all &ldquo;conversion
shares&rdquo; and &ldquo;redemption shares,&rdquo; as such terms are defined in the certificate of designations pertaining to the
Series E Preferred Shares, and all shares of our Common Stock issuable pursuant to the warrants sold in such senior convertible
preferred stock offering. The purchasers of the Series E Preferred Shares had acknowledged that they could not convert their preferred
stock to Common Stock or exercise their warrants for more than 19.9% of the outstanding shares of Common Stock, minus the shares
of Common Stock issued in connection with our offering of the Series E Preferred Stock, or exercise any voting rights, until after
stockholder approval of such issuance was obtained. Such stockholder approval was obtained at the special meeting of our stockholders
held on January 18, 2011.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Dividends.</I> &nbsp;&nbsp;Holders of
Series E Preferred Stock shall be entitled to receive dividends payable in cash (or, at our option, in shares of our Common Stock
if the Equity Conditions are satisfied) on the Liquidation Preference (as defined below) of such Series E Preferred Share at the
per share rate of seven percent (7%) per annum, which shall be cumulative. Dividends on the Series E Preferred Shares shall commence
accruing on the Initial Issuance Date and shall be computed on the basis of a 360-day year of twelve 30-day months. Dividends shall
be payable in arrears on each Mandatory Redemption Date. &ldquo;Mandatory Redemption Date&rdquo; is defined in the certificate
of designations as March 19, 2011, and the 19 <SUP>th</SUP> day of each calendar month thereafter (or the next trading day thereafter)
and ending on and including May 20, 2013 (the &ldquo;Maturity Date&rdquo;). The Maturity Date will be deemed to be a Mandatory
Redemption Date.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Liquidation Preference.</I> &nbsp;&nbsp;In
the event of any liquidation, dissolution or winding up of our company, either voluntary or involuntary (a &ldquo;Liquidation Event&rdquo;),
the holders of the Series E Preferred Shares shall be entitled to receive, out of our assets available for distribution to stockholders
(&ldquo;Liquidation Funds&rdquo;), prior and in preference to any distribution of any of our assets to the holders of any other
class or series of equity securities, the amount of one dollar ($1.00) per share plus all accrued but unpaid dividends (the &ldquo;Liquidation
Preference&rdquo;). After payment of the full amount of the Liquidation Preference, in the case of a Liquidation Event, the holders
will not be entitled to any further participation in any distribution of our assets; provided that the foregoing shall not affect
any rights which holders may have with respect to any requirement that our company repurchase the Series E Preferred Shares or
for any right to monetary damages. All the preferential amounts to be paid to the holders of the Series E Preferred Shares shall
be paid or set apart for payment before the payment or setting apart for payment of any amount for, or the distribution of any
Liquidation Funds of our company to the holders of shares of other classes or series of our preferred stock junior in rank to the
Series E Preferred Shares in connection with a Liquidation Event.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I>Mandatory Monthly Redemption.</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The certificate of designations provides
that &ldquo;Mandatory Redemption Shares&rdquo; means, with respect to (a) any Mandatory Redemption Date (other than the Maturity
Date) an amount equal to &nbsp;1/27 <SUP>th</SUP> of the Series E Preferred Shares initially issued pursuant to the stock purchase
agreement (regardless of whether any holder has converted any Series E Preferred Shares or we have optionally redeemed any Series
E Preferred Shares) and (b) the Maturity Date, all outstanding Series E Preferred Shares. On each applicable Mandatory Redemption
Date, we shall redeem the Mandatory Redemption Shares at an aggregate redemption price equal to the sum of (x) the product of (A)
the Liquidation Preference and (B) the number of Mandatory Redemption Shares required to be redeemed on such Mandatory Redemption
Date plus (y) any and all accrued but unpaid dividends on all of the outstanding Series E Preferred Shares (the &ldquo;Mandatory
Redemption Price&rdquo;). The Mandatory Redemption Price shall be payable, at our option, in cash or shares of our Common Stock
or any combination of cash and shares of our Common Stock, provided, however, that no portion of the Mandatory Redemption Price
may be paid in shares of our Common Stock unless the Equity Conditions are satisfied or waived by the holders of a majority of
the Series E Preferred Shares (the &ldquo;Required Holders&rdquo;) in writing prior to delivery of the applicable Mandatory Redemption
Notice (as defined below); provided, further, however, that the portion of the applicable Mandatory Redemption Price that we elect
to pay in shares of our Common Stock (if any) shall not exceed the Dollar Volume Limitation (unless waived by the Required Holders
in writing).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">On a date not less than twenty-two (22) trading
days, but in no event more than twenty-five (25) trading days, prior to each Mandatory Redemption Date (the &ldquo;Mandatory Redemption
Notice Date&rdquo;), we shall deliver a written notice (a &ldquo;Mandatory Redemption Notice&rdquo;) to the holders, which shall
either: (i) confirm that the entire applicable Mandatory Redemption Price shall be paid in cash; or (ii) (A) state that we elect
to pay all or a portion of the Mandatory Redemption Price in shares of our Common Stock, (B) specify the portion that we elect
to pay in cash (expressed in dollars) (such amount, the &ldquo;Cash Payment Amount&rdquo;) and the portion that we elect to pay
in shares of our Common Stock (expressed in dollars) (such portion a &ldquo;Stock Payment Amount&rdquo;), which amounts when added
together must equal the applicable Mandatory Redemption Price, (C) certify that the Equity Conditions (as defined below) are then
satisfied (or waived by the Required Holders), (D) state the Dollar Volume Limitation (expressed in dollars) and certify that the
Stock Payment Amount does not exceed such Dollar Volume Limitation and (E) certify that the Maximum Share Amount (as defined below)
has not been exceeded. If (x) we do not timely deliver a Mandatory Redemption Notice or (y) the Equity Conditions are not satisfied
(unless waived by the Required Holders), then we shall be deemed to have delivered, a Mandatory Redemption Notice electing to pay
the entire Mandatory Redemption Price in cash. The certificate of designations provides that &ldquo;Dollar Volume Limitation&rdquo;
means fifteen percent (15%) of the aggregate dollar trading volume of our Common Stock on the NYSE Amex Equities (or other applicable
trading market) over the twenty-two (22) consecutive trading day period ending on the trading day immediately preceding the date
of the Mandatory Redemption Notice or Optional Redemption Notice, as applicable. The term &ldquo;dollar trading volume&rdquo; for
any trading day shall be determined by multiplying the Daily VWAP by the volume as reported on Bloomberg for such trading day.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The term &ldquo;Equity Conditions&rdquo;
means each of the following: (i) on each day during the Equity Conditions Measuring Period, all shares of our Common Stock to be
issued on the applicable Mandatory Redemption Date (or such other date on or event for which the Equity Conditions are required
to be satisfied) shall be eligible for resale by the holder without restriction and without need for additional registration under
any applicable federal or state securities laws, and we shall have no knowledge of any fact that would cause any shares of Common
Stock not to be so eligible for resale by the holder without restriction and without need for additional registration under any
applicable federal or state securities laws; (ii) on each day during the Equity Conditions Measuring Period, the shares of Common
Stock are designated for listing on a trading market and shall not have been suspended from trading on such trading market nor
shall delisting or suspension by such exchange or market have been threatened or pending in writing by such exchange nor shall
there be any Securities and Exchange Commission or judicial stop trade order or trading suspension stop order; (iii) any shares
of our Common Stock to be issued in connection with the applicable Mandatory Redemption Date (or such other date on or event for
which the Equity Conditions are required to be satisfied) may be issued in full without violating the rules or regulations of the
trading market or any applicable laws; (iv) on each day during the Equity Conditions Measuring Period, there shall not have occurred
and be continuing, unless waived by the holder, either (A) a Trigger Event (as defined below) or (B) an event that with the passage
of time or giving of notice would constitute a Trigger Event; (v) on each day during the Equity Conditions Measuring Period, we
have not provided any holder with any non-public information; (vi) on each day during the Equity Conditions Measuring Period, neither
the registration statement of which the prospectus supplement pertaining to our senior convertible preferred stock offering is
a part nor the prospectus nor such prospectus supplement contains any untrue statement of a material fact or omits to state a material
fact necessary in order to make the statements made therein, in the light of the circumstances under which they were made, not
misleading and such registration statement, prospectus and such prospectus supplement comply with all applicable securities laws
as to form and substance (unless the issuable shares of Common Stock may be sold without restriction); (vii) our transfer agent
for the shares of our Common Stock is participating in the Depository Trust Company (&ldquo;DTC&rdquo;) Fast Automated Securities
Transfer Program; and (viii) all shares of our Common Stock to be issued in connection with the applicable Mandatory Redemption
Date (or such other date on or event for which the Equity Conditions are required to be satisfied) are duly authorized and will
be validly issued, fully paid and non-assessable upon issuance, free and clear of all liens, claims or encumbrances, and the issuance
thereof will not require any further approvals of our board of directors or stockholders. &ldquo;Equity Conditions Measuring Period&rdquo;
means the period beginning twenty (20) trading days prior to the applicable Mandatory Redemption Date (or such other date on or
event for which the Equity Conditions are required to be satisfied) and ending on and including such Mandatory Redemption Date.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">To the extent that we elect (or are required)
to pay all or any portion of the applicable Mandatory Redemption Price in shares of our Common Stock, the applicable Stock Payment
Amount will be paid as follows:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">(A)</TD><TD>twenty-one (21) trading days prior to the applicable Mandatory Redemption Date (the &ldquo;First Advance Date&rdquo;), we shall
deliver to the holders a number of shares of our Common Stock determined by dividing (x) the Stock Payment Amount for such Mandatory
Redemption Date by (y) ninety-two percent (92%) of the Daily VWAP on the trading day immediately preceding such Advance Date (the
&ldquo;First Advance Shares&rdquo;);</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">(B)</TD><TD>eleven (11) trading days prior to the applicable Mandatory Redemption Date (the &ldquo;Second Advance Date&rdquo; and together
with the First Advance Date, the &ldquo;Advance Dates&rdquo; and each, an &ldquo;Advance Date&rdquo;), we shall deliver to the
holders a number of shares of our Common Stock equal to the positive difference (if any) between (x) the quotient of (1) the Stock
Payment Amount and (2) the average of the five lowest Daily VWAPs during the first (10) ten trading days of the applicable Stock
Payment Pricing Period and (y) the number of First Advance Shares delivered to the holders in connection with such Mandatory Redemption
Date (the &ldquo;Second Advance Shares&rdquo; and together with the First Advance Shares, the &ldquo;Advance Shares&rdquo;); and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">(C)</TD><TD>not later than three (3) trading days after the applicable Mandatory Redemption Date, we shall deliver an additional number
of shares of our Common Stock (the &ldquo;True-Up Shares&rdquo;), if any, to the holders equal to the positive difference between
(a) the Stock Payment Amount divided by the Stock Payment Price for such Mandatory Redemption Date and (b) the Advance Shares;
provided; however, that if clause (b) exceeds clause (a), then each holder shall return its pro rata portion of such excess number
of shares of our Common Stock to us, and such excess shares shall immediately be deemed cancelled effective as of the True Up.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 23.9pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&ldquo;Daily VWAP&rdquo; means, for any date,
(i) the daily volume weighted average price of our Common Stock for such date on the NYSE Amex Equities as reported by Bloomberg;
(ii) if our Common Stock is not then listed on the NYSE Amex Equities, the daily volume weighted average price of our Common Stock
for such date on such other trading market where our Common Stock is then listed as reported by Bloomberg; (iii) if the foregoing
do not apply, the volume weighted average price of our Common Stock in the over-the-counter market on the electronic bulletin board
for our Common Stock as reported by Bloomberg, or, if no volume weighted average price is reported for such security by Bloomberg,
the highest bid as reported on the &ldquo;pink sheets&rdquo; at the close of trading; or (iv) in all other cases, the fair market
value of a share of our Common Stock as determined by an independent appraiser selected in good faith by the Required Holders and
reasonably acceptable to us.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">To the extent that we elect to pay all or
any portion of the applicable Mandatory Redemption Price in shares of our Common Stock:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">(A)</TD><TD>to the extent that the aggregate number of Advance Shares or True-Up Shares to be delivered to a holder in respect of any individual
Stock Payment Amount would cause such holder to exceed the Beneficial Ownership Limitation (as defined below under &ldquo;Ownership
Cap&rdquo;), then, (I) the holder shall provide written notice to us that such delivery of all or a portion of the Advance Shares
or True-Up Shares would cause such holder to exceed the Beneficial Ownership Limitation, and (II) in addition to delivery of the
number of Advance Shares or True-Up Shares that would not cause such holder to exceed the Beneficial Ownership Limitation, we shall
pay to such holder in lieu of such number of Advance Shares or True-Up Shares that would cause such holder to exceed the Beneficial
Ownership Limitation (such excess number of shares, the &ldquo;Excess Shares&rdquo;), not more than the later of three (3) trading
days after the Mandatory Redemption Date or ten (10) trading days after the date of such holder&rsquo;s written notice, an amount
in cash equal to the portion of the Stock Payment Amount that would otherwise be payable in respect of the Excess Shares;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">(B)</TD><TD>to the extent that such Stock Payment Amount, when aggregated with any shares of our Common Stock already issued in respect
of all of the Series E Preferred Shares, would cause the Maximum Share Amount to be exceeded, then that portion of such Stock Payment
Amount that would not exceed the Maximum Share Amount shall be delivered to the holders hereunder in shares of our Common Stock
as provided above, ratably based on the holders&rsquo; relative ownership of the outstanding Series E Preferred Shares, and we
shall pay to the holders, not more than three (3) trading days after the Mandatory Redemption Date, an amount in cash equal to
the Stock Replacement Payment in lieu of any portion of such Stock Payment Amount that would cause the Maximum Share Amount to
be exceeded;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">(C)</TD><TD>if the Equity Conditions are neither (x) satisfied nor (y) waived, on the trading day immediately preceding the First Advance
Date and/or on the First Advance Date, or if the Daily VWAP cannot be determined on the trading day immediately preceding the First
Advance Date, or if we fail to deliver the First Advance Shares to the holders on the First Advance Date, then the holder may,
at its options upon written notice to us, require us to pay to such holder, not later than three (3) trading days after the Mandatory
Redemption Date, an amount of cash equal to the Stock Replacement Payment in lieu of such Stock Payment Amount; or</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">(D)</TD><TD>if subsequent to the delivery of the First Advance Shares (A) the Equity Conditions are neither (x) satisfied nor (y) waived
in accordance with the terms hereof, as applicable, on any day of the Stock Payment Pricing Period or (B) if the Daily VWAP cannot
be determined on any day of the Stock Payment Pricing Period, then each holder may, at its option, elect in a written notice to
us to redeliver all or any portion of the Advance Shares to us and we will pay to such holder, not later than three (3) trading
days after the Mandatory Redemption Date, an amount of cash equal to the Stock Replacement Payment in lieu of such portion of the
Stock Payment Amount for which such holder has elected in writing to redeliver Advance Shares to us.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The &ldquo;Stock Replacement Payment&rdquo;
shall be determined according to the following formula:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">SRP = (X/Y) * S</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">For the purposes of the foregoing formula:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">SRP = Stock Replacement Payment</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">X = the average Daily VWAP of the shares
of our Common Stock for the applicable Stock Payment Pricing Period</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Y = the Stock Payment Price for the applicable
Stock Payment Pricing Period</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">S = the Stock Payment Amount (or, (A) in
the case that either or both of Maximum Share Amount and/or Beneficial Ownership Limitation is exceeded as provided above, only
that portion of such Stock Payment Amount that would exceed the Maximum Share Amount and/or Beneficial Ownership Limitation, as
applicable, and/or (B) that portion of the Stock Payment Amount for which the holder has elected in its written notice to redeliver
Advance Shares to us).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Any shares of our Common Stock required to
be delivered by us to a holder shall be credited to such holder&rsquo;s or its designee&rsquo;s balance account with DTC through
