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Fair Value Measurements Financial instruments with significant Level 3 inputs (Details) - USD ($) | 12 Months Ended |  |  |
--- | --- | --- | --- | ---
Dec. 31, 2015 | Dec. 31, 2014 | Dec. 31, 2013 | Jun. 30, 2015 | May. 08, 2014 | Oct. 31, 2011
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |  |  |  |  |
Business Combination, Liabilities Arising from Contingencies, Amount Recognized | $ 0 | $ 12,800,000 |  |  |  |
Percentage of Net Sales |  |  |  |  |  | 10.00%
Percentage of license cost |  |  |  |  |  | 30.00%
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward] |  |  |  |  |  |
Available-for-sale Securities | 0 | 7,080,000 |  |  |  |
Business Combination, Contingent Consideration, Liability | 0 | 18,260,000 |  |  | $ 11,900,000 |
Fair Value, Net Asset (Liability) | 0 | 18,260,000 |  |  |  |
Changes in acquisition-related contingent consideration | (18,260,000) | (3,080,000) | $ 1,900,000 |  |  |
Fair Value, Inputs, Level 1 [Member] |  |  |  |  |  |
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward] |  |  |  |  |  |
Available-for-sale Securities | 0 | 0 |  |  |  |
Business Combination, Contingent Consideration, Liability | 0 | 0 |  |  |  |
Fair Value, Inputs, Level 2 [Member] |  |  |  |  |  |
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward] |  |  |  |  |  |
Available-for-sale Securities | 0 | 7,080,000 |  |  |  |
Business Combination, Contingent Consideration, Liability | 0 | 0 |  |  |  |
Fair Value, Inputs, Level 3 [Member] |  |  |  |  |  |
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward] |  |  |  |  |  |
Available-for-sale Securities | 0 | 0 |  |  |  |
Business Combination, Contingent Consideration, Liability | $ 0 | 18,260,000 |  |  |  |
Amorcyte, LLC [Member] |  |  |  |  |  |
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward] |  |  |  |  |  |
Business Combination, Contingent Consideration, Liability |  | $ 5,500,000 |  | $ 0 |  |

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