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Shareholders' Equity (Details) (USD $) | 0 Months Ended | 12 Months Ended |  | 0 Months Ended | 1 Months Ended | 3 Months Ended | 12 Months Ended | 1 Months Ended | 3 Months Ended |  | 1 Months Ended | 3 Months Ended |  |  |  |  | 0 Months Ended | 3 Months Ended | 12 Months Ended |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
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Jul. 22, 2011 | Dec. 31, 2012 | Dec. 31, 2011 | Nov. 19, 2010 | Sep. 30, 2012 Underwriting Offering [Member] | Oct. 31, 2012 Underwriting Offering [Member] | Jul. 31, 2012 Underwriting Offering [Member] | Apr. 30, 2012 Underwriting Offering [Member] | Mar. 31, 2012 Underwriting Offering [Member] | Dec. 31, 2012 Underwriting Offering [Member] | Dec. 31, 2012 Common Stock [Member] | Dec. 31, 2011 Common Stock [Member] | Jul. 31, 2012 May-July 2012 private placement warrants [Member] | Aug. 31, 2012 Warrant holder A [Member] | Dec. 31, 2012 Warrant holder A [Member] | Dec. 31, 2009 Warrant holder A [Member] | Aug. 31, 2012 Warrant holder B [Member] | Dec. 31, 2012 Warrant holder B [Member] | Dec. 31, 2012 July 2012 New Warrant [Member] | Jul. 22, 2011 Underwriting Offering [Member] | Aug. 31, 2012 Aspire Capital Purchase Agreement [Member] | Sep. 30, 2011 Aspire Capital Purchase Agreement [Member] | Sep. 28, 2011 Aspire Capital Purchase Agreement [Member] | Sep. 30, 2012 Private Placement [Member] | Dec. 31, 2012 Private Placement [Member] | Dec. 31, 2012 Private Placement [Member] | Dec. 31, 2011 Private Placement [Member] | Jul. 22, 2011 Private Placement [Member] | Jul. 31, 2012 Minimum [Member] July 2012 New Warrant [Member] | Sep. 30, 2012 Minimum [Member] Private Placement [Member] | Jul. 31, 2012 Maximum [Member] July 2012 New Warrant [Member] | Sep. 30, 2012 Maximum [Member] Private Placement [Member] | Apr. 04, 2011 Employee Stock Option [Member] | Oct. 14, 2011 Non US Equity Plan [Member] Employee Stock Option [Member] | Jun. 02, 2010 Non US Equity Plan [Member] Employee Stock Option [Member] | Oct. 29, 2009 Non US Equity Plan [Member] Employee Stock Option [Member] | Dec. 31, 2012 2009 Equity Plan [Member] Employee Stock Option [Member] | Oct. 14, 2011 2009 Equity Plan [Member] Employee Stock Option [Member] | Jan. 18, 2011 2009 Equity Plan [Member] Employee Stock Option [Member] | Jun. 02, 2010 2009 Equity Plan [Member] Employee Stock Option [Member] | Oct. 29, 2009 2009 Equity Plan [Member] Employee Stock Option [Member] | May 09, 2009 2009 Equity Plan [Member] Employee Stock Option [Member]
Class of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common Stock, Shares Authorized |  | 500,000,000 | 500,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
weighted average estimated fair value of restricted stock |  | $ 0.58 | $ 1.03 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, Restricted Stock Award, Gross |  | 2,295,533 | 3,467,451 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, New Issues |  |  |  |  |  |  |  | 2,000,000 | 15,000,000 |  | 35,732,289 | 19,678,224 |  |  |  |  |  |  |  |  |  |  |  |  | 5,300,000 | 13,400,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common Stock, Par or Stated Value Per Share |  | $ 0.001 | $ 0.001 |  |  |  |  |  | $ 0.40 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of Shares of Common Stock Per Unit |  |  |  |  |  |  |  |  | 1 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrant Expiration Period |  |  |  |  |  |  |  |  | 5 years |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights |  |  |  |  |  | 1.45 | 0.51 |  | 0.51 |  |  |  |  |  |  | 2.5 | 1.85 |  |  | 1.45 |  |  |  |  |  |  |  |  | 0.66 | 0.51 | 0.69 | 0.74 |  |  |  |  |  |  |  |  |  |
Proceeds from Issuance of Private Placement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 6,300,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from Warrant Exercises |  | 6,604,418 | 0 |  | 1,100,000 | 300,000 | 1,600,000 |  |  |  |  |  | 1,400,000 |  |  |  |  |  |  |  |  |  |  |  |  | 7,100,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights, Amount Above Closing Price of Common Stock on Date of Subscription Agreement |  |  |  |  | 0.03 | 0.73 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from Issuance of Common Stock Gross |  |  |  |  |  |  |  | 800,000 | 6,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from Issuance of Common Stock Net |  |  |  |  |  |  |  | 744,000 | 5,297,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants Issued During Period |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 8,900,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Additional Number of Securities Called by Warrants or Rights |  |  |  |  | 2,147,873 | 225,000 |  |  |  |  |  |  |  |  |  |  | 300,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise of Warrants Issued |  |  |  |  |  |  | 3,150,344 |  |  |  |  |  | 2,808,140 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrant Inducements |  | 1,012,819 | 0 |  |  |  |  |  |  | 0 |  |  |  |  | 200,000 |  |  | 400,000 | 400,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,100,000 |  |  | 344,825 |  |  | 0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise price of Warrants |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 1.45 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from Issuance of Warrants |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,100,000 |  |  | 1,100,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, Warrant Inducements |  | 419,690 | 670,000 |  |  |  |  |  |  |  | 1,458,952 |  |  |  |  |  | 1,458,952 |  |  |  |  |  |  | 1,612,903 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Investment Warrants, Exercise Price |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 0.60 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Number of Additional Shares Authorized |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 5,700,000 | 8,700,000 | 4,700,000 |  | 23,750,000 | 17,750,000 | 13,750,000 | 9,750,000 | 3,800,000