its Deposit/Withdrawal at Custodian system (&ldquo;DWAC&rdquo;).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Each mandatory redemption (and the related
payment of the Mandatory Redemption Price) shall be made pro rata among the holders based on each holder&rsquo;s relative percentage
ownership of the outstanding Series E Preferred Shares.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Notwithstanding the delivery of a Mandatory
Redemption Notice, the holder may deliver a Conversion Notice with respect to all or any portion of the specific Mandatory Redemption
Shares to be redeemed on the applicable Mandatory Redemption Date at any time prior to such Mandatory Redemption Date. Any Advance
Shares delivered to such holder in connection with such Mandatory Redemption Date shall count towards the number of shares of our
Common Stock that we will be obligated to deliver on the applicable Share Delivery Date (as defined below), and to the extent that
the Advance Shares exceeds the number of shares of our Common Stock that we would be required to deliver on the applicable Share
Delivery Date, the holder shall return such excess to us.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Each and every time that we sell any shares
of our Common Stock pursuant to any Equity Line, we shall immediately deliver a written notice to each holder (an &ldquo;Equity
Line Draw Notice&rdquo;), which Equity Line Draw Notice shall state the aggregate purchase price for such shares of our Common
Stock (the &ldquo;Equity Line Aggregate Purchase Price&rdquo;). Each holder may, at its option, by delivering a written notice
to us, require us to pay the Mandatory Redemption Price (or the appropriate portion thereof) on the next succeeding Mandatory Redemption
Date (or to the extent that the date of such Equity Line Draw notice is subsequent to the date of the Mandatory Redemption Notice
for such Mandatory Redemption Date, then the next succeeding Mandatory Redemption Date) in shares of our Common Stock in an amount
equal to its pro rata portion of the Equity Line Aggregate Purchase Price. To the extent that the Equity Line Aggregate Purchase
Price exceeds the aggregate amount of the entire Mandatory Redemption Price for such Mandatory Redemption Date, then on each succeeding
Mandatory Redemption Date the holder may, at its option, by delivering a written notice to us, require us to pay its pro rata portion
of the applicable Mandatory Redemption Price in shares of our Common Stock until we have made aggregate payments in shares of our
Common Stock equal to its pro rata portion of the entire Equity Line Aggregate Purchase Price. Notwithstanding anything to the
contrary, all payments of Mandatory Redemption Price made in shares of our Common Stock shall be subject the requirement to make
the appropriate Stock Replacement Payment if applicable. Pro rata portion for a holder is the number of Series E Preferred Shares
then held by such holder divided by the aggregate number of outstanding Series E Preferred Shares.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Optional Redemption.</I> &nbsp;&nbsp;We
may, at our option, redeem the Series E Preferred Shares, at any time and from time to time, in whole or in part (but not less
than 1,000,000 Series E Preferred Shares at any one time) for an amount equal to (a) the liquidation preference per Series E Preferred
Share plus any accrued and unpaid dividends through the optional redemption date (the &ldquo;Base Redemption Price&rdquo;) plus
(b) (i) if such prepayment occurs on or before the twelve month anniversary of the closing, an amount equal to 15% of the Base
Redemption Price or (ii) if such prepayment occurs at any time after the twelve month anniversary of the closing date, an amount
equal to 10% of the Base Redemption Price (the additional amount under clause (b) being referred to as the &ldquo;Additional Redemption
Price&rdquo;). The Base Redemption Price will be paid in cash and the Additional Redemption Price will be paid in cash or, at our
option and provided (w) the Equity Conditions are satisfied (unless waived by the Required Holders), (x) the portion of the Additional
Redemption Price to be paid in shares of our Common Stock does not exceed the Dollar Volume Limitation (unless waived by the Required
Holders), (y) the Maximum Share Amount is not exceeded and (z) the Daily VWAP is available on the trading day immediately preceding
the First Optional Redemption Advance Date and on each day of the Stock Payment Pricing Period, in shares of our Common Stock.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">We will deliver written notice of optional
redemption to the holders 30 trading days prior to the date we set for such optional redemption, which may not be a Mandatory Redemption
Date or any day of a Stock Payment Pricing Period with respect to any mandatory redemption date. Each holder may submit a conversion
notice for the specific Series E Preferred Shares to be redeemed at any time prior to the optional redemption date. The optional
redemption notice will specify the number of Series E Preferred Shares to be redeemed and what portion of the Additional Redemption
Price will be paid in shares of our Common Stock (expressed in dollars), what portion of the Additional Redemption Price will be
paid in cash (expressed in dollars) and (A) certify that the Equity Conditions are satisfied, (B) state the Dollar Volume Limitation
(expressed in dollars) and certify that the portion of the Additional Redemption Price to be paid in shares of our Common Stock
does not exceeded such Dollar Volume Limitation and (C) certify that the Maximum Share Amount has not been exceeded. The optional
redemption notice will be irrevocable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">To the extent that any portion of the Additional
Redemption Price will be paid in shares of our Common Stock, 21 trading days prior to the optional redemption date (the &ldquo;First
Optional Redemption Advance Date&rdquo;), we will advance to the holders a number of shares of our Common Stock determined by dividing
(x) that portion of the Additional Redemption Price to be paid in shares of our Common Stock by (y) 92% of the Daily VWAP on the
trading day immediately preceding the First Optional Redemption Advance Date (the &ldquo;First Optional Redemption Advance Shares&rdquo;).
In addition, 11 trading days prior to the applicable optional redemption date (the &ldquo;Second Optional Redemption Advance Date&rdquo;
and together with the First Optional Redemption Advance Date, the &ldquo;Optional Redemption Advance Dates&rdquo; and each, an
&ldquo;Optional Redemption Advance Date&rdquo;), we will advance to the holders an additional number of shares of our Common Stock
equal to the positive difference (if any) between (x) the quotient of (1) the portion of the Additional Redemption Price to be
paid in shares of our Common Stock and (2) the average of the five lowest Daily VWAPs during the first 10 trading days of the applicable
Stock Payment Pricing Period and (y) the number of First Optional Redemption Advance Shares delivered to the holders in connection
with such optional redemption date (the &ldquo;Second Optional Redemption Advance Shares&rdquo; and together with the First Optional
Redemption Advance Shares, the &ldquo;Optional Redemption Advance Shares&rdquo;). Not later than three trading days after the optional
redemption date, we will deliver an additional number of shares of our Common Stock, if any, to the holder equal to the positive
difference between (1) that portion of the Additional Redemption Price to be paid in shares of our Common Stock divided by the
Stock Payment Price and (2) the Optional Redemption Advance Shares. If clause (2) of the immediately preceding sentence exceeds
clause (1) of the immediately preceding sentence, then each holder shall return to us its pro rata portion of such excess number
of shares of our Common Stock. No holder shall have any liability to us to the extent that any Optional Redemption Advance Shares
that are returned to us pursuant to the immediately preceding sentence decrease in value following the applicable Optional Redemption
Advance Date.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Optional Conversion by the Holders.</I>
&nbsp;&nbsp;Each holder of the Series E Preferred Shares shall have the right at any time and from time to time, at the option
of such holder, to convert all or any portion of the Series E Preferred Shares held by such holder, for such number shares of our
Common Stock, free and clear of any liens, claims or encumbrances, as is determined by dividing (i) the Liquidation Preference
times the number of Series E Preferred Shares being converted, by (ii) the Conversion Price (as defined below) in effect on the
Conversion Date (as defined below). Immediately following such conversion, the persons entitled to receive the shares of our Common
Stock upon the conversion of Series E Preferred Shares shall be treated for all purposes as having become the owners of such shares
of our Common Stock, subject to the rights provided herein to holders. Pursuant to the certificate of designations, the initial
&ldquo;Conversion Price&rdquo; was $2.0004, subject to adjustment as provided therein. As of April 11, 2011, the adjusted Conversion
Price was $1.9679. The Conversion Price is subject to further adjustment in accordance with the terms of the certificate of designations.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The Conversion Price is subject to adjustment
under the following circumstances:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">(i)</TD><TD>in the event we effect a stock split or combination of our outstanding Common Stock, then the conversion price then in effect
will be proportionately decreased or increased, as applicable.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">(ii)</TD><TD>in the event we make, issue or set a record date for the determination of holders of our Common Stock entitled to receive a
dividend or other distribution payable in shares of our Common Stock, then the conversion price shall be decreased by multiplying
the conversion price then in effect by a fraction equal to: (a) the total number of shares of our Common Stock issued and outstanding
immediately prior to such issuance or the close of business on such record date divided by (b) the total number of shares our Common
Stock issued and outstanding immediately prior to such issuance or the close of business on such record date plus the number of
shares of our Common Stock issuable in payment of such dividend or distribution.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">(iii)</TD><TD>in the event we make, issue or set a record date for the determination of holders of our Common Stock entitled to receive a
dividend or other distribution payable in securities or property other than shares of our Common Stock, then an appropriate revision
shall be made to conversion price then in effect such that the holders of the Series E Preferred Shares shall receive upon conversion
thereof, in addition to the shares of our Common Stock to which the holders would be entitled, the number of securities or other
property that they would have received had such holders converted their Series E Preferred Shares into shares of our Common Stock
on the date of such event.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">(iv)</TD><TD>in the event we issue or sell shares of our Common Stock (other than as provided above in connection with a stock split or
combination or the payment of certain dividends and distributions) at a price per share less than the Conversion Price, or without
consideration, the Conversion Price then in effect upon each such issuance shall be adjusted by multiplying the Conversion Price
by a fraction equal to: (a) the total number of shares of our Common Stock issued and outstanding immediately prior to such issuance
plus the number of shares of our Common Stock which the aggregate consideration for the total number of such additional shares
of our Common Stock so issued would purchase at a price per share equal to the Conversion Price then in effect divided by (b) the
number of shares of our Common Stock outstanding immediately after the issuance of such additional shares.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">(v)</TD><TD>in the event we shall issue or sell any rights, warrants or options to purchase or other securities convertible into or exchangeable
or exercisable for, directly or indirectly, any shares of our Common Stock or securities convertible into or exchangeable or exercisable
for, directly or indirectly, shares of our Common Stock or common stock equivalents and the price per share at which such additional
shares of our Common Stock may be issued pursuant to any such common stock equivalent shall be less than the Conversion Price then
in effect, or if after the issuance of any common stock equivalents, the price per share at for which such additional shares of
our Common Stock may be issued pursuant to any such common stock equivalent is thereafter amended or adjusted such that the price
as so amended or adjusted shall be less than the Conversion Price then in effect, then the conversion price then in effect upon
each such issuance or adjustment shall be adjusted by multiplying the conversion price by a fraction equal to: (a) the total number
of shares of our Common Stock issued and outstanding immediately prior to such issuance plus the number of shares of our Common
Stock which the aggregate consideration for the total number of such additional shares of our Common Stock so issued would purchase
at a price per share equal to the conversion price then in effect divided by (b) the number of shares of our Common Stock outstanding
immediately after the issuance of such additional shares.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Notwithstanding the foregoing, the Conversion
Price will not be adjusted for the sale or issuance of &ldquo;Excluded Securities,&rdquo; which are defined in the certificate
of designations as the following: (a) shares of our Common Stock or common stock equivalents issued pursuant to a stock option
plan that has been approved by our Board of Directors and our stockholders, pursuant to which our securities may be issued only
to a person eligible for award under such plan, (b) shares of our Common Stock or common stock equivalents issued to employees
or consultants (including in connection with investor relations activities) for compensatory purposes, (c) shares of our Common
Stock or common stock equivalents issued upon the exercise or conversion of common stock equivalents outstanding on the closing
date for the offering of the Series E Preferred Stock, (d) shares of our Common Stock or common stock equivalents issued to investors
in our common stock offering that was conducted concurrently with the offering of Series E Preferred Stock, (e) shares of our Common
Stock or common stock equivalents issued in the PCT Merger, (f) shares of our Common Stock or common stock equivalents issued in
the offering of the Series E Preferred Stock, including pursuant to the certificate of designations or upon exercise of the warrants
offered in connection with the Series E Preferred Stock, and (g) shares of our Common Stock or common stock equivalents issued
or deemed to be issued in connection with any acquisition by our company, whether through a merger, an acquisition of stock or
an acquisition of assets, or a license, of any business, product, assets or technologies, or any strategic partnership, strategic
investment or joint venture involving any technology or product, or any other transaction the primary purpose of which is not to
raise capital; provided however, that the number of shares of our Common Stock which may be issued pursuant to this clause (g)
in any transaction or series of related transactions shall not exceed 33% of the number of shares of our Common Stock outstanding
immediately prior to any such transaction.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">In case of any reorganization or any reclassification
of our capital stock or any consolidation or merger of our company with or into any other corporation or corporations or a sale
or transfer of all or substantially all of our assets to any other person or a &ldquo;going private&rdquo; transaction under Rule
13e-3 promulgated pursuant to the Securities Exchange Act of 1934 (the &ldquo;Exchange Act&rdquo;), as amended, then, as part of
such reorganization, consolidation, merger, or transfer if the holders of shares of our Common Stock receive any publicly traded
securities as part or all of the consideration for such reorganization, reclassification, consolidation, merger or sale, then it
shall be a condition precedent of any such event or transaction that provision shall be made such that each Series E Preferred
Share shall thereafter be convertible into such new securities at a conversion price and pricing formula which places the holders
of Series E Preferred Shares in an economically equivalent position as they would have been if not for such event. The foregoing
does not limit the right that holders of the Series E Preferred Shares have to require us to repurchase the Series E Preferred
Shares. See &ldquo;Mandatory Repurchase By Us&rdquo; below.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Reservation of Shares Issuable Upon Conversion.</I>
&nbsp;&nbsp;We shall at all times reserve and keep available out of our authorized but unissued shares of our Common Stock, solely
for the purposes of effecting the conversion and/or redemption of the Series E Preferred Shares, an number of shares of our Common
Stock equal to 200% of the number of shares issuable upon conversion of the Series E Preferred Shares at the conversion price then
in effect. If at any time while any of the Series E Preferred Shares remain outstanding we do not have a sufficient number of authorized
and unreserved shares of our Common Stock to satisfy such obligation to reserve for issuance upon conversion and/or redemption
of the Series E Preferred Shares, then we shall promptly take all action necessary to increase the number of authorized shares
of our Common Stock to an amount sufficient to allow us to satisfy such obligation to reserve for issuance upon conversion and/or
redemption of the Series E Preferred Shares. Without limiting the generality of the foregoing sentence, as soon as practicable
after the date on which we fail to have a sufficient number of authorized but unissued shares of our Common Stock available to
satisfy such obligation, but in no event later than sixty (60) days (or the lesser of (i) ninety (90) days if the proxy statement
is reviewed by the staff of the Securities and Exchange Commission or (ii) ten (10) days after the staff of the SEC indicated that
it has no further comments to such proxy statement) after the occurrence of such failure, we shall hold a meeting of our stockholders
for the approval of an increase in the number of authorized shares of our Common Stock. In connection with such meeting, we shall
provide each stockholder with a proxy statement and shall use our reasonable best efforts to solicit our stockholders&rsquo; approval
of such increase in authorized shares of our Common Stock and to cause our board of directors to recommend to the stockholders
that they approve such proposal.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Fractional Shares.</I> &nbsp;&nbsp;No
