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Share-Based Compensation (Tables)
6 Months Ended
Jun. 30, 2017
Share-based Compensation [Abstract]  
Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs
The following table summarizes the components of share-based compensation expense for the three and six months ended June 30, 2017 and 2016 (in thousands):
 
Three Months Ended June 30,
 
Six Months Ended June 30,
 
2017
 
2016
 
2017
 
2016
Research and development
$
162.0

 
$

 
$
208.2

 
$
71.0

General and administrative
1,261.7

 
253.5

 
1,611.2

 
812.0

Discontinued operations
751.4

 
82.0

 
888.9

 
352.0

Total share-based compensation expense
$
2,175.1

 
$
335.5

 
$
2,708.3

 
$
1,235.0

 
 
 
 
 
 
 
 
Disclosure of Share-based Compensation Arrangements by Share-based Payment Award
Total compensation cost related to nonvested awards not yet recognized and the weighted-average periods over which the awards are expected to be recognized at June 30, 2017 were as follows (in thousands):
 
Stock Options
 
Restricted Stock
Unrecognized compensation cost
$
38.8

 
$
13.6

Expected weighted-average period in years of compensation cost to be recognized
0.69

 
0.39

Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Total fair value of shares vested and the weighted average estimated fair values of shares granted for the six months ended June 30, 2017 and 2016 were as follows, as adjusted for the Reverse Stock Split (in thousands):
 
Stock Options
 
Six Months Ended June 30,
 
2017
 
2016
Total fair value of shares vested
$
5,001.7

 
$
1,153.1

Weighted average estimated fair value of shares granted
$
1.72

 
$
4.02