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Shareholders' Equity (Tables)
 12 Months Ended
Dec. 31, 2015
Shareholders’ Equity [Abstract]  
Schedule of Compensation Cost for Share-based Payment Arrangements, Allocation of Share-based Compensation Costs by Plan [Table Text Block]
The number of remaining shares authorized to be issued under the various equity plans are as follows as of December 31, 2015:
 
 2003 Equity Plan
 
 2009 Equity Plan
 
 2015 Equity Plan
Shares Authorized for Issuance
250,000

 
8,995,000

 
4,400,000

Outstanding Stock Options
(108,745
)
 
(6,113,425
)
 
(441,100
)
Exercised Stock Options
(9,250
)
 
(80,856
)
 
—

Restricted stock or equity grants issued under Equity Plans
(88,993
)
 
(1,601,033
)
 
—

Shares Expired
(43,012
)
 
—

 
—

Total common shares remaining to be issued under the Equity Plans
—

 
1,199,686

 
3,958,900
Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block]
The following table summarizes the activity for stock options and warrants for the year ended December 31, 2015:
 
Stock Options
 
Warrants
 
Shares
 
Weighted Average Exercise Price
 
Weighted Average Remaining Contractual Term (Years)
 
Aggregate Intrinsic Value (In Thousands)
 
Shares
 
Weighted Average Exercise Price
 
Weighted Average Remaining Contractual Term (Years)
 
Aggregate Intrinsic Value (In Thousands)
Outstanding at December 31, 2014
4,427,234

 
$
9.19

 
6.93
 
$
28.6

 
3,550,956

 
$
14.12

 
2.12
 
$
1.0

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Changes during the Year:
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Granted
3,414,388

 
$
3.01

 
 
 
 
 
—

 
$
—

 
 
 
 
Exercised
—

 
$
—

 
 
 
 
 
—

 
$
—

 
 
 
 
Forfeited
(437,770
)
 
$
4.92

 
 
 
 
 
—

 
$
—

 
 
 
 
Expired
(740,372
)
 
$
7.83

 
 
 
 
 
(336,923
)
 
$
17.91

 
 
 
 
Outstanding at December 31, 2015
6,663,480

 
$
6.46

 
6.88
 
$
0.1

 
3,214,033

 
$
13.72

 
1.26
 
$
—

Vested at December 31, 2015 or expected to vest in the future
6,663,480

 
$
6.58

 
6.79
 
$
0.1

 
3,214,033

 
$
13.72

 
1.26
 
$
—

Exercisable at December 31, 2015
4,837,711

 
$
7.46

 
6.12
 
$
—

 
3,214,033

 
$
13.72

 
1.26
 
$
—

The following table summarizes the components of share-based compensation expense for the years ended December 31, 2015, 2014 , and 2013 ($ in thousands):
 
Year Ended December 31,
 
2015
 
2014
 
2013
Cost of revenues
$
545.3

 
$
494.2

 
$
314.0

Research and development
1,811.5

 
2,058.2

 
822.2

Selling, general and administrative
7,393.3

 
8,657.1

 
5,702.5

Total share-based compensation expense
$
9,750.1

 
$
11,209.5

 
$
6,838.7

 
 
 
 
 
 
Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block]
During the years ended December 31, 2015 and 2014, the Company did not issue warrants for services.
 
 
 
 
 
 
Restricted Stock [Table Text Block]
During the years ended December 31, 2015 and 2014, the Company issued restricted stock for services as follows ($ in thousands, except share data):

 
 
 
  
 
2015
 
2014
 
Number of Restricted Stock Issued
 
928,000

 
917,907

 
Value of Restricted Stock Issued
 
$
2,488.6

 
$
4,996.3