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Shareholders' Equity Components of share-based compensation expense (Details) - USD ($) | 12 Months Ended |  |  |  |  |  |
--- | --- | --- | --- | --- | --- | --- | ---
Dec. 31, 2015 | Dec. 31, 2014 | Dec. 31, 2013 | Oct. 10, 2012 | Oct. 14, 2011 | Jan. 18, 2011 | Jun. 02, 2010 | Oct. 29, 2009 | May. 09, 2009
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number | (3,214,033) |  |  |  |  |  |  |  |
Share-based Compensation Expense | $ 9,750,100 | $ 11,209,500 | $ 6,838,700 |  |  |  |  |  |
Cost of Sales [Member] |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Share-based Compensation Expense | 545,300 | 494,200 | 314,000 |  |  |  |  |  |
Research and Development Expense [Member] |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Share-based Compensation Expense | 1,811,500 | 2,058,200 | 822,200 |  |  |  |  |  |
General and Administrative Expense [Member] |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Share-based Compensation Expense | $ 7,393,300 | $ 8,657,100 | $ 5,702,500 |  |  |  |  |  |
Stock Options [Member] | 2009 Equity Plan [Member] |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Common stock, shares authorized (shares) | 8,995,000 | 5,995,000 |  | 450,000 | 2,375,000 | 1,775,000 | 1,375,000 | 975,000 | 380,000
Stock Options [Member] | Non US Equity Plan [Member] |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Common stock, shares authorized (shares) |  |  |  | 570,000 |  |  |  |  |
2015 Equity Plan [Member] [Member] | US Equity Plan [Member] | Stock Options [Member] | 2015 Equity Plan [Member] [Member] |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number | 0 |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number | 0 |  |  |  |  |  |  |  |
Shares Expired | 0 |  |  |  |  |  |  |  |
Common stock, shares authorized (shares) | 4,400,000 |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number | (441,100) |  |  |  |  |  |  |  |
Common Stock, Shares, Outstanding | (3,958,900) |  |  |  |  |  |  |  |
2009 Equity Plan [Member] | US Equity Plan [Member] | Stock Options [Member] | 2009 Equity Plan [Member] |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number | (80,856) |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number | (1,601,033) |  |  |  |  |  |  |  |
Shares Expired | 0 |  |  |  |  |  |  |  |
Common stock, shares authorized (shares) | 8,995,000 |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number | (6,113,425) |  |  |  |  |  |  |  |
Common Stock, Shares, Outstanding | (1,199,686) |  |  |  |  |  |  |  |
2003 Equity Plan [Member] | US Equity Plan [Member] | Stock Options [Member] | 2003 Equity Plan [Member] |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number | (9,250) |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number | (88,993) |  |  |  |  |  |  |  |
Shares Expired | (43,012) |  |  |  |  |  |  |  |
Common stock, shares authorized (shares) | 250,000 |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number | (108,745) |  |  |  |  |  |  |  |
Common Stock, Shares, Outstanding | 0 |  |  |  |  |  |  |  |

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- Definition Represents the expense recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB TOPIC 14.F) -URI http://asc.fasb.org/extlink&oid=27013229&loc=d3e301413-122809 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5047-113901 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1)(i) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Staff Accounting Bulletin (SAB) -Number Topic 14 -Section F + Details
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