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Stockholders' Equity (Tables) | 12 Months Ended
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Dec. 31, 2017
Equity [Abstract] |
Schedule of Compensation Cost for Share-based Payment Arrangements, Allocation of Share-based Compensation Costs by Plan | The number of remaining shares authorized to be issued under the various equity plans are as follows as of December 31, 2017:
| 2003 Equity Plan |  | 2009 Equity Plan |  | 2015 Equity Plan
Shares Authorized for Issuance | 25,000 |  |  | 899,500 |  |  | 440,000 |
2016 Evergreen increase of shares | — |  |  | — |  |  | 226,932 |
2017 Evergreen increase of shares |  |  |  |  | 328,232 |
Outstanding Stock Options | (5,006 | ) |  | (432,916 | ) |  | (634,577 | )
Exercised Stock Options | (925 | ) |  | (8,093 | ) |  | (3,835 | )
Restricted stock or equity grants issued under Equity Plans | (8,922 | ) |  | (156,467 | ) |  | — |
Shares Expired | (10,147 | ) |  | (302,024 | ) |  | (314,254 | )
Total common shares remaining to be issued under the Equity Plans | — |  |  | — |  |  | 42,498 |
Schedule of Share-based Compensation, Stock Options, Activity | The following table summarizes the activity for stock options and warrants for the year ended December 31, 2017:
| Stock Options |  | Warrants
| Shares |  | Weighted Average Exercise Price |  | Weighted Average Remaining Contractual Term (Years) |  | Aggregate Intrinsic Value (In Thousands) |  | Shares |  | Weighted Average Exercise Price |  | Weighted Average Remaining Contractual Term (Years) |  | Aggregate Intrinsic Value (In Thousands)
Outstanding at December 31, 2016 | 952,790 |  |  | $ | 39.90 |  |  | 7.60 |  | $ | — |  |  | 388,062 |  |  | $ | 76.50 |  |  | 1.24 |  | $ | — |
Changes during the Year: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Granted | 448,057 |  |  | $ | 11.70 |  |  |  |  |  |  | — |  |  | $ | — |  |  |  |  |
Exercised | (3,835 | ) |  | $ | 4.70 |  |  |  |  |  |  | — |  |  | $ | — |  |  |  |  |
Forfeited | (244,413 | ) |  | $ | 18.80 |  |  |  |  |  |  | (1,937 | ) |  | $ | 700.00 |  |  |  |  |
Expired | (80,100 | ) |  | $ | 35.80 |  |  |  |  |  |  | (176,307 | ) |  | $ | 103.90 |  |  |  |  |
Outstanding at December 31, 2017 | 1,072,499 |  |  | $ | 33.50 |  |  | 4.76 |  | $ | 0.1 |  |  | 209,818 |  |  | $ | 53.20 |  |  | 0.95 |  | $ | — |
Vested at December 31, 2017 or expected to vest in the future | 1,072,107 |  |  | $ | 33.5 |  |  | 4.76 |  | $ | 0.1 |  |  | 209,818 |  |  | $ | 53.20 |  |  | 0.95 |  | $ | — |
Exercisable at December 31, 2017 | 1,063,759 |  |  | $ | 32.9 |  |  | 4.77 |  | $ | 0.1 |  |  | 209,818 |  |  | $ | 53.20 |  |  | 0.95 |  | $ | — |
The following table summarizes the components of share-based compensation expense for the years ended December 31, 2017 and 2016 ($ in thousands):
| Year Ended December 31,
| 2017 |  | 2016
Research and development | $ | 268.9 |  |  | $ | 262.3 |
General and administrative | 1,694.3 |  |  | 1,511.5 |
Discontinued operations | 888.9 |  |  | 830.6 |
Total share-based compensation expense | $ | 2,852.1 |  |  | $ | 2,604.3 |
Restricted Stock | During the years ended December 31, 2017 and 2016, the Company issued restricted stock for services as follows ($ in thousands, except share data):
|  | 2017 |  | 2016 |
Number of Restricted Stock Issued |  | 181,908 |  |  | 126,849 |  |
Value of Restricted Stock Issued |  | $ | 627.7 |  |  | $ | 698.1 |  |

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