Committment Value Under Purchase Agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 20,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Term Of Agreement In Months |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 24 |  | 24 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Discount Applied To Weighted Average Price |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 5.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares, Issued |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 990,099 |  |  |  |  | 4,938,125 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Sale of Stock, Price Per Share |  |  |  | $ 0.945 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 1.20 |  |  |  |  |  |  | $ 1.28 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares Purchased By Director |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 390,625 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares Purchased By Chief Medical And Scientific Officer |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 78,125 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Units offered |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 13,750,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Procceds From Sale Of Stock Gross | 16,500,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Procceds From Sale Of Stock Net | 14,800,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,500,000 |  |  |  | 5,700,000 |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 4,500,000 |  |  |  |  |
Stock Issued During Period, Value, Restricted Stock Award, Gross |  | $ 1,325,100 | $ 3,580,600 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

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- Definition The cash inflow from issuance of rights to purchase common shares at predetermined price (usually issued together with corporate debt). + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=6943989&loc=d3e3255-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 95 -Paragraph 18 -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 95 -Paragraph 19 -Subparagraph a -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 + Details
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- Definition The dollar amount received by subsidiary or equity investee for each share of common stock issued or sold in the stock transaction. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Staff Accounting Bulletin (SAB) -Number Topic 5 -Section H + Details
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- Definition The maximum number of shares (or other type of equity) originally approved (usually by shareholders and board of directors), net of any subsequent amendments and adjustments, for awards under the equity-based compensation plan. As stock or unit options and equity instruments other than options are awarded to participants, the shares or units remain authorized and become reserved for issuance under outstanding awards (not necessarily vested). + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 123R -Paragraph A240 -Subparagraph a -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (a)(3) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition The difference between the maximum number of shares (or other type of equity) authorized for issuance under the plan (including the effects of amendments and adjustments), and the sum of: 1) the number of shares (or other type of equity) already issued upon exercise of options or other equity-based awards under the plan; and 2) shares (or other type of equity) reserved for issuance on granting of outstanding awards, net of cancellations and forfeitures, if applicable. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition Number of new stock issued during the period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 505 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.3-04) -URI http://asc.fasb.org/extlink&oid=6959260&loc=d3e187085-122770 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 505 -SubTopic 10 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=6928386&loc=d3e21463-112644 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher AICPA -Name Accounting Principles Board Opinion (APB) -Number 12 -Paragraph 10 -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 04 -Article 3 Reference 5: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 02 -Paragraph 29, 30 -Article 5 + Details
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- Definition Total number of shares issued during the period, including shares forfeited, as a result of Restricted Stock Awards. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 505 -SubTopic 10 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=6928386&loc=d3e21463-112644 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher AICPA -Name Accounting Principles Board Opinion (APB) -Number 12 -Paragraph 10 -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 129 -Paragraph 4, 5 -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 505 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.3-04) -URI http://asc.fasb.org/extlink&oid=6959260&loc=d3e187085-122770 + Details
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