fractional shares shall be issued upon the conversion of any Series E Preferred Shares. All shares of our Common Stock (including
fractions thereof) issuable upon conversion of more than one Series E Preferred Share by a holder thereof and all Series E Preferred
Shares issuable upon the purchase thereof shall be aggregated for purposes of determining whether the conversion and/or purchase
would result in the issuance of any fractional share. If, after the aforementioned aggregation, the conversion and/or purchase
would result in the issuance of a fraction of a share of our Common Stock, we shall, in lieu of issuing any fractional share, either
round up the number of shares to the next highest whole number or, at our option, pay the holder otherwise entitled to such fraction
a sum in cash equal to the fair market value of such fraction on the conversion date (as determined in good faith by our Board
of Directors).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Failure to Redeliver.</I> &nbsp;&nbsp;If
any holder fails to re-deliver shares of our Common Stock to us within ten (10) trading days of being required to do so in connection
with a Mandatory Redemption or an optional redemption by us, then, unless such shares of Common Stock have been called by us, we
may, at our option, redeem a number of Series E Preferred Shares having a Liquidation Preference equal in value to the product
of (x) such number of shares of our Common Stock and (y) the Stock Payment Price for such Mandatory Redemption Date or Optional
Redemption Date, the case may be, in lieu of requiring such holder to return such shares of Common Stock.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Mandatory Repurchase by Us.</I> &nbsp;&nbsp;Each
holder of Series E Preferred Shares shall have the unilateral option and right to compel us to repurchase for cash any or all of
such holder&rsquo;s Series E Preferred Shares within three days of a written notice requiring such repurchase (provided that no
written notice shall be required for if any of the events described in clauses (v) and (vi) below occur and demand for repurchase
shall be deemed automatically made upon the occurrence of any of those events), at a price per Series E Preferred Share equal to
the sum of (a) the liquidation preference plus (b) any and all accrued and unpaid dividends on the Series E Preferred Shares (the
sum of (a) and (b), the &ldquo;Base Mandatory Repurchase Price&rdquo;) plus (c) (i) if such demand for repurchase occurs on or
before the twelve month anniversary of the closing date, an amount equal to 15% of the Base Mandatory Repurchase Price, or (ii)
if such demand for repurchase occurs at any time after the twelve month anniversary of the closing date, an amount equal to 10%
of the Base Mandatory Repurchase Price, if any of the following events shall have occurred or are continuing:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">(i)</TD><TD>A Change in Control Transaction (as defined below);</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">(ii)</TD><TD>A &ldquo;going private&rdquo; transaction under SEC rules;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">(iii)</TD><TD>A tender offer by our company under SEC Rule 13e-4;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">(iv)</TD><TD>the suspension from trading or the failure of our Common Stock to be listed on a trading market for a period of five consecutive
trading days or for more than an aggregate of 10 trading days in any 365-day period;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">(v)</TD><TD>the entry by a competent court of (i) a decree or order for relief pertaining to our company or any of our subsidiaries under
any applicable federal or state bankruptcy, insolvency, reorganization or other similar law or (ii) a decree or order adjudging
our company or any of our subsidiaries as bankrupt or insolvent or (iii) appointing a custodian, receiver, trustee or other similar
official for our company or any of our subsidiaries or of any substantial part of our property, or ordering the liquidation of
our company&rsquo;s affairs, and the continuance of any such decree or order for a period of 60 consecutive days;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">(vi)</TD><TD>the commencement by our company or any of our subsidiaries of a voluntary case or proceeding under any applicable federal or
state bankruptcy, insolvency, reorganization or other similar law, or the consent by us to the entry of a decree or order for relief
in an involuntary case or proceeding under any applicable federal or state bankruptcy, insolvency, reorganization or other similar
law or to the commencement of any bankruptcy or insolvency case or proceeding against our company, or the consent by us to the
appointment of or taking possession by a custodian, receiver, trustee or other similar official of our company or of any substantial
part of our property, or the making by us of an assignment for the benefit of creditors, or the admission by our company in writing
of its inability to pay its debts generally as they become due;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 38.85pt; text-indent: -23.75pt">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">(vii)</TD><TD>following an Authorized Share Failure (as defined), our failure to receive stockholder approval to approve the required increase
in the number of shares of our Common Stock within five days after the Meeting Outside Date (as defined); or</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">(viii)</TD><TD>our failure to deliver shares of our Common Stock on any Share Delivery Date, Advance Date, mandatory redemption date or optional
redemption date, if such failure continues for two (2) trading days after the date that delivery of shares of Common Stock is due;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">(ix)</TD><TD>our failure to pay any amounts when and as due pursuant to the certificate of designations or any other document relating to
the issuance of the Series E Preferred Shares, if such failure continues for two (2) trading days after the date that such payment
is due;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">(x)</TD><TD>our breach of certain covenants contained in the certificate of designations and the stock purchase agreement;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">(xi)</TD><TD>our company or any of its subsidiaries shall (A) default in any payment of any amount or amounts of principal of or interest
on any indebtedness the aggregate principal amount of which indebtedness is in excess of $1,000,000 or (B) default in the observance
or performance of any other agreement or condition relating to any such indebtedness, or any other event shall occur or condition
exist, as a result of which the holder or holders or beneficiary or beneficiaries of such indebtedness or a trustee on their behalf
have declared such indebtedness to be due prior to its stated maturity;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">(xii)</TD><TD>the effectiveness of the registration statement pertaining to the Series E Preferred Shares or the ability to use the applicable
prospectus supplement and the prospectus lapses for any reason and continues for a period of 10 consecutive days or for more than
an aggregate of 20 days in any 365-day period;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">(xiii)</TD><TD>we breach any representation, warranty, covenant or other term or condition of the certificate of designations, the stock purchase
agreement or the warrant to be issued with the Series E Preferred Shares, except to the extent that such breach would not have
a material adverse effect (as defined in the stock purchase agreement), and except in the case of a breach of a covenant which
is curable, only if such breach remains uncured for a period of at least 10 calendar days (the events described in clauses (v),
(vi), (viii), (ix), (x), (xi), (xii) and (xiii) are collectively referred to as the &ldquo;Trigger Events&rdquo; and each, as a
&ldquo;Trigger Event&rdquo;).</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">A &ldquo;Change in Control Transaction&rdquo;
will be deemed to exist if (i) there occurs any consolidation or merger of our company with or into any other corporation or other
entity or person (whether or not our company is the surviving corporation), or any other corporate reorganization or transaction
or series of related transactions in which in excess of 50% of the voting power in our company is transferred through a merger,
consolidation, tender offer or similar transaction, (ii) any person, together with its affiliates and associates, beneficially
owns or is deemed to beneficially own (as described in Rule 13d-3 under the Exchange Act without regard to the 60-day exercise
period) in excess of 50% of the voting power in our company (provided, however, that if any person is immediately prior to the
closing date a beneficial owner of 40% or more of our Common Stock, it shall not be deemed to be a Change of Control Transaction
if such person increases its beneficial ownership percentage by not more than 10 percentage points), (iii) there is a replacement
of more than one-half of the members of our board of directors which is not approved by those individuals who are members of our
board on the date thereof, in one or a series of related transactions or (iv) a sale or transfer of all or substantially all of
our assets, determined on a consolidated basis; provided, however, that a Change in Control Transaction will not be deemed to have
occurred pursuant to clause (iv) if such sale or transfer is the sale or transfer of not more than one business segment during
the period from the closing of the offering of the Series E Preferred Shares (November 19, 2010) through the Maturity Date and
we remain a publicly traded corporation and if, on the effective date of the sale or transfer described therein, we deposit funds
in the escrow account (as defined in the stock purchase agreement) such that the balance in the escrow account after such deposit
is the lesser of $5 million or 100% of the aggregate liquidation preference of the outstanding Series E Preferred Shares.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Ownership Cap.</I> &nbsp;&nbsp;Notwithstanding
anything to the contrary set forth herein, at no time may we issue to a holder, shares of our Common Stock if the number of shares
of our Common Stock to be issued pursuant to such issuance would exceed, when aggregated with all other shares of our Common Stock
beneficially owned by such holder at such time (as determined in accordance with relevant Exchange Act rules), the number of shares
of our Common Stock that would result in the holder beneficially owning (as determined in accordance with relevant Exchange Act
rules) more than 4.9% (the &ldquo;Beneficial Ownership Limitation&rdquo;) of our then issued and outstanding Common Stock. Each
holder shall have the right (with respect to itself only) to waive such ownership cap upon not less than sixty-five (65) days&rsquo;
prior notice to us. Notwithstanding the foregoing, the holder shall have the right to: (A) at any time and from time to time immediately
reduce the Beneficial Ownership Limitation and (B) (subject to waiver) at any time and from time to time, increase the Beneficial
Ownership Limitation immediately in the event of the announcement as pending or planned of a Change in Control Transaction.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Participation.</I> &nbsp;&nbsp;The holders
of the Series E Preferred Shares shall be entitled to such dividends paid and distributions made to the holders of shares of our
Common Stock to the same extent as if such holders of the Series E Preferred Shares had converted the Series E Preferred Shares
into shares of our Common Stock (without regard to any limitations on conversion herein or elsewhere) and had held such shares
of Common Stock on the record date for such dividends and distributions.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Voting Rights.</I> &nbsp;&nbsp;Except
as expressly provided in the certificate of designations, holders of the Series E Preferred Shares shall not have any voting rights.
So long as any Series E Preferred Shares are outstanding, in addition to any other vote or consent of our stockholders required
by law or by our amended and restated certificate of incorporation and except where the vote or written consent of holders of a
greater than number of shares is required by law or by another provision of our amended and restated certificate of incorporation,
the affirmative vote, at a meeting duly called for such purpose or the written consent without a meeting, of the holders of at
least a majority of the Series E Preferred Shares then outstanding, voting together as a single class, shall be required before
we may: (a) amend or repeal any provision of, or add any provision to, the certificate of designations governing the Series E Preferred
Shares, our amended and restated certificate of incorporation or bylaws, or file any articles of amendment, certificate of designations,
preferences, limitations and relative rights of any series of preferred stock, if any such action would adversely alter or change
the preferences, rights, privileges or powers of, or restrictions provided for the benefit of the Series E Preferred Shares, regardless
of whether any such action shall be by means of amendment to our certificate of incorporation or by merger, consolidation or otherwise;
(b) increase or decrease (other than by conversion) the authorized number of Series E Preferred Shares (we may increase or decrease
our number of authorized shares of undesignated &ldquo;blank check&rdquo; preferred stock); (c) create or authorize (by reclassification
or otherwise) any new class or series of shares that has a preference over or is on a parity with the Series E Preferred Shares
with respect to dividends or the distribution of assets on a Liquidation Event; (c) purchase, repurchase or redeem any shares of
our Common Stock or other shares of our capital stock; (e) pay dividends or make any other distribution on our Common Stock or
other capital stock; (f) whether or not prohibited by the terms of the Series E Preferred Shares, circumvent a right of the Series
E Preferred Shares.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Ranking.</I> &nbsp;&nbsp;The Series E
Preferred Shares shall rank senior to our Common Stock and any other class or series of our stock now existing or hereinafter authorized
over which the Series E Preferred Shares has preference or priority in the payment of dividends or in the distribution of assets
on any voluntary or involuntary dissolution or winding up of our affairs. Without the prior written consent of the Required Holders,
we may not authorize or issue additional or other capital stock that is of senior or <I>pari-passu</I> rank to the Series E Preferred
Shares in respect of preferences as to dividends and other distributions, amortization and redemption payments and payments upon
a liquidation event without the prior express written consent of the holders of a majority of the Series E Preferred Shares. We
may issue preferred stock that is junior in rank to the Series E Preferred Shares in respect of the preferences as to dividends
and other distributions, amortization and redemption payments and payments upon a liquidation event, provided, that the maturity
date (or any other date requiring redemption, repayment or any other payment, including without limitation, dividends) of any such
junior preferred shares is not on or before ninety-one (91) days after the maturity date for the Series E Preferred Shares.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Options</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">As of April 11, 2011, we had outstanding
options to purchase an aggregate of approximately 19,067,595 shares of our Common Stock with exercise prices ranging from $0.71
to $15.00 per share, with an approximate weighted average exercise price of $1.82 per share. The shares of our Common Stock underlying
all such options are or will be registered for sale with the SEC prior to exercises.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Warrants</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">As of April 11, 2011, we had outstanding
warrants to purchase an aggregate of 25,137,010 shares of our Common Stock with exercise prices ranging from $0.50 to $7.00, consisting
of: warrants to purchase an aggregate of 7,128,259 shares of our Common Stock at an approximate weighted average exercise price
of $2.54 per share and warrants to purchase an aggregate of 95,250 shares of our Common Stock at an exercise price of $6.50 per
share, certain of which are redeemable if our Common Stock trades at specified prices starting at a minimum of $2.40; Class A Warrants
to purchase an aggregate of 635,000 shares of our Common Stock at an exercise price of $6.00 per share (redemption threshold of
$8.00); Series D Warrants to purchase 12,932,512 shares of our Common Stock at an exercise price of $2.50 per share (redemption
threshold of $3.50, except for the warrant held by RimAsia, which has a $5.00 redemption threshold); warrants (issued in connection
with the November 2010 Preferred Stock Offering (as hereinafter defined)) to purchase an aggregate of 1,345,989 shares of our Common
Stock at a current exercise price of $2.0510 (redemption threshold of twice the exercise price); and three series of warrants (issued
in connection with the PCT Merger) to purchase up to 1,000,000 shares of our Common Stock per series (3,000,000 shares in the aggregate),
at exercise prices of $3.00, $5.00 and $7.00, respectively, per share, and redeemable in certain circumstances (the &ldquo;PCT
Merger Warrants&rdquo;). The holders of a vast majority of such warrants have registration rights for the shares underlying the
warrants.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>Class A Warrants</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>General.</I> &nbsp;&nbsp;Each Class A
warrant entitles the holder to purchase one share of our Common Stock at an exercise price per share of $6.00. The exercise price
per share of each Class A warrant is subject to adjustment upon the occurrence of certain events as provided in the Class A warrant
certificate and summarized below. The Class A warrants may be exercised at any time until July 16, 2012, which is the expiration
date, unless redeemed. The Class A warrants which have not previously been exercised will expire on the expiration date. A Class
A warrant holder will not be deemed to be a holder of the underlying Common Stock for any purpose until the Class A warrant has
been properly exercised.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Redemption.</I> &nbsp;&nbsp;In the event
our Common Stock is trading at a price equal to or exceeding the redemption threshold of $8.00 per share for 20 consecutive trading
days, we have the option to call the Class A warrants. If the holders of the Class A warrants have not exercised the Class A warrants
within 30 days of the written notice to call, we may redeem the Class A warrants at $0.001 per warrant. We will send the written
notice of call by first class mail to Class A warrant holders at their last known addresses appearing on the registration records
maintained by the transfer agent for the Class A warrants. No other form of notice by publication or otherwise will be required.
