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Shareholders' Equity (Details) (USD $)
 0 Months Ended 12 Months Ended 0 Months Ended 1 Months Ended 3 Months Ended 12 Months Ended 1 Months Ended 3 Months Ended 1 Months Ended 3 Months Ended 0 Months Ended 3 Months Ended 12 Months Ended
Jul. 22, 2011
Dec. 31, 2012
Dec. 31, 2011
Nov. 19, 2010
Sep. 30, 2012
Underwriting Offering [Member]
Oct. 31, 2012
Underwriting Offering [Member]
Jul. 31, 2012
Underwriting Offering [Member]
Apr. 30, 2012
Underwriting Offering [Member]
Mar. 31, 2012
Underwriting Offering [Member]
Dec. 31, 2012
Underwriting Offering [Member]
Dec. 31, 2012
Common Stock [Member]
Dec. 31, 2011
Common Stock [Member]
Jul. 31, 2012
May-July 2012 private placement warrants [Member]
Aug. 31, 2012
Warrant holder A [Member]
Dec. 31, 2012
Warrant holder A [Member]
Dec. 31, 2009
Warrant holder A [Member]
Aug. 31, 2012
Warrant holder B [Member]
Dec. 31, 2012
Warrant holder B [Member]
Dec. 31, 2012
July 2012 New Warrant [Member]
Jul. 22, 2011
Underwriting Offering [Member]
Aug. 31, 2012
Aspire Capital Purchase Agreement [Member]
Sep. 30, 2011
Aspire Capital Purchase Agreement [Member]
Sep. 28, 2011
Aspire Capital Purchase Agreement [Member]
Sep. 30, 2012
Private Placement [Member]
Dec. 31, 2012
Private Placement [Member]
Dec. 31, 2012
Private Placement [Member]
Dec. 31, 2011
Private Placement [Member]
Jul. 22, 2011
Private Placement [Member]
Jul. 31, 2012
Minimum [Member]
July 2012 New Warrant [Member]
Sep. 30, 2012
Minimum [Member]
Private Placement [Member]
Jul. 31, 2012
Maximum [Member]
July 2012 New Warrant [Member]
Sep. 30, 2012
Maximum [Member]
Private Placement [Member]
Apr. 04, 2011
Employee Stock Option [Member]
Oct. 14, 2011
Non US Equity Plan [Member]
Employee Stock Option [Member]
Jun. 02, 2010
Non US Equity Plan [Member]
Employee Stock Option [Member]
Oct. 29, 2009
Non US Equity Plan [Member]
Employee Stock Option [Member]
Dec. 31, 2012
2009 Equity Plan [Member]
Employee Stock Option [Member]
Oct. 14, 2011
2009 Equity Plan [Member]
Employee Stock Option [Member]
Jan. 18, 2011
2009 Equity Plan [Member]
Employee Stock Option [Member]
Jun. 02, 2010
2009 Equity Plan [Member]
Employee Stock Option [Member]
Oct. 29, 2009
2009 Equity Plan [Member]
Employee Stock Option [Member]
May 09, 2009
2009 Equity Plan [Member]
Employee Stock Option [Member]
Class of Stock [Line Items]                                                                                    
Common Stock, Shares Authorized   500,000,000 500,000,000                                                                              
weighted average estimated fair value of restricted stock   $ 0.58 $ 1.03                                                                              
Stock Issued During Period, Shares, Restricted Stock Award, Gross   2,295,533 3,467,451                                                                              
Stock Issued During Period, Shares, New Issues               2,000,000 15,000,000   35,732,289 19,678,224                         5,300,000 13,400,000                                
Common Stock, Par or Stated Value Per Share   $ 0.001 $ 0.001           $ 0.40                                                                  
Number of Shares of Common Stock Per Unit                 1                                                                  
Warrant Expiration Period                 5 years                                                                  
Class of Warrant or Right, Exercise Price of Warrants or Rights           1.45 0.51   0.51             2.5 1.85     1.45                 0.66 0.51 0.69 0.74                    
Proceeds from Issuance of Private Placement                                                     $ 6,300,000                              
Proceeds from Warrant Exercises   6,604,418 0   1,100,000 300,000 1,600,000           1,400,000                         7,100,000                                
Class of Warrant or Right, Exercise Price of Warrants or Rights, Amount Above Closing Price of Common Stock on Date of Subscription Agreement         0.03 0.73                                                                        
Proceeds from Issuance of Common Stock Gross               800,000 6,000,000                                                                  
Proceeds from Issuance of Common Stock Net               744,000 5,297,000                                                                  
Warrants Issued During Period                                                   8,900,000                                
Class of Warrant or Right, Additional Number of Securities Called by Warrants or Rights         2,147,873 225,000                     300,000                                                  
Exercise of Warrants Issued             3,150,344           2,808,140                                                          
Warrant Inducements   1,012,819 0             0         200,000     400,000 400,000                                              
Class of Warrant or Right, Number of Securities Called by Warrants or Rights                           2,100,000     344,825     0                                            
Exercise price of Warrants                                 $ 1.45                                                  
Proceeds from Issuance of Warrants                           1,100,000     1,100,000                                                  
Stock Issued During Period, Shares, Warrant Inducements   419,690 670,000               1,458,952           1,458,952             1,612,903                                    
Investment Warrants, Exercise Price                                               $ 0.60                                    
Share-based Compensation Arrangement by Share-based Payment Award, Number of Additional Shares Authorized                                                                   5,700,000 8,700,000 4,700,000   23,750,000 17,750,000 13,750,000 9,750,000 3,800,000
Committment Value Under Purchase Agreement                                             20,000,000                                      
Term Of Agreement In Months                                         24   24                                      
Discount Applied To Weighted Average Price                                             5.00%                                      
Shares, Issued                                           990,099         4,938,125                              
Sale of Stock, Price Per Share       $ 0.945                               $ 1.20             $ 1.28                              
Shares Purchased By Director                                                     390,625                              
Shares Purchased By Chief Medical And Scientific Officer                                                     78,125                              
Units offered                                                       13,750,000                            
Procceds From Sale Of Stock Gross 16,500,000                                                                                  
Procceds From Sale Of Stock Net 14,800,000                                                                                  
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant                                                                 1,500,000       5,700,000          
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized                                                                         4,500,000          
Stock Issued During Period, Value, Restricted Stock Award, Gross   $ 1,325,100 $ 3,580,600