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Share-Based Compensation (Tables) | 12 Months Ended
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Dec. 31, 2017
Disclosure of Compensation Related Costs, Share-based Payments [Abstract] |
Schedule of Share-based Compensation, Stock Options, Activity | The following table summarizes the activity for stock options and warrants for the year ended December 31, 2017:
| Stock Options |  | Warrants
| Shares |  | Weighted Average Exercise Price |  | Weighted Average Remaining Contractual Term (Years) |  | Aggregate Intrinsic Value (In Thousands) |  | Shares |  | Weighted Average Exercise Price |  | Weighted Average Remaining Contractual Term (Years) |  | Aggregate Intrinsic Value (In Thousands)
Outstanding at December 31, 2016 | 952,790 |  |  | $ | 39.90 |  |  | 7.60 |  | $ | — |  |  | 388,062 |  |  | $ | 76.50 |  |  | 1.24 |  | $ | — |
Changes during the Year: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Granted | 448,057 |  |  | $ | 11.70 |  |  |  |  |  |  | — |  |  | $ | — |  |  |  |  |
Exercised | (3,835 | ) |  | $ | 4.70 |  |  |  |  |  |  | — |  |  | $ | — |  |  |  |  |
Forfeited | (244,413 | ) |  | $ | 18.80 |  |  |  |  |  |  | (1,937 | ) |  | $ | 700.00 |  |  |  |  |
Expired | (80,100 | ) |  | $ | 35.80 |  |  |  |  |  |  | (176,307 | ) |  | $ | 103.90 |  |  |  |  |
Outstanding at December 31, 2017 | 1,072,499 |  |  | $ | 33.50 |  |  | 4.76 |  | $ | 0.1 |  |  | 209,818 |  |  | $ | 53.20 |  |  | 0.95 |  | $ | — |
Vested at December 31, 2017 or expected to vest in the future | 1,072,107 |  |  | $ | 33.5 |  |  | 4.76 |  | $ | 0.1 |  |  | 209,818 |  |  | $ | 53.20 |  |  | 0.95 |  | $ | — |
Exercisable at December 31, 2017 | 1,063,759 |  |  | $ | 32.9 |  |  | 4.77 |  | $ | 0.1 |  |  | 209,818 |  |  | $ | 53.20 |  |  | 0.95 |  | $ | — |
The following table summarizes the components of share-based compensation expense for the years ended December 31, 2017 and 2016 ($ in thousands):
| Year Ended December 31,
| 2017 |  | 2016
Research and development | $ | 268.9 |  |  | $ | 262.3 |
General and administrative | 1,694.3 |  |  | 1,511.5 |
Discontinued operations | 888.9 |  |  | 830.6 |
Total share-based compensation expense | $ | 2,852.1 |  |  | $ | 2,604.3 |
Disclosure of Share-based Compensation Arrangements by Share-based Payment Award [Table Text Block] | Total compensation cost related to nonvested awards not yet recognized and the weighted-average periods over which the awards are expected to be recognized at December 31, 2017 were as follows ($ in thousands):
| Stock Options |  | Restricted Stock
Unrecognized compensation cost | $ | 39.5 |  |  | $ | 97.2 |
Expected weighted-average period in years of compensation cost to be recognized | 0.61 |  |  | 1.84 |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value [Table Text Block] | Total fair value of shares vested and the weighted average estimated fair values of shares granted for the years ended December 31, 2017 and 2016 were as follows ($ in thousands):
|  | Stock Options
|  | Year Ended December 31,
|  | 2017 |  | 2016
Total fair value of shares vested |  | $ | 5,001.7 |  |  | $ | 2,359.8 |
Weighted average estimated fair value of shares granted |  | 1.72 |  |  | 3.23 |
Schedule of Range of Fair Value of Stock Options and Warrants | The range of assumptions made in calculating the fair values of stock options was as follow:
| Stock Options
| Year Ended December 31,
| 2017 |  | 2016
Expected term - minimum (in years) | 6 |  | 5
Expected term - maximum (in years) | 6 |  | 10
Expected volatility - minimum | 71% |  | 73%
Expected volatility - maximum | 74% |  | 76%
Weighted Average volatility | 35% |  | 74%
Expected dividend yield | — |  | —
Risk-free interest rate - minimum | 1.99% |  | 1.07%
Risk-free interest rate - maximum | 2.28% |  | 2.19%

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- Definition Tabular disclosure of components of a stock option or other award plan under which equity-based compensation is awarded to employees, typically comprised of the amount of unearned compensation (deferred compensation cost), compensation expense, and changes in the quantity and fair value of the shares (or other type of equity) granted, exercised, forfeited, and issued and outstanding pertaining to that plan. Disclosure may also include nature and general terms of such arrangements that existed during the period and potential effects of those arrangements on shareholders, effect of compensation cost arising from equity-based payment arrangements on the income statement, method of estimating the fair value of the goods or services received, or the fair value of the equity instruments granted, during the period, cash flow effects resulting from equity-based payment arrangements and, for registrants that accelerate vesting of out of the money share options, reasons for the decision to accelerate. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5047-113901 + Details
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- Definition Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (d) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (e) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the weighted-average grant-date fair value of equity options or other equity instruments granted during the year. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (d)(1) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 + Details
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