If we call any Class A warrants for redemption, they will be exercisable until the close of business on the business day next preceding
the specified redemption date.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Exercise.</I> &nbsp;&nbsp;A Class A warrant
holder may exercise our Class A warrants only if an appropriate registration statement is then in effect with the SEC and if the
shares of our Common Stock underlying the Class A warrants are qualified for sale under the securities laws of the state in which
the holder resides.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">During the term of the Class A warrants,
the holders thereof are given the opportunity to profit from a rise in the market of our Common Stock, with a resulting dilution
in the interest of all other stockholders. So long as the Class A warrants are outstanding, the terms on which we could obtain
additional capital may be adversely affected. The holders of the Class A warrants might be expected to exercise them at a time
when we would, in all likelihood, be able to obtain any needed capital by a new offering of securities on terms more favorable
than those provided by the Class A warrants.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Adjustments of Exercise Price.</I> &nbsp;&nbsp;The
exercise price and redemption price of the Class A warrants are subject to adjustment in specified circumstances, including in
the event we declare any stock dividend to stockholders or effect any split or reverse split with respect to our Common Stock after
the issuance thereof.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Therefore, if we effect any stock split or reverse split with
respect to our Common Stock, the exercise price in effect immediately prior to such stock split or reverse split will be proportionately
reduced or increased, respectively. Any adjustment of the exercise price will also result in an adjustment of the number of shares
purchasable upon exercise of a Class A warrant or, if we elect, an adjustment of the number of Class A warrants outstanding. The
Class A warrants do not contain provisions protecting against dilution resulting from the sale of additional shares of our Common
Stock for less than the exercise price of the Class A warrants or the current market price of our Common Stock.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>No Voting and Dividend Rights.</I> &nbsp;&nbsp;Until
exercised, the Class A warrants will have no voting, dividend or other stockholder rights.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>Class D Warrants</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Each Class D warrant entitles the holder
to purchase one share of our Common Stock at an exercise price per share of $2.50. The exercise price per share of each Class D
warrant is subject to adjustment upon the occurrence of certain events as provided in the Class D warrant certificate and summarized
below. The Class D warrants may be exercised at any time during their five year term, or eight year term in the case of a Class
D warrant to purchase an aggregate of 4,000,000 shares held by RimAsia Capital Partners, L.P., a Cayman Islands exempted limited
partnership and an affiliate of NeoStem (&ldquo;RimAsia&rdquo;), unless redeemed. The Class D warrants which have not been previously
exercised will expire at the expiration date. A Class D warrant holder will not be deemed to be a holder of the underlying Common
Stock for any purpose until the Class D warrant is exercised.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">In the event our Common Stock is trading
at a per share price equal to or exceeding the redemption threshold of $3.50, or $5.00 in the case of the Class D warrant held
by RimAsia, for twenty consecutive trading days, we have the option to call the Class D warrants. If the holders of Class D warrants
have not exercised the Class D Warrants within 30 days of the written notice to call, we may redeem the Class D warrants at $0.001
per warrant. We will send the written notice of call by first class mail to Class D warrant holders at their last known addresses
appearing on the registration records maintained by the transfer agent of the Class D warrants. No other form of notice by publication
or otherwise will be required. If we call any Class D Warrants for redemption, they will be exercisable until close of business
on the business day next preceding the specified redemption date.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The exercise price and redemption price of
the Class D warrants are subject to adjustment in specified circumstances, including in the event we declare any stock dividend
to stockholders or effect any split or reverse split with respect to our Common Stock after the issuance thereof. Therefore, if
we effect any stock split or reverse split with respect to our Common Stock, the exercise price in effect immediately prior to
such stock split or reverse split will be proportionately reduced or increased, respectively. Any adjustment of the exercise price
will also result in an adjustment of the number of shares purchasable upon exercise of a Class D warrant or, if we elect, an adjustment
of the number of Class D warrants outstanding. The Class D warrants do not contain provisions protecting against dilution resulting
from the sale of additional shares of our Common Stock for less than the exercise price of the Class D warrants or the current
market price of our Common Stock.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Until exercised, the Class D warrants will
have no voting, dividend or other stockholder rights.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>Warrants Issued in Our November 2010 Common Stock Offering</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">On November 19, 2010, in connection with
a public offering of our Common Stock and certain warrants, we issued (i) 6,337,980 shares of our Common Stock and (ii) warrants
to purchase up to 3,168,993 shares of our Common Stock (the &ldquo; <U>November 2010 Common Stock Offering</U> &rdquo;). The material
terms and provisions of the warrants issued in connection with our November 2010 Common Stock Offering are summarized below.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Term; Exercise Price and Exercisability.</I>
&nbsp;&nbsp;The warrants issued in our November 2010 Common Stock Offering represent the rights to purchase up to an aggregate
of 3,168,993 shares of our Common Stock. Each warrant will have an exercise price of $1.85 per share, will be exercisable six months
after issuance and will expire five years from the date of issuance. The number of warrant shares that may be acquired by any holder
upon any exercise of the warrant will be limited to the extent necessary to insure that, following such exercise (or other issuance),
the total number of shares of our Common Stock then beneficially owned by such holder and its affiliates and any other persons
whose beneficial ownership of common stock would be aggregated with the holder&rsquo;s for purposes of Section 13(d) of the Securities
Exchange Act of 1934, as amended, does not exceed 4.99% of the total number of issued and outstanding shares of our Common Stock
(including for such purpose the shares of our Common Stock issuable upon such exercise), which is referred to as the &ldquo;beneficial
ownership limitation.&rdquo; The holder may elect to change this beneficial ownership limitation from 4.99% to 9.99% of the total
number of issued and outstanding shares of our Common Stock (including for such purpose the shares of our Common Stock issuable
upon such exercise) upon providing us with not less than 61 days&rsquo; prior written notice.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Call Provision.</I> &nbsp;&nbsp;Subject
to certain exceptions, while the warrants are outstanding, if the volume weighted average price of a share of our Common Stock
for each of 20 consecutive Trading Days (the &ldquo;Measurement Period,&rdquo; which 20 consecutive Trading Day period shall not
have commenced until after the Initial Exercise Date) exceeds $3.70 (subject to adjustment), (i) the average daily volume for such
Measurement Period exceeds $100,000 per Trading Day (subject to adjustment) and (ii) the holder is not in possession of any information
that constitutes, or might constitute, material non-public information which was provided by us, then we may, within 1 Trading
Day of the end of such Measurement Period, upon notice, call for cancellation of all or any portion of the warrants (a &ldquo;Call&rdquo;)
for consideration equal to $0.001 per share. Our right to Call the warrants shall be exercised ratably among the holders based
on each holder&rsquo;s initial purchase of warrants from us.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Fundamental Transaction.</I> &nbsp;&nbsp;If,
at any time while the warrants are outstanding, (1) we consolidate or merge with or into another corporation, (2) we sell, lease,
license, assign, transfer, convey or otherwise dispose of all or substantially all of our assets, (3) any purchase offer, tender
offer or exchange offer (whether by us or another individual or entity) is completed pursuant to which holders of our Common Stock
are permitted to sell, tender or exchange their shares for other securities, cash or property and has been accepted by the holders
of 50% or more of our outstanding Common Stock or (4) we effect any reclassification or recapitalization of our Common Stock or
any compulsory share exchange pursuant to which our Common Stock is converted into or exchanged for other securities, cash or property
(each, a &ldquo;Fundamental Transaction&rdquo;), then upon any subsequent exercise of the warrants, each holder thereof will have
the right to receive the same amount and kind of securities, as it would have been entitled to receive upon the occurrence of such
Fundamental Transaction if it had been, immediately prior to such Fundamental Transaction, the holder of the number of warrant
shares then issuable upon exercise of the warrant, and any additional consideration payable as part of the Fundamental Transaction;
<I>provided, however</I> , that in the event of a change of control transaction (as defined in the warrant) other than one in which
the successor entity is a publicly traded corporation whose stock is listed or quoted for trading on the New York Stock Exchange,
NASDAQ markets or the NYSE Amex and results in the warrants being exercisable for publicly traded common stock of such successor
entity, at the request of a holder of a warrant delivered before the 90th calendar day after consummation of such change of control
transaction, we (or the successor entity) will purchase the warrant by paying to the holder, cash in an amount equal to the Black
Scholes value, as described in the warrant, of the remaining unexercised portion of the warrant on the date of consummation of
such change of control transaction.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Certain Adjustments.</I> &nbsp;&nbsp;The
exercise price and the number of shares of our Common Stock purchasable upon the exercise of the warrants are subject to adjustment
upon the occurrence of specific events, including stock dividends, stock splits, combinations and reclassifications of our Common
Stock. Additionally, the exercise price of the warrants issued to the investors is subject to certain adjustments if we (i) issue
rights, options or warrants to all holders of our Common Stock (and not to the warrant holder) entitling them to subscribe for
or purchase shares of our Common Stock at a price per share less than the volume weighted average price (the &ldquo;VWAP&rdquo;)
of our Common Stock on the record date for the determination of stockholders entitled to receive such rights, options or warrants,
or (ii) distribute to all holders of our Common Stock (and not to the warrant holder) evidences of our indebtedness or assets (including
cash and cash dividends) or rights or warrants to purchase any security.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Fractional Shares.</I> &nbsp;&nbsp;No
fractional shares or scrip representing fractional shares shall be issued upon the exercise of the warrants. As to any fraction
of a share which the holder would otherwise be entitled to purchase upon such exercise, we will, at our election, either pay a
cash adjustment in respect of such final fraction in an amount equal to such fraction multiplied by the exercise price or round
up to the next whole share.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Exchange Listing.</I> &nbsp;&nbsp;We do
not plan on making an application to list the warrants on the NYSE Amex or any other national securities exchange or recognized
trading system. Our Common Stock underlying the warrants is listed on the NYSE Amex.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The description of the warrants contained
herein does not purport to be complete and is qualified in its entirety by reference to the form of warrant, which was filed as
Exhibit 4.1 to our Current Report on Form 8-K filed with the SEC on November 16, 2010 in connection with the November 2010 Common
Stock Offering.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>Warrants Issued in Our November 2010 Preferred Stock Offering</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">On November 19, 2010, in connection with
a registered direct placement of certain preferred stock, warrants and Common Stock, we issued (i) 10,582,011 shares of our Series
E Preferred Stock, (ii) warrants to purchase up to 1,322,486 shares of our Common Stock (subject to adjustment) and (iii) 164,418
shares of our Common Stock (the &ldquo; <U>November 2010 Preferred Stock Offering</U> &rdquo;). The material terms and provisions
of the warrants issued in connection with our November 2010 Preferred Stock Offering are summarized below.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Term; Exercise Price and Exercisability.</I>
&nbsp;&nbsp;As of April 11, 2011, the warrants issued in our November 2010 Preferred Stock Offering represent the rights to purchase
up to an aggregate of 1,345,989 shares of our Common Stock (as adjusted). Each warrant will have an exercise price of $2.0510 per
share (as adjusted), will be exercisable six months after issuance and will expire three years from the date of issuance. The number
of warrant shares that may be acquired by any holder upon any exercise of the warrant will be limited to the extent necessary to
insure that, following such exercise, the total number of shares of our Common Stock then beneficially owned by such holder and
its affiliates and any other persons whose beneficial ownership of our Common Stock would be aggregated with the holder&rsquo;s
for purposes of Section 13(d) of the Securities Exchange Act of 1934, as amended, does not exceed 4.9% of the then issued and outstanding
shares of our Common Stock (including for such purpose the shares of our Common Stock issuable upon such exercise), which is referred
to as the &ldquo;beneficial ownership limitation.&rdquo; However, in the event of the announcement of a Change in Control Transaction
(as defined in the certificate of designations with respect to the Series E Preferred Stock), the holder will have the right to
(A) at any time and from time to time immediately reduce the beneficial ownership limitation and (B) (subject to waiver) at any
time and from time to time, increase the beneficial ownership limitation immediately.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Exercise Elected by Us.</I> &nbsp;&nbsp;Subject
to certain exceptions, while the warrants are outstanding, if the daily volume weighted average price (the &ldquo;Daily VWAP&rdquo;)
of a share of our Common Stock for each of 20 trading days out of 30 consecutive trading days (the &ldquo;Trigger Period&rdquo;)
has remained at least 100% above the exercise price, then we may, subject to certain conditions, require the holder to exercise
the warrant in full upon not less than 10 business days prior written notice (the &ldquo;Mandatory Notice Period&rdquo;). Notwithstanding
such a notice, the holder may exercise the warrant at any time during the Mandatory Notice Period. Our right to require the exercise
of the warrants is subject to the following additional conditions: (i) during each trading day of the Trigger Period and during
each trading day of the Mandatory Notice Period, the Equity Conditions (as defined below) shall be satisfied; and (ii) the Daily
VWAP of our Common Stock has remained at or above 100% of the exercise price during all trading days in the Mandatory Notice Period.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&ldquo;Equity Conditions&rdquo; means each
of the following: (i) on each day of the Trigger Period and on each day of the Mandatory Notice Period, all warrants shares shall
be eligible for resale by the holder without restriction and without need for additional registration under any applicable federal
or state securities laws and we shall have no knowledge of any fact that would cause any warrant shares not to be so eligible for
resale by the holder without restriction and without the need for additional registration under any applicable federal or state
securities laws; (ii) on each day during the Trigger Period and the Mandatory Notice Period, our Common Stock is designated for
listing on a Trading Market (as defined in the certificate of designations with respect to the Series E Preferred Stock) and shall
not have been suspended from trading on such Trading Market nor shall delisting or suspension by such exchange or market have been
threatened or pending in writing by such Trading Market nor shall there be any Securities and Exchange Commission or judicial stop
trade order or trading suspension stop order; (iii) any warrant shares may be issued in full without violating the rules or regulations
of the Trading Market or any applicable laws; (iv) on each day during the Trigger Period and the Mandatory Notice Period, there
shall not have occurred and be continuing, unless waived by the holder, either (A) a Trigger Event (as defined in the certificate
of designations with respect to the Series E Preferred Stock) or (B) an event that with the passage of time or giving of notice
would constitute a Trigger Event; (v) on each day during the Trigger Period and the Mandatory Notice Period, we have not provided
the holder with any non-public information; (vi) on each day during the Trigger Period and the Mandatory Notice Period, neither
the registration statement, the prospectus supplement nor the prospectus applicable to the November 2010 Preferred Stock Offering
contains any untrue statement of a material fact or omits to state a material fact necessary in order to make the statements made
therein, in light of the circumstances under which they were made not misleading, and the prospectus supplement and the prospectus
comply with all applicable securities laws as to form and substance, (vii) the transfer agent for our Common Stock is participating
in the Depository Trust Company (&ldquo;DTC&rdquo;) Fast Automated Securities Transfer Program; and (viii) all warrants shares
are duly authorized and will be validly issued, fully paid and non-assessable upon issuance, free and clear of all liens, claims
or encumbrances, and the issuance of the warrant shares will not require any further approvals of our Board of Directors or stockholders.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Certain Adjustments.</I> &nbsp;&nbsp;The
exercise price and the number of shares of Common Stock purchasable upon the exercise of the warrants are subject to adjustment
upon the occurrence of specific events, including stock dividends, stock splits, combinations and reclassifications of our Common
Stock. Additionally, the exercise price of the warrants is subject to certain weighted average adjustments if NeoStem issues or
sells any additional shares of Common Stock or common stock equivalents at a price per share less than the exercise price then
