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Consolidated Statements of Cash Flows - USD ($)
 3 Months Ended
Mar. 31, 2017
Mar. 31, 2016
Cash flows from operating activities:    
Net loss $ (9,793,324) $ (12,047,796)
Adjustments to reconcile net loss to net cash used in operating activities:    
Share-based compensation 533,198 851,246
Depreciation and amortization 655,340 737,158
Loss on disposal of assets 47,301 591,307
Deferred income taxes 49,531 53,378
Changes in operating assets and liabilities:    
Prepaid and other current assets 241,087 (116,610)
Accounts receivable (277,033) (46,730)
Deferred costs 43,657 (1,074,435)
Unearned revenues 126,468 3,069,840
Other assets 57,968 81,754
Accounts payable, accrued liabilities and other liabilities (1,772,101) (127,410)
Net cash used in operating activities (10,087,908) (8,028,298)
Cash flows from investing activities:    
Acquisition of property, plant and equipment (171,276) (1,044,827)
Net cash used in investing activities (171,276) (1,044,827)
Cash flows from financing activities:    
Payments Related to Tax Withholding for Share-based Compensation (23,647) 0
Net proceeds from issuance of common stock 3,241,460 1,096,208
Repayment of long-term debt (756,966) (6,348,646)
Proceeds from notes payable 400,998 368,615
Repayment of notes payable (310,063) (335,297)
Proceeds From Licensing Agreements, Milestone Payments 5,000,000 0
Sale of ownership interest in subsidiary 0 19,400,000
Net cash provided by financing activities 7,551,782 14,180,880
Net (decrease) increase in cash and cash equivalents (2,707,402) 5,107,755
Cash and cash equivalents at beginning of period 14,705,008 20,318,411
Cash and cash equivalents at end of period 11,997,606 25,426,166
Cash paid during the period for:    
Interest 130,204 973,729
Proceeds from Stock Options Exercised 0 0
Proceeds from exercise of warrants 0 $ 0
Hitachi Chemical Co., LTD [Member]    
Cash flows from financing activities:    
Proceeds From Licensing Agreements, Milestone Payments $ (5,000,000)