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Shareholders' Equity - Stock options and warrants (Details) | 3 Months Ended | 12 Months Ended
--- | --- | ---
Mar. 31, 2017 USD ($) $ / shares $ / warrant shares | Dec. 31, 2016 USD ($) $ / shares $ / warrant shares
Stock Options and Warrants [Line Items] |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value | $ | $ 386,500 | $ 0
Common Stock Warrants, Shares | 336,062 | 388,062
Weighted Average Exercise Price, Warrants Outstanding | $ / warrant | 80.40 | 76.50
Weighted Average Remaining Contractual Term warrant outstanding | 1 year 1 month 24 days | 1 year 2 months 27 days
Aggregate Intrinsic Value, Warrants Outstanding | $ | $ 0 | $ 0
Warrants Granted | 0 |
Warrants Canceled | (52,000) |
Weighted Average Exercise Price, Warrants Granted | $ / shares | $ 0.00 |
Warrants Exercised | 0 |
Weighted Average Exercise Price, Warrants Exercised | $ / shares | $ 0.00 |
Warrants Expired | 0 |
Weighted Average Exercise Price, Warrants Expired | $ / shares | $ 0.00 |
Weighted Average Exercise Price, Warrants Canceled | $ / shares | $ 51.30 |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Exercisable, Aggregate Intrinsic Value | $ | $ 357,700 |
shares, vested and expected to vest | 336,062 |
Weighted Average Exercise Price, Warrants vested & expected to vest | $ / warrant | 80.40 |
Aggregate Intrinsic Value, Warrants vested and expected to vest | $ | $ 0 |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value | $ | $ 133,600 |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number | 336,062 |
Weighted Average Exercise Price, Warrants Exercisable | $ / warrant | 80.40 |
weighted Average Remaining Contractual Term, warrants vested | 1 year 1 month 24 days |
Aggregate Intrinsic Value, Warrants vested | $ | $ 0 |
US Equity Plan [Member] |  |
Stock Options and Warrants [Line Items] |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number | 1,133,459 | 952,790
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price | $ / shares | $ 33.30 | $ 39.90
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term | 7 years 9 months 18 days | 7 years 7 months 6 days
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Net of Forfeitures | 209,418 |
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price | $ / shares | $ 3.60 |
Stock Options Exercised | 0 |
Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price | $ / shares | $ 0.00 |
Stock Options Expired | (6,294) |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Expirations in Period, Weighted Average Exercise Price | $ / shares | $ 8.40 |
Stock Options Forfeited | (22,455) |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price | $ / shares | $ 43.20 |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number | 1,103,988 |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price | $ / shares | $ 34.00 |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term | 7 years 9 months 4 days |
Weighted Average Remaining Contractual Term, Warrants Vested and Expect to Vest | 1 year 1 month 24 days |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Exercisable, Number | 821,156 |
Weighted average estimated fair value of shares granted | $ / shares | $ 43.10 |
Options, Vested, weighted Average Remaining Contractual Term | 7 years 2 months 23 days |

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