in effect, or without consideration, the exercise price then in effect will be adjusted. Notwithstanding the foregoing, there will
be no adjustment to the exercise price with respect to the sale or issuance of certain Excluded Securities, as defined in the certificate
of designations with respect to the Series E Preferred Stock. See &ldquo;Series E 7% Senior Convertible Preferred Stock&nbsp;&mdash;&nbsp;Optional
Conversion by the Holders.&rdquo; As of April 11, 2011, (i) the exercise price of the warrants had been adjusted to $2.0510, and
(ii) the number of shares of Common Stock purchasable upon the exercise of the warrants had been adjusted (in the aggregate) to
1,345,989 shares of Common Stock.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Fractional Shares.</I> &nbsp;&nbsp;No
fractional shares or scrip representing fractional shares shall be issued upon the exercise of the warrants. As to any fraction
of a share which the holder would otherwise be entitled to purchase upon such exercise, we will, at our election, either pay a
cash adjustment in respect of such final fraction in an amount equal to such fraction multiplied by the exercise price or round
up to the next whole share.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Exchange Listing.</I> &nbsp;&nbsp;We do
not plan on making an application to list the warrants on the NYSE Amex or any other national securities exchange or recognized
trading system. Our Common Stock underlying the warrants is listed on the NYSE Amex.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The description of the warrants contained
herein does not purport to be complete and is qualified in its entirety by reference to the form of warrant, which was filed as
Exhibit 4.2 to our Current Report on Form 8-K filed with the SEC on November 16, 2010 in connection with our November 2010 Preferred
Stock Offering.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B><I>Warrants Issued in Connection With the PCT Merger</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">In connection with the closing of the PCT
Merger on January 19, 2011 (and in addition to the Common Stock consideration for the PCT Merger which we deposited into an escrow
account), we issued seven-year warrants to purchase an aggregate 3,000,000 shares of our Common Stock (collectively, the &ldquo;PCT
Merger Warrants&rdquo;). The PCT Merger Warrants are being delivered in book entry form to the former members of PCT after receipt
by us of an appropriate letter of transmittal from the respective former member. The PCT Merger Warrants are divided into three
series as follows: (i) warrants to purchase an aggregate 1,000,000 shares of our Common Stock at an exercise price of $3.00 per
share (the &ldquo;$3.00 Warrants&rdquo;); (ii) warrants to purchase an aggregate 1,000,000 shares of our Common Stock at an exercise
price of $5.00 per share (the &ldquo;$5.00 Warrants&rdquo;); and (iii) warrants to purchase an aggregate 1,000,000 shares of our
Common Stock at an exercise price of $7.00 per share, and which will vest only if the $7.00 Warrant Condition (as defined below)
is accomplished within three years of the closing of the PCT Merger (the &ldquo;$7.00 Warrants&rdquo;). The material terms and
provisions of the PCT Merger Warrants are summarized below.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 15.1pt"><B><I>$3.00 Warrants and $5.00 Warrants</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 15.1pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>General.</I> &nbsp;&nbsp;Each $3.00 Warrant
and $5.00 Warrant entitles the holder to purchase one share of Common Stock at an exercise price per share of $3.00 and $5.00,
respectively. The exercise price per share of each $3.00 Warrant and $5.00 Warrant is subject to adjustment upon the occurrence
of certain events as provided in the applicable warrant certificate and summarized below. The $3.00 Warrants and $5.00 Warrants
may be exercised at any time during their seven year term, unless redeemed. The $3.00 Warrants and $5.00 Warrants which have not
been previously exercised will expire at the expiration date. Holders of the warrants will not be deemed to be a holder of the
underlying Common Stock for any purpose until such warrant is exercised. As described below, the Warrants are redeemable in certain
circumstances. Transfer of the shares issuable upon exercise of the Warrants is restricted until the one year anniversary of the
Closing Date.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Redemption.</I> &nbsp;&nbsp;In the event
Common Stock is trading at a per share price equal to or exceeding the redemption threshold of $5.00 with respect to the $3.00
Warrant or $7.00 with respect to the $5.00 Warrant for twenty (20) out of thirty (30) consecutive trading days, NeoStem has the
option to call the applicable warrant. If the warrant holders have not exercised the warrants within 14 days of the redemption
notice, NeoStem may redeem the warrants at $0.001 per warrant. NeoStem will send the redemption notice by first class mail to warrant
holders at their last known addresses appearing on the registration records maintained by the transfer agent of the warrants. No
other form of notice by publication or otherwise will be required. If NeoStem calls any warrants for redemption, they will be exercisable
until close of business on the business day next preceding the specified redemption date. Notwithstanding the foregoing, NeoStem
may not redeem the Warrants unless (i) NeoStem waives the lock-up provisions in the applicable Warrant and (ii) the issuance of
the shares underlying the Warrants is covered by an effective registration statement or there is an effective resale registration
statement available to the holders of the Warrants with respect to the shares underlying the Warrants.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Adjustments of Exercise Price.</I> &nbsp;&nbsp;The
exercise price and redemption price of the warrants are subject to adjustment in specified circumstances, including in the event
(i) there is a merger or consolidation and NeoStem is not the surviving corporation; (ii) there is subdivision, combination or
reclassification of securities, recapitalization, automatic conversion, or other similar event affecting the number or character
of outstanding shares of Common Stock; or (iii) NeoStem declares any stock dividend to stockholders or effects any split or reverse
split with respect to the Common Stock after the issuance thereof. The warrants do not contain provisions protecting against dilution
resulting from the sale of additional shares of Common Stock for less than the exercise price of the warrants or the current market
price of the Common Stock.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>No Voting and Dividend Rights.</I> &nbsp;&nbsp;Until
exercised, the holders of the warrants will have no voting, dividend or other stockholder rights.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Registration Rights.</I> &nbsp;&nbsp;NeoStem
has agreed to use its commercially reasonable efforts to maintain the effectiveness of a registration statement covering the shares
underlying the Warrants at any time that both (a) the Warrants are exercisable and (b) the exercise price of the Warrants is less
than 105% of the price at which the Common Stock is trading on the NYSE Amex (or, such other stock exchange on which the Common
Stock trades). Under certain limited circumstances, if a registration statement is not effective or a prospectus supplement is
not available during the last 20 business days prior to the expiration date of the Warrants, the exercise period of the Warrants
would be extended for a period of 20 business days following such effectiveness or availability.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 15.1pt"><B><I>$7.00 Warrants</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 15.1pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>General.</I> &nbsp;&nbsp;Each $7.00 Warrant
entitles the holder to purchase one share of Common Stock at an exercise price per share of $7.00. The exercise price per share
of each $7.00 Warrant is subject to adjustment upon the occurrence of certain events as provided in the $7.00 Warrant certificate
and summarized below. The $7.00 Warrants may be exercised only if the $7.00 Warrant Condition (as defined below) is satisfied and
at any time thereafter during their seven year term, unless redeemed. The $7.00 Warrants which have not been previously exercised
will expire at the expiration date. A $7.00 Warrant holder will not be deemed to be a holder of the underlying Common Stock for
any purpose until the $7.00 Warrant is exercised.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Performance Condition.</I> &nbsp;&nbsp;The
$7.00 Warrant Condition is a performance condition that provides that the $7.00 Warrants will not vest and will not become exercisable
unless PCT secures, prior to the third annual anniversary of the Closing Date, one or more material binding commercial manufacturing
contracts with one or more third parties, each on an arm&rsquo;s length basis, which commercial manufacturing contracts result
in aggregate revenues to PCT in excess of $5 million per year over a period of at least 3 years and in the reasonable judgment
of NeoStem&rsquo;s Board of Directors the manufacturing contracts will be profitable each year during the term of such contracts
in accordance with GAAP.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Redemption.</I> &nbsp;&nbsp;In the event
Common Stock is trading at a per share price equal to or exceeding the redemption threshold of $9.00 for twenty (20) out of thirty
(30) consecutive trading days, NeoStem has the option to call the $7.00 Warrants. If the holders of $7.00 Warrants have not exercised
the $7.00 Warrants within 14 days of the redemption notice, NeoStem may redeem the $7.00 Warrants at $0.001 per warrant. NeoStem
will send the redemption notice by first class mail to $7.00 Warrant holders at their last known addresses appearing on the registration
records maintained by the transfer agent of the $7.00 Warrants. No other form of notice by publication or otherwise will be required.
If NeoStem calls any $7.00 Warrants for redemption, they will be exercisable until close of business on the business day next preceding
the specified redemption date. Notwithstanding the foregoing, NeoStem may not redeem the $7.00 Warrants unless (i) NeoStem waives
the lock-up provisions in the applicable Warrant, (ii) the issuance of the shares of Common Stock underlying the $7.00 Warrants
is covered by an effective registration statement or there is an effective resale registration statement available to the holders
of the $7.00 Warrants with respect to such shares and (iii) the $7.00 Warrant Condition has been achieved or NeoStem waives the
$7.00 Warrant Condition concurrently with its provision of the redemption notice.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Adjustments of Exercise Price.</I> &nbsp;&nbsp;The
exercise price and redemption price of the $7.00 Warrants are subject to adjustment in specified circumstances, including in the
event (i) there is a merger or consolidation and NeoStem is not the surviving corporation; (ii) there is subdivision, combination
or reclassification of securities, recapitalization, automatic conversion, or other similar event affecting the number or character
of outstanding shares of Common Stock; or (iii) NeoStem declares any stock dividend to stockholders or effect any split or reverse
split with respect to the Common Stock after the issuance thereof. The $7.00 Warrants do not contain provisions protecting against
dilution resulting from the sale of additional shares of Common Stock for less than the exercise price of the $7.00 Warrants or
the current market price of the Common Stock.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>No Voting and Dividend Rights.</I> &nbsp;&nbsp;Until
exercised, the $7.00 Warrants will have no voting, dividend or other stockholder rights.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Registration Rights.</I> &nbsp;&nbsp;NeoStem
has agreed to use its commercially reasonable efforts to maintain the effectiveness of a registration statement covering the shares
underlying the Warrants at any time that both (a) the Warrants are exercisable and (b) the exercise price of the Warrants is less
than 105% of the price at which the Common Stock is trading on the NYSE Amex (or, such other stock exchange on which the Common
Stock trades). Under certain limited circumstances, if a registration statement is not effective or a prospectus supplement is
not available during the last 20 business days prior to the expiration date of the Warrants, the exercise period of the Warrants
would be extended for a period of 20 business days following such effectiveness or availability.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The above description of the PCT Merger Warrants
does not purport to be complete and is qualified in its entirety by reference to the Warrant Agreement (with the forms of $3.00
Warrant, $5.00 Warrant and $7.00 Warrant attached thereto), which was filed as Exhibit 4.1 to our Current Report on Form 8-K dated
January 18, 2011 and filed with the SEC on January 24, 2011 in connection with the closing of the PCT Merger.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Anti-Takeover Effects of Certain Provisions of Delaware Law
and Our Certificate of Incorporation and Bylaws</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Our Amended and Restated Certificate of Incorporation
and bylaws contain a number of provisions that could make our acquisition by means of a tender or exchange offer, a proxy contest
or otherwise more difficult. These provisions are summarized below.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Classified Board of Directors.</I> &nbsp;&nbsp;Pursuant
to Article ELEVENTH of our Amended and Restated Certificate of Incorporation, the directors constituting our Board of Directors
are classified, with respect to the time for which they severally hold office, into three classes as nearly equal in number as
possible. In implementing the classified Board, our Board of Directors assigned members of the Board of Directors already in office
into three classes, with one class assigned a term expiring at the annual meeting of stockholders to be held in 2010, a second
class assigned a term expiring at the annual meeting of stockholders to be held in 2011, and a third class assigned a term expiring
at the annual meeting of stockholders to be held in 2012, with each class to hold office until its successor is elected and qualified.
At each annual meeting of stockholders commencing with the election in 2010, the successors of the class of directors whose term
expires at that meeting are elected to hold office for a term expiring at the annual meeting of stockholders held in the third
year following the year of their election. Pursuant to the Delaware General Corporation Law, if a board of directors is classified
(as is our Board of Directors), unless the certificate of incorporation otherwise provides, members of the board of directors may
be removed by the stockholders before the expiration of their respective terms only for cause.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Our classified Board of Directors may have
an anti-takeover effect of making more difficult and discouraging a takeover attempt, merger, tender offer, or proxy fight. Additionally,
our classified Board of Directors extends the time it would take for holders of a majority of our shares to remove incumbent management
to obtain control of the Board of Directors. That is, as a general matter a majority stockholder could not obtain control of the
Board of Directors until the second annual stockholder&rsquo;s meeting after it acquired a majority of the voting stock. Our classified
Board of Directors may have the effect of making it more difficult for stockholders to remove our existing management.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Special Meetings.</I> &nbsp;&nbsp;Our
bylaws provide that special meetings of our stockholders may, unless otherwise prescribed by law, be called by our Chairman of
the Board (if any), our Board of Directors or our Chief Executive Officer and shall be held at such place, on such date and at
such time as shall be fixed by our Board of Directors or the person calling the meeting. Business transacted at any special meeting
shall be limited to matters relating to the purpose or purposes stated in the notice of the meeting.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Undesignated Preferred Stock.</I> &nbsp;&nbsp;The
ability to authorize undesignated preferred stock makes it possible for our Board of Directors to issue preferred stock with voting
or other rights or preferences that could impede the success of any attempt to acquire us. The ability to issue preferred stock
may have the effect of deferring hostile takeovers or delaying changes in control or management of our company.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt"><I>Delaware Anti-Takeover Statute.</I> &nbsp;&nbsp;We
are subject to the provisions of Section 203 of the Delaware General Corporation Law regulating corporate takeovers. In general,
Section 203 prohibits a publicly held Delaware corporation from engaging in a business combination with an interested stockholder
for a period of three years following the date the person became an interested stockholder unless:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>prior to the date of the transaction, the board of directors of the corporation approved either the business combination or
the transaction which resulted in the stockholder becoming an interested stockholder;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>upon completion of the transaction that resulted in the stockholder becoming an interested stockholder, the stockholder owned
at least 85% of the voting stock of the corporation outstanding at the time the transaction commenced, excluding for purposes of
determining the number of shares outstanding (1) shares owned by persons who are directors and also officers and (2) shares owned
by employee stock plans in which employee participants do not have the right to determine confidentially whether shares held subject
to the plan will be tendered in a tender or exchange offer; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>on or subsequent to the date of the transaction, the business combination is approved by the board and authorized at an annual
or special meeting of stockholders, and not by written consent, by the affirmative vote of at least 66&nbsp;2/3% of the outstanding
voting stock which is not owned by the interested stockholder.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Generally, a business combination includes
a merger, asset or stock sale, or other transaction resulting in a financial benefit to the interested stockholder. An interested
stockholder is a person who, together with affiliates and associates, owns or, within three years prior to the determination of
interested stockholder status, owned 15% or more of a corporation&rsquo;s outstanding voting securities. We expect the existence
of this provision to have an anti-takeover effect with respect to transactions our Board of Directors does not approve in advance.
We also anticipate that Section 203 may discourage attempted acquisitions that might result in a premium over the market price
for the shares of our Common Stock held by stockholders.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The provisions of Delaware law, our Amended
and Restated Certificate of Incorporation and our bylaws could have the effect of discouraging others from attempting hostile takeovers
and, as a consequence, they may also inhibit temporary fluctuations in the market price of our Common Stock that often result from
actual or rumored hostile takeover attempts. These provisions may also have the effect of preventing changes in our management.
It is possible that these provisions could make it more difficult to accomplish transactions that stockholders may otherwise deem
to be in their best interests.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Potential Effects of Authorized but Unissued Stock</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">We have shares of Common Stock and preferred
stock available for future issuance without stockholder approval. We may utilize these additional shares for a variety of corporate
purposes, including future public offerings to raise additional capital, to facilitate corporate acquisitions or payment as a dividend
on the capital stock.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The existence of unissued and unreserved
Common Stock and preferred stock may enable our Board of Directors to issue shares to persons friendly to current management or
to issue preferred stock with terms that could render more difficult or discourage a third-party attempt to obtain control of us
by means of a merger, tender offer, proxy contest or otherwise, thereby protecting the continuity of our management. In addition,
the Board of Directors has the discretion to determine designations, rights, preferences, privileges and restrictions, including
voting rights, dividend rights, conversion rights, redemption privileges and liquidation preferences of each series of preferred
stock, all to the fullest extent permissible under the Delaware General Corporation Law and subject to any limitations set forth
in our certificate of incorporation. The purpose of authorizing the Board of Directors to issue preferred stock and to determine
the rights and preferences applicable to such preferred stock is to eliminate delays associated with a stockholder vote on specific
issuances. The issuance of preferred stock, while providing desirable flexibility in connection with possible financings, acquisitions
and other corporate purposes, could have the effect of making it more difficult for a third party to acquire, or could discourage
a third party from acquiring, a majority of our outstanding voting stock.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Limitations of Director Liability and Indemnification of
Directors, Officers and Employees</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Section 145 of the Delaware General Corporation
Law, permits indemnification of directors, officers, agents and controlling persons of a corporation under certain conditions and
subject to certain limitations. Section 145 empowers a corporation to indemnify any person who was or is a party or is threatened
to be made a party to any threatened, pending or completed action, suit or proceeding whether civil, criminal, administrative or
investigative, by reason of the fact that he or she is or was a director, officer or agent of the corporation or another enterprise
if serving at the request of the corporation. Depending on the character of the proceeding, a corporation may indemnify against
expenses (including attorneys&rsquo; fees), judgments, fines and amounts paid in settlement actually and reasonably incurred in
connection with such action, suit or proceeding if the person indemnified acted in good faith and in a manner he or she reasonably
believed to be in or not opposed to, the best interests of the corporation, and, with respect to any criminal action or proceeding,
had no reasonable cause to believe his or her conduct was unlawful. In the case of an action by or in the right of the corporation,
no indemnification may be made with respect to any claim, issue or matter as to which such person shall have been adjudged to be
liable to the corporation unless and only to the extent that the Court of Chancery or the court in which such action or suit was
brought shall determine that despite the adjudication of liability such person is fairly and reasonably entitled to indemnity for
such expenses which the court shall deem proper. Section 145 further provides that to the extent a present or former director or
officer of a corporation has been successful in the defense of any action, suit or proceeding referred to above or in the defense
of any claim, issue or matter therein, such person shall be indemnified against expenses (including attorneys&rsquo; fees) actually
and reasonably incurred by such person in connection therewith.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Indemnification Agreements</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">We have entered into indemnification agreements
with each of our Chief Executive Officer, Chief Financial Officer, General Counsel, certain other employees and each of our directors
pursuant to which we have agreed to indemnify such party to the full extent permitted by law, subject to certain exceptions, if
such party becomes subject to an action because such party is our director, officer, employee, agent or fiduciary.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Transfer Agent</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The transfer agent and registrar for our
Common Stock is Continental Stock Transfer &amp; Trust Company. Its address is 17 Battery Place, New York, New York, 10004 and
its telephone number is (212) 509-4000.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>DESCRIPTION OF DEBT SECURITIES</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">We summarize below some of the provisions
that will apply to the debt securities unless the applicable prospectus supplement provides otherwise. This summary may not contain
all information that is important to you. The complete terms of the debt securities will be contained in the applicable notes.
The notes will be included or incorporated by reference as exhibits to the registration statement of which this prospectus is a
part. You should read the provisions of the notes. You should also read the prospectus supplement, which will contain additional
information and which may update or change some of the information below.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>General</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">This prospectus describes certain general
terms and provisions of the debt securities. The debt securities will be issued under an indenture between us and a trustee to
be designated prior to the issuance of the debt securities. When we offer to sell a particular series of debt securities, we will
describe the specific terms of the securities in a supplement to this prospectus. The prospectus supplement will also indicate
whether the general terms and provisions described in this prospectus apply to a particular series of debt securities.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">We may issue, from time to time, debt securities,
in one or more series, that will consist of either our senior debt (&ldquo;senior debt securities&rdquo;), our senior subordinated
debt (&ldquo;senior subordinated debt securities&rdquo;), our subordinated debt (&ldquo;subordinated debt securities&rdquo;) or
our junior subordinated debt (&ldquo;junior subordinated debt securities&rdquo; and, together with the senior subordinated debt
securities and the subordinated debt securities, the &ldquo;subordinated securities&rdquo;). Debt securities, whether senior, senior
subordinated, subordinated or junior subordinated, may be issued as convertible debt securities or exchangeable debt securities.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">We have summarized herein certain terms and
provisions of the form of indenture (the &ldquo;indenture&rdquo;). The summary is not complete and is qualified in its entirety
by reference to the actual text of the indenture. The indenture is an exhibit to the registration statement of which this prospectus
is a part. You should read the indenture for the provisions which may be important to you. The indenture is subject to and governed
by the Trust Indenture Act of 1939, as amended.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The indenture does not limit the amount of
debt securities which we may issue. We may issue debt securities up to an aggregate principal amount as we may authorize from time
to time which securities may be in any currency or currency unit designated by us. The terms of each series of debt securities
will be established by or pursuant to (a) a supplemental indenture, (b) a resolution of our board of directors, or (c) an officers&rsquo;
certificate pursuant to authority granted under a resolution of our board of directors. The prospectus supplement will describe
the terms of any debt securities being offered, including:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>the title of the debt securities;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>the limit, if any, upon the aggregate principal amount or issue price of the debt securities of a series;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>ranking of the specific series of debt securities relative to other outstanding indebtedness, including any debt of any of
our subsidiaries;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>the price or prices at which the debt securities will be issued;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>the designation, aggregate principal amount and authorized denominations of the series of debt securities;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>the issue date or dates of the series and the maturity date of the series;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>whether the securities will be issued at par or at a premium over or a discount from their face amount;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>the interest rate, if any, and the method for calculating the interest rate and basis upon which interest shall be calculated;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>the right, if any, to extend interest payment periods and the duration of the extension;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>the interest payment dates and the record dates for the interest payments;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>any mandatory or optional redemption terms or prepayment, conversion, sinking fund or exchangeability or convertibility provisions;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>the currency of denomination of the securities;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>the place where we will pay principal, premium, if any, and interest, if any, and the place where the debt securities may be
presented for transfer;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>if payments of principal of, premium, if any, or interest, if any, on the debt securities will be made in one or more currencies
or currency units other than that or those in which the debt securities are denominated, the manner in which the exchange rate
with respect to these payments will be determined;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>if other than denominations of $1,000 or multiples of $1,000, the denominations the debt securities will be issued in;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>whether the debt securities will be issued in the form of global securities or certificates;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>the applicability of and additional provisions, if any, relating to the defeasance of the debt securities;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>the portion of principal amount of the debt securities payable upon declaration of acceleration of the maturity date, if other
than the entire principal amount;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>the currency or currencies, if other than the currency of the United States, in which principal and interest will be paid;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>the dates on which premium, if any, will be paid;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>any addition to or change in the &ldquo;Events of Default&rdquo; described in this prospectus or in the indenture with respect
to the debt securities and any change in the acceleration provisions described in this prospectus or in the indenture with respect
to the debt securities;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>any addition to or change in the covenants described in the prospectus or in the indenture with respect to the debt securities;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>our right, if any, to defer payment of interest and the maximum length of this deferral period; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>other specific terms, including any additional events of default or covenants.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">We may issue debt securities at a discount
below their stated principal amount. Even if we do not issue the debt securities below their stated principal amount, for United
States federal income tax purposes the debt securities may be deemed to have been issued with a discount because of certain interest
payment characteristics. We will describe in any applicable prospectus supplement the United States federal income tax considerations
applicable to debt securities issued at a discount or deemed to be issued at a discount, and will describe any special United States
federal income tax considerations that may be applicable to the particular debt securities.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Senior Debt</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Senior debt securities will rank equally
and <I>pari passu</I> with all of our other unsecured and unsubordinated debt from time to time outstanding.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Subordinated Debt</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The indenture does not limit our ability
to issue subordinated debt securities. Any subordination provisions of a particular series of debt securities will be set forth
in the supplemental indenture, board resolution or officers&rsquo; certificate related to that series of debt securities and will
be described in the relevant prospectus supplement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">If this prospectus is being delivered in
connection with a series of subordinated debt securities, the accompanying prospectus supplement or the information incorporated
by reference in this prospectus will set forth the approximate amount of senior indebtedness outstanding as of the end of the most
recent fiscal quarter.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Conversion or Exchange Rights</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Debt securities may be convertible into or
exchangeable for our other securities or property. The terms and conditions of conversion or exchange will be set forth in the
supplemental indenture, board resolution or officers&rsquo; certificate related to that series of debt securities and will be described
in the relevant prospectus supplement. The terms will include, among others, the following:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>the conversion or exchange price;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>the conversion or exchange period;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>provisions regarding our ability or the ability of the holder to convert or exchange the debt securities;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>events requiring adjustment to the conversion or exchange price; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>provisions affecting conversion or exchange in the event of our redemption of the debt securities.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Merger, Consolidation or Sale of Assets</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The indenture prohibits us from merging into
or consolidating with any other person or selling, leasing or conveying substantially all of our assets and the assets of our subsidiaries,
taken as a whole, to any person, unless:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>either we are the continuing corporation or the successor corporation or the person which acquires by sale, lease or conveyance
substantially all our or our subsidiaries&rsquo; assets is a corporation organized under the laws of the United States, any state
thereof, or the District of Columbia, and expressly assumes the due and punctual payment of the principal of, and premium, if any,
and interest, if any, on all the debt securities and the due performance of every covenant of the indenture to be performed or
observed by us, by supplemental indenture satisfactory to the trustee, executed and delivered to the trustee by such corporation;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>immediately after giving effect to such transactions, no Event of Default described under the caption &ldquo;Events of Default
and Remedies&rdquo; below or event which, after notice or lapse of time or both would become an Event of Default, has happened
and is continuing; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>we have delivered to the trustee an officers&rsquo; certificate and an opinion of counsel each stating that such transaction
and such supplemental indenture comply with the indenture provisions relating to merger, consolidation and sale of assets.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Upon any consolidation or merger with or
into any other person or any sale, conveyance, lease, or other transfer of all or substantially all of our or our subsidiaries&rsquo;
assets to any person, the successor person shall succeed, and be substituted for, us under the indenture and each series of outstanding
debt securities, and we shall be relieved of all obligations under the indenture and each series of outstanding debt securities
to the extent we were the predecessor person.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Events of Default and Remedies</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">When we use the term &ldquo;Event of Default&rdquo;
in the indenture with respect to the debt securities of any series, we mean:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">(1)</TD><TD>default in paying interest on the debt securities when it becomes due and the default continues for a period of 30 days or
more;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">(2)</TD><TD>default in paying principal, or premium, if any, on the debt securities when due;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">(3)</TD><TD>default is made in the payment of any sinking or purchase fund or analogous obligation when the same becomes due, and such
default continues for 30 days or more;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">(4)</TD><TD>default in the performance, or breach, of any covenant or warranty in the indenture (other than defaults specified in clause
(1), (2) or (3) above) and the default or breach continues for a period of 60 days or more after we receive written notice of such
default from the trustee or we and the trustee receive notice from the holders of at least 25% in aggregate principal amount of
the outstanding debt securities of the series;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">(5)</TD><TD>certain events of bankruptcy, insolvency, reorganization, administration or similar proceedings with respect to us have occurred;
and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">(6)</TD><TD>any other Event of Default provided with respect to debt securities of that series that is set forth in the applicable prospectus
supplement accompanying this prospectus.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">No Event of Default with respect to a particular
series of debt securities (except as to certain events of bankruptcy, insolvency or reorganization) necessarily constitutes an
Event of Default with respect to any other series of debt securities. The occurrence of certain Events of Default or an acceleration
under the indenture may constitute an event of default under certain of our other indebtedness that we may have outstanding from
time to time. Unless otherwise provided by the terms of an applicable series of debt securities, if an Event of Default under the
indenture occurs with respect to the debt securities of any series and is continuing, then the trustee or the holders of not less
than 51% of the aggregate principal amount of the outstanding debt securities of that series may by written notice require us to
repay immediately the entire principal amount of the outstanding debt securities of that series (or such lesser amount as may be
provided in the terms of the securities), together with all accrued and unpaid interest and premium, if any. In the case of an
Event of Default resulting from certain events of bankruptcy, insolvency or reorganization, the principal (or such specified amount)
of and accrued and unpaid interest, if any, on all outstanding debt securities will become and be immediately due and payable without
any declaration or other act on the part of the trustee or any holder of outstanding debt securities. We refer you to the prospectus
supplement relating to any series of debt securities that are discount securities for the particular provisions relating to acceleration
of a portion of the principal amount of such discount securities upon the occurrence of an Event of Default.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">After a declaration of acceleration, the
holders of a majority in aggregate principal amount of outstanding debt securities of any series may rescind this accelerated payment
requirement if all existing Events of Default, except for nonpayment of the principal on the debt securities of that series that
has become due solely as a result of the accelerated payment requirement, have been cured or waived and if the rescission of acceleration
would not conflict with any judgment or decree. The holders of a majority in aggregate principal amount of the outstanding debt
securities of any series also have the right to waive past defaults, except a default in paying principal or interest on any outstanding
debt security, or in respect of a covenant or a provision that cannot be modified or amended without the consent of all holders
of the debt securities of that series.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">No holder of any debt security may seek to
institute a proceeding with respect to the indenture unless such holder has previously given written notice to the trustee of a
continuing Event of Default, the holders of not less than 51% in aggregate principal amount of the outstanding debt securities
of the series have made a written request to the trustee to institute proceedings in respect of the Event of Default, the holder
or holders have offered reasonable indemnity to the trustee and the trustee has failed to institute such proceeding within 60 days
after it received this notice. In addition, within this 60-day period the trustee must not have received directions inconsistent
with this written request by holders of a majority in aggregate principal amount of the outstanding debt securities of that series.
These limitations do not apply, however, to a suit instituted by a holder of a debt security for the enforcement of the payment
of principal, interest or any premium on or after the due dates for such payment.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">During the existence of an Event of Default
actually known to a responsible officer of the trustee, the trustee is required to exercise the rights and powers vested in it
under the indenture and use the same degree of care and skill in its exercise as a prudent person would under the circumstances
in the conduct of that person&rsquo;s own affairs. If an Event of Default has occurred and is continuing, the trustee is not under
any obligation to exercise any of its rights or powers at the request or direction of any of the holders unless the holders have
offered to the trustee security or indemnity reasonably satisfactory to the trustee. Subject to certain provisions, the holders
of a majority in aggregate principal amount of the outstanding debt securities of any series have the right to direct the time,
method and place of conducting any proceeding for any remedy available to the trustee, or exercising any trust, or power conferred
on the trustee.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

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    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The trustee will, within 90 days after receiving
notice of any default, give notice of the default to the holders of the debt securities of that series, unless the default was
already cured or waived. Unless there is a default in paying principal, interest or any premium when due, the trustee can withhold
giving notice to the holders if it determines in good faith that the withholding of notice is in the interest of the holders. In
the case of a default specified in clause (4) above describing Events of Default, no notice of default to the holders of the debt
securities of that series will be given until 60 days after the occurrence of the event of default.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The indenture requires us, within 120 days
after the end of our fiscal year, to furnish to the trustee a statement as to compliance with the indenture. The indenture provides
that the trustee may withhold notice to the holders of debt securities of any series of any Event of Default (except in payment
on any debt securities of that series) with respect to debt securities of that series if it in good faith determines that withholding
notice is in the interest of the holders of those debt securities.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Modification and Waiver</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The indenture may be amended or modified
without the consent of any holder of debt securities in order to:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>evidence a successor to the trustee;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>cure ambiguities, defects or inconsistencies;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>provide for the assumption of our obligations in the case of a merger or consolidation or transfer of all or substantially
all of our assets that complies with the covenant described under &ldquo;&mdash; Merger, Consolidation or Sale of Assets&rdquo;;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>make any change that would provide any additional rights or benefits to the holders of the debt securities of a series;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>add guarantors or co-obligors with respect to the debt securities of any series;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>secure the debt securities of a series;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>establish the form or forms of debt securities of any series;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>add additional Events of Default with respect to the debt securities of any series;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>add additional provisions as may be expressly permitted by the Trust Indenture Act;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>maintain the qualification of the indenture under the Trust Indenture Act; or</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>make any change that does not adversely affect in any material respect the interests of any holder.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Other amendments and modifications of the
indenture or the debt securities issued may be made with the consent of the holders of not less than a majority in aggregate principal
amount of the outstanding debt securities of each series affected by the amendment or modification. However, no modification or
amendment may, without the consent of the holder of each outstanding debt security affected:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>change the maturity date or the stated payment date of any payment of premium or interest payable on the debt securities;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>reduce the principal amount, or extend the fixed maturity, of the debt securities;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>change the method of computing the amount of principal or any interest of any debt security;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>change or waive the redemption or repayment provisions of the debt securities;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>change the currency in which principal, any premium or interest is paid or the place of payment;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>reduce the percentage in principal amount outstanding of debt securities of any series which must consent to an amendment,
supplement or waiver or consent to take any action;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>impair the right to institute suit for the enforcement of any payment on the debt securities;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>waive a payment default with respect to the debt securities;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>reduce the interest rate or extend the time for payment of interest on the debt securities;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>adversely affect the ranking or priority of the debt securities of any series; or</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>release any guarantor or co-obligor from any of its obligations under its guarantee or the indenture, except in compliance
with the terms of the indenture.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Satisfaction, Discharge and Covenant Defeasance</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">We may terminate our obligations under the
indenture with respect to the outstanding debt securities of any series, when:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>either:</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 38.85pt"></TD><TD STYLE="width: 16.8pt">&bull;</TD><TD>all debt securities of any series issued that have been authenticated and delivered have been delivered to the trustee for
cancellation; or</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 38.85pt"></TD><TD STYLE="width: 16.8pt">&bull;</TD><TD>all the debt securities of any series issued that have not been delivered to the trustee for cancellation have become due and
payable, will become due and payable within one year, or are to be called for redemption within one year and we have made arrangements
satisfactory to the trustee for the giving of notice of redemption by such trustee in our name and at our expense, and in each
case, we have irrevocably deposited or caused to be deposited with the trustee sufficient funds to pay and discharge the entire
indebtedness on the series of debt securities; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>we have paid or caused to be paid all other sums then due and payable under the indenture; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>we have delivered to the trustee an officers&rsquo; certificate and an opinion of counsel, each stating that all conditions
precedent under the indenture relating to the satisfaction and discharge of the indenture have been complied with.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">We may elect to have our obligations under
the indenture discharged with respect to the outstanding debt securities of any series (&ldquo;legal defeasance&rdquo;). Legal
defeasance means that we will be deemed to have paid and discharged the entire indebtedness represented by the outstanding debt
securities of such series under the indenture, except for:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>the rights of holders of the debt securities to receive principal, interest and any premium when due;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>our obligations with respect to the debt securities concerning issuing temporary debt securities, registration of transfer
of debt securities, mutilated, destroyed, lost or stolen debt securities and the maintenance of an office or agency for payment
for security payments held in trust;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>the rights, powers, trusts, duties and immunities of the trustee; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>the defeasance provisions of the indenture.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">In addition, we may elect to have our obligations
released with respect to certain covenants in the indenture (&ldquo;covenant defeasance&rdquo;). If we so elect, any failure to
comply with these obligations will not constitute a default or an event of default with respect to the debt securities of any series.
In the event covenant defeasance occurs, certain events, not including non-payment, bankruptcy and insolvency events, described
under &ldquo;Events of Default and Remedies,&rdquo; will no longer constitute an event of default for that series.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">In order to exercise either legal defeasance
or covenant defeasance with respect to outstanding debt securities of any series:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>we must irrevocably have deposited or caused to be deposited with the trustee as trust funds for the purpose of making the
following payments, specifically pledged as security for, and dedicated solely to the benefits of the holders of the debt securities
of a series:</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 38.85pt"></TD><TD STYLE="width: 16.8pt">&bull;</TD><TD>money in an amount; or</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 38.85pt"></TD><TD STYLE="width: 16.8pt">&bull;</TD><TD>U.S. government obligations (or equivalent government obligations in the case of debt securities denominated in other than
U.S. dollars or a specified currency) that will provide, not later than one day before the due date of any payment, money in an
amount; or</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 38.85pt"></TD><TD STYLE="width: 16.8pt">&bull;</TD><TD>a combination of money and U.S. government obligations (or equivalent government obligations, as applicable),</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">in each case sufficient, in the written opinion (with respect
to U.S. or equivalent government obligations or a combination of money and U.S. or equivalent government obligations, as applicable)
of a nationally recognized firm of independent public accountants to pay and discharge, and which shall be applied by the trustee
to pay and discharge, all of the principal (including mandatory sinking fund payments), interest and any premium at due date or
maturity;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>in the case of legal defeasance, we have delivered to the trustee an opinion of counsel stating that, under then applicable
federal income tax law, the holders of the debt securities of that series will not recognize income, gain or loss for federal income
tax purposes as a result of the deposit, defeasance and discharge to be effected and will be subject to the same federal income
tax as would be the case if the deposit, defeasance and discharge did not occur;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>in the case of covenant defeasance, we have delivered to the trustee an opinion of counsel to the effect that the holders of
the debt securities of that series will not recognize income, gain or loss for federal income tax purposes as a result of the deposit
and covenant defeasance to be effected and will be subject to the same federal income tax as would be the case if the deposit and
covenant defeasance did not occur;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>no event of default or default with respect to the outstanding debt securities of that series has occurred and is continuing
at the time of such deposit after giving effect to the deposit or, in the case of legal defeasance, no default relating to bankruptcy
or insolvency has occurred and is continuing at any time on or before the 91 st day after the date of such deposit, it being understood
that this condition is not deemed satisfied until after the 91 st day;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>the legal defeasance or covenant defeasance will not cause the trustee to have a conflicting interest within the meaning of
the Trust Indenture Act, assuming all debt securities of a series were in default within the meaning of such Act;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>the legal defeasance or covenant defeasance will not result in a breach or violation of, or constitute a default under, any
other agreement or instrument to which we are a party;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>if prior to the stated maturity date, notice shall have been given in accordance with the provisions of the indenture;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>the legal defeasance or covenant defeasance will not result in the trust arising from such deposit constituting an investment
company within the meaning of the Investment Company Act of 1940, as amended, unless the trust is registered under such Act or
exempt from registration; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>we have delivered to the trustee an officers&rsquo; certificate and an opinion of counsel stating that all conditions precedent
with respect to the legal defeasance or covenant defeasance have been complied with.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Covenants</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">We will set forth in the applicable prospectus
supplement any restrictive covenants applicable to any issue of debt securities.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Paying Agent and Registrar</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The trustee will initially act as paying
agent and registrar for all debt securities. We may change the paying agent or registrar for any series of debt securities without
prior notice, and we or any of our subsidiaries may act as paying agent or registrar.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B>&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Form of Securities</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Each debt security will be represented either
by a certificate issued in definitive form to a particular investor or by one or more global securities representing the entire
issuance of the series of debt securities. Certificated securities will be issued in definitive form and global securities will
be issued in registered form. Definitive securities name you or your nominee as the owner of the security, and in order to transfer
or exchange these securities or to receive payments other than interest or other interim payments, you or your nominee must physically
deliver the securities to the trustee, registrar, paying agent or other agent, as applicable. Global securities name a depositary
or its nominee as the owner of the debt securities represented by these global securities. The depositary maintains a computerized
system that will reflect each investor&rsquo;s beneficial ownership of the securities through an account maintained by the investor
with its broker/dealer, bank, trust company or other representative, as we explain more fully below.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Global Securities</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">We may issue the registered debt securities
in the form of one or more fully registered global securities that will be deposited with a depositary or its custodian identified
in the applicable prospectus supplement and registered in the name of that depositary or its nominee. In those cases, one or more
registered global securities will be issued in a denomination or aggregate denominations equal to the portion of the aggregate
principal or face amount of the securities to be represented by registered global securities. Unless and until it is exchanged
in whole for securities in definitive registered form, a registered global security may not be transferred except as a whole by
and among the depositary for the registered global security, the nominees of the depositary or any successors of the depositary
or those nominees.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">If not described below, any specific terms
of the depositary arrangement with respect to any securities to be represented by a registered global security will be described
in the prospectus supplement relating to those securities. We anticipate that the following provisions will apply to all depositary
arrangements.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Ownership of beneficial interests in a registered
global security will be limited to persons, called participants, that have accounts with the depositary or persons that may hold
interests through participants. Upon the issuance of a registered global security, the depositary will credit, on its book-entry
registration and transfer system, the participants&rsquo; accounts with the respective principal or face amounts of the securities
beneficially owned by the participants. Any dealers, underwriters or agents participating in the distribution of the securities
will designate the accounts to be credited. Ownership of beneficial interests in a registered global security will be shown on,
and the transfer of ownership interests will be effected only through, records maintained by the depositary, with respect to interests
of participants, and on the records of participants, with respect to interests of persons holding through participants. The laws
of some states may require that some purchasers of securities take physical delivery of these securities in definitive form. These
laws may impair your ability to own, transfer or pledge beneficial interests in registered global securities.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">So long as the depositary, or its nominee,
is the registered owner of a registered global security, that depositary or its nominee, as the case may be, will be considered
the sole owner or holder of the securities represented by the registered global security for all purposes under the indenture.
Except as described below, owners of beneficial interests in a registered global security will not be entitled to have the securities
represented by the registered global security registered in their names, will not receive or be entitled to receive physical delivery
of the securities in definitive form and will not be considered the owners or holders of the securities under the indenture. Accordingly,
each person owning a beneficial interest in a registered global security must rely on the procedures of the depositary for that
registered global security and, if that person is not a participant, on the procedures of the participant through which the person
owns its interest, to exercise any rights of a holder under the indenture. We understand that under existing industry practices,
if we request any action of holders or if an owner of a beneficial interest in a registered global security desires to give or
take any action that a holder is entitled to give or take under the indenture, the depositary for the registered global security
would authorize the participants holding the relevant beneficial interests to give or take that action, and the participants would
authorize beneficial owners owning through them to give or take that action or would otherwise act upon the instructions of beneficial
owners holding through them.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Principal, premium, if any, and interest
payments on debt securities represented by a registered global security registered in the name of a depositary or its nominee will
be made to the depositary or its nominee, as the case may be, as the registered owner of the registered global security. Neither
we nor the trustee or any other agent of ours or the trustee will have any responsibility or liability for any aspect of the records
relating to payments made on account of beneficial ownership interests in the registered global security or for maintaining, supervising
or reviewing any records relating to those beneficial ownership interests.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">We expect that the depositary for any of
the securities represented by a registered global security, upon receipt of any payment of principal, premium, interest or other
distribution of underlying securities or other property to holders on that registered global security, will immediately credit
participants&rsquo; accounts in amounts proportionate to their respective beneficial interests in that registered global security
as shown on the records of the depositary. We also expect that payments by participants to owners of beneficial interests in a
registered global security held through participants will be governed by standing customer instructions and customary practices,
as is now the case with the securities held for the accounts of customers in bearer form or registered in &ldquo;street name,&rdquo;
and will be the responsibility of those participants.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">If the depositary for any of these securities
represented by a registered global security is at any time unwilling or unable to continue as depositary or ceases to be a clearing
agency registered under the Exchange Act, and a successor depositary registered as a clearing agency under the Exchange Act is
not appointed by us within 90 days, we will issue securities in definitive form in exchange for the registered global security
that had been held by the depositary. Any securities issued in definitive form in exchange for a registered global security will
be registered in the name or names that the depositary gives to the trustee or other relevant agent of ours or theirs. It is expected
that the depositary&rsquo;s instructions will be based upon directions received by the depositary from participants with respect
to ownership of beneficial interests in the registered global security that had been held by the depositary.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Unless we state otherwise in a prospectus
supplement, the Depository Trust Company (&ldquo;DTC&rdquo;) will act as depositary for each series of debt securities issued as
global securities. DTC has advised us that DTC is a limited-purpose trust company created to hold securities for its participating
organizations (collectively, the &ldquo;Participants&rdquo;) and to facilitate the clearance and settlement of transactions in
those securities between Participants through electronic book-entry changes in accounts of its Participants. The Participants include
securities brokers and dealers, banks, trust companies, clearing corporations and certain other organizations. Access to DTC&rsquo;s
system is also available to other entities such as banks, brokers, dealers and trust companies that clear through or maintain a
custodial relationship with a Participant, either directly or indirectly (collectively, the &ldquo;Indirect Participants&rdquo;).
Persons who are not Participants may beneficially own securities held by or on behalf of DTC only through the Participants or the
Indirect Participants. The ownership interests in, and transfers of ownership interests in, each security held by or on behalf
of DTC are recorded on the records of the Participants and the Indirect Participants.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Governing Law</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The indenture and each series of debt securities
are governed by, and construed in accordance with, the laws of the State of New York.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>DESCRIPTION OF WARRANTS</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The following description, together with
the additional information we may include in any applicable prospectus supplements, summarizes the material terms and provisions
of the warrants that we may offer under this prospectus and the related warrant agreements and warrant certificates. While the
terms summarized below will apply generally to any warrants that we may offer, we will describe the particular terms of any series
of warrants in more detail in the applicable prospectus supplement. If we indicate in the prospectus supplement, the terms of any
warrants offered under that prospectus supplement may differ from the terms described below. Specific warrant agreements will contain
additional important terms and provisions and will be incorporated by reference as an exhibit to the registration statement that
includes this prospectus.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>General</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">We may issue warrants for the purchase of
common stock, preferred stock or debt securities in one or more series. We may issue warrants independently or together with common
stock, preferred stock and debt securities, and the warrants may be attached to or separate from these securities.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">We will evidence each series of warrants
by warrant certificates that we will issue under a separate agreement. We may enter into a warrant agreement with a warrant agent.
If we engage a warrant agent, each warrant agent will be a bank that we select which has its principal office in the United States
and a combined capital and surplus of at least $50,000,000. We will indicate the name and address of the warrant agent in the applicable
prospectus supplement relating to a particular series of warrants.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Before exercising their warrants, holders
of warrants will not have any of the rights of holders of the securities purchasable upon such exercise, including:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>in the case of warrants to purchase debt securities, the right to receive payments of principal of, or premium, if any, or
interest on, the debt securities purchasable upon exercise or to enforce covenants in the applicable indenture; or</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>in the case of warrants to purchase common stock or preferred stock, the right to receive dividends, if any, or, payments upon
our liquidation, dissolution or winding up or to exercise voting rights, if any.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Additional Information</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">We will describe in the applicable prospectus
supplement the terms of the series of warrants, including:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>the offering price and aggregate number of warrants offered;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>the currency for which the warrants may be purchased;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>if applicable, the designation and terms of the securities with which the warrants are issued and the number of warrants issued
with each such security or each principal amount of such security;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>if applicable, the date on and after which the warrants and the related securities will be separately transferable;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>in the case of warrants to purchase debt securities, the principal amount of debt securities purchasable upon exercise of one
warrant and the price at, and currency in which, this principal amount of debt securities may be purchased upon such exercise;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>in the case of warrants to purchase common stock or preferred stock, the number of shares of common stock or preferred stock,
as the case may be, purchasable upon the exercise of one warrant and the price at which these shares may be purchased upon such
exercise;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>the effect of any merger, consolidation, sale or other disposition of our business on the warrant agreement and the warrants;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>the terms of any rights to redeem or call the warrants;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>any provisions for changes to or adjustments in the exercise price or number of securities issuable upon exercise of the warrants;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>the dates on which the right to exercise the warrants will commence and expire;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>the manner in which the warrant agreement and warrants may be modified;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>a discussion on any material or special United States federal income tax consequences of holding or exercising the warrants;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>the terms of the securities issuable upon exercise of the warrants; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>any other specific terms, preferences, rights or limitations of or restrictions on the warrants.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Exercise of Warrants</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Each warrant will entitle the holder to purchase
the securities that we specify in the applicable prospectus supplement at the exercise price that we describe in the applicable
prospectus supplement. Unless we otherwise specify in the applicable prospectus supplement, holders of the warrants may exercise
the warrants at any time up to 5 p.m., Eastern time, on the expiration date that we set forth in the applicable prospectus supplement.
After the close of business on the expiration date, unexercised warrants will become void.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Holders of the warrants may exercise the
warrants by delivering the warrant certificate representing the warrants to be exercised together with specified information, and
paying the required amount to the warrant agent in immediately available funds, as provided in the applicable prospectus supplement.
We will set forth on the reverse side of the warrant certificate and in the applicable prospectus supplement the information that
the holder of the warrant will be required to deliver to the warrant agent.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Upon receipt of the required payment and
the warrant certificate properly completed and duly executed at the corporate trust office of the warrant agent or any other office
indicated in the applicable prospectus supplement, we will issue and deliver the securities purchasable upon such exercise. If
fewer than all of the warrants represented by the warrant certificate are exercised, then we will issue a new warrant certificate
for the remaining amount of warrants. If we so indicate in the applicable prospectus supplement, holders of the warrants may surrender
securities as all or part of the exercise price for warrants.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Enforceability of Rights by Holders of Warrants</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Each warrant agent will act solely as our
agent under the applicable warrant agreement and will not assume any obligation or relationship of agency or trust with any holder
of any warrant. A single bank or trust company may act as warrant agent for more than one issue of warrants. A warrant agent will
have no duty or responsibility in case of any default by us under the applicable warrant agreement or warrant, including any duty
or responsibility to initiate any proceedings at law or otherwise, or to make any demand upon us. Any holder of a warrant may,
without the consent of the related warrant agent or the holder of any other warrant, enforce by appropriate legal action its right
to exercise, and receive the securities purchasable upon exercise of, its warrants.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>DESCRIPTION OF UNITS</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">We may issue units comprised of one or more
of the other securities described in this prospectus in any combination. Each unit will be issued so that the holder of the unit
is also the holder of each security included in the unit. Thus, the holder of a unit will have the rights and obligations of a
holder of each included security. The unit agreement under which a unit is issued may provide that the securities included in the
unit may not be held or transferred separately, at any time or at any time before a specified date. The applicable prospectus supplement
may describe:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>the designation and terms of the units and of the securities comprising the units, including whether and under what circumstances
those securities may be held or transferred separately;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>any provisions for the issuance, payment, settlement, transfer or exchange of the units or of the securities comprising the
units;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>the terms of the unit agreement governing the units;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>United States federal income tax considerations relevant to the units; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>whether the units will be issued in fully registered global form.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">This summary of certain general terms of
units and any summary description of units in the applicable prospectus supplement do not purport to be complete and are qualified
in their entirety by reference to all provisions of the applicable unit agreement and, if applicable, collateral arrangements and
depositary arrangements relating to such units. The forms of the unit agreements and other documents relating to a particular issue
of units will be filed with the SEC each time we issue units, and you should read those documents for provisions that may be important
to you.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>PLAN OF DISTRIBUTION</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">We may sell the securities through underwriters
or dealers, through agents, or directly to one or more purchasers. The accompanying prospectus supplement will describe the terms
of the offering of the securities, including:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>the name or names of any underwriters;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>the purchase price of the securities being offered and the proceeds we will receive from the sale;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>any over-allotment options pursuant to which underwriters may purchase additional securities from us;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>any agency fees or underwriting discounts and other items constituting agents&rsquo; or underwriters&rsquo; compensation;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>any public offering price;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>any discounts or concessions allowed or reallowed or paid to dealers; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD>any securities exchange or market on which the securities may be listed.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">If underwriters are used in the sale, they
will acquire the securities for their own account and may resell the securities from time to time in one or more transactions at
a fixed public offering price or at varying prices determined at the time of the sale. The obligations of the underwriters to purchase
the securities will be subject to the conditions set forth in the applicable underwriting agreement. We may offer the securities
to the public through underwriting syndicates represented by managing underwriters or by underwriters without a syndicate. Subject
to certain conditions, the underwriters will be obligated to purchase all the securities offered by the prospectus supplement.
We may change from time to time the public offering price and any discounts or concessions allowed or reallowed or paid to dealers.
We may use underwriters with whom we have a material relationship. We will describe such relationships in the prospectus supplement
naming the underwriter and the nature of any such relationship.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">We may engage in &ldquo;at the market&rdquo;
offerings of our common stock, which are offerings into an existing trading market, at other than a fixed price, on or through
the facilities of a national securities exchange or to or through a market maker otherwise than on an exchange.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">We may sell securities directly or through
agents we designate from time to time. We will name any agent involved in the offering and sale of the securities, and we will
describe any commissions we will pay the agent in the prospectus supplement. Unless the prospectus supplement states otherwise,
our agent will act on a best efforts basis for the period of its appointment.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">We may enter into derivative transactions
with third parties, or sell securities not covered by this prospectus to third parties in privately negotiated transactions. If
the applicable prospectus supplement indicates, in connection with those derivatives, the third parties may sell securities covered
by this prospectus and the applicable prospectus supplement, including short sale transactions. If so, the third party may use
securities pledged by us or borrowed from us or others to settle those sales or to close out any related open borrowings of common
shares, and may use securities received from us in settlement of those derivatives to close out any related open borrowings of
common shares. The third party in such sale transactions will be an underwriter and, if not identified in this prospectus, will
be identified in the applicable prospectus supplement or a post-effective amendment to this registration statement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">All securities we offer other than common
stock will be new issues of securities with no established trading market. Any underwriters may make a market in these securities,
but will not be obligated to do so and may discontinue any market making at any time without notice. We cannot guarantee the liquidity
of the trading markets for any securities.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">We may provide agents and underwriters with
indemnification against civil liabilities related to this offering, including liabilities under the Securities Act, or contribution
with respect to payments that the agents or underwriters may make with respect to these liabilities. Agents and underwriters may
engage in transactions with, or perform services for, us in the ordinary course of business.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Rules of the Securities and Exchange Commission
may limit the ability of any underwriters to bid for or purchase securities before the distribution of the securities is completed.
However, underwriters may engage in the following activities in accordance with the rules:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD><I>Stabilizing transactions </I>&nbsp;&mdash;&nbsp;Underwriters may make bids or purchases for the purpose of pegging, fixing
or maintaining the price of the shares, so long as stabilizing bids do not exceed a specified maximum.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD><I>Over-allotments and syndicate covering transactions </I>&nbsp;&mdash;&nbsp;Underwriters may sell more shares of our common
stock than the number of shares that they have committed to purchase in any underwritten offering. This over-allotment creates
a short position for the underwriters. This short position may involve either &ldquo;covered&rdquo; short sales or &ldquo;naked&rdquo;
short sales. Covered short sales are short sales made in an amount not greater than the underwriters&rsquo; over-allotment option
to purchase additional shares in any underwritten offering. The underwriters may close out any covered short position either by
exercising their over-allotment option or by purchasing shares in the open market. To determine how they will close the covered
short position, the underwriters will consider, among other things, the price of shares available for purchase in the open market,
as compared to the price at which they may purchase shares through the over-allotment option. Naked short sales are short sales
in excess of the over-allotment option. The underwriters must close out any naked position by purchasing shares in the open market.
A naked short position is more likely to be created if the underwriters are concerned that, in the open market after pricing, there
may be downward pressure on the price of the shares that could adversely affect investors who purchase shares in the offering.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">&bull;</TD><TD><I>Penalty bids</I> &nbsp;&mdash;&nbsp;If underwriters purchase shares in the open market in a stabilizing transaction or syndicate
covering transaction, they may reclaim a selling concession from other underwriters and selling group members who sold those shares
as part of the offering.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">Similar to other purchase transactions, an
underwriter&rsquo;s purchases to cover the syndicate short sales or to stabilize the market price of our securities may have the
effect of raising or maintaining the market price of our securities or preventing or mitigating a decline in the market price of
our securities. As a result, the price of the securities may be higher than the price that might otherwise exist in the open market.
The imposition of a penalty bid might also have an effect on the price of shares if it discourages resales of the securities.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">If commenced, the underwriters may discontinue
any of the activities at any time.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">In compliance with guidelines of the Financial
Industry Regulatory Authority, or FINRA, the maximum consideration or discount to be received by any FINRA member or independent
broker dealer may not exceed 8% of the aggregate amount of the securities offered pursuant to this prospectus and any applicable
prospectus supplement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>LEGAL MATTERS</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The validity of the issuance of the securities
offered by this prospectus will be passed upon for us by Lowenstein Sandler PC, Roseland, New Jersey.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>EXPERTS</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The consolidated financial statements as
of and for the year ended December 31, 2010, incorporated in this prospectus by reference from the Company&rsquo;s Annual Report
on Form 10-K for the year ended December 31, 2010, have been audited by Deloitte &amp; Touche LLP, an independent registered public
accounting firm, as stated in their report, which is incorporated herein by reference. Such consolidated financial statements have
been so incorporated in reliance upon the report of such firm given upon their authority as experts in accounting and auditing.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The consolidated financial statements as
of and for the years ended December 31, 2009 and 2008, incorporated in this prospectus by reference from the Company&rsquo;s Annual
Report on Form 10-K for the year ended December 31, 2010, have been audited by Holtz Rubenstein Reminick LLP, an independent registered
public accounting firm, as stated in their report, which is incorporated herein by reference. Such consolidated financial statements
have been so incorporated in reliance upon the report of such firm given upon their authority as experts in accounting and auditing.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0.5in"><B>INCORPORATION OF
CERTAIN DOCUMENTS BY REFERENCE</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">The following documents previously filed
by us with the SEC are incorporated in this prospectus by reference:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">(a)</TD><TD>Our Annual Report on Form 10-K for the year ended December 31, 2010, filed with the SEC on April 6, 2011.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">(b)</TD><TD>Amendment No. 1 on Form 10-K/A to our Annual Report on Form 10-K for the year ended December 31, 2010, filed with the SEC on
May 2, 2011.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">(c)</TD><TD>Our Current Reports on Form 8-K and amendments thereto dated January 4, 2011, January 18, 2011 and March 4, 2011 (filed with
the SEC on January 10, 2011, January 24, 2011 and March 8, 2011, respectively) (excluding any information deemed furnished pursuant
to Item 2.02 or Item 7.01 of any such Current Report on Form 8-K).</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 15.1pt"></TD><TD STYLE="width: 23.75pt">(d)</TD><TD>Description of our units, common stock and Class A warrants contained in the Registration Statement on Form 8-A, declared effective
on August 8, 2007 (including any amendment or report filed with the SEC for the purpose of updating such description).</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">All reports and other documents that we file
pursuant to Section 13(a) and 13(c), 14 and 15(d) of the Exchange Act prior to the filing of a post-effective amendment which indicates
that all securities offered hereunder have been sold or which deregisters all such securities then remaining unsold shall be deemed
to be incorporated by reference in this prospectus and to be a apart hereof from the date of filing of such reports and documents.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">We will provide to each person, including
any beneficial owner, to whom a prospectus is delivered, copies of these filings, excluding all exhibits unless an exhibit has
been specifically incorporated by reference in such filings, at no cost, upon written or oral request made to:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">NeoStem, Inc.<BR>
420 Lexington Avenue, Suite 450<BR>
New York, NY 10170<BR>
(212) 584-4180<BR>
Attention: Catherine M. Vaczy, Esq., Vice President and General Counsel</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>WHERE YOU CAN FIND MORE INFORMATION</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">We have filed a registration statement on
Form S-3 with the Securities and Exchange Commission under the Securities Act of 1933. This prospectus omits some information and
exhibits included in the registration statement, copies of which may be obtained upon payment of a fee prescribed by the Commission
or may be examined free of charge at the principal office of the SEC in Washington, D.C.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">We are subject to the informational requirements
of the Securities Exchange Act of 1934 and in accordance therewith file reports, proxy statements and other information with the
SEC. The reports, proxy statements and other information filed by us with the SEC can be inspected and copied at the Public Reference
Room maintained by the SEC at 100 Fifth Street, N.E., Washington, D.C. 20549. Copies of filings can be obtained from the Public
Reference Room maintained by the SEC by calling the SEC at 1-800-SEC-0330. In addition, the Commission maintains a website that
contains reports, proxy and informational statements and other information filed electronically with the SEC at <I>http://www.sec.gov</I>
..</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">You may request, orally or in writing, a
copy of these documents, which will be provided to you at no cost, by contacting Catherine M. Vaczy, Esq., Vice President and General
Counsel, NeoStem, Inc., 420 Lexington Avenue, Suite 450, New York, NY 10170, telephone (212) 584-4180.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">You should rely only on the information contained
in this prospectus, including information incorporated by reference as described above, or any prospectus supplement that we have
specifically referred you to. We have not authorized anyone else to provide you with different information. You should not assume
that the information in this prospectus or any prospectus supplement is accurate as of any date other than the date on the front
of those documents or that any document incorporated by reference is accurate as of any date other than its filing date. You should
not consider this prospectus to be an offer or solicitation relating to the securities in any jurisdiction in which such an offer
or solicitation relating to the securities is not authorized. Furthermore, you should not consider this prospectus to be an offer
or solicitation relating to the securities if the person making the offer or solicitation is not qualified to do so, or if it is
unlawful for you to receive such an offer or solicitation.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 15pt">&nbsp;&nbsp;</P>

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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif"><TR><TD STYLE="text-align: center; width: 100%">&nbsp;</TD></TR></TABLE></DIV>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;15,000,000
Units</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><img src="logo.jpg"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Units Consisting of<BR>
One Share of Common Stock and</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>a Warrant to
Purchase One Share of Common Stock<BR STYLE="mso-special-character: line-break"> </B></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><B>PROSPECTUS SUPPLEMENT</B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: Black 1pt solid">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Maxim Group LLC</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">March 29, 2012</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0.5in"></P>

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    <!-- Field: /Page -->
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left">&nbsp;</P>



<P STYLE="margin: 0"></P>

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end
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
